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    Method for ischemia detection and apparatus for using same
    1.
    发明授权
    Method for ischemia detection and apparatus for using same 有权
    缺血检测方法及其使用方法

    公开(公告)号：US6128526A

    公开(公告)日：2000-10-03

    申请号：US280286

    申请日：1999-03-29

    申请人： Robert Stadler ,  Shannon Nelson ,  Lee Stylos ,  Todd J. Sheldon

    发明人： Robert Stadler ,  Shannon Nelson ,  Lee Stylos ,  Todd J. Sheldon

    IPC分类号： A61B5/0452 ,  A61B5/0472 ,  A61N1/37 ,  A61N1/39 ,  A61B5/0402

    CPC分类号： A61N1/3956 ,  A61B5/0452 ,  A61B5/0472 ,  A61B5/7203 ,  A61N1/3702

    摘要： In determining whether a patient has ischemia or other conditions discernible in the variation occurring in the ST portion of the electrocardiogram signal, we filter out bad ST change parameters that are not changing at a rate representative of human ischemia ST change parameter rates of change. This can be used for driving therapy systems to alleviate cardiac ischemia. This filtering can be enhanced by using multiple cardiac electrical vectors for the electrogram signal vectors, and using a determination of Axis shift to modify filter parameters and the expected ranges of precursors to the ST change parameter (an ST change variable) to eliminate bad cardiac cycles, that is cardiac cycle information that may be misleading.

    摘要翻译： 在确定心电图信号的ST部分发生的变化中患者是否存在缺血或其他状况时，我们滤除不以代表人类缺血ST变化参数变化率的速率变化的不良ST变化参数。 这可以用于驱动治疗系统以减轻心脏缺血。 可以通过使用多个心电向量作为电描记图信号向量来增强该滤波，并且使用轴移动的确定来修改滤波器参数和ST变化参数（ST变化变量）的前体预期范围，以消除不良心脏周期 ，那可能是误导的心脏周期信息。

    Ischemia detection
    3.
    发明申请
    Ischemia detection 审中-公开

    公开(公告)号：US20060009811A1

    公开(公告)日：2006-01-12

    申请号：US11215710

    申请日：2005-08-30

    申请人： Todd Sheldon ,  Lee Stylos ,  Shannon Nelson ,  Robert Stadler

    发明人： Todd Sheldon ,  Lee Stylos ,  Shannon Nelson ,  Robert Stadler

    IPC分类号： A61N1/365 ,  A61B5/04

    CPC分类号： A61B5/4839 ,  A61B5/04011 ,  A61B5/0452 ,  A61B5/1107 ,  A61B5/6869 ,  A61B5/7203 ,  A61B2562/028 ,  A61B2562/222 ,  A61N1/36542 ,  A61N1/368

    摘要： Techniques for detection and treatment of myocardial ischemia are described that monitor both the electrical and dynamic mechanical activity of the heart to detect and verify the occurrence of myocardial ischemia in a more reliable manner. The occurrence of myocardial ischemia can be detected by monitoring changes in an electrical signal such as an ECG or EGM, and changes in dynamic mechanical activity of the heart. Dynamic mechanical activity can be represented, for example, by a heart acceleration signal or pressure signal. The electrical signal can be obtained from a set of implanted or external electrodes. The heart acceleration signal can be obtained from an accelerometer or pressure sensor deployed within or near the heart. The techniques correlate contractility changes detected by an accelerometer or pressure sensor with changes in the ST electrogram segment detected by the electrodes to increase the reliability of ischemia detection.

    Ischemia detection during non-standard cardiac excitation patterns
    4.
    发明授权
    Ischemia detection during non-standard cardiac excitation patterns 有权
    非标准心脏激发模式下的缺血检测

    公开(公告)号：US06381493B1

    公开(公告)日：2002-04-30

    申请号：US09407602

    申请日：1999-09-28

    申请人： Robert Stadler ,  Shannon Nelson

    发明人： Robert Stadler ,  Shannon Nelson

    IPC分类号： A61N1362

    CPC分类号： A61B5/0452 ,  A61B5/7203 ,  A61B5/7239

    摘要： In using electrogram signals to determine physiologic conditions like ischemia, the bad cardiac cycle information due to noise, axis shifts in the cardiac electrical axis, and the like must be removed if the electrogram signal can be made to be a good indicator. If this is accomplished through the adaptive filtering techniques shown here, the signal can be used to drive a closed loop therapy system responsive to those physiologic conditions discernible from good cardiac cycle electrocardiogram signals.

