公开(公告)号：US07429248B1

公开(公告)日：2008-09-30

申请号：US09925193

申请日：2001-08-09

申请人： Alan A. Winder ,  Roger J. Talish

发明人： Alan A. Winder ,  Roger J. Talish

IPC分类号： A61H1/00

CPC分类号： A61N7/00 ,  A61N2007/0078

摘要： A modal converter having at least one ultrasonic transducer or at least one array of such transducers positioned on the modal converter at various angles relative to a tissue surface and bone tissue surface, such that some combination of one or more of the following occur: longitudinal waves are produced perpendicular to the bone surface, longitudinal waves propagate along the surface of the skin after incidence at the skin tissue surface, and both longitudinal and shear waves propagate along the surface of the bone after incidence at the bone tissue surface. Illuminating an open tissue wound and bone fracture site with these acoustic modes enhances and promotes angiogenesis and the biological endostial or periostial healing phases, or both, of the bone fracture healing process. The spatial and temporal distribution of acoustic waves directed to the treatment area via the ultrasonic transducers and the modal converter may be controlled.

摘要翻译： 模态转换器具有相对于组织表面和骨组织表面以各种角度定位在模态转换器上的至少一个超声波换能器或至少一个这样的换能器的阵列，使得发生以下一种或多种的某些组合：纵波 垂直于骨表面产生纵向波，在皮肤组织表面入射后沿着皮肤表面传播，并且纵向波和剪切波在骨组织表面入射之后沿骨表面传播。 利用这些声学模式照射开放性组织伤口和骨折部位增强并促进骨折愈合过程的血管生成和生物内皮或骨膜内愈合期或两者。 可以控制经由超声波换能器和模态转换器指向治疗区域的声波的空间和时间分布。

公开(公告)号：US07429249B1

公开(公告)日：2008-09-30

申请号：US09980329

申请日：2000-06-14

申请人： Alan A. Winder ,  Roger J. Talish

发明人： Alan A. Winder ,  Roger J. Talish

IPC分类号： A61N7/00

CPC分类号： A61N7/00

摘要： A method and kit for therapeutically treating bone and tissue injuries using ultrasound. The method includes the steps of introducing an ultrasound contrast agent into the patient, preferably, the patient's blood stream, and impinging ultrasonic waves in proximity to an injury. The ultrasound contrast agent facilitate in lowering the cavitation threshold, i.e., the energy required for the cavitation, to a level attainable by the ultrasonic waves to induce acoustic intracellular microstreaming to accelerate the healing process. The method further includes the steps of maintaining the resonance bubble frequency of the microbubbles of the ultrasound contrast agent from 0.5 MHz to 10 MHz; maintaining the acoustic transmit frequency of the ultrasound waves from 10 kHz to 10 MHz; and maintaining the acoustic spatial average-temporal average (SATA) intensity of the ultrasonic waves from 5 to 500 mW/cm2. The kit of the invention includes at least one ergonomically constructed ultrasonic transducer (16) configured to cooperate with a placement module (14) for placement in proximity to an injury and a portable, ergonomically constructed main operating unit (12) constructed to fit within a pouch (18) worn by the patient.

摘要翻译： 使用超声波治疗骨组织损伤的方法和试剂盒。 该方法包括以下步骤：将超声造影剂引入患者，优选地，将患者的血流引入患者的血流中，并在伤害附近撞击超声波。 超声造影剂有助于将空化阈值（即空化所需的能量）降低到由超声波可达到的水平以诱导声学细胞内微流加速愈合过程。 该方法还包括将超声造影剂的微泡的共振气泡频率保持在0.5MHz至10MHz的步骤; 将超声波的声发射频率从10kHz维持到10MHz; 并将超声波的声学空间平均 - 时间平均（SATA）强度保持在5至500mW / cm 2之间。 本发明的套件包括至少一个符合人体工程学的构造的超声波换能器（16），其被配置为与放置模块（14）配合以放置在伤害附近并且被构造成便于符合人体工程学的构造的主操作单元（12） 患者佩戴的小袋（18）。

