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公开(公告)号：US08784862B2
公开(公告)日：2014-07-22
申请号：US12827710
申请日：2010-06-30
申请人： Roland Horres , Marita Katharina Linssen , Michael Hoffmann , Erika Hoffmann , Donate DiBiase , Volker Faust
发明人： Roland Horres , Marita Katharina Linssen , Michael Hoffmann , Erika Hoffmann , Donate DiBiase , Volker Faust
IPC分类号： A61F2/82 , A61K31/337 , A61K31/436 , A61K9/00 , A61P29/00 , A61L31/10 , C08L5/10 , A61L33/08 , A61L31/16 , A61K31/722 , A61K31/727 , A61K31/095 , A61K31/045 , A61K31/075 , A61K31/11 , A61K31/12 , A61K31/28 , A61K31/33 , A61K31/21 , A61K31/13
CPC分类号： A61L31/10 , A61K31/045 , A61K31/075 , A61K31/095 , A61K31/11 , A61K31/12 , A61K31/13 , A61K31/21 , A61K31/28 , A61K31/33 , A61K31/722 , A61K31/727 , A61L31/16 , A61L33/08 , C08B37/0075 , C08L5/10 , C09D105/08 , Y02A50/475
摘要： The invention concerns oligosaccharides and polysaccharides as well as the use of these oligosaccharides and/or polysaccharides, which contain the sugar unit N-acylglucosamine or N-acylgalactosamine for the production of hemocompatible surfaces as well as methods for the hemocompatible coating of surfaces with said oligosaccharides and/or polysaccharides, which imitate the common biosynthetic precursor substance of heparin, heparan sulphates and chitosan. The invention further describes methods for producing said oligosaccharides and/or polysaccharides and discloses various possibilities of using hemocompatibly coated surfaces. The invention relates particularly to the use of said oligosaccharides and/or polysaccharides on stents with at least one according to invention deposited hemocompatible coating, which contains an antiproliferative, antiinflammatory and/or antithrombotic active agent, methods for the preparation of said stents as well as the use of said stents for the prevention of restenosis.
摘要翻译： 本发明涉及寡糖和多糖以及这些寡糖和/或多糖的用途，其含有糖单元N-酰基葡糖胺或N-酰基半乳糖胺用于生产血液相容性表面，以及用所述低聚糖表面的血液相容性涂布方法 和/或多糖，其模拟肝素，硫酸乙酰肝素和壳聚糖的常见生物合成前体物质。 本发明进一步描述了制备所述寡糖和/或多糖的方法，并公开了使用血液混合涂覆表面的各种可能性。 本发明特别涉及所述寡糖和/或多糖在具有至少一种根据本发明的沉积的血液相容性包衣的支架上的用途，其包含抗增生性，抗炎和/或抗血栓形成活性剂，用于制备所述支架的方法以及 使用所述支架预防再狭窄。
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公开(公告)号：US20110009955A1
公开(公告)日：2011-01-13
申请号：US12827710
申请日：2010-06-30
申请人： Roland Horres , Marita Katharina Linssen , Michael Hoffmann , Erika Hoffmann , Donate DiBiase , Volker Faust
发明人： Roland Horres , Marita Katharina Linssen , Michael Hoffmann , Erika Hoffmann , Donate DiBiase , Volker Faust
IPC分类号： A61F2/82 , A61K9/00 , A61K31/436 , A61K31/337 , A61P37/06 , A61P35/00 , A61P7/02 , A61P29/00
CPC分类号： A61L31/10 , A61K31/045 , A61K31/075 , A61K31/095 , A61K31/11 , A61K31/12 , A61K31/13 , A61K31/21 , A61K31/28 , A61K31/33 , A61K31/722 , A61K31/727 , A61L31/16 , A61L33/08 , C08B37/0075 , C08L5/10 , C09D105/08 , Y02A50/475
摘要： The invention concerns oligosaccharides and polysaccharides as well as the use of these oligosaccharides and/or polysaccharides, which contain the sugar unit N-acylglucosamine or N-acylgalactosamine for the production of hemocompatible surfaces as well as methods for the hemocompatible coating of surfaces with said oligosaccharides and/or polysaccharides, which imitate the common biosynthetic precursor substance of heparin, heparan sulphates and chitosan. The invention further describes methods for producing said oligosaccharides and/or polysaccharides and discloses various possibilities of using hemocompatibly coated surfaces. The invention relates particularly to the use of said oligosaccharides and/or polysaccharides on stents with at least one according to invention deposited hemocompatible coating, which contains an antiproliferative, antiinflammatory and/or antithrombotic active agent, methods for the preparation of said stents as well as the use of said stents for the prevention of restenosis.
