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    Pharmaceutical compositions in particulate form
    1.
    发明授权
    Pharmaceutical compositions in particulate form 有权
    药物组合物为颗粒形式

    公开(公告)号：US07842310B2

    公开(公告)日：2010-11-30

    申请号：US10299012

    申请日：2002-11-19

    申请人： Robin Hwang ,  Vincent Sullivan ,  Juan Huang ,  Zhaolin Wang ,  John A. Mikszta ,  David Montgomery ,  Brandi Ford ,  Anjana Bhuta-Wills

    发明人： Robin Hwang ,  Vincent Sullivan ,  Juan Huang ,  Zhaolin Wang ,  John A. Mikszta ,  David Montgomery ,  Brandi Ford ,  Anjana Bhuta-Wills

    IPC分类号： A61K9/19 ,  F26B5/04 ,  F26B5/06 ,  F26B5/00

    CPC分类号： A61K9/1694 ,  A61K9/0019 ,  A61K9/0043 ,  A61K9/0075 ,  A61K9/0078 ,  A61K9/1623 ,  A61K9/1652 ,  A61K9/1688 ,  A61K47/26

    摘要： A method of preparing a pharmaceutical composition is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles at about atmospheric pressure to produce a powder, wherein said drying is performed in the presence of vibration, internals, mechanical stirring, or a combination thereof. Another method is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles to produce a powder; wherein the atomized formulation comprises droplets having an average mean diameter of between about 35μ and about 300μ, and/or the powder comprises dried particles having an average mean diameter of between about 35μ and about 300μ. Compositions made by the above methods, and methods of using the compositions, are also described.

    摘要翻译： 描述了制备药物组合物的方法，其包括：1）雾化治疗剂的液体制剂以产生雾化制剂; 2）冷冻所述雾化制剂以形成固体颗粒; 和3）在大气压下干燥所述固体颗粒以产生粉末，其中所述干燥在振动，内部，机械搅拌或其组合的存在下进行。 描述了另一种方法，其包括：1）雾化治疗剂的液体制剂以产生雾化制剂; 2）冷冻所述雾化制剂以形成固体颗粒; 和3）干燥所述固体颗粒以产生粉末; 其中所述雾化制剂包含平均直径在约35μ至约300μ之间的液滴，和/或所述粉末包含平均直径在约35μ至约300μ之间的干燥颗粒。 还描述了通过上述方法制备的组合物，以及使用组合物的方法。

    PHARMACEUTICAL COMPOSITIONS IN PARTICULATE FORM
    2.
    发明申请
    PHARMACEUTICAL COMPOSITIONS IN PARTICULATE FORM 审中-公开
    颗粒形式的药物组合物

    公开(公告)号：US20070190158A1

    公开(公告)日：2007-08-16

    申请号：US11691280

    申请日：2007-03-26

    申请人： Robin Hwang ,  Vincent Sullivan ,  Juan Huang ,  Zhaolin Wang ,  John Mikszta ,  David Montgomery ,  Brandi Ford ,  Anjana Bhuta-Wills

    发明人： Robin Hwang ,  Vincent Sullivan ,  Juan Huang ,  Zhaolin Wang ,  John Mikszta ,  David Montgomery ,  Brandi Ford ,  Anjana Bhuta-Wills

    IPC分类号： A61K9/14

    CPC分类号： A61K9/1694 ,  A61K9/0019 ,  A61K9/0043 ,  A61K9/0075 ,  A61K9/0078 ,  A61K9/1623 ,  A61K9/1652 ,  A61K9/1688 ,  A61K47/26

    摘要： A method of preparing a pharmaceutical composition is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles at about atmospheric pressure to produce a powder, wherein said drying is performed in the presence of vibration, internals, mechanical stirring, or a combination thereof. Another method is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles to produce a powder; wherein the atomized formulation comprises droplets having an average mean diameter of between about 35μ and about 300μ, and/or the powder comprises dried particles having an average mean diameter of between about 35μ and about 300μ. Compositions made by the above methods, and methods of using the compositions, are also described.

    摘要翻译： 描述了制备药物组合物的方法，其包括：1）雾化治疗剂的液体制剂以产生雾化制剂; 2）冷冻所述雾化制剂以形成固体颗粒; 和3）在大气压下干燥所述固体颗粒以产生粉末，其中所述干燥在振动，内部，机械搅拌或其组合的存在下进行。 描述了另一种方法，其包括：1）雾化治疗剂的液体制剂以产生雾化制剂; 2）冷冻所述雾化制剂以形成固体颗粒; 和3）干燥所述固体颗粒以产生粉末; 其中所述雾化制剂包含平均平均直径在约35mu至约300mu之间的液滴，和/或所述粉末包含平均直径在约35μm至约300μm之间的干燥颗粒。 还描述了通过上述方法制备的组合物，以及使用组合物的方法。