公开(公告)号：US07410469B1

公开(公告)日：2008-08-12

申请号：US09574461

申请日：2000-05-18

申请人： Roger J. Talish ,  Alan A. Winder

发明人： Roger J. Talish ,  Alan A. Winder

IPC分类号： A61H1/00 ,  A61H5/00

CPC分类号： A61N2/002 ,  A61N2/02 ,  A61N7/00

摘要： The invention relates to apparatus and method for ultrasonically and electromagnetically treating tissue to treat, for example, traumatized tissue or a bone injury. The apparatus includes at least one ultrasonic transducer assembly and at least one electromagnetic coil-assembly configured to cooperate with a placement module for placement in proximity to the treatment area. The apparatus also utilizes a portable main operating unit constructed to fit within a pouch or carrying case worn by the patient. In operation, at least one ultrasonic transducer and at least one electromagnetic coil are activated by transmitting control signals to the placement module from the main operating unit. The activation of the at least one ultrasonic transducer causes ultrasonic waves to be propagated toward the treatment area which are modulated by electrostatic and magnetic forces generated by the at least one electromagnetic coil. The activation of the at least one ultrasonic transducer and the at least one electromagnetic coil may be performed at the same time or at different times for varying periods.

摘要翻译： 本发明涉及用于超声波和电磁处理组织以治疗例如创伤组织或骨损伤的装置和方法。 该装置包括至少一个超声换能器组件和至少一个电磁线圈组件，其配置成与放置模块配合以放置在靠近治疗区域的位置。 该装置还利用便携式主操作单元，其构造成装配在患者佩戴的小袋或手提箱内。 在操作中，通过从主操作单元将控制信号发送到放置模块来激活至少一个超声换能器和至少一个电磁线圈。 至少一个超声波换能器的激活导致超声波向处理区域传播，该处理区域被由至少一个电磁线圈产生的静电和磁力调制。 至少一个超声波换能器和至少一个电磁线圈的激活可以在不同的时间段的同时或不同的时间进行。

公开(公告)号：US07108663B2

公开(公告)日：2006-09-19

申请号：US10026290

申请日：2001-12-20

申请人： Roger J. Talish ,  John P. Ryaby ,  Emery Rose ,  Alan A. Winder ,  Kenneth Urgovitch, Sr.

发明人： Roger J. Talish ,  John P. Ryaby ,  Emery Rose ,  Alan A. Winder ,  Kenneth Urgovitch, Sr.

IPC分类号： A61H1/00

CPC分类号： A61N7/00 ,  A61B17/16 ,  A61B17/1677 ,  A61B18/20

摘要： The invention relates to apparatus and method for ultrasonically stimulating cartilage growth. The apparatus includes at least one ergonomically constructed ultrasonic transducer configured to cooperate with a placement module or strip for placement in proximity to an area where cartilage growth is desired. The apparatus also utilizes a portable, ergonomically constructed main operating unit constructed to fit within a pouch worn by the patient. In operation, at least one ultrasonic transducer positioned in proximity to an osteochondral site is excited for a predetermined period of time. To ensure that at least one ultrasonic transducer is properly positioned, and to insure compliance with a treatment protocol, a safety interlock is provided to prevent inadvertent excitation of the at least one ultrasonic transducer.

公开(公告)号：US06355006B1

公开(公告)日：2002-03-12

申请号：US09436999

申请日：1999-11-09

申请人： John P. Ryaby ,  Roger J. Talish ,  Emery Rose ,  Alan A. Winder ,  Kenneth Urgovitch, Sr.

发明人： John P. Ryaby ,  Roger J. Talish ,  Emery Rose ,  Alan A. Winder ,  Kenneth Urgovitch, Sr.

