公开(公告)号：US20230052545A1

公开(公告)日：2023-02-16

申请号：US17822587

申请日：2022-08-26

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Werner Hoelke ,  Michaela Fischer ,  Johann-Peter Thalhofer ,  Markus Weber

IPC: C12N9/96 ,  C12N9/54 ,  C12N9/64 ,  C12N9/52

Abstract: Described are compositions, in particular lyophilizates, containing proteolytic enzymes, and methods for producing the compositions. Typically these compositions contain one or more proteases with collagenase activity and a neutral protease, for example, thermolysin. The compositions are free of acetate salts. Surprisingly, such compositions can be dissolved in water more rapidly than lyophilized protease mixtures of the state of the art.

公开(公告)号：US20170247679A1

公开(公告)日：2017-08-31

申请号：US15595126

申请日：2017-05-15

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Werner Hoelke ,  Michaela Fischer ,  Johann-Peter Thalhofer ,  Markus Weber

IPC: C12N9/96 ,  C12N9/54 ,  C12N9/52

CPC classification number: C12N9/96 ,  C12N9/52 ,  C12N9/54 ,  C12N9/6491 ,  C12Y304/24003 ,  C12Y304/24027

Abstract: Described are compositions, in particular lyophilizates, containing proteolytic enzymes, and methods for producing the compositions. Typically these compositions contain one or more proteases with collagenase activity and a neutral protease, for example, thermolysin. The compositions are free of acetate salts. Surprisingly, such compositions can be dissolved in water more rapidly than lyophilized protease mixtures of the state of the art.

公开(公告)号：US11459556B2

公开(公告)日：2022-10-04

申请号：US16865487

申请日：2020-05-04

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Werner Hoelke ,  Michaela Fischer ,  Johann-Peter Thalhofer ,  Markus Weber

IPC: C12N9/96 ,  C12N9/54 ,  C12N9/64 ,  C12N9/52

Abstract: Described are compositions, in particular lyophilizates, containing proteolytic enzymes, and methods for producing the compositions. Typically these compositions contain one or more proteases with collagenase activity and a neutral protease, for example, thermolysin. The compositions are free of acetate salts. Surprisingly, such compositions can be dissolved in water more rapidly than lyophilized protease mixtures of the state of the art.

公开(公告)号：US20200263160A1

公开(公告)日：2020-08-20

申请号：US16865487

申请日：2020-05-04

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Werner Hoelke ,  Michaela Fischer ,  Johann-Peter Thalhofer ,  Markus Weber

IPC: C12N9/96 ,  C12N9/52 ,  C12N9/64 ,  C12N9/54

Abstract: Described are compositions, in particular lyophilizates, containing proteolytic enzymes, and methods for producing the compositions. Typically these compositions contain one or more proteases with collagenase activity and a neutral protease, for example, thermolysin. The compositions are free of acetate salts. Surprisingly, such compositions can be dissolved in water more rapidly than lyophilized protease mixtures of the state of the art.

公开(公告)号：US20160319268A1

公开(公告)日：2016-11-03

申请号：US14699299

申请日：2015-04-29

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Werner Hoelke ,  Michaela Fischer ,  Johann-Peter Thalhofer ,  Markus Weber

IPC: C12N9/96 ,  C12N9/54 ,  C12N9/52

CPC classification number: C12N9/96 ,  C12N9/52 ,  C12N9/54 ,  C12N9/6491 ,  C12Y304/24003 ,  C12Y304/24027

Abstract: Described are compositions, in particular lyophilizates, containing proteolytic enzymes, and methods for producing the compositions. Typically these compositions contain one or more proteases with collagenase activity and a neutral protease, for example, thermolysin. The compositions are free of acetate salts. Surprisingly, such compositions can be dissolved in water more rapidly than lyophilized protease mixtures of the state of the art.

Abstract translation: 描述了含有蛋白水解酶的组合物，特别是冻干物，以及用于制备组合物的方法。 通常，这些组合物含有一种或多种具有胶原酶活性的蛋白酶和中性蛋白酶，例如嗜热菌蛋白酶。 组合物不含乙酸盐。 令人惊奇的是，这种组合物可以比现有技术的冻干蛋白酶混合物更快地溶解在水中。