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公开(公告)号：US08706223B2
公开(公告)日：2014-04-22
申请号：US13353891
申请日：2012-01-19
申请人： Xiaohong Zhou , Lilian Kornet , Richard N. M. Cornelussen , Paul D. Ziegler , Robert Stadler , Eduardo Warman , Karen J. Kleckner , Lucy Nichols , Alberto Della Scala
发明人： Xiaohong Zhou , Lilian Kornet , Richard N. M. Cornelussen , Paul D. Ziegler , Robert Stadler , Eduardo Warman , Karen J. Kleckner , Lucy Nichols , Alberto Della Scala
IPC分类号： A61N1/04
CPC分类号： A61N1/36139 , A61N1/36053 , A61N1/36114 , A61N1/368 , A61N1/37235
摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.
摘要翻译： 本文的公开内容一般涉及使用迷走神经刺激治疗心脏病症的方法，还涉及用于进行这种治疗的系统和装置。 这样的方法可以包括监测患者的生理参数，检测心脏状况，以及向患者输送迷走神经刺激（例如，对迷走神经或具有副交感神经功能的神经元的电刺激）以治疗检测到的心脏状况。
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公开(公告)号：US08725259B2
公开(公告)日：2014-05-13
申请号：US13353861
申请日：2012-01-19
申请人： Lilian Kornet , Richard N. M. Cornelussen , Paul D. Ziegler , Xiaohong Zhou , Eduardo Warman , Karen J. Kleckner , Lucy Nichols , Alberto Della Scala
发明人： Lilian Kornet , Richard N. M. Cornelussen , Paul D. Ziegler , Xiaohong Zhou , Eduardo Warman , Karen J. Kleckner , Lucy Nichols , Alberto Della Scala
IPC分类号： A61N1/365
CPC分类号： A61N1/36114
摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.
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公开(公告)号：US08781582B2
公开(公告)日：2014-07-15
申请号：US13353802
申请日：2012-01-19
申请人： Paul D. Ziegler , Lilian Kornet , Xiaohong Zhou , Richard N. M. Cornelussen , Robert Stadler , Eduardo Warman , Karen J. Kleckner , Alberto Della Scala
发明人： Paul D. Ziegler , Lilian Kornet , Xiaohong Zhou , Richard N. M. Cornelussen , Robert Stadler , Eduardo Warman , Karen J. Kleckner , Alberto Della Scala
IPC分类号： A61N1/37
CPC分类号： A61N1/36139 , A61N1/36053 , A61N1/36114 , A61N1/3621 , A61N1/3627 , A61N1/36564 , A61N1/3682 , A61N1/3702 , A61N1/37235 , A61N1/3962
摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.
摘要翻译： 本文的公开内容一般涉及使用迷走神经刺激治疗心脏病症的方法，还涉及用于进行这种治疗的系统和装置。 这样的方法可以包括监测患者的生理参数，检测心脏状况，以及向患者输送迷走神经刺激（例如，对迷走神经或具有副交感神经功能的神经元的电刺激）以治疗检测到的心脏状况。
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公开(公告)号：US08718763B2
公开(公告)日：2014-05-06
申请号：US13353824
申请日：2012-01-19
申请人： Xiaohong Zhou , Robert Stadler , Richard N. M. Cornelussen , Lilian Kornet , Paul D. Ziegler , Karen J. Kleckner , Alberto Della Scala
发明人： Xiaohong Zhou , Robert Stadler , Richard N. M. Cornelussen , Lilian Kornet , Paul D. Ziegler , Karen J. Kleckner , Alberto Della Scala
IPC分类号： A61N1/365
CPC分类号： A61N1/36114
摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.
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公开(公告)号：US08781583B2
公开(公告)日：2014-07-15
申请号：US13353919
申请日：2012-01-19
IPC分类号： A61N1/36
CPC分类号： A61N1/36114 , A61N1/36053 , A61N1/36585
摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.
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公开(公告)号：US08639327B2
公开(公告)日：2014-01-28
申请号：US12848019
申请日：2010-07-30
IPC分类号： A61N1/05
CPC分类号： A61N1/36139 , A61N1/36053 , A61N1/36114 , A61N1/3621 , A61N1/36514 , A61N1/3937 , A61N1/3987
摘要： Methods of nerve signal differentiation, methods of delivering therapy using such nerve signal differentiation, and to systems and devices for performing such methods. Nerve signal differentiation may include locating two electrodes proximate nerve tissue and differentiating between efferent and afferent components of nerve signals monitored using the two electrodes.
