公开(公告)号：US5972890A

公开(公告)日：1999-10-26

申请号：US398046

申请日：1995-02-28

申请人： Robert S. Lees ,  Ann M. Lees ,  Allan Fischman ,  Ing-Lung Shih ,  Mark A. Findeis

发明人： Robert S. Lees ,  Ann M. Lees ,  Allan Fischman ,  Ing-Lung Shih ,  Mark A. Findeis

IPC分类号： A61K38/00 ,  A61K49/14 ,  A61K51/08 ,  A61K51/12 ,  C07K14/775 ,  C07K14/78 ,  A61K38/02 ,  A61K49/00 ,  C07K5/00

CPC分类号： A61K49/14 ,  A61K49/085 ,  A61K51/08 ,  C07K14/775 ,  C07K14/78 ,  A61K2123/00 ,  A61K38/00

摘要： Vascular disease including asymptomatic atherosclerosis can be diagnosed by administering a synthetic peptide or peptide analog having an affinity for, and propensity to accumulate at, a site of vascular injury to a patient, and then detecting the location of the peptide or peptide analog within the patient's vascular system. The synthetic peptide or peptide analog may include an amino acid sequence sufficiently duplicative of the amino acid sequence of a region of either the apolipoprotein B, apolipoprotein A-I, or elastin proteins such that the peptide or peptide analog accumulates at a site of vascular injury.

摘要翻译： 包括无症状动脉粥样硬化的血管疾病可以通过施用对患者的血管损伤部位具有亲和性和倾向积累的合成肽或肽类似物来诊断，然后检测患者体内肽或肽类似物的位置 血管系统。 合成肽或肽类似物可以包括足够重复载脂蛋白B，载脂蛋白A-1或弹性蛋白蛋白的区域的氨基酸序列的氨基酸序列，使得肽或肽类似物在血管损伤部位积累。

公开(公告)号：US5955055A

公开(公告)日：1999-09-21

申请号：US469692

申请日：1995-06-06

申请人： Robert S. Lees ,  Ann M. Lees ,  Allan Fischman ,  Ing-Lung Shih ,  Mark A. Findeis

发明人： Robert S. Lees ,  Ann M. Lees ,  Allan Fischman ,  Ing-Lung Shih ,  Mark A. Findeis

IPC分类号： A61K38/00 ,  A61K49/14 ,  A61K51/08 ,  A61K51/12 ,  C07K14/775 ,  C07K14/78

CPC分类号： A61K49/14 ,  A61K49/085 ,  A61K51/08 ,  C07K14/775 ,  C07K14/78 ,  A61K2123/00 ,  A61K38/00

摘要： Vascular disease including asymptomatic atherosclerosis can be diagnosed by administering a synthetic peptide or peptide analog having an affinity for, and propensity to accumulate at, a site of vascular injury to a patient, and then detecting the location of the peptide or peptide analog within the patient's vascular system. The synthetic peptide or peptide analog may include an amino acid sequence sufficiently duplicative of the amino acid sequence of a region of either the apolipoprotein B, apolipoprotein A-I, or elastin proteins such that the peptide or peptide analog accumulates at a site of vascular injury.

摘要翻译： 包括无症状动脉粥样硬化的血管疾病可以通过施用对患者的血管损伤部位具有亲和性和倾向积累的合成肽或肽类似物来诊断，然后检测患者的肽或肽类似物的位置 血管系统。 合成肽或肽类似物可以包括足够重复载脂蛋白B，载脂蛋白A-1或弹性蛋白蛋白的区域的氨基酸序列的氨基酸序列，使得肽或肽类似物在血管损伤部位积累。

公开(公告)号：US5726153A

公开(公告)日：1998-03-10

申请号：US468543

申请日：1995-06-06

申请人： Robert S. Lees ,  Ann M. Lees ,  Allan Fischman ,  Ing-Lung Shih ,  Mark A. Findeis

发明人： Robert S. Lees ,  Ann M. Lees ,  Allan Fischman ,  Ing-Lung Shih ,  Mark A. Findeis

