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    4-piperazinyl benzenesulfonyl indoles and uses thereof
    3.
    发明授权
    4-piperazinyl benzenesulfonyl indoles and uses thereof 失效
    4-哌嗪基苯磺酰基吲哚及其用途

    公开(公告)号：US07022708B2

    公开(公告)日：2006-04-04

    申请号：US10687091

    申请日：2003-10-16

    申请人： Robin Douglas Clark ,  Ralph New Harris, III ,  David Bruce Repke

    发明人： Robin Douglas Clark ,  Ralph New Harris, III ,  David Bruce Repke

    IPC分类号： C07D403/04 ,  A61K31/496

    CPC分类号： C07D209/08 ,  C07D209/30

    摘要： This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula I: wherein R1, R2, R3, R4, and R5 are as defined herein; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.

    摘要翻译： 本发明涉及通常具有5-HT 6受体亲和性并由式I表示的化合物：其中R 1，R 2，R 3， >，R 4，R 5和R 5如本文所定义; 或各异构体，异构体的外消旋或非外消旋混合物，或其药学上可接受的盐或溶剂合物。 本发明还涉及含有这些化合物的药物组合物，其用作治疗剂的方法及其制备方法。

    4-piperazinylindole derivatives with 5-HT6 receptor affinity
    4.
    发明授权
    4-piperazinylindole derivatives with 5-HT6 receptor affinity 失效
    具有5-HT 6受体亲和力的4-哌嗪基吲哚衍生物

    公开(公告)号：US06790848B2

    公开(公告)日：2004-09-14

    申请号：US10172360

    申请日：2002-06-14

    申请人： Andrew John Briggs ,  Robin Douglas Clark ,  Ralph New Harris, III ,  David Bruce Repke ,  Douglas Leslie Wren

    发明人： Andrew John Briggs ,  Robin Douglas Clark ,  Ralph New Harris, III ,  David Bruce Repke ,  Douglas Leslie Wren

    IPC分类号： C07D40304

    CPC分类号： C07D209/40

    摘要： This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula I: wherein R3 is SO2—Ar, Ar is aryl or heteroaryl; and R1, R2, R4 and R5 are as defined herein; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.

    摘要翻译： 本发明涉及通常具有5-HT 6受体亲和性并由式I表示的化合物：其中R 3是SO 2 -Ar，Ar是芳基或杂芳基; 且R 1，R 2，R 4和R 5如本文所定义; 或各异构体，异构体的外消旋或非外消旋混合物，或其药学上可接受的盐或溶剂合物。 本发明还涉及含有这些化合物的药物组合物，其用作治疗剂的方法及其制备方法。