摘要翻译： 神经信号分化方法，使用这种神经信号分化的治疗方法，以及用于执行这些方法的系统和装置。 神经信号分化可能包括将两个电极定位在神经组织附近，并使用两个电极来监测神经信号的传出和传入分量。
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公开(公告)号：US08620425B2
公开(公告)日：2013-12-31
申请号：US12848010
申请日：2010-07-30
IPC分类号： A61N1/05
CPC分类号： A61N1/36139 , A61B5/04001 , A61N1/36114 , A61N1/36514 , A61N1/3684 , A61N1/3686 , A61N1/3962
摘要： Methods of nerve signal differentiation, methods of delivering therapy using such nerve signal differentiation, and to systems and devices for performing such methods. Nerve signal differentiation may include locating two electrodes proximate nerve tissue and differentiating between efferent and afferent components of nerve signals monitored using the two electrodes.
摘要翻译： 神经信号分化方法，使用这种神经信号分化的治疗方法，以及用于执行这些方法的系统和装置。 神经信号分化可能包括将两个电极定位在神经组织附近，并使用两个电极来监测神经信号的传出和传入分量。
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公开(公告)号：US09227069B2
公开(公告)日：2016-01-05
申请号：US13047928
申请日：2011-03-15
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： An implantable medical device senses atrial depolarizations having associated refractory periods thereafter and delivers electrical stimulation pulses during the associated refractory periods to stimulate the atrioventricular (AV) node to cause a prolonged conduction time of an atrial depolarization to a ventricular chamber. The device delivers a pacing pulse to a first ventricular chamber during the prolonged conduction time to cause a contraction and associated refractory period of the first ventricular chamber, the first ventricular chamber contraction occurring earlier than a contraction of a second ventricular chamber.
摘要翻译： 植入式医疗装置感测其后具有相关不应期的心房去极化，并且在相关联的不应期期间传递电刺激脉冲以刺激房室（AV）节点，从而导致心室去极化延长到心室的传导时间。 该设备在延长的传导时间期间将起搏脉冲递送到第一心室，以引起第一心室的收缩和相关联的不应期，第一心室的收缩早于第二心室的收缩。
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公开(公告)号：US08805500B2
公开(公告)日：2014-08-12
申请号：US13047958
申请日：2011-03-15
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： A method and medical device for delivering an atrial pacing pulse to an atrial chamber to generate an evoked atrial depolarization, delivering a stimulation pulse to an atrioventricular node during a stimulation window to increase a PR interval of the heart, the stimulation window having a start time corresponding to the delivered atrial pacing pulse so that the stimulation pulse is delivered during a refractory period corresponding to the evoked atrial depolarization, and delivering a ventricular pacing pulse to a first ventricular chamber during the increased PR interval to cause a contraction of the first ventricular chamber to occur prior to a contraction of a second ventricular chamber to increase dyssynchrony between the contraction of the first ventricular chamber and the contraction of the second ventricular chamber.
摘要翻译： 一种用于将心房起搏脉冲递送到心房的方法和医疗装置以产生诱发的心房去极化，在刺激窗口期间将刺激脉冲递送到房室结，以增加心脏的PR间隔，刺激窗口具有开始时间 对应于递送的心房起搏脉冲，使得刺激脉冲在对应于诱发的心房去极化的难治期期间递送，并且在增加的PR间隔期间将心室起搏脉冲递送到第一心室，以引起第一心室的收缩 在第二心室的收缩之前发生，以增加第一心室的收缩与第二心室的收缩之间的不同步。
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公开(公告)号：US20110270342A1
公开(公告)日：2011-11-03
申请号：US13094231
申请日：2011-04-26
申请人： Hendrik Peter Johan Buschman , John Edward Burnes , Richard N. M. Cornelussen , Michael Roland Scott Hill , Lilian Kornet , Simone Cornelia Maria Anna Ordelman , Petrus Hermanus Veltink
发明人： Hendrik Peter Johan Buschman , John Edward Burnes , Richard N. M. Cornelussen , Michael Roland Scott Hill , Lilian Kornet , Simone Cornelia Maria Anna Ordelman , Petrus Hermanus Veltink
CPC分类号： A61N1/36114 , A61N1/365
摘要： Methods for treating a patient and further to devices for performing such treatment, e.g., methods and devices to perturb at least one physiological system and deliver therapy to the patient based on the effects of such perturbation. For example, a method for using an implantable medical device is disclosed that involves delivering electrical stimuli to an efferent nerve associated with the selected organ. Afferent electrical activity is monitored during delivery of electrical stimuli to the efferent nerve, the monitored afferent electrical activity includes an indirect component of a compound action potential (CAP). A status of the selected organ is assessed based upon the indirect component. A determination is made as to whether to deliver therapy to the selected organ in response to assessing the status of the selected organ.
摘要翻译： 用于治疗患者和进一步进行这种治疗的装置的方法，例如用于扰乱至少一个生理系统的方法和装置，并且基于这种扰动的影响向患者递送治疗。 例如，公开了一种使用可植入医疗装置的方法，其涉及将电刺激递送至与选定器官相关的传出神经。 在传递电刺激到传出神经时监测传入的电活动，所监测的传入电活动包括复合动作电位（CAP）的间接成分。 所选器官的状态根据间接成分进行评估。 根据评估所选器官的状态，确定是否对所选择的器官进行治疗。
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