摘要翻译： 本发明涉及寡糖和多糖以及这些寡糖和/或多糖的用途，其含有糖单元N-酰基葡糖胺或N-酰基半乳糖胺用于生产血液相容性表面，以及用所述低聚糖表面的血液相容性涂布方法 和/或多糖，其模拟肝素，硫酸乙酰肝素和壳聚糖的常见生物合成前体物质。 本发明进一步描述了制备所述寡糖和/或多糖的方法，并公开了使用血液混合涂覆表面的各种可能性。 本发明特别涉及所述寡糖和/或多糖在具有至少一种根据本发明的沉积的血液相容性包衣的支架上的用途，其包含抗增生性，抗炎和/或抗血栓形成活性剂，用于制备所述支架的方法以及 使用所述支架预防再狭窄。
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3.发明授权Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis 有权用于治疗身体通道狭窄并防止威胁性再狭窄的气囊导管公开(公告)号：US09192697B2
公开(公告)日：2015-11-24
申请号：US13023594
申请日：2011-02-09
申请人： Erika Hoffmann , Roland Horres , Volker Faust , Helmut Schreiber , Armin Von Holst , Michael Hoffmann
发明人： Erika Hoffmann , Roland Horres , Volker Faust , Helmut Schreiber , Armin Von Holst , Michael Hoffmann
CPC分类号： A61L29/16 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2300/426 , A61L2300/80 , A61M25/1029 , A61M2025/1031 , A61M2025/1075
摘要： The present invention is directed to a method for coating catheter balloons with a defined amount of a pharmacologically active agent, wherein the coating method uses a coating device having a volume measuring device for releasing a measurable amount of a coating solution by means of a dispensing device specifically onto the surface of the catheter balloon.
摘要翻译： 本发明涉及一种用限定量的药理活性剂涂覆导管球囊的方法，其中所述涂覆方法使用具有体积测量装置的涂覆装置，用于通过分配装置释放可测量量的涂布溶液 特别是在导管气囊的表面上。
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4.发明申请公开(公告)号：US20050176678A1
公开(公告)日：2005-08-11
申请号：US10513982
申请日：2003-04-15
申请人： Roland Horres , Marita Linssen , Michael Hoffmann , Erika Hoffmann , Donato Di Baise , Volker Faust
发明人： Roland Horres , Marita Linssen , Michael Hoffmann , Erika Hoffmann , Donato Di Baise , Volker Faust
IPC分类号： A61L27/00 , A61K31/165 , A61K31/337 , A61K31/366 , A61K31/436 , A61K31/727 , A61K31/728 , A61K45/00 , A61L31/00 , A61L31/10 , A61L31/16 , A61L33/00 , A61L33/08 , A61L33/10 , A61P3/06 , A61P7/02 , A61P19/06 , A61P35/00 , A61P37/06 , C08B37/00 , C08B37/08 , C08B37/10 , C09D105/08
CPC分类号： A61L31/10 , A61K31/045 , A61K31/075 , A61K31/095 , A61K31/11 , A61K31/12 , A61K31/13 , A61K31/21 , A61K31/28 , A61K31/33 , A61K31/722 , A61K31/727 , A61L31/16 , A61L33/08 , C08B37/0075 , C08L5/10 , C09D105/08 , Y02A50/475
摘要： The invention concerns oligosaccharides and polysaccharides as well as the use of these oligosaccharides and/or polysaccharides, which contain the sugar unit N-acylglucosamine or N-acylgalactosamine for the production of hemocompatible surfaces as well as methods for the hemocompatible coating of surfaces with said oligosaccharides and/or polysaccharides, which imitate the common biosynthetic precursor substance of heparin, heparan sulphates and chitosan. The invention further describes methods for producing said oligosaccharides and/or polysaccharides and discloses various possibilities of using hemocompatibly coated surfaces. The invention relates particularly to the use of said oligosaccharides and/or polysaccharides on stents with at least one according to invention deposited hemocompatible coating, which contains an antiproliferative, antiinflammatory and/or antithrombotic active agent, methods for the preparation of said stents as well as the use of said stents for the prevention of restenosis.