IPC分类号： A61K38/00 ,  A61K49/14 ,  A61K51/08 ,  A61K51/12 ,  C07K14/775 ,  C07K14/78 ,  A61K38/04 ,  C07K5/00 ,  C07K7/00

CPC分类号： A61K49/085 ,  A61K49/14 ,  A61K51/08 ,  C07K14/775 ,  C07K14/78 ,  A61K2123/00 ,  A61K38/00

摘要： Vascular disease including asymptomatic atherosclerosis can be diagnosed by administering a synthetic peptide or peptide analog having an affinity for, and propensity to accumulate at, a site of vascular injury to a patient, and then detecting the location of the peptide or peptide analog within the patient's vascular system. The synthetic peptide or peptide analog may include an amino acid sequence sufficiently duplicative of the amino acid sequence of a region of either the apolipoprotein B, apolipoprotein A-I, or elastin proteins such that the peptide or peptide analog accumulates at a site of vascular injury.

公开(公告)号：US07807384B2

公开(公告)日：2010-10-05

申请号：US12137832

申请日：2008-06-12

申请人： Ann M. Lees ,  Robert S. Lees ,  Simon W. Law ,  Anibal A. Arjona

发明人： Ann M. Lees ,  Robert S. Lees ,  Simon W. Law ,  Anibal A. Arjona

IPC分类号： G01N33/53 ,  C07K1/00

CPC分类号： A61K49/0004 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/705 ,  G01N33/6893 ,  G01N33/92 ,  G01N2800/044 ,  G01N2800/323

摘要： Isolated polynucleotides encoding novel polypeptides which are capable of binding to native and methylated LDL (low density lipoprotein), the isolated polypeptides, called LBPs (LDL binding proteins), and biologically active fragments and analogs thereof, are described. Also described are methods for determining if an animal is at risk for atherosclerosis, methods for evaluating an agent for use in treating atherosclerosis, methods for treating atherosclerosis, and methods for treating a cell having an abnormality in structure or metabolism of LBP. Pharmaceutical compositions and vaccine compositions are also provided.

摘要翻译： 描述了编码能够结合天然和甲基化的LDL（低密度脂蛋白），所述分离的多肽（称为LBP（LDL结合蛋白））及其生物活性片段及其类似物的分离的多核苷酸的分离多核苷酸。 还描述了用于确定动物是否处于动脉粥样硬化风险的方法，用于评估用于治疗动脉粥样硬化的药剂的方法，治疗动脉粥样硬化的方法，以及用于治疗LBP的结构或代谢异常的细胞的方法。 还提供药物组合物和疫苗组合物。

公开(公告)号：US06632923B1

公开(公告)日：2003-10-14

申请号：US09616289

申请日：2000-07-14

申请人： Ann M. Lees ,  Robert S. Lees ,  Simon W. Law ,  Anibal A. Arjona

发明人： Ann M. Lees ,  Robert S. Lees ,  Simon W. Law ,  Anibal A. Arjona

IPC分类号： C07K1400

CPC分类号： A61K49/0004 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/705 ,  G01N33/6893 ,  G01N33/92 ,  G01N2800/044 ,  G01N2800/323

摘要： Isolated polynucleotides encoding novel polypeptides which are capable of binding to native and methylated LDL (low density lipoprotein), the isolated polypeptides, called LBPs (LDL binding proteins), and biologically active fragments and analogs thereof, are described. Also described are methods for determining if an animal is at risk for atherosclerosis, methods for evaluating an agent for use in treating atherosclerosis, methods for treating atherosclerosis, and methods for treating a cell having an abnormality in structure or metabolism of LBP. Pharmaceutical compositions and vaccine compositions are also provided.

