公开(公告)号：US20240276959A1

公开(公告)日：2024-08-22

申请号：US18540440

申请日：2023-12-14

申请人： Roger Kingdon Craig ,  ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM

发明人： Roger Kingdon Craig ,  Franklin Gerardus Grosveld ,  Richard Wilhelm Janssens ,  Marinus Johannes Van Haperen

IPC分类号： A01K67/0278 ,  A01K67/0276 ,  C12N15/85 ,  C12P21/00

CPC分类号： A01K67/0278 ,  A01K67/0276 ,  C12P21/005 ,  A01K2207/15 ,  A01K2217/072 ,  A01K2217/15 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2267/01 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/56 ,  C12N15/8509

摘要： A transgenic non-human mammal containing a heterologous lambda light chain gene locus, and/or a heterologous kappa light chain gene locus, and/or a heterologous heavy chain gene locus, each of which can re-arrange so that immunoglobulin heavy and light chain genes are formed and expressed in B-cells following antigen challenge.

公开(公告)号：US11877565B2

公开(公告)日：2024-01-23

申请号：US14806802

申请日：2015-07-23

申请人： Erasmus University Medical Center ,  Roger Kingdon Craig

发明人： Roger Kingdon Craig ,  Franklin Gerardus Grosveld ,  Richard Wilhelm Janssens ,  Marinus Johannes Van Haperen

IPC分类号： A01K67/027 ,  C12P21/00 ,  C07K16/00 ,  C12N15/85

CPC分类号： A01K67/0278 ,  A01K67/0276 ,  C12P21/005 ,  A01K2207/15 ,  A01K2217/072 ,  A01K2217/15 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2267/01 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/56 ,  C12N15/8509

摘要： A transgenic non-human mammal containing a heterologous lambda light chain gene locus, and/or a heterologous kappa light chain gene locus, and/or a heterologous heavy chain gene locus, each of which can re-arrange so that immunoglobulin heavy and light chain genes are formed and expressed in B-cells following antigen challenge.

公开(公告)号：US09980470B2

公开(公告)日：2018-05-29

申请号：US14211130

申请日：2014-03-14

申请人： ERASMUS UNIVERSITY MEDICAL CENTER ,  Roger Kingdon Craig

发明人： Franklin Gerardus Grosveld ,  Richard Wilhelm Janssens ,  Marinus Johannes Van Haperen ,  Roger Kingdon Craig ,  Ernie De Boer

IPC分类号： A01K67/00 ,  A01K67/027 ,  C12N15/85 ,  C12P21/02

CPC分类号： A01K67/0278 ,  A01K2207/15 ,  A01K2217/052 ,  A01K2217/15 ,  A01K2227/10 ,  A01K2227/105 ,  A01K2267/01 ,  C07K2317/24 ,  C12N15/85 ,  C12N15/8509 ,  C12N2015/8518 ,  C12N2830/46 ,  C12P21/02

摘要： A transgenic non-human mammal containing a heterologous lambda light chain gene locus, and/or a heterologous kappa light chain gene locus, and/or a heterologous heavy chain gene locus, each of which can re-arrange so that immunoglobulin heavy and light chain genes are formed and expressed in B-cells following antigen challenge.

公开(公告)号：US09131669B2

公开(公告)日：2015-09-15

申请号：US13815676

申请日：2013-03-14

申请人： Roger Kingdon Craig ,  Franklin Gerardus Grosveld ,  Richard Wilhelm Janssens ,  Marinus Johannes Van Haperen

发明人： Roger Kingdon Craig ,  Franklin Gerardus Grosveld ,  Richard Wilhelm Janssens ,  Marinus Johannes Van Haperen

IPC分类号： C12P21/08 ,  A01K67/027 ,  C07K16/00 ,  C12N15/85

CPC分类号： A01K67/0278 ,  A01K67/0276 ,  A01K2207/15 ,  A01K2217/072 ,  A01K2217/15 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2267/01 ,  C07K16/00 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/56 ,  C12N15/8509 ,  C12P21/005

摘要： A transgenic non-human mammal containing a heterologous lambda light chain gene locus, and/or a heterologous kappa light chain gene locus, and/or a heterologous heavy chain gene locus, each of which can re-arrange so that immunoglobulin heavy and light chain genes are formed and expressed in B-cells following antigen challenge.

摘要翻译： 含有异源λ轻链基因座和/或异源κ轻链基因座和/或异源重链基因座的转基因非人哺乳动物，其可以重新排列使得免疫球蛋白重链和轻链 基因在抗原攻击后在B细胞中形成和表达。

公开(公告)号：US20160295842A1

公开(公告)日：2016-10-13

申请号：US14806802

申请日：2015-07-23

申请人： Roger Kingdon Craig ,  Erasmus University Medical Center

发明人： Roger Kingdon Craig ,  Franklin Gerardus Grosveld ,  Richard Wilhelm Janssens ,  Marinus Johannes Van Haperen

IPC分类号： A01K67/027 ,  C12P21/00 ,  C07K16/00

CPC分类号： A01K67/0278 ,  A01K67/0276 ,  A01K2207/15 ,  A01K2217/072 ,  A01K2217/15 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2267/01 ,  C07K16/00 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/56 ,  C12N15/8509 ,  C12P21/005

摘要： A transgenic non-human mammal containing a heterologous lambda light chain gene locus, and/or a heterologous kappa light chain gene locus, and/or a heterologous heavy chain gene locus, each of which can re-arrange so that immunoglobulin heavy and light chain genes are formed and expressed in B-cells following antigen challenge.