摘要翻译： 本发明涉及寡糖和多糖以及这些寡糖和/或多糖的用途，其含有糖单元N-酰基葡糖胺或N-酰基半乳糖胺用于生产血液相容性表面，以及用所述低聚糖表面的血液相容性涂布方法 和/或多糖，其模拟肝素，硫酸乙酰肝素和壳聚糖的常见生物合成前体物质。 本发明进一步描述了制备所述寡糖和/或多糖的方法，并公开了使用血液混合涂覆表面的各种可能性。 本发明特别涉及所述寡糖和/或多糖在具有至少一种根据本发明的沉积的血液相容性包衣的支架上的用途，其包含抗增生性，抗炎和/或抗血栓形成活性剂，用于制备所述支架的方法以及 使用所述支架预防再狭窄。
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5.发明申请MEDICAL PRODUCT FOR TREATING STENOSIS OF BODY PASSAGES AND FOR PREVENTING THREATENING RESTENOSIS 有权用于治疗身体通行障碍和预防止痛药物的医疗产品公开(公告)号：US20100179475A1
公开(公告)日：2010-07-15
申请号：US12521863
申请日：2008-01-21
申请人： Erika Hoffmann , Roland Horres , Volker Faust , Helmut Schreiber , Armin Von Holst , Michael Hoffmann
发明人： Erika Hoffmann , Roland Horres , Volker Faust , Helmut Schreiber , Armin Von Holst , Michael Hoffmann
CPC分类号： A61M25/1029 , A61L29/16 , A61L2300/606 , A61L2300/802 , A61L2420/02 , A61M2025/0057 , A61M2025/1031 , A61M2025/1088
摘要： A method for coating catheter balloons with a defined amount of a pharmacologically active agent, uses a coating device having a volume measuring device for releasing a measurable amount of a coating solution by means of a dispensing device specifically onto the surface of the catheter balloon.
摘要翻译： 使用具有确定量的药理活性剂涂覆导管球囊的方法，使用具有体积测量装置的涂覆装置，用于通过分配装置将可测量量的涂布溶液特异性地释放到导管气囊的表面上。
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6.发明申请MEDICAL PRODUCT FOR TREATING STENOSIS OF BODY PASSAGES AND FOR PREVENTING THREATENING RESTENOSIS 审中-公开用于治疗身体通行障碍和预防止痛药物的医疗产品公开(公告)号：US20110287169A1
公开(公告)日：2011-11-24
申请号：US13115782
申请日：2011-05-25
申请人： Erika Hoffmann , Roland Horres , Volker Faust , Helmut Schreiber , Armin Von Holst , Michael Hoffmann
发明人： Erika Hoffmann , Roland Horres , Volker Faust , Helmut Schreiber , Armin Von Holst , Michael Hoffmann
IPC分类号： A61M25/10
CPC分类号： A61M25/1029 , A61L29/16 , A61L2300/606 , A61L2300/802 , A61L2420/02 , A61M2025/0057 , A61M2025/1031 , A61M2025/1088
摘要： A method for coating catheter balloons with a defined amount of a pharmacologically active agent, uses a coating device having a volume measuring device for releasing a measurable amount of a coating solution by means of a dispensing device specifically onto the surface of the catheter balloon.
摘要翻译： 使用具有限定量的药理活性剂涂覆导管球囊的方法，使用具有体积测量装置的涂覆装置，用于通过分配装置将可测量量的涂布溶液特异性释放到导管气囊的表面上。
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公开(公告)号：US08679520B2
公开(公告)日：2014-03-25
申请号：US10493157
申请日：2002-10-15
IPC分类号： A61F2/00
CPC分类号： A61L31/16 , A61L31/10 , A61L33/0011 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2420/08
摘要： The invention relates to stents with at least one hemocompatible coating which contains an antiproliferative, antiinflammatory and/or antithrombotic active agent, methods for the preparation of said stents as well as the use of said stents for the prevention of restenosis.