摘要翻译： 描述了编码能够结合天然和甲基化的LDL（低密度脂蛋白），所述分离的多肽（称为LBP（LDL结合蛋白））及其生物活性片段及其类似物的分离的多核苷酸的分离多核苷酸。 还描述了用于确定动物是否处于动脉粥样硬化风险的方法，用于评估用于治疗动脉粥样硬化的药剂的方法，治疗动脉粥样硬化的方法，以及用于治疗LBP的结构或代谢异常的细胞的方法。 还提供了药物组合物和疫苗组合物

公开(公告)号：US06355451B1

公开(公告)日：2002-03-12

申请号：US08979608

申请日：1997-11-26

申请人： Ann M. Lees ,  Robert S. Lees ,  Simon W. Law ,  Anibal A. Arjona

发明人： Ann M. Lees ,  Robert S. Lees ,  Simon W. Law ,  Anibal A. Arjona

IPC分类号： C12P2106

CPC分类号： A61K49/0004 ,  A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C07K14/705 ,  G01N33/6893 ,  G01N33/92 ,  G01N2800/044 ,  G01N2800/323

摘要： Isolated polynucleotides encoding novel polypeptides which are capable of binding to native and methylated LDL (low density lipoprotein), the isolated polypeptides, called LBPs (LDL binding proteins), and biologically active fragments and analogs thereof, are described. Also described are methods for determining if an animal is at risk for atherosclerosis, methods for evaluating an agent for use in treating atherosclerosis, methods for treating atherosclerosis, and methods for treating a cell having an abnormality in structure or metabolism of LBP. Pharmaceutical compositions and vaccine compositions are also provided.

摘要翻译： 描述了编码能够结合天然和甲基化的LDL（低密度脂蛋白），所述分离的多肽（称为LBP（LDL结合蛋白））及其生物活性片段及其类似物的分离的多核苷酸的分离多核苷酸。 还描述了用于确定动物是否处于动脉粥样硬化风险的方法，用于评估用于治疗动脉粥样硬化的药剂的方法，治疗动脉粥样硬化的方法，以及用于治疗LBP的结构或代谢异常的细胞的方法。 还提供药物组合物和疫苗组合物。

公开(公告)号：US06605588B1

公开(公告)日：2003-08-12

申请号：US09517849

申请日：2000-03-02

申请人： Ann M. Lees ,  Robert S. Lees ,  Simon W. Law ,  Anibal A. Arjona

发明人： Ann M. Lees ,  Robert S. Lees ,  Simon W. Law ,  Anibal A. Arjona

IPC分类号： A01N3718

CPC分类号： A61K49/0004 ,  A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C07K14/705 ,  G01N33/6893 ,  G01N33/92 ,  G01N2800/044 ,  G01N2800/323 ,  Y10S514/814

摘要： Isolated polynucleotides encoding novel polypeptides which are capable of binding to native and methylated LDL (low density lipoprotein), the isolated polypeptides, called LBPs (LDL binding proteins), and biologically active fragments and analogs thereof, are described. Also described are methods for determining if an animal is at risk for atherosclerosis, methods for evaluating an agent for use in treating atherosclerosis, methods for treating atherosclerosis, and methods for treating a cell having an abnormality in structure or metabolism of LBP. Pharmaceutical compositions and vaccine compositions are also provided.

公开(公告)号：US07244410B2

公开(公告)日：2007-07-17

申请号：US10616187

申请日：2003-07-09

申请人： Ann M. Lees ,  Robert S. Lees ,  Simon W. Law ,  Anibal A. Arjona

发明人： Ann M. Lees ,  Robert S. Lees ,  Simon W. Law ,  Anibal A. Arjona

IPC分类号： A61K51/10 ,  G01N33/53

CPC分类号： A61K49/0004 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/705 ,  G01N33/6893 ,  G01N33/92 ,  G01N2800/044 ,  G01N2800/323

摘要： Isolated polynucleotides encoding novel polypeptides which are capable of binding to native and methylated LDL (low density lipoprotein), the isolated polypeptides, called LBPs (LDL binding proteins), and biologically active fragments and analogs thereof, are described. Also described are methods for determining if an animal is at risk for atherosclerosis, methods for evaluating an agent for use in treating atherosclerosis, methods for treating atherosclerosis, and methods for treating a cell having an abnormality in structure or metabolism of LBP. Pharmaceutical compositions and vaccine compositions are also provided.

