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公开(公告)号：US20080090891A1
公开(公告)日：2008-04-17
申请号：US11954894
申请日：2007-12-12
申请人： Robert Zelle , Vincent Galullo , Hormoz Mazdiyasni
发明人： Robert Zelle , Vincent Galullo , Hormoz Mazdiyasni
IPC分类号： A61K31/4178 , A61K31/4164 , A61P9/00
CPC分类号： C07D233/84 , A61K31/4164 , A61K31/4178 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D417/12 , C07D417/14
摘要： The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.
摘要翻译： 本发明涉及化合物，包含该化合物的组合物，以及使用该化合物和化合物组合物的方法。 本文所述的化合物，组合物和方法可用于治疗性调节离子通道功能，以及治疗疾病和疾病症状，特别是由某些钙通道亚型靶标介导的那些症状。
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公开(公告)号：US20050203159A1
公开(公告)日：2005-09-15
申请号：US11075629
申请日：2005-03-07
申请人： Robert Zelle , Vincent Galullo , Hormoz Mazdiyasni
发明人： Robert Zelle , Vincent Galullo , Hormoz Mazdiyasni
IPC分类号： A61K31/4166 , A61K31/4178 , C07D233/84 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D417/12 , C07D417/14
CPC分类号： C07D233/84 , A61K31/4164 , A61K31/4178 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D417/12 , C07D417/14
摘要： The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.
摘要翻译： 本发明涉及化合物，包含该化合物的组合物，以及使用该化合物和化合物组合物的方法。 本文所述的化合物，组合物和方法可用于治疗性调节离子通道功能，以及治疗疾病和疾病症状，特别是由某些钙通道亚型靶标介导的那些症状。
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公开(公告)号：US20070281937A1
公开(公告)日：2007-12-06
申请号：US10592451
申请日：2005-03-07
申请人： Robert Zelle , Vincent Galullo , Christopher Baker , Paul Will , William Frazee , Hormoz Mazdiyasni , Jinsong Guo
发明人： Robert Zelle , Vincent Galullo , Christopher Baker , Paul Will , William Frazee , Hormoz Mazdiyasni , Jinsong Guo
IPC分类号： A61K31/4184 , A61K31/4164 , A61K31/4196 , A61K31/4245 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/5377 , A61P9/12 , A61P9/10 , A61P9/00 , A61P25/00 , A61P13/00 , A61K31/497 , A61K31/47 , A61K31/444 , A61K31/433 , A61K31/426 , A61K31/42 , A61K31/4178
CPC分类号： C07D403/12 , C07D233/84 , C07D249/12 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12
摘要： The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.
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公开(公告)号：US07368467B2
公开(公告)日：2008-05-06
申请号：US11075629
申请日：2005-03-07
IPC分类号： A61K31/4184 , C07D233/54 , C07D235/04 , C07D403/12
CPC分类号： C07D233/84 , A61K31/4164 , A61K31/4178 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D417/12 , C07D417/14
摘要： The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.
