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    Apparatus and method for the treatment of headache
    1.
    发明授权
    Apparatus and method for the treatment of headache 有权
    用于治疗头痛的装置和方法

    公开(公告)号：US08560075B2

    公开(公告)日：2013-10-15

    申请号：US12578369

    申请日：2009-10-13

    Applicant: Alejandro Covalin

    Inventor： Alejandro Covalin

    IPC: A61N1/00

    CPC classification number: A61B18/00 ,  A61N1/0456 ,  A61N1/36021

    Abstract: A battery-operated transcutaneous electrical nerve stimulator (TENS) to treat headache pain in an abortive and/or preventive manner. The TENS unit and its electrodes are built into a unitary device which facilitates a self-administered treatment. In some embodiments, the pulses are monophasic. In other embodiments, pairs of biphasic pulses are provided, wherein each pair of biphasic pulses includes a first pulse having a first polarity separated by a gap in time from a second pulsed having an opposite polarity. In some embodiments, each pulse in each biphasic pair is of a duration equal to that of the other pulse of the pair. In some embodiments, the duration of each pulse is between about 50 microseconds and about 400 microseconds, and the gap in time between pulses of a pair is between about 50 and 100 microseconds.

    Abstract translation: 电池操作的经皮电神经刺激器（TENS）以流产和/或预防方式治疗头痛。 TENS单元及其电极内置于一体式设备中，便于进行自我管理。 在一些实施例中，脉冲是单相的。 在其它实施例中，提供成对的双相脉冲，其中每对双相脉冲包括具有第一极性的第一脉冲，第一脉冲具有与具有相反极性的第二脉冲的时间间隔分开的第一极性。 在一些实施例中，每个双相对中的每个脉冲的持续时间等于该对中另一个脉冲的持续时间。 在一些实施例中，每个脉冲的持续时间在约50微秒和约400微秒之间，并且一对脉冲之间的时间间隔在大约50和100微秒之间。

    Powered stimulation device
    2.
    发明授权
    Powered stimulation device 有权
    动力刺激装置

    公开(公告)号：US07634314B2

    公开(公告)日：2009-12-15

    申请号：US11290724

    申请日：2005-11-30

    Applicant: Robert Applebaum ,  Alejandro Covalin ,  Philip Klein

    Inventor： Robert Applebaum ,  Alejandro Covalin ,  Philip Klein

    IPC: A61N1/00 ,  A61H1/00 ,  A61H1/02 ,  A61H5/00

    CPC classification number: A61H15/0085 ,  A61H39/002 ,  A61H2015/0035 ,  A61H2201/169

    Abstract: A device and related method of use are disclosed which employ electrically-conductive wheels to massage and contact the skin to deliver electrical current. The present invention has both cosmetic and drug applications. In a cosmetic application, the rolling action of the wheels provides a light pressure skin massage that is important to reduce the appearance of skin surface irregularities. In a drug application, the device may be used to deliver ingredients of a conductive gel to or into the skin.

    Abstract translation: 公开了一种使用的装置和相关方法，其使用导电轮来按摩和接触皮肤以传递电流。 本发明具有化妆品和药物应用。 在化妆品应用中，轮的滚动动作提供了轻压皮肤按摩，其对于减少皮肤表面不规则的外观是重要的。 在药物应用中，该装置可用于将导电凝胶的成分递送至皮肤或进入皮肤。

    COLLECTING AND TRANSFERRING PHYSIOLOGICAL DATA
    4.
    发明申请
    COLLECTING AND TRANSFERRING PHYSIOLOGICAL DATA 审中-公开
    收集和转移生理数据

    公开(公告)号：US20140108025A1

    公开(公告)日：2014-04-17

    申请号：US13800659

    申请日：2013-03-13

    Applicant: Ruben Gerardo Echeverria Cabrera ,  Hugo Luis Villalobos Canto ,  Luis Alberto Munoz Ubando ,  Jose Ramon Atoche Ensenat ,  Freddy Antonio Ix Andrade ,  Alejandro Covalin Shaftman

    Inventor： Ruben Gerardo Echeverria Cabrera ,  Hugo Luis Villalobos Canto ,  Luis Alberto Munoz Ubando ,  Jose Ramon Atoche Ensenat ,  Freddy Antonio Ix Andrade ,  Alejandro Covalin Shaftman

    IPC: G06F19/00

    CPC classification number: G06F19/3418 ,  G16H10/60

    Abstract: The present invention extends to methods, systems, and computer program products for collecting and transferring physiological data. Different physiological monitoring appliances can be attached to a portable physiological data collection device. Each physiological monitoring appliance can collect a different physiological data (blood glucose data, heart rate data, etc.) from an individual. Different physiological data can be collected and stored at the portable physiological data collection device. In response to a triggering event, a connection can be established to an external computer system. The stored physiological data can be transferred over the established connection to the external computer system. In some embodiments, the external computer system is a healthcare server that shares collected physiological data as well as other healthcare information with designated entities (e.g., family, doctors, etc.). The healthcare server can share healthcare information in accordance with patient configured rules so that patients have control over dissemination their healthcare information.

