公开(公告)号：US07625580B1

公开(公告)日：2009-12-01

申请号：US09724382

申请日：2000-11-28

申请人： Robert S. Langer ,  Jennifer Elisseeff ,  Kristi Anseth ,  Derek Sims

发明人： Robert S. Langer ,  Jennifer Elisseeff ,  Kristi Anseth ,  Derek Sims

IPC分类号： A61K2/02

CPC分类号： A61L27/50 ,  A61L27/38 ,  A61L27/3817 ,  A61L27/3852 ,  A61L27/52 ,  A61L2400/06 ,  A61L2430/06

摘要： Compositions for tissue engineering and drug delivery have been developed based on solutions of two or more polymers which form semi-interpenetrating or interpenetrating polymer networks upon exposure to active species following injection at a site in a patient in need thereof. The polymers crosslink to themselves but not to each other; semi-interpenetrating networks are formed when only one of the polymers crosslink. The resulting viscous solutions retain the biologically active molecules or cells at the site of injection until release or tissue formation, respectfully, occurs.As a result of studies conducted with polymer-cell suspensions forming interpenetrating polymer networks, it has been determined that polymer solutions can be formulated wherein the active species is provided by exposure of the polymer solution to an exogenous source of active species, typically electromagnetic radiation, preferably light. Studies demonstrate that light will penetrate through skin, body fluids (such as synovial fluid) and membranes and polymerize the polymer solutions. The polymer solutions can be crosslinked ionically or covalently, to form a hydrogel, semi-interpenetrating polymer network or an interpenetrating polymer network.

摘要翻译： 已经开发了用于组织工程和药物递送的组合物，其基于在需要其的患者的部位注射后暴露于活性物质时形成半互穿或互穿聚合物网络的两种或更多种聚合物的溶液。 聚合物自身交联而不是彼此交联; 当只有一种聚合物交联时，形成半互穿网络。 所得粘稠溶液将生物活性分子或细胞保留在注射部位，直到发生释放或组织形成。 作为通过形成互穿聚合物网络的聚合物 - 细胞悬浮液进行的研究的结果，已经确定可以配制聚合物溶液，其中通过将聚合物溶液暴露于外源性活性物质（通常是电磁辐射）来提供活性物质， 最好是光。 研究表明，光将穿透皮肤，体液（如滑液）和膜，并聚合聚合物溶液。 聚合物溶液可以离子交换或共价交联，以形成水凝胶，半互穿聚合物网络或互穿聚合物网络。

公开(公告)号：US06224893B1

公开(公告)日：2001-05-01

申请号：US08862740

申请日：1997-05-23

申请人： Robert S. Langer ,  Jennifer H. Elisseeff ,  Kristi Anseth ,  Derek Sims

发明人： Robert S. Langer ,  Jennifer H. Elisseeff ,  Kristi Anseth ,  Derek Sims

IPC分类号： A61K908

CPC分类号： A61K9/0024 ,  A61K9/0019 ,  A61K47/32 ,  A61L27/26 ,  A61L27/38 ,  A61L27/3804 ,  A61L27/3852 ,  A61L27/50 ,  A61L27/52 ,  Y10S525/903 ,  Y10S525/937

摘要： Compositions for tissue engineering and drug delivery have been developed based on solutions of two or more polymers which form semi-interpenetrating or interpenetrating polymer networks upon exposure to active species following injection at a site in a patient in need thereof. The polymers crosslink to themselves but not to each other; semi-interpenetrating networks are formed when only one of the polymers crosslink. The resulting viscous solutions retain the biologically active molecules or cells at the site of injection until release or tissue formation, respectfully, occurs. As a result of studies conducted with polymer-cell suspensions forming interpenetrating polymer networks, it has been determined that polymer solutions can be formulated wherein the active species is provided by exposure of the polymer solution to an exogenous souce of active species, typically electromagnetic radiation, preferably light. Studies demonstrate that light will penetrate through skin, body fluids (such as synovial fluid) and membranes and polymerize the polymer solutions. The polymer solutions can be crosslinked ionically or covalently, to form a hydrogel, semi-interpenetrating polymer network or an interpenetrating polymer network.

摘要翻译： 已经开发了用于组织工程和药物递送的组合物，其基于在需要其的患者的部位注射后暴露于活性物质时形成半互穿或互穿聚合物网络的两种或更多种聚合物的溶液。 聚合物自身交联而不是彼此交联; 当只有一种聚合物交联时，形成半互穿网络。 所得到的粘性溶液将生物活性分子或细胞保留在注射部位，直到发生释放或组织形成。作为通过聚合物 - 细胞悬浮液形成互穿聚合物网络进行的研究的结果，已经确定聚合物溶液可以 其中通过将聚合物溶液暴露于活性物质的外源性水，通常是电磁辐射，优选轻的提供活性物质。 研究表明，光将穿透皮肤，体液（如滑液）和膜，并聚合聚合物溶液。 聚合物溶液可以离子交换或共价交联，以形成水凝胶，半互穿聚合物网络或互穿聚合物网络。

公开(公告)号：US20050098953A1

公开(公告)日：2005-05-12

申请号：US11003116

申请日：2004-12-03

申请人： Dana Kirk ,  Shaun Mitchell ,  Derek Sims

发明人： Dana Kirk ,  Shaun Mitchell ,  Derek Sims

IPC分类号： A63F9/02 ,  F41J5/20 ,  F41J5/24 ,  G09F7/12 ,  A63B67/00

CPC分类号： F41J5/24 ,  A63F9/0243 ,  A63F2250/0428 ,  A63F2250/0442 ,  F41J5/20 ,  G09F7/12

摘要： A method for temporarily adhering an image to a surface is shown utilizing liquid soluble substrates that have printed images of liquid insoluble ink. The liquid soluble substrate is positioned on a surface, such as a billboard, sidewalk, parking lot, telephone pole, skin, clothing, etc., and a liquid, typically water, is applied to the liquid soluble substrate and/or to the surface in such a quantity, and at such a temperature, and at such a pressure and velocity so as to be absorbed by the liquid soluble substrate in a sponge-like fashion. As the substrate dries, it takes on the shape of the surface, conforming and adhering to the surface through a mechanical interlock therewith. Various coatings may be applied to extend the longevity of the substrate. The liquid soluble substrate may be removed from the surface by applying a sufficient quantity of liquid at a sufficient temperature, pressure and velocity.

摘要翻译： 使用具有液体不溶性油墨的印刷图像的液体可溶性基材，示出了将图像暂时粘附到表面的方法。 液体可溶性基材定位在诸如广告牌，人行道，停车场，电话杆，皮肤，衣服等的表面上，液体（通常为水）被施加到液体可溶性基底和/或表面 以这样的量，在这样的温度下，以这样的压力和速度，以海绵状的方式被液体可溶性基材吸收。 当基材干燥时，它采取表面的形状，通过与其表面的机械互锁，使其表面贴合并附着在表面上。 可以施加各种涂层以延长基材的寿命。 可以通过在足够的温度，压力和速度下施加足够量的液体来从表面除去液体可溶性基材。