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    Immune-derived moieties reactive against lysophosphatidic acid
    9.
    发明授权
    Immune-derived moieties reactive against lysophosphatidic acid 有权
    对溶血磷脂酸具有反应性的免疫衍生部分

    公开(公告)号：US09217749B2

    公开(公告)日：2015-12-22

    申请号：US11755721

    申请日：2007-05-30

    申请人： Roger A. Sabbadini ,  William A. Garland ,  Genevieve Hansen

    发明人： Roger A. Sabbadini ,  William A. Garland ,  Genevieve Hansen

    IPC分类号： G01N33/92 ,  C07K16/18 ,  C07K16/30 ,  C12P21/08 ,  A61K47/48 ,  A61K39/00

    CPC分类号： G01N33/92 ,  A61K47/544 ,  A61K47/60 ,  A61K47/643 ,  A61K47/646 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/74

    摘要： Compositions and methods for producing monoclonal antibodies and their derivatives reactive against bioactive lipid targets are described. These compositions include derivatized lipids, each of which comprises a bioactive lipid that having a polar head group and at least one hydrocarbon chain (e.g., a lysolipid such as lysophosphatidic acid or sphingosine-1-phosphate) in which a carbon atom has been derivatized with a pendant reactive group; immunogens made by linking a derivatized lipid to a carrier moiety (e.g., a carrier protein, polyethylene glycol, colloidal gold, alginate, or a silicone bead); monoclonal antibodies and derivatives produced by immunizing an animal with such an immunogen; and therapeutic and diagnostic compositions containing such antibodies and antibody derivatives. Methods for making such derivatized lipids, immunogens, and monoclonal antibodies and derivatives, methods for detecting such antibodies once generated, and therapeutic and diagnostic methods for using such antibodies and derivatives, are also described.

    摘要翻译： 描述了用于产生针对生物活性脂质靶标的反应性的单克隆抗体及其衍生物的组合物和方法。 这些组合物包括衍生的脂质，其各自包含具有极性头基团和至少一个烃链的生物活性脂质（例如溶血磷脂酸或鞘氨醇-1-磷酸酯等溶血磷脂酸或鞘氨醇-1-磷酸酯），其中碳原子已被衍生化， 吊坠反应组; 通过将衍生的脂质与载体部分（例如载体蛋白，聚乙二醇，胶体金，藻酸盐或硅酮珠）连接而制备的免疫原; 通过用这种免疫原免疫动物产生的单克隆抗体和衍生物; 以及含有此类抗体和抗体衍生物的治疗和诊断组合物。 还描述了制备这种衍生化脂质，免疫原和单克隆抗体及其衍生物的方法，一旦产生的检测此类抗体的方法，以及使用这些抗体和衍生物的治疗和诊断方法。

    Methods and reagents for detecting bioactive lipids
    10.
    发明授权
    Methods and reagents for detecting bioactive lipids 有权
    检测生物活性脂质的方法和试剂

    公开(公告)号：US09274129B2

    公开(公告)日：2016-03-01

    申请号：US11755699

    申请日：2007-05-30

    申请人： Roger A. Sabbadini ,  William A. Garland ,  Genevieve Hansen

    发明人： Roger A. Sabbadini ,  William A. Garland ,  Genevieve Hansen

    IPC分类号： C07K17/14 ,  C07K17/06 ,  G01N33/532 ,  G01N33/92 ,  C07K16/18 ,  C07K16/30 ,  G01N33/68 ,  A61K39/00

    CPC分类号： G01N33/92 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/73 ,  G01N33/6854

    摘要： Compositions and methods for producing monoclonal antibodies and their derivatives reactive against bioactive lipid targets are described. These compositions include derivatized lipids, each of which comprises a bioactive lipid that having a polar head group and at least one hydrocarbon chain (e.g., a lysolipid such as lysophosphatidic acid or sphingosine-1-phosphate) in which a carbon atom has been derivatized with a pendant reactive group; immunogens made by linking a derivatized lipid to a carrier moiety (e.g., a carrier protein, polyethylene glycol, colloidal gold, alginate, or a silicone bead); monoclonal antibodies and derivatives produced by immunizing an animal with such an immunogen; and therapeutic and diagnostic compositions containing such antibodies and antibody derivatives. Methods for making such derivatized lipids, immunogens, and monoclonal antibodies and derivatives, methods for detecting such antibodies once generated, and therapeutic and diagnostic methods for using such antibodies and derivatives, are also described.

    摘要翻译： 描述了用于产生针对生物活性脂质靶标的反应性的单克隆抗体及其衍生物的组合物和方法。 这些组合物包括衍生的脂质，其各自包含具有极性头基团和至少一个烃链的生物活性脂质（例如溶血磷脂酸或鞘氨醇-1-磷酸酯等溶血磷脂酸或鞘氨醇-1-磷酸酯），其中碳原子已被衍生化， 吊坠反应组; 通过将衍生的脂质与载体部分（例如载体蛋白，聚乙二醇，胶体金，藻酸盐或硅酮珠）连接而制备的免疫原; 通过用这种免疫原免疫动物产生的单克隆抗体和衍生物; 以及含有此类抗体和抗体衍生物的治疗和诊断组合物。 还描述了制备这种衍生化脂质，免疫原和单克隆抗体及其衍生物的方法，一旦产生的检测此类抗体的方法，以及使用这些抗体和衍生物的治疗和诊断方法。