摘要翻译： 描述了编码能够结合天然和甲基化的LDL（低密度脂蛋白），所述分离的多肽（称为LBP（LDL结合蛋白））及其生物活性片段及其类似物的分离的多核苷酸的分离多核苷酸。 还描述了用于确定动物是否处于动脉粥样硬化风险的方法，用于评估用于治疗动脉粥样硬化的药剂的方法，治疗动脉粥样硬化的方法，以及用于治疗LBP的结构或代谢异常的细胞的方法。 还提供药物组合物和疫苗组合物。

公开(公告)号：US06878817B2

公开(公告)日：2005-04-12

申请号：US09976740

申请日：2001-10-12

申请人： Ann M. Lees ,  Robert S. Lees ,  Simon W. Law ,  Anibal A. Arjona

发明人： Ann M. Lees ,  Robert S. Lees ,  Simon W. Law ,  Anibal A. Arjona

IPC分类号： G01N33/50 ,  A61K35/74 ,  A61K35/76 ,  A61K36/00 ,  A61K38/00 ,  A61K39/00 ,  A61K39/39 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61K49/00 ,  A61P9/10 ,  C07K14/47 ,  C07K14/705 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  G01N33/68 ,  G01N33/92 ,  C07H21/04 ,  C07K1/00 ,  C12N15/00

CPC分类号： A61K49/0004 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/705 ,  G01N33/6893 ,  G01N33/92 ,  G01N2800/044 ,  G01N2800/323

摘要： Isolated polynucleotides encoding novel polypeptides which are capable of binding to native and methylated LDL (low density lipoprotein), the isolated polypeptides, called LBPs (LDL binding proteins), and biologically active fragments and analogs thereof, are described. Also described are methods for determining if an animal is at risk for atherosclerosis, methods for evaluating an agent for use in treating atherosclerosis, methods for treating atherosclerosis, and methods for treating a cell having an abnormality in structure or metabolism of LBP. Pharmaceutical compositions and vaccine compositions are also provided.

摘要翻译： 描述了编码能够结合天然和甲基化的LDL（低密度脂蛋白），所述分离的多肽（称为LBP（LDL结合蛋白））及其生物活性片段及其类似物的分离的多核苷酸的分离多核苷酸。 还描述了用于确定动物是否处于动脉粥样硬化风险的方法，用于评估用于治疗动脉粥样硬化的药剂的方法，治疗动脉粥样硬化的方法，以及用于治疗LBP的结构或代谢异常的细胞的方法。 还提供药物组合物和疫苗组合物。

公开(公告)号：US07402395B2

公开(公告)日：2008-07-22

申请号：US10671242

申请日：2003-09-24

申请人： Ann M. Lees ,  Robert S. Lees ,  Simon W. Law ,  Anibal A. Arjona

发明人： Ann M. Lees ,  Robert S. Lees ,  Simon W. Law ,  Anibal A. Arjona

IPC分类号： G01N33/53 ,  C07K14/00

CPC分类号： A61K49/0004 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/705 ,  G01N33/6893 ,  G01N33/92 ,  G01N2800/044 ,  G01N2800/323

摘要： Isolated polynucleotides encoding novel polypeptides which are capable of binding to native and methylated LDL (low density lipoprotein), the isolated polypeptides, called LBPs (LDL binding proteins), and biologically active fragments and analogs thereof, are described. Also described are methods for determining if an animal is at risk for atherosclerosis, methods for evaluating an agent for use in treating atherosclerosis, methods for treating atherosclerosis, and methods for treating a cell having an abnormality in structure or metabolism of LBP. Pharmaceutical compositions and vaccine compositions are also provided.

摘要翻译： 描述了编码能够结合天然和甲基化的LDL（低密度脂蛋白），所述分离的多肽（称为LBP（LDL结合蛋白））及其生物活性片段及其类似物的分离的多核苷酸的分离多核苷酸。 还描述了用于确定动物是否处于动脉粥样硬化风险的方法，用于评估用于治疗动脉粥样硬化的药剂的方法，治疗动脉粥样硬化的方法，以及用于治疗LBP的结构或代谢异常的细胞的方法。 还提供药物组合物和疫苗组合物。