IPC分类号： A61H100

CPC分类号： A61B17/1677 ,  A61B17/16 ,  A61B18/20 ,  A61N7/00

摘要： A kit of elements including an ultrasonic generator, transducers with connecting cables, and a means for locating the transducers over areas of the body containing cartilage, is provided with the surgical instruments for post-surgical application to ultrasonically stimulate the cartilage growth, thus relieving the effects of surgical intervention.

摘要翻译： 包括超声波发生器，具有连接电缆的换能器和用于将换能器定位在包含软骨的身体的区域上的装置的一组元件设置有用于手术后应用的外科手术器械，以超声刺激软骨生长，从而缓解 手术干预的效果。

公开(公告)号：US5520612A

公开(公告)日：1996-05-28

申请号：US367471

申请日：1994-12-30

申请人： Alan A. Winder ,  Roger J. Talish ,  John P. Ryaby

发明人： Alan A. Winder ,  Roger J. Talish ,  John P. Ryaby

IPC分类号： A61N1/00 ,  A61B17/225 ,  A61B17/58 ,  A61H23/02 ,  A61H39/00 ,  A61N7/00

CPC分类号： A61N7/00 ,  A61B17/58

摘要： A transducer for non-invasive transcutaneous transmission of pulsed ultrahigh-frequency acoustic radiation, in body tissue and/or fluids adjacent a bone fracture is "on target" when a fraction of the propagated energy within the longitudinal-response lobe of the transducer encounters a crack or other open feature of the fracture, where a gap or space exists between closely spaced fracture walls. The ultrahigh-frequency acoustic radiation sees this "on target" feature as the entrance to a waveguide, whereby pulsed ultrahigh-frequency acoustic radiation is guided within the crack. When this acoustic radiation encounters a gap of at least a quarter wavelength (at the ultrahigh frequency), a standing wave condition establishes itself, with dissipation of the ultrahigh frequency and with demodulation to establish a therapeutically beneficial low-frequency acoustic condition, within the fracture, and acting where most needed, namely, on and between wall regions of adjacent fragments of the broken bone. Collagen, callus and cartilage development is accelerated, closing the gap in a matter of days, so that thereafter zone-flooding of shear waves from transducer radiation can be osteogenically operative upon both bone fragments of the fracture and on the collagen through which they are united at first tentatively and then increasingly more securely as treatment continues, from day to day, as with one or more single treatments of 20 minutes per day.

摘要翻译： 在传感器的纵向响应波瓣内的传播能量的一部分遇到一个或多个传感器时，用于非侵入式经皮传输脉冲超声频辐射的传感器在身体组织和/或邻近骨折的流体中是“目标的” 裂缝或裂缝的其他开放特征，其中在紧密间隔的裂缝壁之间存在间隙或空间。 超高频声辐射将这种“目标”特征视为波导的入口，由此在裂纹内引导脉冲超高频声辐射。 当这种声辐射遇到至少四分之一波长（在超高频）的间隙时，驻波条件本身就与超高频的耗散和解调有关，以在断层内建立治疗有益的低频声学条件 ，并且在最需要的地方，即在断骨的相邻碎片的壁区域之间和之间起作用。 胶原蛋白，愈伤组织和软骨发育加速，在几天内弥合差距，于是此后，来自传感器辐射的剪切波的区域淹没可以在骨折的两个骨碎片和它们结合的胶原上成骨操作 起初，随着治疗的持续日益增加，日益变得越来越安全，如同每天20分钟的一次或多次单次治疗一样。

