公开(公告)号：US08620422B2

公开(公告)日：2013-12-31

申请号：US11862508

申请日：2007-09-27

申请人： Robert S. Kieval ,  Martin Rossing ,  Adam Cates ,  Alejandro Covalin

发明人： Robert S. Kieval ,  Martin Rossing ,  Adam Cates ,  Alejandro Covalin

IPC分类号： A61N1/36

CPC分类号： A61N1/0551 ,  A61N1/0556 ,  A61N1/0558 ,  A61N1/36114 ,  A61N1/36117

摘要： A tissue stimulation device includes an electrode array having at least four independently switchable electrodes. In one embodiment, the electrode array comprises a flexible base to which the electrodes are fixed that flexes to encompass at least a portion of an artery or other elongate biological structure. The electrodes are electrically coupled to and energized by a signal generator coupled to a control system. In one embodiment, the array of electrodes are configured such that a suitable signal pattern for stimulation pulses between or among a set of the switchable electrodes may be determined without having to reposition the electrode assembly by using a series of signal patterns activating different combinations of switchable electrodes in response to sub-stimulation test signals to determine a signal pattern that provides suitable patient response. In another embodiment, the array of electrodes includes an array of selectively activatable multi-polar electrodes.

摘要翻译： 组织刺激装置包括具有至少四个可独立切换的电极的电极阵列。 在一个实施例中，电极阵列包括柔性基座，电极被固定到柔性基座上，该电极弯曲以包围动脉或其他细长生物结构的至少一部分。 电极电耦合到耦合到控制系统的信号发生器并由其激励。 在一个实施例中，电极阵列被配置为使得可以确定用于在一组可切换电极之间或之间进行刺激脉冲的合适信号图案，而不必通过使用一系列信号图案来激活电极组件，所述信号图案激活不同的可切换组合 电极响应亚刺激测试信号以确定提供合适的患者反应的信号图案。 在另一个实施例中，电极阵列包括可选择性激活的多极电极的阵列。

公开(公告)号：US08249705B1

公开(公告)日：2012-08-21

申请号：US12043754

申请日：2008-03-06

申请人： Robert S. Kieval ,  Martin Rossing

发明人： Robert S. Kieval ,  Martin Rossing

IPC分类号： A61N1/362

CPC分类号： A61N1/36114 ,  A61N1/36117

摘要： Described here are devices, systems, and methods for improving left ventricular function in a patient with systolic heart failure with left ventricular dysfunction using baroreflex activation therapy. In general the systems have at least one electrode and a control system in communication with the electrode, the control system including a processor and memory, wherein the memory includes software defining a stimulus regime configured to effect improvement in left ventricular function. The methods for improving left ventricular function in a subject typically include identifying a patient in need of left ventricular function improvement and stimulating a baroreceptor with a baroreceptor activation device to improve left ventricular function.

摘要翻译： 这里描述的是用于使用压力反射激活治疗来改善具有左心室功能障碍的收缩期心力衰竭患者的左心室功能的装置，系统和方法。 通常，系统具有至少一个与电极连通的电极和控制系统，所述控制系统包括处理器和存储器，其中所述存储器包括限定被配置为实现左心室功能改善的刺激方案的软件。 用于改善受试者左心室功能的方法通常包括识别需要左心室功能改善的患者，并用压力感受器激活装置刺激压力感受器以改善左心室功能。

公开(公告)号：US20080208286A1

公开(公告)日：2008-08-28

申请号：US12112899

申请日：2008-04-30

申请人： Robert S. Kieval ,  Martin Rossing

发明人： Robert S. Kieval ,  Martin Rossing

IPC分类号： A61N1/34

CPC分类号： A61N1/08 ,  A61N1/0556 ,  A61N1/36071 ,  A61N1/36114

摘要： Systems and methods provide baroreflex activation to treat or reduce pain and/or to cause or enhance sedation or sleep. Methods involve activating the baroreflex system to provide pain reduction, sedation, improved sleep or some combination thereof. Systems include at least one baroreflex activation device, at least one sensor for sensing physiological activity of the patient, and a processor coupled with the baroreflex activation device(s) and the sensor(s) for processing sensed data received from the sensor and for activating the baroreflex activation device. In some embodiments, the system is fully implantable within a patient, such as in an intravascular, extravascular or intramural location.

