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    Pharmaceutical compositions in particulate form
    1.
    发明授权
    Pharmaceutical compositions in particulate form 有权
    药物组合物为颗粒形式

    公开(公告)号：US07842310B2

    公开(公告)日：2010-11-30

    申请号：US10299012

    申请日：2002-11-19

    申请人： Robin Hwang ,  Vincent Sullivan ,  Juan Huang ,  Zhaolin Wang ,  John A. Mikszta ,  David Montgomery ,  Brandi Ford ,  Anjana Bhuta-Wills

    发明人： Robin Hwang ,  Vincent Sullivan ,  Juan Huang ,  Zhaolin Wang ,  John A. Mikszta ,  David Montgomery ,  Brandi Ford ,  Anjana Bhuta-Wills

    IPC分类号： A61K9/19 ,  F26B5/04 ,  F26B5/06 ,  F26B5/00

    CPC分类号： A61K9/1694 ,  A61K9/0019 ,  A61K9/0043 ,  A61K9/0075 ,  A61K9/0078 ,  A61K9/1623 ,  A61K9/1652 ,  A61K9/1688 ,  A61K47/26

    摘要： A method of preparing a pharmaceutical composition is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles at about atmospheric pressure to produce a powder, wherein said drying is performed in the presence of vibration, internals, mechanical stirring, or a combination thereof. Another method is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles to produce a powder; wherein the atomized formulation comprises droplets having an average mean diameter of between about 35μ and about 300μ, and/or the powder comprises dried particles having an average mean diameter of between about 35μ and about 300μ. Compositions made by the above methods, and methods of using the compositions, are also described.

    摘要翻译： 描述了制备药物组合物的方法，其包括：1）雾化治疗剂的液体制剂以产生雾化制剂; 2）冷冻所述雾化制剂以形成固体颗粒; 和3）在大气压下干燥所述固体颗粒以产生粉末，其中所述干燥在振动，内部，机械搅拌或其组合的存在下进行。 描述了另一种方法，其包括：1）雾化治疗剂的液体制剂以产生雾化制剂; 2）冷冻所述雾化制剂以形成固体颗粒; 和3）干燥所述固体颗粒以产生粉末; 其中所述雾化制剂包含平均直径在约35μ至约300μ之间的液滴，和/或所述粉末包含平均直径在约35μ至约300μ之间的干燥颗粒。 还描述了通过上述方法制备的组合物，以及使用组合物的方法。

    PHARMACEUTICAL COMPOSITIONS IN PARTICULATE FORM
    2.
    发明申请
    PHARMACEUTICAL COMPOSITIONS IN PARTICULATE FORM 审中-公开
    颗粒形式的药物组合物

    公开(公告)号：US20070190158A1

    公开(公告)日：2007-08-16

    申请号：US11691280

    申请日：2007-03-26

    申请人： Robin Hwang ,  Vincent Sullivan ,  Juan Huang ,  Zhaolin Wang ,  John Mikszta ,  David Montgomery ,  Brandi Ford ,  Anjana Bhuta-Wills

    发明人： Robin Hwang ,  Vincent Sullivan ,  Juan Huang ,  Zhaolin Wang ,  John Mikszta ,  David Montgomery ,  Brandi Ford ,  Anjana Bhuta-Wills

    IPC分类号： A61K9/14

    CPC分类号： A61K9/1694 ,  A61K9/0019 ,  A61K9/0043 ,  A61K9/0075 ,  A61K9/0078 ,  A61K9/1623 ,  A61K9/1652 ,  A61K9/1688 ,  A61K47/26

    摘要： A method of preparing a pharmaceutical composition is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles at about atmospheric pressure to produce a powder, wherein said drying is performed in the presence of vibration, internals, mechanical stirring, or a combination thereof. Another method is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles to produce a powder; wherein the atomized formulation comprises droplets having an average mean diameter of between about 35μ and about 300μ, and/or the powder comprises dried particles having an average mean diameter of between about 35μ and about 300μ. Compositions made by the above methods, and methods of using the compositions, are also described.

