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公开(公告)号：US20140005232A1
公开(公告)日：2014-01-02
申请号：US13901930
申请日：2013-05-24
申请人： Robin Alec Fairhurst , Vito Guagnano , Patricia Imbach-Weese , Giorgio Caravatti , Pascal Furet
发明人： Robin Alec Fairhurst , Vito Guagnano , Patricia Imbach-Weese , Giorgio Caravatti , Pascal Furet
IPC分类号： C07D417/14
CPC分类号： A61K31/4439 , A61K45/06 , C07D417/14
摘要： The present invention relates to a compound of formula (I) or a salt thereof, wherein the substituents are as defined in the description, to compositions and use of the compounds in the treatment of diseases ameliorated by inhibition of phosphatidylinositol 3-kinase.
摘要翻译： 本发明涉及式（I）化合物或其盐，其中取代基如说明书中所定义，化合物在治疗通过抑制磷脂酰肌醇3-激酶而改善的疾病中的组合物和用途。
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公开(公告)号：US20140186469A1
公开(公告)日：2014-07-03
申请号：US14192633
申请日：2014-02-27
申请人： Robin Alec Fairhurst , Vito Guagnano , Patricia Imbach-Weese , Giorgio Caravatti , Pascal Furet
发明人： Robin Alec Fairhurst , Vito Guagnano , Patricia Imbach-Weese , Giorgio Caravatti , Pascal Furet
IPC分类号： A61K31/4439 , A61K45/06
CPC分类号： A61K31/4439 , A61K45/06 , C07D417/14
摘要： The present invention relates to a compound of formula (I) or a salt thereof, wherein the substituents are as defined in the description, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol 3-kinase.
摘要翻译： 本发明涉及式（I）化合物或其盐，其中取代基如说明书中所定义，化合物在治疗通过抑制磷脂酰肌醇3-激酶而变性的疾病中的组合物和用途。
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公开(公告)号：US08710085B2
公开(公告)日：2014-04-29
申请号：US13901930
申请日：2013-05-24
申请人： Vito Guagnano , Robin Alec Fairhurst , Patricia Imbach-Weese , Giorgio Caravatti , Pascal Furet
发明人： Vito Guagnano , Robin Alec Fairhurst , Patricia Imbach-Weese , Giorgio Caravatti , Pascal Furet
IPC分类号： A61K31/4436 , C07D417/04
CPC分类号： A61K31/4439 , A61K45/06 , C07D417/14
摘要： The present invention relates to a compound of formula (I) or a salt thereof, wherein the substituents are as defined in the description, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol 3-kinase.
摘要翻译： 本发明涉及式（I）化合物或其盐，其中取代基如说明书中所定义，化合物在治疗通过抑制磷脂酰肌醇3-激酶而变性的疾病中的组合物和用途。
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公开(公告)号：US08476268B2
公开(公告)日：2013-07-02
申请号：US13488589
申请日：2012-06-05
申请人： Robin Alec Fairhurst , Vito Guagnano , Patricia Imbach-Weese , Giorgio Caravatti , Pascal Furet
发明人： Robin Alec Fairhurst , Vito Guagnano , Patricia Imbach-Weese , Giorgio Caravatti , Pascal Furet
IPC分类号： C07D417/14 , A61K31/4439
CPC分类号： A61K31/4439 , A61K45/06 , C07D417/14
摘要： The present invention relates to a compound of formula (I) or a salt thereof, wherein the substituents are as defined in the description, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol 3-kinase.
摘要翻译： 本发明涉及式（I）化合物或其盐，其中取代基如说明书中所定义，化合物在治疗通过抑制磷脂酰肌醇3-激酶而变态化的疾病中的组合物和用途。
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公开(公告)号：US20100105711A1
公开(公告)日：2010-04-29
申请号：US12556964
申请日：2009-09-10
IPC分类号： A61K31/4439 , C07D417/14 , A61K31/506 , A61P43/00
CPC分类号： A61K31/4439 , A61K45/06 , C07D417/14
摘要： The present invention relates to a compound of formula (I) or a salt thereof, wherein the substituents are as defined in the description, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol 3-kinase.
摘要翻译： 本发明涉及式（I）化合物或其盐，其中取代基如说明书中所定义，化合物在治疗通过抑制磷脂酰肌醇3-激酶而变态化的疾病中的组合物和用途。
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公开(公告)号：US08940771B2
公开(公告)日：2015-01-27
申请号：US12338432
申请日：2008-12-18
IPC分类号： A61K31/4439 , A61K31/427 , C07D417/14 , C07D417/12
CPC分类号： C07D417/14 , A61K31/427 , A61K31/4439 , C07D417/12
摘要： The present invention relates to compounds of formula I and its salts, wherein the substituents are as defined in the description, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol 3-kinase.
