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公开(公告)号：US20080090891A1
公开(公告)日：2008-04-17
申请号：US11954894
申请日：2007-12-12
申请人： Robert Zelle , Vincent Galullo , Hormoz Mazdiyasni
发明人： Robert Zelle , Vincent Galullo , Hormoz Mazdiyasni
IPC分类号： A61K31/4178 , A61K31/4164 , A61P9/00
CPC分类号： C07D233/84 , A61K31/4164 , A61K31/4178 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D417/12 , C07D417/14
摘要： The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.
摘要翻译： 本发明涉及化合物，包含该化合物的组合物，以及使用该化合物和化合物组合物的方法。 本文所述的化合物，组合物和方法可用于治疗性调节离子通道功能，以及治疗疾病和疾病症状，特别是由某些钙通道亚型靶标介导的那些症状。
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公开(公告)号：US20050203159A1
公开(公告)日：2005-09-15
申请号：US11075629
申请日：2005-03-07
申请人： Robert Zelle , Vincent Galullo , Hormoz Mazdiyasni
发明人： Robert Zelle , Vincent Galullo , Hormoz Mazdiyasni
IPC分类号： A61K31/4166 , A61K31/4178 , C07D233/84 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D417/12 , C07D417/14
CPC分类号： C07D233/84 , A61K31/4164 , A61K31/4178 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D417/12 , C07D417/14
摘要： The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.
摘要翻译： 本发明涉及化合物，包含该化合物的组合物，以及使用该化合物和化合物组合物的方法。 本文所述的化合物，组合物和方法可用于治疗性调节离子通道功能，以及治疗疾病和疾病症状，特别是由某些钙通道亚型靶标介导的那些症状。
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公开(公告)号：US20070281937A1
公开(公告)日：2007-12-06
申请号：US10592451
申请日：2005-03-07
申请人： Robert Zelle , Vincent Galullo , Christopher Baker , Paul Will , William Frazee , Hormoz Mazdiyasni , Jinsong Guo
发明人： Robert Zelle , Vincent Galullo , Christopher Baker , Paul Will , William Frazee , Hormoz Mazdiyasni , Jinsong Guo
IPC分类号： A61K31/4184 , A61K31/4164 , A61K31/4196 , A61K31/4245 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/5377 , A61P9/12 , A61P9/10 , A61P9/00 , A61P25/00 , A61P13/00 , A61K31/497 , A61K31/47 , A61K31/444 , A61K31/433 , A61K31/426 , A61K31/42 , A61K31/4178
CPC分类号： C07D403/12 , C07D233/84 , C07D249/12 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12
摘要： The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.
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公开(公告)号：US20070208070A1
公开(公告)日：2007-09-06
申请号：US10592269
申请日：2005-03-07
申请人： Robert Zelle , Vincent Galullo
发明人： Robert Zelle , Vincent Galullo
IPC分类号： A61K31/4166 , A61K31/4178 , C07D403/02 , C07D233/42
CPC分类号： C07D233/42 , C07D233/84 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D413/12 , C07D417/06 , C07D417/12
摘要： The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.
摘要翻译： 本发明涉及化合物，包含该化合物的组合物，以及使用该化合物和化合物组合物的方法。 本文所述的化合物，组合物和方法可用于治疗性调节离子通道功能，以及治疗疾病和疾病症状，特别是由某些钙通道亚型靶标介导的那些症状。
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公开(公告)号：US20070208064A1
公开(公告)日：2007-09-06
申请号：US10592203
申请日：2005-03-07
申请人： Robert Zelle , Vincent Galullo , Paul Will
发明人： Robert Zelle , Vincent Galullo , Paul Will
IPC分类号： A61K31/428 , A61K31/427 , A61K31/423 , A61K31/422 , A61K31/4184 , A61K31/4178 , C07D417/02 , C07D403/02 , C07D413/02
CPC分类号： C07D233/84 , C07D233/90 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/12
摘要： The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.
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公开(公告)号：US20070191448A1
公开(公告)日：2007-08-16
申请号：US10592046
申请日：2005-03-07
申请人： Robert Zelle , Vincent Galullo
发明人： Robert Zelle , Vincent Galullo
IPC分类号： A61K31/4178 , A61K31/4164
CPC分类号： A61K31/4164 , A61K31/4178
摘要： The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.
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公开(公告)号：US20070203194A1
公开(公告)日：2007-08-30
申请号：US10592270
申请日：2005-03-07
申请人： Robert Zelle , Vincent Galullo , Christopher Baker , Paul Will , William Frazee
发明人： Robert Zelle , Vincent Galullo , Christopher Baker , Paul Will , William Frazee
IPC分类号： A61K31/4196 , A61K31/435
CPC分类号： C07D417/14 , A61K31/4196 , A61K31/435 , A61K45/06 , C07D249/12 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04 , A61K2300/00
摘要： The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein cab be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.
摘要翻译： 本发明涉及化合物，包含该化合物的组合物，以及使用该化合物和化合物组合物的方法。 本文所述的化合物，组合物和方法可用于离子通道功能的治疗调节，以及疾病和疾病症状的治疗，特别是由某些钙通道亚型靶标介导的那些症状。
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公开(公告)号：US07598277B2
公开(公告)日：2009-10-06
申请号：US11671440
申请日：2007-02-05
申请人： John Cochran , Vincent Galullo , Guy W. Bemis
发明人： John Cochran , Vincent Galullo , Guy W. Bemis
IPC分类号： A61K31/44 , C07D213/75
CPC分类号： C07D213/75 , C07D401/12 , C07F9/58
摘要： The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to inhibitors of ZAP70. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
摘要翻译： 本发明涉及p38的抑制剂，哺乳动物蛋白激酶涉及细胞增殖，细胞死亡和对细胞外刺激的反应。 本发明还涉及ZAP70的抑制剂。 本发明还涉及生产这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用这些组合物治疗和预防各种疾病的方法。
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公开(公告)号：US07186737B2
公开(公告)日：2007-03-06
申请号：US10365719
申请日：2003-02-11
申请人： John Cochran , Vincent Galullo , Guy W. Bemis
发明人： John Cochran , Vincent Galullo , Guy W. Bemis
IPC分类号： A61K31/44 , C07D211/72
CPC分类号： C07D213/75 , C07D401/12 , C07F9/58
摘要： The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to inhibitors of ZAP70. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
摘要翻译： 本发明涉及p38的抑制剂，其涉及细胞增殖，细胞死亡和对细胞外刺激的反应的哺乳动物蛋白激酶。 本发明还涉及ZAP70的抑制剂。 本发明还涉及生产这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用这些组合物治疗和预防各种疾病的方法。
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公开(公告)号：US20090318452A1
公开(公告)日：2009-12-24
申请号：US12550042
申请日：2009-08-28
申请人： John Cochran , Vincent Galullo , Guy W. Bemis
发明人： John Cochran , Vincent Galullo , Guy W. Bemis
IPC分类号： C07D213/04 , C07D413/12 , C07D401/12 , A61K31/44 , A61K31/497 , A61K31/5377
CPC分类号： C07D213/75 , C07D401/12 , C07F9/58
摘要： The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to inhibitors of ZAP70. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
摘要翻译： 本发明涉及p38的抑制剂，哺乳动物蛋白激酶涉及细胞增殖，细胞死亡和对细胞外刺激的反应。 本发明还涉及ZAP70的抑制剂。 本发明还涉及生产这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用这些组合物治疗和预防各种疾病的方法。
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