Abstract:
The present disclosure relates to magnetic particles, wherein each particle has a polymer matrix and at least one magnetic core (M), wherein the polymer matrix has at least one crosslinked polymer and wherein the magnetic particle has a particle size in the range of from 1 to 60 micrometer. Further, the present disclosure relates to a method of preparing such particles, and to particles obtainable or obtained by said method. Moreover, the present disclosure uses these magnetic particles for qualitative and/or quantitative determination of at least one analyte in a fluid. Further, the present disclosure relates to a method for determining at least one analyte in a fluid sample using the contacting of a magnetic particle of the disclosure or a magnetic particle obtained by the method of the present disclosure with a fluid sample having or suspected to have the at least one analyte.
Abstract:
Disclosed is a simplified process for producing magnetic polymer particles. The process comprises: (a) providing a composition having a liquid monomer which is radical polymerizable, a radical initiator soluble in the monomer, a steric stabilizer, and a ferrofluid comprising surfactant-coated colloidal magnetic particles in a carrier fluid which is miscible with the monomer; (b) preparing an emulsion from a polar solvent which is immiscible with the monomer, and the composition of step (a); (c) adding seed polymer particles to the emulsion, mixing to form a seeded emulsion, and incubating the seeded emulsion, thereby swelling the seed polymer particles; and (d) activating the radical initiator and polymerizing the monomer in the swollen seed polymer particles; thereby producing the magnetic polymer particles. The process forms monodisperse magnetic particles. The particles are characterized by a uniform distribution of magnetic material, and an absence of magnetite bleeding.
Abstract:
Disclosed is a simplified process for producing magnetic polymer particles. The process comprises: (a) providing a composition having a liquid monomer which is radical polymerizable, a radical initiator soluble in the monomer, a steric stabilizer, and a ferrofluid comprising surfactant-coated colloidal magnetic particles in a carrier fluid which is miscible with the monomer; (b) preparing an emulsion from a polar solvent which is immiscible with the monomer, and the composition of step (a); (c) adding seed polymer particles to the emulsion, mixing to form a seeded emulsion, and incubating the seeded emulsion, thereby swelling the seed polymer particles; and (d) activating the radical initiator and polymerizing the monomer in the swollen seed polymer particles; thereby producing the magnetic polymer particles. The process forms monodisperse magnetic particles. The particles are characterized by a uniform distribution of magnetic material, and an absence of magnetite bleeding.