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    SUBSTITUTED-(QUINAZOLINYL)PHENYL THIOPHENYL-SULFONYLUREAS, METHODS FOR MAKING AND INTERMEDIATES THEREOF
    1.
    发明申请
    SUBSTITUTED-(QUINAZOLINYL)PHENYL THIOPHENYL-SULFONYLUREAS, METHODS FOR MAKING AND INTERMEDIATES THEREOF 审中-公开
    取代 - （喹喔啉基）苯基噻吩磺酰亚胺，其制备方法及其中间体

    公开(公告)号：US20070208045A1

    公开(公告)日：2007-09-06

    申请号：US11556518

    申请日：2006-11-03

    申请人： Robert Scarborough ,  Carroll Scarborough ,  Anjali Pandey ,  Mukund Mehrotra ,  Michael Cruskie ,  David White ,  George Yiannikouros

    发明人： Robert Scarborough ,  Carroll Scarborough ,  Anjali Pandey ,  Mukund Mehrotra ,  Michael Cruskie ,  David White ,  George Yiannikouros

    IPC分类号： A61K31/517 ,  C07D409/02

    CPC分类号： C07D409/12

    摘要： The present invention provides sulfonylurea compounds of formula (VIII) and pharmaceutically acceptable derivatives thereof and a process for making thereof. The compounds in their various forms are effective platelet ADP receptor inhibitors and may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also provides intermediate compounds useful in the process, as well as final products produced by the process, and salts or prodrugs thereof. The invention also provides a method for inhibition platelet ADP receptor and preventing or treating thrombosis and thrombosis related conditions in a mammal comprising the step of administering a therapeutically effective amount of a compound of formula (VIII) or a pharmaceutically acceptable salt or forms thereof.

    摘要翻译： 本发明提供式（VIII）的磺酰脲化合物及其药学上可接受的衍生物及其制备方法。 各种形式的化合物是有效的血小板ADP受体抑制剂，可用于各种药物组合物中，并且特别有效预防和/或治疗心血管疾病，特别是与血栓形成有关的疾病。 本发明还提供了可用于该方法的中间体化合物，以及通过该方法生产的最终产物及其盐或前药。 本发明还提供了抑制血小板ADP受体并预防或治疗哺乳动物血栓形成和血栓形成相关病症的方法，包括施用治疗有效量的式（Ⅷ）化合物或其药学上可接受的盐或其形式的步骤。

    [4-(6-HALO-7-SUBSTITUTED-2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL)-PHENYL]-5-CHLORO-THIOPHEN-2-YL-SULFONYLUREAS AND FORMS AND METHODS RELATED THERETO
    2.
    发明申请
    [4-(6-HALO-7-SUBSTITUTED-2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL)-PHENYL]-5-CHLORO-THIOPHEN-2-YL-SULFONYLUREAS AND FORMS AND METHODS RELATED THERETO 有权
    [4-（6-羟基-7-取代-2,4-二氧代-1,4-二氢-2H-喹唑啉-3-基） - 苯基] -5-氯代 - 噻吩-2-基] - 磺酰基和形式 方法相关

    公开(公告)号：US20070123547A1

    公开(公告)日：2007-05-31

    申请号：US11556490

    申请日：2006-11-03

    申请人： Robert Scarborough ,  Wolin Huang ,  Mukund Mehrotra ,  Xiaoming Zhang ,  Hilary Cannon ,  Craig Grant ,  Carroll Scarborough

    发明人： Robert Scarborough ,  Wolin Huang ,  Mukund Mehrotra ,  Xiaoming Zhang ,  Hilary Cannon ,  Craig Grant ,  Carroll Scarborough

    IPC分类号： A61K31/517 ,  C07D409/02

    CPC分类号： C07D409/12

    摘要： The present invention provides novel sulfonylurea compounds of formula (I) and pharmaceutically acceptable derivatives and polymorph and amorphous forms thereof. The compounds in their various forms are effective platelet ADP receptor inhibitors and may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also provides a method for preparing such compounds and forms and for preventing or treating thrombosis and thrombosis related conditions in a mammal comprising the step of administering a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or forms thereof.

    摘要翻译： 本发明提供式（I）的新型磺酰脲化合物及其药学上可接受的衍生物及其多晶型物和无定形形式。 各种形式的化合物是有效的血小板ADP受体抑制剂，可用于各种药物组合物中，并且特别有效预防和/或治疗心血管疾病，特别是与血栓形成有关的疾病。 本发明还提供了一种制备此类化合物和形式并用于预防或治疗哺乳动物血栓形成和血栓形成相关病症的方法，包括施用治疗有效量的式（I）化合物或其药学上可接受的盐或其形式的步骤 。