-
1.发明公开公开(公告)号：US20230201229A1
公开(公告)日：2023-06-29
申请号：US17860723
申请日：2022-07-08
申请人： SMITH & NEPHEW, INC.
发明人： Aleksa JOVANOVIC , Lei SHI , Eric ROCHE , Paul RENICK
IPC分类号： A61K31/7036 , A61P31/04 , A61K38/48
CPC分类号： A61K31/7036 , A61P31/04 , A61K38/4886 , C12Y304/24027
摘要： Methods are disclosed for the reduction or elimination of bacterial biofilms on biological and non-biological surfaces, as well as methods for the treatment of wounds, skin lesions, mucous membrane lesions, and other biological surfaces infected or contaminated with bacterial biofilms using compositions comprising a synergistic combination of thermolysin and at least one aminoglycoside antibacterial agent.
-
公开(公告)号：US09976134B2
公开(公告)日：2018-05-22
申请号：US14794687
申请日：2015-07-08
申请人： Danisco US Inc.
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38618 , C11D3/38636 , C12Y304/24027
摘要： The present invention provides methods and compositions comprising at least one thermolysin-like neutral protease enzyme with improved storage stability and/or catalytic activity. In some embodiments, the thermolysin finds use in cleaning and other applications comprising detergent. In some particularly preferred embodiments, the present invention provides methods and compositions comprising thermolysin formulated and/or engineered to resist detergent-induced inactivation.
-
公开(公告)号：US09045743B2
公开(公告)日：2015-06-02
申请号：US13488824
申请日：2012-06-05
CPC分类号： C12N9/54 , C12N9/96 , C12Y304/24027
摘要： The present invention deals with the proteolytic enzyme thermolysin which tends to be unstable in aqueous solution. The invention provides methods and compositions to enhance the stability of dissolved thermolysin in aqueous solution. Thermolysin, crude thermolysin or a lyophilizate containing thermolysin and one or more salts, is contacted with an aqueous buffer with a low salt concentration and a first solution is formed. Subsequently, a further salt in solid form is added and dissociated, thereby forming a second solution comprising thermolysin in a stabilized form.
摘要翻译： 本发明涉及在水溶液中趋于不稳定的蛋白水解酶嗜热溶菌酶。 本发明提供了增加溶解的嗜热溶菌酶在水溶液中的稳定性的方法和组合物。 将嗜热菌蛋白酶，粗嗜热菌蛋白酶或含有嗜热菌蛋白酶和一种或多种盐的冻干物与低盐浓度的水性缓冲液接触，形成第一溶液。 随后，加入固体形式的另外的盐并解离，由此形成稳定形式的包含嗜热菌蛋白酶的第二溶液。
-
公开(公告)号：US12016907B2
公开(公告)日：2024-06-25
申请号：US17888229
申请日：2022-08-15
申请人： SMITH & NEPHEW, INC.
发明人： Lei Shi , Aleksa Jovanovic , Dennis Carson
IPC分类号： A61K38/48
CPC分类号： A61K38/4886 , C12Y304/24027
摘要： Disclosed is a hydrogel comprising a hydrophilic gelling agent that includes a nonionic cellulose ether, and active thermolysin, wherein the proteolytic activity of the thermolysin does not decrease by more than 20% when stored at room temperature for 6 months.
-
公开(公告)号：US20240150418A1
公开(公告)日：2024-05-09
申请号：US18547133
申请日：2022-03-02
申请人： Arla Foods amba
发明人： Hans Peter Sørensen , Hans Bertelsen , Søren Klitgaard , Lotte Neergaard Jacobsen , Ditte Møller Nielsen
CPC分类号： C07K14/47 , A61P37/08 , C12N9/6408 , C12N9/6472 , C12N9/6489 , C12P21/06 , A61K38/00 , C12Y304/21062 , C12Y304/22039 , C12Y304/24027
摘要： The present invention relates to a new whey protein hydrolysate having reduced allergenicity and retained immunogenicity. The new whey protein hydrolysate is also characterized by having a low amount of larger peptides. The invention furthermore relates to a method of preparing the new whey protein hydrolysates, uses of the new whey protein hydrolysates and food products comprising this new whey protein hydrolysate.
-
公开(公告)号：US11957698B2
公开(公告)日：2024-04-16
申请号：US17860723
申请日：2022-07-08
申请人： SMITH & NEPHEW, INC.
发明人： Aleksa Jovanovic , Lei Shi , Eric Roche , Paul Renick
IPC分类号： A61K31/7036 , A61K38/48 , A61P31/04
CPC分类号： A61K31/7036 , A61K38/4886 , A61P31/04 , C12Y304/24027
摘要： Methods are disclosed for the reduction or elimination of bacterial biofilms on biological and non-biological surfaces, as well as methods for the treatment of wounds, skin lesions, mucous membrane lesions, and other biological surfaces infected or contaminated with bacterial biofilms using compositions comprising a synergistic combination of thermolysin and at least one aminoglycoside antibacterial agent.