摘要翻译： 本发明涉及化合物，包含该化合物的组合物，以及使用该化合物和化合物组合物的方法。 本文所述的化合物，组合物和方法可用于治疗性调节离子通道功能，以及治疗疾病和疾病症状，特别是由某些钙通道亚型靶标介导的那些症状。
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公开(公告)号：US20100267697A1
公开(公告)日：2010-10-21
申请号：US12518342
申请日：2007-12-11
申请人： Vincent P. Galullo , Robert Zelle , Danielle Soenen , Christopher Todd Baker , Paul Will , Hormoz Mazdiyasni , Jinsong Guo , Andrew Fensome , Jeffrey Curtis Kern , William Jay Moore , Edward George Melenski , Justin Kaplan
发明人： Vincent P. Galullo , Robert Zelle , Danielle Soenen , Christopher Todd Baker , Paul Will , Hormoz Mazdiyasni , Jinsong Guo , Andrew Fensome , Jeffrey Curtis Kern , William Jay Moore , Edward George Melenski , Justin Kaplan
IPC分类号： A61K31/5513 , A61K31/55 , A61K31/54 , A61K31/535 , A61K31/5355 , A61K31/4995 , A61K31/501 , A61K31/497 , A61K31/506 , A61K31/44 , A61K31/4725 , A61K31/426 , A61K31/4709 , A61K31/4458 , A61K31/4453 , A61K31/4402 , A61K31/445 , A61K31/166 , C07D403/04 , C07D401/04 , C07D413/04 , C07D417/04 , C07D413/12 , C07D403/12 , C07D241/36 , C07D497/10 , C07D217/00 , C07D215/00 , C07D401/12 , C07D211/98 , C07D213/04 , C07D405/12 , C07D213/73 , C07D277/593 , C07C233/42
CPC分类号： C07D213/72 , C07D277/42
摘要： The present teachings provide compounds of Formula (I) and pharmaceutically acceptable salts, hydrates, and esters thereof, wherein Ar, R1, R2, R3, p, and X are defined herein. The present teachings also provide processes for producing said compounds and their pharmaceutically acceptable salts, hydrates and esters, and methods of treating a pathological condition or disorder, or alleviating a symptom thereof, using said compounds including their pharmaceutically acceptable salts, hydrates and esters. The compounds can be useful in modulating ion channel activity including treating a variety of conditions associated with the abnormal modulation of one or more voltage-gated calcium channels.
摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐，水合物和酯，其中Ar，R 1，R 2，R 3，p和X如本文所定义。 本教导还提供使用所述化合物，包括其药学上可接受的盐，水合物和酯来制备所述化合物及其药学上可接受的盐，水合物和酯的方法，以及治疗病理状况或病症或减轻其症状的方法。 该化合物可用于调节离子通道活性，包括治疗与一个或多个电压门控钙通道的异常调节相关的多种病症。
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公开(公告)号：US20100029610A1
公开(公告)日：2010-02-04
申请号：US12492180
申请日：2009-06-26
申请人： Juswinder Singh , Russell Petter , Richland Wayne Tester , Arthur F. Kluge , Hormoz Mazdiyasni , William Frederick Westlin, III , Deqiang Niu , Lixin Qiao
发明人： Juswinder Singh , Russell Petter , Richland Wayne Tester , Arthur F. Kluge , Hormoz Mazdiyasni , William Frederick Westlin, III , Deqiang Niu , Lixin Qiao
IPC分类号： A61K31/397 , C07D239/02 , A61K31/505 , C12N9/99 , C12Q1/48 , C07D401/02 , C07D265/36 , A61K31/538 , C07D413/02 , A61K31/5377 , A61K31/496 , A61P37/00 , A61P35/00
CPC分类号： A61K31/505 , A61K31/506 , A61K31/5377 , C07D239/47 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/18
摘要： The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
摘要翻译： 本发明提供化合物，其药学上可接受的组合物及其使用方法。
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公开(公告)号：US20100093713A1
公开(公告)日：2010-04-15
申请号：US12640335
申请日：2009-12-17
申请人： Michael E. Hepperle , Julie Fields Liu , Francois Soucy , Yingchun Ye , Robert S. Murray , Raman Prakash , Jeremy D. Little , Alfredo Castro , Hormoz Mazdiyasni , Paul E. Fleming , Dominic Reynolds
发明人： Michael E. Hepperle , Julie Fields Liu , Francois Soucy , Yingchun Ye , Robert S. Murray , Raman Prakash , Jeremy D. Little , Alfredo Castro , Hormoz Mazdiyasni , Paul E. Fleming , Dominic Reynolds
IPC分类号： A61K31/541 , C07D471/04 , A61P35/04 , A61P37/00 , A61K31/5377 , A61P29/00 , A61K31/501 , A61K31/437 , C07D295/10
CPC分类号： C07D265/30 , C07D471/04
摘要： This invention provides beta-carboline compounds of formula wherein Ring A is a substituted pyridinyl, pyrimidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl, pyranyl, tetrahydrofuranyl, cyclohexyl, cyclopentyl or thiomorpholinyl ring and R1, R2 and R3 are as described in the specification. The compounds are IKK-2 inhibitors that are useful for treating IKK-2-mediated diseases such as inflammatory diseases and cancer.
