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1.发明授权Methods of using humanized antibodies and compositions for binding sphingosine-1-phosphate 有权使用人源化抗体和用于结合鞘氨醇-1-磷酸的组合物的方法公开(公告)号：US08025877B2
公开(公告)日：2011-09-27
申请号：US12258355
申请日：2008-10-24
申请人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Williams
发明人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Williams
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/00
CPC分类号： C07K16/44 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to anti-S1P agents, particularly humanized monoclonal antibodies (and antigen binding fragments thereof) specifically reactive with S1P, compositions containing such antibodies (or fragments), and the use of such antibodies (or fragments), for example, to treat diseases and conditions associated with aberrant levels of S1P.
摘要翻译： 本发明涉及与S1P特异性反应的抗S1P试剂，特别是人源化单克隆抗体（及其抗原结合片段），含有此类抗体（或片段）的组合物，以及使用这种抗体（或片段），例如 治疗与S1P异常水平相关的疾病和病症。
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公开(公告)号：US08026342B2
公开(公告)日：2011-09-27
申请号：US12258383
申请日：2008-10-24
申请人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
发明人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/00
CPC分类号： C07K16/44 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to anti-S1P agents, for example, humanized monoclonal antibodies, and their uses for detection of S1P or for treatment of diseases and conditions associated with S1P.
摘要翻译： 本发明涉及抗S1P剂，例如人源化单克隆抗体及其用于检测S1P或用于治疗与S1P相关的疾病和病症的用途。
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公开(公告)号：US07829674B2
公开(公告)日：2010-11-09
申请号：US11924890
申请日：2007-10-26
申请人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
发明人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/00
CPC分类号： C07K16/44 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to anti-S1P agents, for example, humanized monoclonal antibodies, and their uses for detection of S1P or for treatment of diseases and conditions associated with S1P.
摘要翻译： 本发明涉及抗S1P剂，例如人源化单克隆抗体及其用于检测S1P或用于治疗与S1P相关的疾病和病症的用途。
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4.发明授权Humanized antibody compositions and methods for binding lysophosphatidic acid 失效人源化抗体组合物和结合溶血磷脂酸的方法公开(公告)号：US08604172B2
公开(公告)日：2013-12-10
申请号：US12761584
申请日：2010-04-16
申请人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
发明人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
IPC分类号： C12P21/08
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/44 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/70 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Compositions and methods for making and using humanized anti-LPA monoclonal antibodies, and fragments and derivatives thereof, are described.
摘要翻译： 描述了制备和使用人源化抗LPA单克隆抗体的组合物和方法及其片段和衍生物。
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5.发明授权公开(公告)号：US08222373B2
公开(公告)日：2012-07-17
申请号：US12258346
申请日：2008-10-24
申请人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
发明人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/00
CPC分类号： C07K16/44 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to anti-S1P agents, particularly humanized monoclonal antibodies (and antigen binding fragments thereof) specifically reactive with S1P, compositions containing such antibodies (or fragments), and the use of such antibodies (or fragments), for example, to treat diseases and conditions associated with aberrant levels of S1P.
摘要翻译： 本发明涉及与S1P特异性反应的抗S1P试剂，特别是人源化单克隆抗体（及其抗原结合片段），含有此类抗体（或片段）的组合物，以及使用这种抗体（或片段），例如 治疗与S1P异常水平相关的疾病和病症。
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6.发明授权公开(公告)号：US08067549B2
公开(公告)日：2011-11-29
申请号：US12258337
申请日：2008-10-24
申请人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
发明人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/00
CPC分类号： C07K16/44 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to anti-S1P agents, particularly humanized monoclonal antibodies (and antigen binding fragments thereof) specifically reactive with S1P, compositions containing such antibodies (or fragments), and the use of such antibodies (or fragments), for example, to treat diseases and conditions associated with aberrant levels of S1P.
摘要翻译： 本发明涉及与S1P特异性反应的抗S1P试剂，特别是人源化单克隆抗体（及其抗原结合片段），含有此类抗体（或片段）的组合物，以及使用这种抗体（或片段），例如 治疗与S1P异常水平相关的疾病和病症。
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7.发明授权Nucleic acids coding for humanized antibodies for binding sphingosine-1-phosphate 有权编码用于结合鞘氨醇-1-磷酸的人源化抗体的核酸公开(公告)号：US07956173B2
公开(公告)日：2011-06-07
申请号：US12258353
申请日：2008-10-24
申请人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
发明人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
IPC分类号： C07H21/04 , C07K16/00 , C12P21/08 , A61K39/395 , A61K39/00
CPC分类号： C07K16/44 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to anti-S1P agents, particularly humanized monoclonal antibodies (and antigen binding fragments thereof) specifically reactive with S1P, compositions containing such antibodies (or fragments), and the use of such antibodies (or fragments), for example, to treat diseases and conditions associated with aberrant levels of S1P.
