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19 条记录 (耗时 0.026 秒)

    Ion channel modulators
    1.
    发明申请
    Ion channel modulators 失效
    离子通道调节剂

    公开(公告)号：US20070208070A1

    公开(公告)日：2007-09-06

    申请号：US10592269

    申请日：2005-03-07

    申请人： Robert Zelle ,  Vincent Galullo

    发明人： Robert Zelle ,  Vincent Galullo

    IPC分类号： A61K31/4166 ,  A61K31/4178 ,  C07D403/02 ,  C07D233/42

    CPC分类号： C07D233/42 ,  C07D233/84 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12

    摘要： The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.

    摘要翻译： 本发明涉及化合物，包含该化合物的组合物，以及使用该化合物和化合物组合物的方法。 本文所述的化合物，组合物和方法可用于治疗性调节离子通道功能，以及治疗疾病和疾病症状，特别是由某些钙通道亚型靶标介导的那些症状。

    Ion channel modulators
    6.
    发明申请
    Ion channel modulators 审中-公开

    公开(公告)号：US20070191448A1

    公开(公告)日：2007-08-16

    申请号：US10592046

    申请日：2005-03-07

    申请人： Robert Zelle ,  Vincent Galullo

    发明人： Robert Zelle ,  Vincent Galullo

    IPC分类号： A61K31/4178 ,  A61K31/4164

    CPC分类号： A61K31/4164 ,  A61K31/4178

    摘要： The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.

    NOVEL 1,2,3,4- TETRAHYDROQUINOLINE DERIVATIVES
    9.
    发明申请
    NOVEL 1,2,3,4- TETRAHYDROQUINOLINE DERIVATIVES 审中-公开
    新的1,2,3,4-四氢喹啉衍生物

    公开(公告)号：US20100029716A1

    公开(公告)日：2010-02-04

    申请号：US12296927

    申请日：2007-04-10

    申请人： Roger Tung ,  Robert Zelle

    发明人： Roger Tung ,  Robert Zelle

    IPC分类号： A61K31/47 ,  C07D215/00 ,  G01N31/00 ,  C12Q1/00

    CPC分类号： C07D215/42 ,  Y10T436/10

    摘要： The present invention relates to a novel derivative of Compound 1 selectively substituted with fluorine and/or deuterium and optionally further substituted with deuterium and 13C elsewhere in the molecule. The compounds of this invention are cholesterol esterase transfer protein inhibitors and possess unique biopharmaceutical and pharmacokinetic properties compared to Compound 1. They may also be used to accurately determine the concentration of Compound 1 in biological fluids and tissues and to determine metabolic patterns of Compound 1 and its isotopologues. The invention further provides compositions comprising these compounds and methods of treating diseases and conditions that are responsive to inhibition of cholesterol esterase transfer protein, alone and in combination with additional agents.

    摘要翻译： 本发明涉及化合物1的新型衍生物，其选择性地被氟和/或氘取代并且任选进一步被分子中的氘和13C取代。 本发明的化合物是胆固醇酯酶转移蛋白抑制剂，与化合物1相比具有独特的生物药物和药代动力学特性。它们还可用于准确测定化合物1在生物流体和组织中的浓度，并确定化合物1和 其同位素学。 本发明进一步提供了包含这些化合物的组合物以及治疗单独和与其它试剂组合对胆固醇酯酶转移蛋白的抑制有反应的疾病和病症的方法。