摘要翻译： 本发明涉及式I化合物及其盐，其中取代基如说明书中所定义，化合物在治疗通过抑制磷脂酰肌醇3-激酶而变性的疾病中的组合物和用途。
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公开(公告)号：US08227462B2
公开(公告)日：2012-07-24
申请号：US12556964
申请日：2009-09-10
IPC分类号： C07D417/14 , A61K31/4439
CPC分类号： A61K31/4439 , A61K45/06 , C07D417/14
摘要： The present invention relates to a compound of formula (I) or a salt thereof, wherein the substituents are as defined in the description, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol 3-kinase.
摘要翻译： 本发明涉及式（I）化合物或其盐，其中取代基如说明书中所定义，化合物在治疗通过抑制磷脂酰肌醇3-激酶而变性的疾病中的组合物和用途。
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公开(公告)号：US20090163469A1
公开(公告)日：2009-06-25
申请号：US12338432
申请日：2008-12-18
IPC分类号： A61K31/397 , C07D277/38 , A61K31/426 , C07D417/14 , C07D223/14 , A61P35/00 , A61P37/00 , A61P3/00 , A61P17/00 , A61K31/55 , A61K31/506 , A61K31/4439 , A61K31/496
CPC分类号： C07D417/14 , A61K31/427 , A61K31/4439 , C07D417/12
摘要： The present invention relates to compounds of formula I and its salts, wherein the substituents are as defined in the description, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol 3-kinase.
摘要翻译： 本发明涉及式I化合物及其盐，其中取代基如说明书中所定义，化合物在治疗通过抑制磷脂酰肌醇3-激酶而变质的疾病中的组合物和用途。
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公开(公告)号：US09458177B2
公开(公告)日：2016-10-04
申请号：US14478523
申请日：2014-09-05
申请人： Giorgio Caravatti , Robin Alec Fairhurst , Pascal Furet , Clive McCarthy , Heinrich Rueeger , Frank Hans Seiler , Frédéric Stauffer
发明人： Giorgio Caravatti , Robin Alec Fairhurst , Pascal Furet , Clive McCarthy , Heinrich Rueeger , Frank Hans Seiler , Frédéric Stauffer
IPC分类号： C07D403/04 , C07D498/04 , C07D413/14 , A61K31/5377 , A61K45/06
CPC分类号： C07D498/04 , A61K31/5377 , A61K45/06 , C07D413/14
摘要： The present invention relates to oxazolidin-2-one substituted pyrimidine compounds that act as PI3K (phosphatidylinositol-3-kinase) inhibitors, as well as pharmaceutical compositions thereof, methods for their manufacture and uses for the treatment of conditions, diseases and disorders dependent on PI3K.
摘要翻译： 本发明涉及作为PI3K（磷脂酰肌醇-3-激酶）抑制剂的恶唑烷-2-酮取代的嘧啶化合物及其药物组合物，其制备方法和用于治疗依赖于 PI3K。
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公开(公告)号：US08552002B2
公开(公告)日：2013-10-08
申请号：US11570983
申请日：2005-06-23
申请人： Qiang Ding , Nathanael Schiander Gray , Bing Li , Yi Liu , Taebo Sim , Tetsuo Uno , Guobao Zhang , Carole Pissot Soldermann , Werner Breitenstein , Guido Bold , Giorgio Caravatti , Pascal Furet , Vito Guagnano , Marc Lang , Paul William Manley , Joseph Schoepfer , Carsten Spanka
发明人： Qiang Ding , Nathanael Schiander Gray , Bing Li , Yi Liu , Taebo Sim , Tetsuo Uno , Guobao Zhang , Carole Pissot Soldermann , Werner Breitenstein , Guido Bold , Giorgio Caravatti , Pascal Furet , Vito Guagnano , Marc Lang , Paul William Manley , Joseph Schoepfer , Carsten Spanka
IPC分类号： A01N43/54 , C07D239/02
CPC分类号： C07D239/48 , C07D251/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The invention relates to compounds of formula (I) wherein the substituents X1, R1, R2, R3 and R4 have the meaning as set forth and explained in the description of the invention, to processes for the preparation of these compounds, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity, and a method for the treatment of such a disease.
摘要翻译： 本发明涉及式（I）化合物，其中取代基X1，R1，R2，R3和R4具有本发明说明书中阐述和解释的含义，制备这些化合物的方法，含有它们的药物组合物 ，其任选与一种或多种其它药学活性化合物组合用于治疗对蛋白激酶活性的抑制作出反应的疾病的用途，以及治疗这种疾病的方法。
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