摘要翻译： 本发明涉及与S1P特异性反应的抗S1P试剂，特别是人源化单克隆抗体（及其抗原结合片段），含有此类抗体（或片段）的组合物，以及使用这种抗体（或片段），例如 治疗与S1P异常水平相关的疾病和病症。
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公开(公告)号：US5817790A
公开(公告)日：1998-10-06
申请号：US436717
申请日：1995-05-08
申请人： Masayuki Tsuchiya , Koh Sato , Mary Margaret Bendig , Steven Tarran Jones , Jose William Saldanha
发明人： Masayuki Tsuchiya , Koh Sato , Mary Margaret Bendig , Steven Tarran Jones , Jose William Saldanha
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61P35/00 , C07K16/18 , C07K16/24 , C07K16/26 , C07K16/28 , C07K19/00 , C12N5/10 , C12N15/13 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/577 , C07H21/04
CPC分类号： C07K16/2866 , A61K38/00 , C07K2317/24 , C07K2319/00
摘要： A reshaped human antibody to the human IL-6R, comprising: (A) an L chain comprising, (1) a human L chain C region, and (2) an L chain V region comprising human L chain framework regions (FRs), and mouse L chain complementary determination regions (CDRs) of a monoclonal antibody to the IL-6 receptor (IL-6R); and (B) an H chain comprising, (1) a human H chain C region, and (2) an H chain V region comprising human H chain FRs, and mouse H chain CDRs of a monoclonal antibody to the IL-6R. Since major portion of the reshaped human antibody is derived from a human antibody and the mouse CDRs which are less immunogenic, the present reshaped human antibody is less immunogenic to human, and therefor is promised for therapeutic uses.
摘要翻译： 对人IL-6R的重构人抗体包含：（A）包含（1）人L链C区的L链，和（2）包含人L链框架区（FR）的L链V区， 和IL-6受体（IL-6R）的单克隆抗体的小鼠L链互补决定区（CDR）; 和（B）包含（1）人H链C区的H链和（2）包含人H链FR的H链V区和IL-6R单克隆抗体的小鼠H链CDR。 由于重构的人抗体的大部分衍生自人抗体和免疫原性较小的小鼠CDR，所以本发明的重组人抗体对人的免疫原性较低，因此被用于治疗用途。
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公开(公告)号：US5795965A
公开(公告)日：1998-08-18
申请号：US137117
申请日：1993-12-20
申请人： Masayuki Tsuchiya , Koh Sato , Mary Margaret Bendig , Steven Tarran Jones , Jose William Saldanha
发明人： Masayuki Tsuchiya , Koh Sato , Mary Margaret Bendig , Steven Tarran Jones , Jose William Saldanha
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61P35/00 , C07K16/18 , C07K16/24 , C07K16/26 , C07K16/28 , C07K19/00 , C12N5/10 , C12N15/13 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/577 , C07K16/00
CPC分类号： C07K16/2866 , A61K38/00 , C07K2317/24 , C07K2319/00
摘要： A reshaped human antibody to the human IL-6R, comprising: (A) an L chain comprising, (1) a human L chain C region, and (2) an L chain V region comprising human L chain framework regions (FRs), and mouse L chain complementary determination regions (CDRS) of a momoclonal antibody to the IL-6 receptor (IL-6R); and (B) an H chain comprising, (1) a human H chain C region, and (2) an H chain V region comprising human H chain FRs, and mouse H chain CDRs of a monoclonal antibody to the IL-6R. Since major portion of the reshaped human antibody is derived from a human antibody and the mouse CDRs which are less immunogenic, the present reshaped human antibody is less immunogenic to human, and therefor is promised for therapeutic uses.
摘要翻译： PCT No.PCT / JP92 / 00544 Sec。 371日期：1993年12月20日 102（e）日期1993年12月20日PCT提交1992年4月24日PCT公布。 WO92 / 19759 PCT公开号 日期：1992年11月12日，对人IL-6R重整人抗体，其包含：（A）包含（1）人L链C区的L链，（2）包含人L链骨架的L链V区 区域（FR）和IL-6受体（IL-6R）的单克隆抗体的小鼠L链互补决定区（CDRS）; 和（B）包含（1）人H链C区的H链和（2）包含人H链FR的H链V区和IL-6R单克隆抗体的小鼠H链CDR。 由于重构的人抗体的大部分衍生自人抗体和免疫原性较小的小鼠CDR，所以本发明的重组人抗体对人的免疫原性较低，因此被用于治疗用途。
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10.发明授权Humanized immunomodulatory monoclonal antibodies for the treatment of immunodeficiency 有权人源免疫调节单克隆抗体用于治疗免疫缺陷公开(公告)号：US07981416B2
公开(公告)日：2011-07-19
申请号：US12406492
申请日：2009-03-18
申请人： Britta Hardy , Steven Tarran Jones , Leah Klapper
发明人： Britta Hardy , Steven Tarran Jones , Leah Klapper
IPC分类号： A61K39/395 , C12P21/04 , C12P21/08 , C12N5/06 , C07K16/00 , C07H21/04 , G01N33/574
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/73
摘要： The present invention provides to a humanized monoclonal antibody having immunostimulatory effects. This antibody binds specifically to B lymphoblastoid cells, induces proliferation and activation of peripheral blood lymphocytes, particularly T cells, and is capable of eliciting an anti-tumor effect upon administration to subjects suffering from an immune deficiency.
摘要翻译： 本发明提供具有免疫刺激作用的人源化单克隆抗体。 该抗体特异性结合B淋巴母细胞，诱导外周血淋巴细胞，特别是T细胞的增殖和活化，并且能够在给予患有免疫缺陷的受试者时引发抗肿瘤作用。
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