公开(公告)号：US08784862B2

公开(公告)日：2014-07-22

申请号：US12827710

申请日：2010-06-30

申请人： Roland Horres ,  Marita Katharina Linssen ,  Michael Hoffmann ,  Erika Hoffmann ,  Donate DiBiase ,  Volker Faust

发明人： Roland Horres ,  Marita Katharina Linssen ,  Michael Hoffmann ,  Erika Hoffmann ,  Donate DiBiase ,  Volker Faust

IPC分类号： A61F2/82 ,  A61K31/337 ,  A61K31/436 ,  A61K9/00 ,  A61P29/00 ,  A61L31/10 ,  C08L5/10 ,  A61L33/08 ,  A61L31/16 ,  A61K31/722 ,  A61K31/727 ,  A61K31/095 ,  A61K31/045 ,  A61K31/075 ,  A61K31/11 ,  A61K31/12 ,  A61K31/28 ,  A61K31/33 ,  A61K31/21 ,  A61K31/13

CPC分类号： A61L31/10 ,  A61K31/045 ,  A61K31/075 ,  A61K31/095 ,  A61K31/11 ,  A61K31/12 ,  A61K31/13 ,  A61K31/21 ,  A61K31/28 ,  A61K31/33 ,  A61K31/722 ,  A61K31/727 ,  A61L31/16 ,  A61L33/08 ,  C08B37/0075 ,  C08L5/10 ,  C09D105/08 ,  Y02A50/475

摘要： The invention concerns oligosaccharides and polysaccharides as well as the use of these oligosaccharides and/or polysaccharides, which contain the sugar unit N-acylglucosamine or N-acylgalactosamine for the production of hemocompatible surfaces as well as methods for the hemocompatible coating of surfaces with said oligosaccharides and/or polysaccharides, which imitate the common biosynthetic precursor substance of heparin, heparan sulphates and chitosan. The invention further describes methods for producing said oligosaccharides and/or polysaccharides and discloses various possibilities of using hemocompatibly coated surfaces. The invention relates particularly to the use of said oligosaccharides and/or polysaccharides on stents with at least one according to invention deposited hemocompatible coating, which contains an antiproliferative, antiinflammatory and/or antithrombotic active agent, methods for the preparation of said stents as well as the use of said stents for the prevention of restenosis.

摘要翻译： 本发明涉及寡糖和多糖以及这些寡糖和/或多糖的用途，其含有糖单元N-酰基葡糖胺或N-酰基半乳糖胺用于生产血液相容性表面，以及用所述低聚糖表面的血液相容性涂布方法 和/或多糖，其模拟肝素，硫酸乙酰肝素和壳聚糖的常见生物合成前体物质。 本发明进一步描述了制备所述寡糖和/或多糖的方法，并公开了使用血液混合涂覆表面的各种可能性。 本发明特别涉及所述寡糖和/或多糖在具有至少一种根据本发明的沉积的血液相容性包衣的支架上的用途，其包含抗增生性，抗炎和/或抗血栓形成活性剂，用于制备所述支架的方法以及 使用所述支架预防再狭窄。

公开(公告)号：US20110009955A1

公开(公告)日：2011-01-13

申请号：US12827710

申请日：2010-06-30

申请人： Roland Horres ,  Marita Katharina Linssen ,  Michael Hoffmann ,  Erika Hoffmann ,  Donate DiBiase ,  Volker Faust

发明人： Roland Horres ,  Marita Katharina Linssen ,  Michael Hoffmann ,  Erika Hoffmann ,  Donate DiBiase ,  Volker Faust

IPC分类号： A61F2/82 ,  A61K9/00 ,  A61K31/436 ,  A61K31/337 ,  A61P37/06 ,  A61P35/00 ,  A61P7/02 ,  A61P29/00

CPC分类号： A61L31/10 ,  A61K31/045 ,  A61K31/075 ,  A61K31/095 ,  A61K31/11 ,  A61K31/12 ,  A61K31/13 ,  A61K31/21 ,  A61K31/28 ,  A61K31/33 ,  A61K31/722 ,  A61K31/727 ,  A61L31/16 ,  A61L33/08 ,  C08B37/0075 ,  C08L5/10 ,  C09D105/08 ,  Y02A50/475

摘要： The invention concerns oligosaccharides and polysaccharides as well as the use of these oligosaccharides and/or polysaccharides, which contain the sugar unit N-acylglucosamine or N-acylgalactosamine for the production of hemocompatible surfaces as well as methods for the hemocompatible coating of surfaces with said oligosaccharides and/or polysaccharides, which imitate the common biosynthetic precursor substance of heparin, heparan sulphates and chitosan. The invention further describes methods for producing said oligosaccharides and/or polysaccharides and discloses various possibilities of using hemocompatibly coated surfaces. The invention relates particularly to the use of said oligosaccharides and/or polysaccharides on stents with at least one according to invention deposited hemocompatible coating, which contains an antiproliferative, antiinflammatory and/or antithrombotic active agent, methods for the preparation of said stents as well as the use of said stents for the prevention of restenosis.

摘要翻译： 本发明涉及寡糖和多糖以及这些寡糖和/或多糖的用途，其含有糖单元N-酰基葡糖胺或N-酰基半乳糖胺用于生产血液相容性表面，以及用所述低聚糖表面的血液相容性涂布方法 和/或多糖，其模拟肝素，硫酸乙酰肝素和壳聚糖的常见生物合成前体物质。 本发明进一步描述了制备所述寡糖和/或多糖的方法，并公开了使用血液混合涂覆表面的各种可能性。 本发明特别涉及所述寡糖和/或多糖在具有至少一种根据本发明的沉积的血液相容性包衣的支架上的用途，其包含抗增生性，抗炎和/或抗血栓形成活性剂，用于制备所述支架的方法以及 使用所述支架预防再狭窄。