摘要翻译： 本发明涉及具有至少一种含有抗增殖性，抗炎和/或抗血栓形成活性剂的血液相容性涂层的支架，用于制备所述支架的方法以及所述支架用于预防再狭窄的用途。
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8.发明授权Medical product for treating stenosis of body passages and for preventing threatening restenosis 有权用于治疗身体通道狭窄和预防威胁性再狭窄的医疗产品公开(公告)号：US08597720B2
公开(公告)日：2013-12-03
申请号：US12521863
申请日：2008-01-21
申请人： Erika Hoffmann , Roland Horres , Volker Faust , Helmut Schreiber , Armin Von Holst , Michael Hoffmann
发明人： Erika Hoffmann , Roland Horres , Volker Faust , Helmut Schreiber , Armin Von Holst , Michael Hoffmann
CPC分类号： A61M25/1029 , A61L29/16 , A61L2300/606 , A61L2300/802 , A61L2420/02 , A61M2025/0057 , A61M2025/1031 , A61M2025/1088
摘要： A method for coating catheter balloons with a defined amount of a pharmacologically active agent, uses a coating device having a volume measuring device for releasing a measurable amount of a coating solution by means of a dispensing device specifically onto the surface of the catheter balloon.
摘要翻译： 使用具有确定量的药理活性剂涂覆导管球囊的方法，使用具有体积测量装置的涂覆装置，用于通过分配装置将可测量量的涂布溶液特异性地释放到导管气囊的表面上。
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9.发明申请Balloon Catheter for Treating Stenosis of Body Passages and for Preventing Threatening Restenosis 有权用于治疗身体通过狭窄和预防威胁性再狭窄的气球导管公开(公告)号：US20110160698A1
公开(公告)日：2011-06-30
申请号：US13023594
申请日：2011-02-09
申请人： Erika Hoffmann , Roland Horres , Volker Faust , Helmut Schreiber , Armin Von Holst , Michael Hoffmann
发明人： Erika Hoffmann , Roland Horres , Volker Faust , Helmut Schreiber , Armin Von Holst , Michael Hoffmann
CPC分类号： A61L29/16 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2300/426 , A61L2300/80 , A61M25/1029 , A61M2025/1031 , A61M2025/1075
摘要： The present invention is directed to a method for coating catheter balloons with a defined amount of a pharmacologically active agent, wherein the coating method uses a coating device having a volume measuring device for releasing a measurable amount of a coating solution by means of a dispensing device specifically onto the surface of the catheter balloon.
摘要翻译： 本发明涉及一种用限定量的药理活性剂涂覆导管球囊的方法，其中所述涂覆方法使用具有体积测量装置的涂覆装置，用于通过分配装置释放可测量量的涂布溶液 特别是在导管气囊的表面上。
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公开(公告)号：US20050129731A1
公开(公告)日：2005-06-16
申请号：US10979977
申请日：2004-11-03
IPC分类号： A61F2/06 , A61K31/365 , A61K31/4745 , A61K31/704 , A61K31/737 , A61K36/47 , A61K38/16 , A61K35/78
CPC分类号： A61K31/704 , A61F2250/0067 , A61K31/365 , A61K31/4745 , A61K31/737 , A61K38/00 , A61L31/10
摘要： The invention relates to medical products with at least one biocompatible biostable polysulfone coating with which the elution kinetics of the incorporated and/or deposited at least one antiproliferative, antiinflammatory, antiphlogistic and/or antithrombotic active agent can be controlled via the admixing of at least one hydrophilic polymer in a suitable amount and as well as an local separation of different active agents and active agent combinations respectively can be achieved by means of the layer system of biostable polymers, methods of manufacturing these medical products as well as their use especially in the form of stents for prevention of restenosis.
摘要翻译： 本发明涉及具有至少一种生物相容的生物稳定的聚砜涂层的医疗产品，通过该药物产品可以通过混合至少一种抗生素稳定聚砜涂层来控制所掺入和/或沉积的至少一种抗增殖，抗炎，抗炎和/或抗血栓活性剂的洗脱动力学 可以通过生物稳定聚合物的层系统，制造这些医疗产品的方法以及它们的使用特别是以形式来实现适当量的亲水性聚合物以及不同活性剂和活性剂组合的局部分离 的支架用于预防再狭窄。
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