    摘要翻译： 描述了制备药物组合物的方法，其包括：1）雾化治疗剂的液体制剂以产生雾化制剂; 2）冷冻所述雾化制剂以形成固体颗粒; 和3）在大气压下干燥所述固体颗粒以产生粉末，其中所述干燥在振动，内部，机械搅拌或其组合的存在下进行。 描述了另一种方法，其包括：1）雾化治疗剂的液体制剂以产生雾化制剂; 2）冷冻所述雾化制剂以形成固体颗粒; 和3）干燥所述固体颗粒以产生粉末; 其中所述雾化制剂包含平均平均直径在约35mu至约300mu之间的液滴，和/或所述粉末包含平均直径在约35μm至约300μm之间的干燥颗粒。 还描述了通过上述方法制备的组合物，以及使用组合物的方法。

    Seal carried by a vertically storing dock leveler
    4.
    发明授权
    Seal carried by a vertically storing dock leveler 失效
    密封件由垂直存放的平台矫直机承载

    公开(公告)号：US5001799A

    公开(公告)日：1991-03-26

    申请号：US331983

    申请日：1989-04-03

    申请人： James C. Alexander ,  Vincent Sullivan

    发明人： James C. Alexander ,  Vincent Sullivan

    IPC分类号： B65G69/28

    CPC分类号： B65G69/2876

    摘要： A seal for a vertically storing dock leveler employs a foam pad connected to the underside of the deck. As the leveller is lowered, the pad contacts the shelf on to which the leveller is mounted and deflects inward and compresses to seal the space between the underside of the leveller and the shelf. The pad is a tapered foam with a fabric covering.

    摘要翻译： 垂直储存平台矫直机的密封件采用连接到甲板下侧的泡沫垫。 当调平器降低时，垫接触平整机安装在其上的搁架，并向内偏转并压缩以密封整平机的下侧和搁板之间的空间。 垫是具有织物覆盖物的锥形泡沫。

    Vertically storing dock leveler
    7.
    发明授权
    Vertically storing dock leveler 失效
    垂直存放码头调平器

    公开(公告)号：US5396676A

    公开(公告)日：1995-03-14

    申请号：US978725

    申请日：1992-11-19

    申请人： James C. Alexander ,  Vincent Sullivan

    发明人： James C. Alexander ,  Vincent Sullivan

    IPC分类号： B65G69/28 ,  E01D1/00

    CPC分类号： B65G69/2876

    摘要： A seal for a vertically storing dock leveler employs a foam pad connected to the underside of the deck. As the leveler is lowered, the pad contacts the shelf on to which the leveler is mounted and deflects inward and compresses to seal the space between the underside of the leveler and the shelf. The pad is a tapered foam with a fabric covering.

    摘要翻译： 垂直储存平台矫直机的密封件采用连接到甲板下侧的泡沫垫。 当调平器降低时，垫接触平整器安装在其上的搁架，并向内偏转并压缩以密封整平机的下侧和搁板之间的空间。 垫是具有织物覆盖物的锥形泡沫。

    Formulations of phosphodiesterase 5 inhibitors and methods of use
    9.
    发明申请
    Formulations of phosphodiesterase 5 inhibitors and methods of use 审中-公开
    磷酸二酯酶5抑制剂的制剂和使用方法

    公开(公告)号：US20060035905A1

    公开(公告)日：2006-02-16

    申请号：US11042012

    申请日：2005-01-25

    申请人： Ge Jiang ,  Vincent Sullivan ,  Ronald Pettis ,  Chorng-Fure Hwang

    发明人： Ge Jiang ,  Vincent Sullivan ,  Ronald Pettis ,  Chorng-Fure Hwang

    IPC分类号： A61K31/519

    CPC分类号： A61K31/519 ,  A61K9/0019 ,  A61K9/0021 ,  A61K9/0043 ,  A61K9/0056 ,  A61K9/006 ,  A61K9/19 ,  A61K47/10 ,  A61K47/14 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  A61K47/44

    摘要： The present invention provides compositions and delivery methods to enhance treatment for sexual dysfunction or hypofunction through the delivery of phosphodiesterase 5 inhibitors to a mammal. Phosphodiesterase 5 inhibitors are one example of a compound class used for this indication. Examples of compounds in this class include taldalafil and vardenafil and sildenafil. Furthermore, the present invention provides compositions and delivery methods to enhance the sildenafil concentration in solution, suspension and gel formulations and methods of parenteral, intradermal, sublingual, intranasal, and buccal sildenafil delivery.

    摘要翻译： 本发明提供了通过向哺乳动物递送磷酸二酯酶5抑制剂来增强对性功能障碍或功能减退的治疗的组合物和递送方法。 磷酸二酯酶5抑制剂是用于该适应症的化合物类别的一个实例。 该类化合物的实例包括塔拉他非和伐地那非和西地那非。 此外，本发明提供用于增强溶液，悬浮液和凝胶制剂中西地那非浓度的组合物和递送方法以及胃肠外，皮内，舌下，鼻内和口腔西地那非递送的方法。