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    METHOD FOR PREPARATION OF RUTHENIUM-INDENYLIDENE CARBENE CATALYSTS
    5.
    发明申请
    METHOD FOR PREPARATION OF RUTHENIUM-INDENYLIDENE CARBENE CATALYSTS 有权
    制备亚苄基碳二亚胺催化剂的方法

    公开(公告)号：US20110190524A1

    公开(公告)日：2011-08-04

    申请号：US13122248

    申请日：2009-10-02

    申请人： Roland Winde ,  Ralf Karch ,  Andreas Rivas-Nass ,  Angelino Doppiu ,  Gerhard Peter ,  Eileen Woerner

    发明人： Roland Winde ,  Ralf Karch ,  Andreas Rivas-Nass ,  Angelino Doppiu ,  Gerhard Peter ,  Eileen Woerner

    IPC分类号： C07F15/00

    CPC分类号： C07F15/0046

    摘要： The present invention is directed to a method for the preparation of ruthenium indenylidene carbene catalysts of the type (L)(L′)X2Ru(II)(aryl-indenylidene). The method comprises the steps of reacting the precursor compound Ru(PPh3)nX2 (n=3-4) with a propargyl alcohol derivative in an cyclic diether solvent such as 1,4-dioxane at temperatures in the range of 80 to 130° C. and reaction times of 1 to 60 minutes. Optionally, additional neutral electron donor ligands such as PCy3, phobane ligands or NHC ligands are added to the reaction mixture for ligand exchange. The method includes a precipitation step for purification, after which the product is isolated. The ruthenium-indenylidene carbene catalysts are obtained in high purity and are used as catalysts for metathesis reactions (RCM, ROMP and CM) and as precursors for the synthesis of modified ruthenium carbene catalysts.

    摘要翻译： 本发明涉及一种（L）（L'）X2Ru（II）（芳基 - 亚茚基）类型的钌亚茚基碳烯催化剂的制备方法。 该方法包括以下步骤：使前体化合物Ru（PPh 3）n X 2（n = 3-4）与炔丙醇衍生物在环状二醚溶剂如1,4-二恶烷中的反应温度范围为80-130℃ ，反应时间为1〜60分钟。 任选地，向反应混合物中加入另外的中性电子给体配体如PCy3，phobane配体或NHC配体用于配体交换。 该方法包括用于纯化的沉淀步骤，之后分离产物。 获得高纯度的钌 - 亚茚基碳烯催化剂，并用作复分解反应（RCM，ROMP和CM）的催化剂，并用作合成改性钌卡宾催化剂的前体。

    Process for preparing ruthenium(0)-olefin complexes
    6.
    发明授权
    Process for preparing ruthenium(0)-olefin complexes 有权
    制备钌（O） - 烯烃络合物的方法

    公开(公告)号：US08716509B2

    公开(公告)日：2014-05-06

    申请号：US13505796

    申请日：2010-11-11

    申请人： Angelino Doppiu ,  Andreas Rivas-Nass ,  Ralf Karch ,  Roland Winde ,  Eileen Woerner

    发明人： Angelino Doppiu ,  Andreas Rivas-Nass ,  Ralf Karch ,  Roland Winde ,  Eileen Woerner

    IPC分类号： C07F15/00 ,  C23C16/00

    CPC分类号： C23C16/18 ,  A61K31/28 ,  B01J31/00

    摘要： The present invention relates to a process for preparing ruthenium(0)-olefin complexes of the (arene)(diene)Ru(0) type by reacting a ruthenium starting compound of the formula Ru(+II)(X)p(Y)q (in which X=an anionic group, Y=an uncharged two-electron donor ligand, p=1 or 2, q=an integer from 1 to 6), with a cyclohexadiene derivative or a diene mixture comprising a cyclohexadiene derivative, in the presence of a base. In this process, the arene bound in the (arene)(diene)Ru(0) complex is formed from this cyclohexadiene derivative by oxidation. Suitable ruthenium(II) starting compounds are, for example, RuCl2(acetonitrile)4, RuCl2(pyridine)4 or RuCl2(DMSO)4. The bases used are inorganic or organic bases. The ruthenium(0)-olefin complexes prepared by the process according to the invention have a high purity and can be used as precursors for homogeneous catalysts, for preparation of functional ruthenium- or ruthenium oxide-containing layers and for therapeutic applications.

