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公开(公告)号:US20050170254A1
公开(公告)日:2005-08-04
申请号:US10971507
申请日:2004-10-21
申请人: Robert West , Khalil Amine , Zhengcheng Zhang , Qingzheng Wang , Nicholas Rossi , Donald Vissers
发明人: Robert West , Khalil Amine , Zhengcheng Zhang , Qingzheng Wang , Nicholas Rossi , Donald Vissers
IPC分类号: H01M6/18
CPC分类号: H01M10/052 , H01G11/56 , H01M10/0565 , H01M10/0567 , H01M2300/0082 , Y02E60/13
摘要: One example of the disiloxanes include a backbone with a first silicon and a second silicon. The first silicon is linked to a first substituent selected from a group consisting of: a first side chain that includes a cyclic carbonate moiety; a first side chain that includes a poly(alkylene oxide) moiety; and a first cross link links the disiloxane to a second siloxane and that includes a poly(alkylene oxide) moiety. In some instance, the second silicon is linked to a second substituent selected from a group consisting of: a second side chain that includes a cyclic carbonate moiety, and a second side chain that includes a poly(alkylene oxide) moiety.
摘要翻译: 二硅氧烷的一个实例包括具有第一硅和第二硅的骨架。 第一硅连接到选自下组的第一取代基:包含环状碳酸酯部分的第一侧链; 包含聚(环氧烷)部分的第一侧链; 并且第一交联将二硅氧烷连接到第二硅氧烷并且包括聚(环氧烷)部分。 在一些情况下,第二硅连接到选自包括环状碳酸酯部分的第二侧链和包含聚(环氧烷)部分的第二侧链的第二取代基。
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公开(公告)号:US20220214469A1
公开(公告)日:2022-07-07
申请号:US17377190
申请日:2021-07-15
申请人: Nicholas Rossi
发明人: Nicholas Rossi
摘要: Certain exemplary embodiments can provide a device comprising an upper housing, a lower housing, an electronics module, an electronics button, a side button, and a strip magnet. The strip magnet is coupled to the lower housing. The strip magnet is constructed to cause resistance to motion across a metal fastener. The resistance to motion is perceptible to a user of the device. The resistance is indicative of a location of the metal fastener and, thereby, allows the user of the device to locate the metal fastener if the electronics module fails to detect the metal fastener.
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公开(公告)号:US08933047B2
公开(公告)日:2015-01-13
申请号:US13592403
申请日:2012-08-23
申请人: Darren H. Wakefield , David B. Rozema , Nicholas Rossi , Lauren Almeida , Anthony L. Perillo-Nicholas
发明人: Darren H. Wakefield , David B. Rozema , Nicholas Rossi , Lauren Almeida , Anthony L. Perillo-Nicholas
IPC分类号: C12N15/11 , C08F20/10 , C08F120/10 , C08F220/10 , A61K47/32 , C08F220/00 , C08F220/36
CPC分类号: B25F5/02 , A61K47/32 , A61K47/58 , B23D45/16 , B23Q13/00 , B27B5/29 , B27B9/00 , C08F220/00 , C08F220/34 , C08F220/36 , C08F220/18
摘要: The present invention is directed membrane active poly(acrylate) polymers and compositions for targeted delivery of RNA interference (RNAi) polynucleotides cells in vivo. RNAi polynucleotides are conjugated to the poly(acrylate) polymers and the polymers are reversibly modified to enable in vivo targeted delivery. Membrane activity of the poly(acrylate) provides for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness.
摘要翻译: 本发明涉及膜活性聚(丙烯酸酯)聚合物和用于在体内靶向递送RNA干扰(RNAi)多核苷酸细胞的组合物。 RNAi多核苷酸与聚(丙烯酸酯)聚合物缀合,并且可逆地修饰聚合物以实现体内靶向递送。 聚(丙烯酸酯)的膜活性提供了从细胞外部到细胞内的RNAi多核苷酸的移动。 可逆修饰提供生理反应。
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公开(公告)号:US08932572B2
公开(公告)日:2015-01-13
申请号:US13592393
申请日:2012-08-23
申请人: Darren H. Wakefield , Nicholas Rossi , Dan Sheik
发明人: Darren H. Wakefield , Nicholas Rossi , Dan Sheik
IPC分类号: A61K31/74 , A61K47/48 , C08F226/02 , C08F218/04
CPC分类号: A61K47/48176 , A61K31/7105 , A61K47/58 , C08F218/04 , C08F218/10 , C08F2218/22 , C12N15/113 , C12N2310/14 , C12N2310/351 , C12N2320/30
摘要: The present invention is directed membrane active poly(vinyl ester) polymers and compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cells in vivo. RNAi polynucleotides are conjugated to the poly(vinyl ester) polymers and the polymers are reversibly modified to enable in vivo targeted delivery. Membrane activity of the poly(vinyl ester) provides for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness.
摘要翻译: 本发明涉及膜活性聚(乙烯基酯)聚合物和用于将RNA干扰(RNAi)多核苷酸靶向递送至细胞体内的组合物。 RNAi多核苷酸与聚(乙烯基酯)聚合物缀合,并且可逆地修饰聚合物以实现体内靶向递送。 聚(乙烯基酯)的膜活性提供了RNAi多核苷酸从细胞外部到细胞内的运动。 可逆修饰提供生理反应。
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公开(公告)号:US20130317079A1
公开(公告)日:2013-11-28
申请号:US13592403
申请日:2012-08-23
申请人: Darren H. Wakefield , David B. Rozema , Nicholas Rossi , Lauren Almeida , Anthony L. Perillo-Nicholas
发明人: Darren H. Wakefield , David B. Rozema , Nicholas Rossi , Lauren Almeida , Anthony L. Perillo-Nicholas
IPC分类号: A61K47/32
CPC分类号: B25F5/02 , A61K47/32 , A61K47/58 , B23D45/16 , B23Q13/00 , B27B5/29 , B27B9/00 , C08F220/00 , C08F220/34 , C08F220/36 , C08F220/18
摘要: The present invention is directed membrane active poly(acrylate) polymers and compositions for targeted delivery of RNA interference (RNAi) polynucleotides cells in vivo. RNAi polynucleotides are conjugated to the poly(acrylate) polymers and the polymers are reversibly modified to enable in vivo targeted delivery. Membrane activity of the poly(acrylate) provides for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness.
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