-
公开(公告)号：US20190060509A1
公开(公告)日：2019-02-28
申请号：US16171070
申请日：2018-10-25
申请人： SMITH & NEPHEW, INC.
发明人： Lei SHI , Aleksa JOVANOVIC , Duncan AUST
IPC分类号： A61L15/26 , A61K38/48 , A61L26/00 , A61L15/44 , A61K47/10 , A61K47/44 , A61L15/38 , A61K9/10 , A61K9/06 , A61L15/34 , C08L71/02
CPC分类号： A61L15/26 , A61K9/06 , A61K9/10 , A61K38/4826 , A61K38/4873 , A61K38/488 , A61K38/4886 , A61K47/10 , A61K47/44 , A61L15/34 , A61L15/38 , A61L15/44 , A61L26/0019 , A61L26/0066 , A61L2300/254 , C12Y304/24027 , C08L71/02
摘要： The present invention is directed to topical enzymatic wound debriding compositions with enhanced enzymatic activity. These compositions comprise a dispersed phase comprising at least one proteolytic enzyme and at least one hydrophilic polyol; and a continuous phase comprising a hydrophobic base.
-
公开(公告)号：US20180073006A1
公开(公告)日：2018-03-15
申请号：US15725627
申请日：2017-10-05
申请人： DANISCO US INC.
发明人： Lilia M. Babe , Richard R. Bott , Roopa Ghirnikar , Frits Goedegebuur , Xiaogang Gu , Marc Kolkman , Jian Yao , Shukun Yu
CPC分类号： C12N9/54 , C11D3/386 , C12Y304/24 , C12Y304/24027
摘要： Aspects of the present compositions and methods relate to novel metalloproteases polynucleotides encoding the novel metalloprotease, compositions and methods for use thereof.
-
公开(公告)号：US09574186B2
公开(公告)日：2017-02-21
申请号：US14697843
申请日：2015-04-28
CPC分类号： C12N9/54 , C12N9/96 , C12Y304/24027
摘要： The present invention deals with the proteolytic enzyme thermolysin which tends to be unstable in aqueous solution. The invention provides methods and compositions to enhance the stability of dissolved thermolysin in aqueous solution. Thermolysin, crude thermolysin or a lyophilisate containing thermolysin and one or more salts, is contacted with an aqueous buffer with a low salt concentration and a first solution is formed. Subsequently, a further salt in solid form is added and dissociated, thereby forming a second solution comprising thermolysin in a stabilized form.
摘要翻译： 本发明涉及在水溶液中趋于不稳定的蛋白水解酶嗜热溶菌酶。 本发明提供了增加溶解的嗜热溶菌酶在水溶液中的稳定性的方法和组合物。 将含有嗜热菌蛋白酶和一种或多种盐的溶血素酶，粗嗜热菌蛋白酶或冻干物质与低盐浓度的水性缓冲液接触，形成第一溶液。 随后，加入固体形式的另外的盐并解离，由此形成稳定形式的包含嗜热菌蛋白酶的第二溶液。
-
10.发明申请PRODUCTION OF THERMOLYSIN AND VARIANTS THEREOF AND USE IN LIQUID DETERGENTS 有权生产热变性蛋白酶及其变体，并用于液体洗涤剂公开(公告)号：US20160032266A1
公开(公告)日：2016-02-04
申请号：US14794687
申请日：2015-07-08
申请人： Danisco US Inc.
发明人： David A. Estell , Ronaldus W.J. Hommes , Amy D. Liu , Andrew Shaw
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38618 , C11D3/38636 , C12Y304/24027
摘要： The present invention provides methods and compositions comprising at least one thermolysin-like neutral protease enzyme with improved storage stability and/or catalytic activity. In some embodiments, the thermolysin finds use in cleaning and other applications comprising detergent. In some particularly preferred embodiments, the present invention provides methods and compositions comprising thermolysin formulated and/or engineered to resist detergent-induced inactivation.
摘要翻译： 本发明提供包含至少一种具有改善的储存稳定性和/或催化活性的嗜热菌蛋白酶样中性蛋白酶的方法和组合物。 在一些实施方案中，嗜热菌蛋白酶用于清洁和其它包含洗涤剂的应用。 在一些特别优选的实施方案中，本发明提供包含热溶菌素的方法和组合物，其配制和/或工程化以抵抗洗涤剂诱导的失活。
-
-
-
-
-
-
-
-
-
搜索结果
51 条记录 (耗时 0.038 秒)