    Abstract translation: 本发明扩展到用于收集和传送生理数据的方法，系统和计算机程序产品。 可以将不同的生理监测装置附接到便携式生理数据采集装置。 每个生理监测装置可从个体收集不同的生理数据（血糖数据，心率数据等）。 不同的生理数据可以被收集并存储在便携式生理数据采集装置中。 响应于触发事件，可以建立到外部计算机系统的连接。 存储的生理数据可以通过建立的连接传送到外部计算机系统。 在一些实施例中，外部计算机系统是与指定实体（例如，家庭，医生等）共享所收集的生理数据以及其他保健信息的保健服务器。 保健服务器可以根据患者配置的规则分享医疗保健信息，以便患者能够控制传播其医疗保健信息。

    Systems, devices and methods for the treatment of neurological disorders and conditions
    5.
    发明授权
    Systems, devices and methods for the treatment of neurological disorders and conditions 有权
    用于治疗神经障碍和病症的系统，装置和方法

    公开(公告)号：US08688220B2

    公开(公告)日：2014-04-01

    申请号：US12898675

    申请日：2010-10-05

    Applicant: Christopher DeGiorgio ,  Ian A. Cook ,  Alejandro Covalin

    Inventor： Christopher DeGiorgio ,  Ian A. Cook ,  Alejandro Covalin

    IPC: A61N1/04

    CPC classification number: A61N1/36082 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/0492 ,  A61N1/0504 ,  A61N1/0529 ,  A61N1/0551 ,  A61N1/36014 ,  A61N1/36021 ,  A61N1/36025 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36075 ,  A61N1/36096 ,  A61N1/36157 ,  A61N1/3616 ,  A61N1/36171 ,  A61N1/36175

    Abstract: The present disclosure relates to methods, devices, and systems used for the treatment of and/or promoting recovery from various neurological disorders and conditions, including epilepsy and other seizure disorders and movement and other related disorders; for promoting recovery from acute or chronic brain injury (e.g. stroke, hypoxia/ischemia, head trauma, subarachnoid hemorrhage, and other forms of brain injury, for awakening and/or promoting the recovery of patients in various levels of coma, altered mental status or vegetative state); or for promoting recovery from chronic daily headache and migraine and related disorders via external (cutaneous) stimulation of the sensory branches of the trigeminal nerve in the face and forehead. More specifically, devices and electrode assemblies configured for stimulation of the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, nasal and infratrochlear nerves are disclosed.

    Abstract translation: 本公开涉及用于治疗和/或促进从各种神经障碍和病症恢复的方法，装置和系统，包括癫痫和其他癫痫发作障碍以及运动和其它相关疾病; 用于促进急性或慢性脑损伤（例如中风，缺氧/缺血，头部创伤，蛛网膜下腔出血和其他形式的脑损伤）的恢复，用于唤醒和/或促进各种昏迷水平的患者的恢复，改变的精神状态或 营养状态）; 或通过外部（皮肤）刺激面部和额头中三叉神经的感觉分支来促进慢性日常头痛和偏头痛及相关疾病的恢复。 更具体地，公开了被配置用于刺激眶上，眶上，眶下，z骨，z骨，z骨，z骨，鼻和神经性神经的装置和电极组件。

    METHOD AND SYSTEM FOR MODULATING ENERGY EXPENDITURE AND NEUROTROPHIC FACTORS
    7.
    发明申请
    METHOD AND SYSTEM FOR MODULATING ENERGY EXPENDITURE AND NEUROTROPHIC FACTORS 审中-公开
    调节能源支出和神经营养因子的方法和系统

    公开(公告)号：US20080046012A1

    公开(公告)日：2008-02-21

    申请号：US11851821

    申请日：2007-09-07

    Applicant: Alejandro Covalin ,  Jack Judy ,  Avi Feshali

    Inventor： Alejandro Covalin ,  Jack Judy ,  Avi Feshali

    IPC: A61N1/00

    CPC classification number: A61N1/36025 ,  A61N1/36082

    Abstract: A method system for modulating the energy expenditure and/or the expressed brain-derived neurotrophic factor (BDNF) in the brain of an individual is performed by a system that includes a control device that generates a stimulation pattern from a predetermined set of stimulation parameters, and that converts the stimulation pattern into a stimulation signal. A stimulation signal delivery mechanism, configured for implantation into a selected part of the brain, receives the stimulation signal from the control device and delivers the signal to the selected part of the brain. The stimulation signal may be an electrical signal delivered by a brain-implantable electrode, or a chemical signal in the form of a drug dosage regimen delivered by an implantable micropump under the control of the control device. Modulation of the energy expenditure and/or BDNF is achieved by the stimulation of the hypothalamus, either directly or indirectly, by the stimulation signal.