摘要翻译： 系统和方法提供压力反射激活以治疗或减少疼痛和/或引起或增强镇静或睡眠。 方法包括激活压力反射系统以提供疼痛减轻，镇静，改善的睡眠或其某些组合。 系统包括至少一个压力反射激活装置，用于感测患者的生理活动的至少一个传感器，以及与压力反射激活装置和传感器耦合的处理器，用于处理从传感器接收的感测数据并激活 压力反射激活装置。 在一些实施例中，该系统可完全植入患者体内，例如在血管内，血管外或壁内位置。

公开(公告)号：US20120289844A1

公开(公告)日：2012-11-15

申请号：US13556830

申请日：2012-07-24

申请人： Robert S. KIEVAL ,  Martin Rossing

发明人： Robert S. KIEVAL ,  Martin Rossing

IPC分类号： A61N1/365 ,  A61B5/02 ,  A61N1/362

CPC分类号： A61N1/36114 ,  A61N1/36117

摘要： Described here are devices, systems, and methods for improving left ventricular function in a patient with systolic heart failure with left ventricular dysfunction using baroreflex activation therapy. In general the systems have at least one electrode and a control system in communication with the electrode, the control system including a processor and memory, wherein the memory includes software defining a stimulus regime configured to effect improvement in left ventricular function. The methods for improving left ventricular function in a subject typically include identifying a patient in need of left ventricular function improvement and stimulating a baroreceptor with a baroreceptor activation device to improve left ventricular function.

摘要翻译： 这里描述的是用于使用压力反射激活治疗来改善具有左心室功能障碍的收缩期心力衰竭患者的左心室功能的装置，系统和方法。 通常，系统具有至少一个与电极连通的电极和控制系统，所述控制系统包括处理器和存储器，其中所述存储器包括限定被配置为实现左心室功能改善的刺激方案的软件。 用于改善受试者左心室功能的方法通常包括识别需要左心室功能改善的患者，并用压力感受器激活装置刺激压力感受器以改善左心室功能。

公开(公告)号：US20110137374A1

公开(公告)日：2011-06-09

申请号：US12940798

申请日：2010-11-05

申请人： Robert S. Kieval ,  Martin Rossing

发明人： Robert S. Kieval ,  Martin Rossing

IPC分类号： A61N1/36

CPC分类号： A61N1/08 ,  A61N1/0556 ,  A61N1/36071 ,  A61N1/36114

摘要： Systems and methods provide baroreflex activation to treat or reduce pain and/or to cause or enhance sedation or sleep. Methods involve activating the baroreflex system to provide pain reduction, sedation, improved sleep or some combination thereof. Systems include at least one baroreflex activation device, at least one sensor for sensing physiological activity of the patient, and a processor coupled with the baroreflex activation device(s) and the sensor(s) for processing sensed data received from the sensor and for activating the baroreflex activation device. In some embodiments, the system is fully implantable within a patient, such as in an intravascular, extravascular or intramural location.

摘要翻译： 系统和方法提供压力反射激活以治疗或减少疼痛和/或引起或增强镇静或睡眠。 方法包括激活压力反射系统以提供疼痛减轻，镇静，改善的睡眠或其某些组合。 系统包括至少一个压力反射激活装置，用于感测患者的生理活动的至少一个传感器，以及与压力反射激活装置和传感器耦合的处理器，用于处理从传感器接收的感测数据并激活 压力反射激活装置。 在一些实施例中，该系统可完全植入患者体内，例如在血管内，血管外或壁内位置。

公开(公告)号：US20090030262A1

公开(公告)日：2009-01-29

申请号：US12245636

申请日：2008-10-03

申请人： Robert S. Kieval ,  Martin Rossing

发明人： Robert S. Kieval ,  Martin Rossing

IPC分类号： A61M21/00 ,  A61M19/00

CPC分类号： A61N1/08 ,  A61N1/0556 ,  A61N1/36071 ,  A61N1/36114

摘要： Systems and methods provide baroreflex activation to treat or reduce pain and/or to cause or enhance sedation or sleep. Methods involve activating the baroreflex system to provide pain reduction, sedation, improved sleep or some combination thereof. Systems include at least one baroreflex activation device, at least one sensor for sensing physiological activity of the patient, and a processor coupled with the baroreflex activation device(s) and the sensor(s) for processing sensed data received from the sensor and for activating the baroreflex activation device. In some embodiments, the system is fully implantable within a patient, such as in an intravascular, extravascular or intramural location.

摘要翻译： 系统和方法提供压力反射激活以治疗或减少疼痛和/或引起或增强镇静或睡眠。 方法包括激活压力反射系统以提供疼痛减轻，镇静，改善的睡眠或其某些组合。 系统包括至少一个压力反射激活装置，用于感测患者的生理活动的至少一个传感器，以及与压力反射激活装置和传感器耦合的处理器，用于处理从传感器接收的感测数据并激活 压力反射激活装置。 在一些实施例中，该系统可完全植入患者体内，例如在血管内，血管外或壁内位置。

公开(公告)号：US20080215111A1

公开(公告)日：2008-09-04

申请号：US11933218

申请日：2007-10-31

申请人： Robert S. Kieval ,  Martin Rossing

发明人： Robert S. Kieval ,  Martin Rossing

IPC分类号： A61N1/05 ,  A61N1/08

CPC分类号： A61N1/36114 ,  A61N1/08 ,  A61N1/36117

摘要： Devices, systems and methods are described which control blood pressure, nervous system activity, and neurohormonal activity by activating baroreceptors. By selectively and controllably activating baroreceptors, the present invention reduces excessive blood pressure, sympathetic nervous system activity and neurohormonal activity, thereby minimizing their deleterious effects on the heart, vasculature and other organs and tissues. A baroreceptor activation device is positioned near a low-pressure baroreceptor, preferably in the venous system, heart, or pulmonary vasculature.