公开(公告)号：US07211060B1

公开(公告)日：2007-05-01

申请号：US09700014

申请日：1999-05-06

申请人： Roger J. Talish ,  Alan A. Winder

发明人： Roger J. Talish ,  Alan A. Winder

IPC分类号： A61F5/00

CPC分类号： A61N7/00 ,  A61H23/0245 ,  A61N2007/0078 ,  G10K11/004 ,  Y10T29/42

摘要： Ultrasound bandages (10) and ultrasound transducer array bandages are provided herein to accelerate the healing of wounds by positioning the ultrasound bandages (10) and ultrasound transducer array bandages adjacent to a wound and generating ultrasonic pulses. The ultrasound bandages (10) generally include (a) a backing layer (12), (b) an adhesive layer (14) applied to, and substantially coextensive with the backing layer (12), and (c) a transducer material (16) disposed on at least a portion of the adhesive layer (14). The ultrasound transducer array bandages generally include (a) a backing layer (13), (b) an adhesive layer applied to, and substantially coextensive with, the backing layer, and (c) an array comprising a plurality of transducer materials arranged in adjacent relation to define spaces therebetween, the array being disposed on at least a portion of the adhesive layer. The resulting ultrasound bandages (10) and ultrasound transducer array bandages allows for medical therapeutic applications as promoting the healing of wounds such as abrasions, lacerations, incisions and ulcers at any section or multiple sections of the human anatomy with the ultrasound bandages (10) and ultrasound transducer array bandages being conveniently discarded after each application and a new bandage then being applied for the next application.

摘要翻译： 本文提供超声波绷带（10）和超声波传感器阵列绷带，以通过将超声波绷带（10）和超声换能器阵列绷带定位在伤口附近并产生超声波脉冲来加速伤口的愈合。 超声波绷带（10）通常包括（a）背衬层（12），（b）施​​加到背衬层（12）上基本上共同延伸的粘合剂层（14），和（c）换能器材料 ）设置在所述粘合剂层（14）的至少一部分上。 超声换能器阵列绷带通常包括（a）背衬层（13），（b）涂覆到背衬层并基本上与背衬层共同延伸的粘合剂层，以及（c）包括布置在邻近的多个换能器材料的阵列 关系来限定它们之间的空间，该阵列设置在粘合剂层的至少一部分上。 所得到的超声波绷带（10）和超声换能器阵列绷带允许医疗治疗应用，以促进伤口的愈合，例如人体解剖结构的任何部分或多个部位的擦伤，撕裂，切口和溃疡，并用超声波绷带（10）和 超声换能器阵列绷带在每次使用后方便地丢弃，然后将新的绷带用于下一个应用。

公开(公告)号：US06432070B1

公开(公告)日：2002-08-13

申请号：US09568481

申请日：2000-05-09

申请人： Roger J. Talish ,  Alan A. Winder

发明人： Roger J. Talish ,  Alan A. Winder

IPC分类号： A61H100

CPC分类号： A61N7/00

摘要： The invention relates to apparatus and method for therapeutically treating reflex sympathetic dystrophy using ultra sound. The apparatus includes at least one ergonomically constructed ultrasonic transducer configured to cooperate with a placement module or strip for placement in proximity to pain receptors of the sympathetic nervous system. The apparatus also utilizes a portable, ergonomically constructed main operating unit constructed to fit within a pouch worn by the patient. In operation, at least one ultrasonic transducer positioned in proximity to the pain receptors of the sympathetic nervous system is excited for a predetermined period of time. To ensure that at least one ultrasonic transducer is properly positioned, and to insure compliance with a treatment protocol, a safety interlock is provided to prevent inadvertent excitation of the at least one ultrasonic transducer. In an alternate embodiment, the apparatus includes a treatment basin having a plurality of ultrasonic transducer assemblies placed on the perimeter thereof. The patient places an injured part of the body therein and the transducer assemblies are excited to impinge ultrasonic waves to the injured part of the body.