    Abstract translation: 用于调节个体脑中能量消耗和/或表达的脑源性神经营养因子（BDNF）的方法系统由包括从预定刺激参数组产生刺激模式的控制装置的系统执行， 并将刺激模式转换为刺激信号。 被配置为植入到脑的选定部分中的刺激信号传递机构接收来自控制装置的刺激信号，并将该信号传送到脑的选定部分。 刺激信号可以是由脑可植入电极传递的电信号，或者是由控制装置的控制下由可植入的微型泵递送的药物剂量形式的化学信号。 通过刺激信号直接或间接地刺激下丘脑来实现能量消耗和/或BDNF的调节。

    Continuous blood glucose monitor
    8.
    发明授权
    Continuous blood glucose monitor 有权
    连续血糖监测仪

    公开(公告)号：US09204828B2

    公开(公告)日：2015-12-08

    申请号：US13306335

    申请日：2011-11-29

    Applicant: Daniel Rogers Burnett ,  Alejandro Covalin

    Inventor： Daniel Rogers Burnett ,  Alejandro Covalin

    IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/1486

    CPC classification number: A61B5/14532 ,  A61B5/1455 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/4839

    Abstract: A device may be implanted subcutaneously with an attached catheter inserted within, e.g., the peritoneal cavity of a subject. The catheter and/or device may also be inserted into another space, e.g., subcutaneous, vascular, peritoneal, cerebrospinal, pleural spaces, etc. The peritoneal fluid which normally collects and/or flows through the peritoneal cavity may be detected by the catheter and analyzed via the device to detect the concentration of glucose within the fluid.

    Abstract translation: 皮下可以将装置植入插入在受试者的例如腹膜腔内的附接的导管。 导管和/或装置也可插入另一空间，例如皮下，血管，腹膜，脑脊液，胸膜腔等。通常通过腹膜腔收集和/或流经的腹膜液可通过导管和 通过装置分析以检测流体内葡萄糖的浓度。

    METHOD AND APPARATUS FOR THE TREATMENT OF HEADACHE
    9.
    发明申请
    METHOD AND APPARATUS FOR THE TREATMENT OF HEADACHE 审中-公开
    治疗头痛的方法和装置

    公开(公告)号：US20140236052A1

    公开(公告)日：2014-08-21

    申请号：US14054721

    申请日：2013-10-15

    Applicant: Alejandro Covalin

    Inventor： Alejandro Covalin

    IPC: A61B18/00

    CPC classification number: A61B18/00 ,  A61N1/0456 ,  A61N1/36021

    Abstract: A battery-operated transcutaneous electrical nerve stimulator (TENS) to treat headache pain in an abortive and/or preventive manner. The TENS unit and its electrodes are built into a unitary device which facilitates a self-administered treatment. In some embodiments, the pulses are monophasic. In other embodiments, pairs of biphasic pulses are provided, wherein each pair of biphasic pulses includes a first pulse having a first polarity separated by a gap in time from a second pulsed having an opposite polarity. In some embodiments, each pulse in each biphasic pair is of a duration equal to that of the other pulse of the pair. In some embodiments, the duration of each pulse is between about 50 microseconds and about 400 microseconds, and the gap in time between pulses of a pair is between about 50 and 100 microseconds.

    Abstract translation: 电池操作的经皮电神经刺激器（TENS）以流产和/或预防方式治疗头痛。 TENS单元及其电极内置于一体式设备中，便于进行自我管理。 在一些实施例中，脉冲是单相的。 在其它实施例中，提供成对的双相脉冲，其中每对双相脉冲包括具有第一极性的第一脉冲，第一脉冲具有与具有相反极性的第二脉冲的时间间隔分开的第一极性。 在一些实施例中，每个双相对中的每个脉冲的持续时间等于该对中另一个脉冲的持续时间。 在一些实施例中，每个脉冲的持续时间在约50微秒和约400微秒之间，并且一对脉冲之间的时间间隔在大约50和100微秒之间。

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