摘要翻译： 描述了通过激活压力感受器来控制血压，神经系统活性和神经激素活性的装置，系统和方法。 本发明通过选择性地和可控制地激活压力感受器，降低过度的血压，交感神经系统活性和神经激素活性，从而使其对心脏，脉管系统和其他器官和组织的有害作用最小化。 压力感受器激活装置位于低压压力感受器附近，优选位于静脉系统，心脏或肺脉管系统中。

公开(公告)号：US20080082137A1

公开(公告)日：2008-04-03

申请号：US11862508

申请日：2007-09-27

申请人： Robert S. Kieval ,  Martin Rossing

发明人： Robert S. Kieval ,  Martin Rossing

IPC分类号： A61N1/08

CPC分类号： A61N1/0551 ,  A61N1/0556 ,  A61N1/0558 ,  A61N1/36114 ,  A61N1/36117

摘要： A tissue stimulation device includes an electrode array having at least four independently switchable electrodes. In one embodiment, the electrode array comprises a flexible base to which the electrodes are fixed that flexes to encompass at least a portion of an artery or other elongate biological structure. The electrodes are electrically coupled to and energized by a signal generator coupled to a control system. In one embodiment, the array of electrodes are configured such that a suitable signal pattern for stimulation pulses between or among a set of the switchable electrodes may be determined without having to reposition the electrode assembly by using a series of signal patterns activating different combinations of switchable electrodes in response to sub-stimulation test signals to determine a signal pattern that provides suitable patient response. In another embodiment, the array of electrodes includes an array of selectively activatable multi-polar electrodes.

摘要翻译： 组织刺激装置包括具有至少四个可独立切换的电极的电极阵列。 在一个实施例中，电极阵列包括柔性基座，电极被固定到柔性基座上，该电极弯曲以包围动脉或其他细长生物结构的至少一部分。 电极电耦合到耦合到控制系统的信号发生器并由其激励。 在一个实施例中，电极阵列被配置为使得可以确定用于在一组可切换电极之间或之间进行刺激脉冲的合适信号图案，而不必通过使用一系列信号图案来激活电极组件，所述信号图案激活不同的可切换组合 电极响应亚刺激测试信号以确定提供合适的患者反应的信号图案。 在另一个实施例中，电极阵列包括可选择性激活的多极电极的阵列。

公开(公告)号：US08560076B2

公开(公告)日：2013-10-15

申请号：US12940798

申请日：2010-11-05

申请人： Robert S. Kieval ,  Martin Rossing

发明人： Robert S. Kieval ,  Martin Rossing

IPC分类号： A61N1/18

CPC分类号： A61N1/08 ,  A61N1/0556 ,  A61N1/36071 ,  A61N1/36114

摘要： Systems and methods provide baroreflex activation to treat or reduce pain and/or to cause or enhance sedation or sleep. Methods involve activating the baroreflex system to provide pain reduction, sedation, improved sleep or some combination thereof. Systems include at least one baroreflex activation device, at least one sensor for sensing physiological activity of the patient, and a processor coupled with the baroreflex activation device(s) and the sensor(s) for processing sensed data received from the sensor and for activating the baroreflex activation device. In some embodiments, the system is fully implantable within a patient, such as in an intravascular, extravascular or intramural location.

摘要翻译： 系统和方法提供压力反射激活以治疗或减少疼痛和/或引起或增强镇静或睡眠。 方法包括激活压力反射系统以提供疼痛减轻，镇静，改善的睡眠或其某些组合。 系统包括至少一个压力反射激活装置，用于感测患者的生理活动的至少一个传感器，以及与压力反射激活装置和传感器耦合的处理器，用于处理从传感器接收的感测数据并激活 压力反射激活装置。 在一些实施例中，该系统可完全植入患者体内，例如在血管内，血管外或壁内位置。

公开(公告)号：US08478414B2

公开(公告)日：2013-07-02

申请号：US12112899

申请日：2008-04-30

申请人： Robert S. Kieval ,  Martin Rossing

发明人： Robert S. Kieval ,  Martin Rossing

IPC分类号： A61N1/08

CPC分类号： A61N1/08 ,  A61N1/0556 ,  A61N1/36071 ,  A61N1/36114

摘要： Systems and methods provide baroreflex activation to treat or reduce pain and/or to cause or enhance sedation or sleep. Methods involve activating the baroreflex system to provide pain reduction, sedation, improved sleep or some combination thereof. Systems include at least one baroreflex activation device, at least one sensor for sensing physiological activity of the patient, and a processor coupled with the baroreflex activation device(s) and the sensor(s) for processing sensed data received from the sensor and for activating the baroreflex activation device. In some embodiments, the system is fully implantable within a patient, such as in an intravascular, extravascular or intramural location.