摘要翻译： 本发明提供下式的β-咔啉化合物，其中环A是取代的吡啶基，嘧啶基，吗啉基，哌啶基，哌嗪基，吡咯烷基，吡喃基，四氢呋喃基，环己基，环戊基或硫代吗啉基，R1，R2和R3如说明书中所述。 这些化合物是可用于治疗IKK-2介导的疾病如炎性疾病和癌症的IKK-2抑制剂。
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公开(公告)号：US08450335B2
公开(公告)日：2013-05-28
申请号：US12492180
申请日：2009-06-26
申请人： Juswinder Singh , Russell Petter , Richland Wayne Tester , Arthur F. Kluge , Hormoz Mazdiyasni , William Frederick Westlin, III , Deqiang Niu , Lixin Qiao
发明人： Juswinder Singh , Russell Petter , Richland Wayne Tester , Arthur F. Kluge , Hormoz Mazdiyasni , William Frederick Westlin, III , Deqiang Niu , Lixin Qiao
IPC分类号： A61K31/505
CPC分类号： A61K31/505 , A61K31/506 , A61K31/5377 , C07D239/47 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/18
摘要： The present invention provides 2,4-disubstituted pyrimidine compounds useful as kinase inhibitors, pharmaceutically acceptable compositions thereof, and methods of using the same. In some embodiments, the present invention provides a compound of formula I-b: wherein each of Ring A, Ring B, W1, W2, Ry, Rv, Rx, m, p, and R1 is described herein.
摘要翻译： 本发明提供可用作激酶抑制剂的2,4-二取代嘧啶化合物，其药学上可接受的组合物及其使用方法。 在一些实施方案中，本发明提供式I-b的化合物：其中环A，环B，W1，W2，Ry，Rv，Rx，m，p和R1各自在本文中进行描述。
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公开(公告)号：US20100249092A1
公开(公告)日：2010-09-30
申请号：US12648693
申请日：2009-12-29
申请人： Juswinder Singh , Russell Petter , Richland Wayne Tester , Arthur F. Kluge , Hormoz Mazdiyasni , William Frederick Westlin, III , Deqiang Niu , Lixin Qiao
发明人： Juswinder Singh , Russell Petter , Richland Wayne Tester , Arthur F. Kluge , Hormoz Mazdiyasni , William Frederick Westlin, III , Deqiang Niu , Lixin Qiao
IPC分类号： A61K31/505 , C07D239/48 , C07D401/12 , A61K31/506 , C07D401/04 , C07D403/12 , C07D413/14 , A61K31/538 , C07D413/12 , C07D401/14 , A61K31/5377 , C07D417/14 , A61K31/541 , C07D405/14 , A61P3/10 , A61P37/06 , A61P29/00 , A61P35/00 , A61P17/00 , A61P1/00 , A61P11/00 , A61P19/00 , A61P7/02 , C12Q1/48 , G01N33/53
CPC分类号： A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/541 , A61K45/06 , C07D239/47 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D413/12 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D487/18 , C07D495/04
摘要： The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
摘要翻译： 本发明提供化合物，其药学上可接受的组合物及其使用方法。
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公开(公告)号：US07348336B2
公开(公告)日：2008-03-25
申请号：US11390287
申请日：2006-03-28
申请人： Olaf Ritzeler , Alfredo Castro , Louis Grenier , Francois Soucy , Wayne W. Hancock , Hormoz Mazdiyasni , Vito Palombella , Julian Adams
发明人： Olaf Ritzeler , Alfredo Castro , Louis Grenier , Francois Soucy , Wayne W. Hancock , Hormoz Mazdiyasni , Vito Palombella , Julian Adams
IPC分类号： C07D471/02 , A61K31/44
CPC分类号： A61K31/437 , C07D471/04 , Y02A50/411
摘要： The subject matter of the present invention is directed to novel substituted β-carbolines, and specifically compounds of the formula I, which are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of IκB kinase is involved.
摘要翻译： 本发明的主题涉及新的取代的β-咔啉，特别是式I化合物，其适用于生产用于预防和治疗IkappaB激酶活性增加的病症的药物 。
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