    摘要翻译： 在使用电描记图信号来确定如缺血的生理条件时，如果电描记图信号可以作为良好的指示器，则必须去除由噪声引起的心脏心脏循环信息不良，心脏电轴轴移动等。 如果这是通过这里显示的自适应滤波技术来实现的，则该信号可用于驱动闭环治疗系统，以响应于从良好的心动周期心电图信号中辨别出的生理条件。

    Implantable medical device system and method with signal quality monitoring and response
    7.
    发明申请
    Implantable medical device system and method with signal quality monitoring and response 有权
    可植入医疗器械系统和方法，具有信号质量监测和响应

    公开(公告)号：US20070239220A1

    公开(公告)日：2007-10-11

    申请号：US11392065

    申请日：2006-03-29

    申请人： Saul Greenhut ,  Robert Stadler ,  Holly Vitense

    发明人： Saul Greenhut ,  Robert Stadler ,  Holly Vitense

    IPC分类号： A61N1/00

    CPC分类号： A61N1/3704 ,  A61B5/042 ,  A61B5/0452 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/726 ,  A61N1/05

    摘要： An implantable medical device system and method are provided for monitoring the quality of signals sensed by a subcutaneously implanted device using subcutaneous electrodes. In one embodiment, the method includes selecting one or more sensing vectors; sensing signals from selected sensing vectors, determining a signal quality metric in response to a sensed signal, comparing the signal quality metric to a predetermined threshold, and generating a loss of signal quality response in response to the signal quality crossing the threshold.

    摘要翻译： 提供了一种植入式医疗装置系统和方法，用于监测由皮下植入装置使用皮下电极感测的信号的质量。 在一个实施例中，该方法包括选择一个或多个感测向量; 感测来自所选择的感测向量的信号，响应于感测到的信号确定信号质量度量，将信号质量度量与预定阈值进行比较，以及响应于穿过阈值的信号质量而产生信号质量响应的损失。

    Method and apparatus for detection and monitoring of T-wave alternans
    9.
    发明申请
    Method and apparatus for detection and monitoring of T-wave alternans 审中-公开
    用于检测和监测T波交替的方法和装置

    公开(公告)号：US20060116596A1

    公开(公告)日：2006-06-01

    申请号：US11000541

    申请日：2004-12-01

    申请人： Xiaohong Zhou ,  Thomas Mullen ,  Jeffrey Gillberg ,  Robert Stadler

    发明人： Xiaohong Zhou ,  Thomas Mullen ,  Jeffrey Gillberg ,  Robert Stadler

    IPC分类号： A61B5/04

    CPC分类号： A61N1/3702 ,  A61B5/0422 ,  A61B5/0452

    摘要： A system and method are provided for assessing T-wave alternans (TWA) using cardiac EGM signals received from implanted electrodes. A T-wave signal parameter is measured from signals received by an automatic gain control sense amplifier. A TWA measurement is computed from a beat-by-beat comparison of T-wave parameter measurements or using frequency spectrum techniques. The TWA measurement magnitude and measurement conditions are used in detecting a clinically important TWA. TWA assessment further includes discriminating concordant and discordant TWA in a multi-vector TWA assessment, and determining the association of a TWA measurement with QRS alternans, mechanical alternans, and other physiological events. A prediction of a pathological cardiac event is made in response to a TWA assessment. A response to a cardiac event prediction is provided.

    摘要翻译： 提供了一种使用从植入电极接收的心脏EGM信号评估T波交替（TWA）的系统和方法。 从由自动增益控制读出放大器接收的信号测量T波信号参数。 通过T波参数测量或使用频谱技术的逐拍比较来计算TWA测量。 TWA测量值和测量条件用于检测临床重要的TWA。 TWA评估还包括在多向量TWA评估中区分一致和不一致的TWA，并确定TWA测量与QRS交替，机械交替和其他生理事件的关联。 病理性心脏事件的预测是针对TWA评估做出的。 提供对心脏事件预测的响应。