摘要翻译： 本发明涉及使用超声疗法治疗反射性交感神经营养不良的装置和方法。 该装置包括至少一个符合人体工程学的构造的超声波换能器，其构造成与放置模块或条带配合以放置在交感神经系统的疼痛受体附近。 该装置还使用便携式，符合人体工程学的构造的主操作单元，其被构造成装配在患者佩戴的小袋内。 在操作中，定位在交感神经系统的疼痛受体附近的至少一个超声波换能器被激发预定的时间段。 为了确保至少一个超声波换能器被适当地定位并且确保符合治疗方案，提供安全互锁以防止至少一个超声波换能器的无意激励。 在替代实施例中，该装置包括具有放置在其周边上的多个超声换能器组件的处理盆。 患者将身体的受伤部分放置在其中，并且换能器组件被激发以将超声波撞击到身体的受伤部分。

公开(公告)号：US06585647B1

公开(公告)日：2003-07-01

申请号：US09744136

申请日：2001-01-19

申请人： Alan A. Winder

发明人： Alan A. Winder

IPC分类号： A61B800

CPC分类号： A61B8/08 ,  A61B8/485 ,  Y10S128/916

摘要： A system (10) having a processor, a memory, generates low frequency ultrasound signals to be applied to tissue (14) to generate a weighted sum of tissue ramp, step, and impulse signatures. The system (10) analyzes the tissue signatures to determine the low frequency target profile which is used to generate a graphic representation of the tissue as well as to estimate the volume of the tissue; to classify the tissue (14) as to type, and condition of the tissue using a set of stored tissue data. The classifier may include a neural network (34), and/or a nearest neighbor rule processor (36). The system (10) performs as a non-invasive acoustic measurement, an imaging system, and method which uses Synthetic Structural Imaging (SSI) techniques to provide unique information concerning the size, shape of biological structures for classification, visualization of normal, abnormal tissues, organs, biological structures, etc.

摘要翻译： 具有处理器，存储器的系统（10）产生要施加到组织（14）的低频超声信号以产生组织斜坡，步长和脉冲特征的加权和。 系统（10）分析组织特征以确定用于产生组织的图形表示以及估计组织体积的低频目标轮廓; 使用一组存储的组织数据对组织（14）进行分类以及组织的状况。 分类器可以包括神经网络（34）和/或最近邻规则处理器（36）。 系统（10）作为非侵入性声学测量，成像系统和方法，其使用合成结构成像（SSI）技术来提供有关分类的生物结构的大小，形状，关于正常的异常组织的可视化的唯一信息 ，器官，生物结构等

公开(公告)号：US06213958B1

公开(公告)日：2001-04-10

申请号：US09167868

申请日：1998-10-07

申请人： Alan A. Winder

发明人： Alan A. Winder

IPC分类号： A61B500

CPC分类号： A61B5/6843 ,  A61B5/7257 ,  A61B5/7264 ,  A61B5/7267 ,  A61B8/0875 ,  A61B8/42 ,  A61B8/4227 ,  G06F19/00

摘要： A non-invasive bone condition data acquisition system performs sensitive and reliable clinical data acquisition, localization and classification of bone disease, particularly osteoporosis. The bone condition data acquisition system measures a correlation between a wideband AE signature and a spatially localized bone microarchitecture, which is used to determine fracture risk. The bone condition data acquisition system includes processors and memory for analyzing AE signals from bone tissue to generate information-bearing attributes, for extracting a set of times-of-arrival and a feature vector from the attributes, for utilizing the set of times-of-arrival to derive the locations of the AE events, and for responding to the feature vector to classify the bone using a neural network and a nearest neighbor rule processor.

摘要翻译： 非侵入性骨条件数据采集系统对骨疾病，特别是骨质疏松症进行灵敏可靠的临床数据采集，定位和分类。 骨条件数据采集系统测量宽带AE签名和空间定位骨微架构之间的相关性，用于确定骨折风险。 骨条件数据采集系统包括用于分析来自骨组织的AE信号以产生信息承载属性的处理器和存储器，用于从属性中提取一组到达时间和特征向量，以利用一组时间 - 用于导出AE事件的位置，以及响应特征向量以使用神经网络和最近邻规则处理器对骨骼进行分类。