    摘要翻译： 本发明涉及一种制备（芳烃）（二烯）Ru（O）型钌（O） - 烯烃络合物的方法，通过使式钌（+ II）（X）p（Y） q（其中X =阴离子基团，Y =不带电荷的双电子供体配体，p = 1或2，q = 1至6的整数）与环己二烯衍生物或包含环己二烯衍生物的二烯混合物 一个基地的存在。 在该方法中，通过氧化由该环己二烯衍生物形成（芳烃）（二烯）Ru（O）络合物中的芳烃。 合适的钌（II）起始化合物是例如RuCl 2（乙腈）4，RuCl 2（吡啶）4或RuCl 2（DMSO）4。 使用的碱是无机或有机碱。 通过本发明方法制备的钌（O） - 烯烃络合物具有高纯度，可用作均相催化剂的前体，用于制备功能性含钌或氧化钌层并用于治疗应用。

    Method for preparation of ruthenium-indenylidene carbene catalysts
    7.
    发明授权
    Method for preparation of ruthenium-indenylidene carbene catalysts 有权
    制备钌 - 亚茚基碳烯催化剂的方法

    公开(公告)号：US08703985B2

    公开(公告)日：2014-04-22

    申请号：US13122248

    申请日：2009-10-02

    申请人： Roland Winde ,  Ralf Karch ,  Andreas Rivas-Nass ,  Angelino Doppiu ,  Gerhard Peter ,  Eileen Woerner

    发明人： Roland Winde ,  Ralf Karch ,  Andreas Rivas-Nass ,  Angelino Doppiu ,  Gerhard Peter ,  Eileen Woerner

    IPC分类号： C07F15/00

    CPC分类号： C07F15/0046

    摘要： The present invention is directed to a method for the preparation of ruthenium indenylidene carbene catalysts of the type (L)(L′)X2Ru(II)(aryl-indenylidene). The method comprises the steps of reacting the precursor compound Ru(PPh3)nX2 (n=3-4) with a propargyl alcohol derivative in an cyclic diether solvent such as 1,4-dioxane at temperatures in the range of 80 to 130° C. and reaction times of 1 to 60 minutes. Optionally, additional neutral electron donor ligands such as PCy3, phobane ligands or NHC ligands are added to the reaction mixture for ligand exchange. The method includes a precipitation step for purification, after which the product is isolated. The ruthenium-indenylidene carbene catalysts are obtained in high purity and are used as catalysts for metathesis reactions (RCM, ROMP and CM) and as precursors for the synthesis of modified ruthenium carbene catalysts.

    摘要翻译： 本发明涉及一种（L）（L'）X2Ru（II）（芳基 - 亚茚基）类型的钌亚茚基碳烯催化剂的制备方法。 该方法包括以下步骤：使前体化合物Ru（PPh 3）n X 2（n = 3-4）与炔丙醇衍生物在环状二醚溶剂如1,4-二恶烷中的反应温度范围为80-130℃ ，反应时间为1〜60分钟。 任选地，向反应混合物中加入另外的中性电子给体配体如PCy3，phobane配体或NHC配体用于配体交换。 该方法包括用于纯化的沉淀步骤，之后分离产物。 获得高纯度的钌 - 亚茚基碳烯催化剂，并用作复分解反应（RCM，ROMP和CM）的催化剂，并用作合成改性钌卡宾催化剂的前体。

    PROCESS FOR PREPARING RUTHENIUM(0)-OLEFIN COMPLEXES
    8.
    发明申请
    PROCESS FOR PREPARING RUTHENIUM(0)-OLEFIN COMPLEXES 有权
    制备（0） - 烯烃复合物的方法

    公开(公告)号：US20120277456A1

    公开(公告)日：2012-11-01

    申请号：US13505796

    申请日：2010-11-11

    申请人： Angelino Doppiu ,  Andreas Rivas-Nass ,  Ralf Karch ,  Roland Winde ,  Eileen Woerner

    发明人： Angelino Doppiu ,  Andreas Rivas-Nass ,  Ralf Karch ,  Roland Winde ,  Eileen Woerner

    IPC分类号： C07F15/00

    CPC分类号： C23C16/18 ,  A61K31/28 ,  B01J31/00

    摘要： The present invention relates to a process for preparing ruthenium(0)-olefin complexes of the (arene)(diene)Ru(0) type by reacting a ruthenium starting compound of the formula Ru(+II)(X)p(Y)q (in which X=an anionic group, Y=an uncharged two-electron donor ligand, p=1 or 2, q=an integer from 1 to 6), with a cyclohexadiene derivative or a diene mixture comprising a cyclohexadiene derivative, in the presence of a base. In this process, the arene bound in the (arene)(diene)Ru(0) complex is formed from this cyclohexadiene derivative by oxidation. Suitable ruthenium(II) starting compounds are, for example, RuCl2(acetonitrile)4, RuCl2(pyridine)4 or RuCl2(DMSO)4. The bases used are inorganic or organic bases. The ruthenium(0)-olefin complexes prepared by the process according to the invention have a high purity and can be used as precursors for homogeneous catalysts, for preparation of functional ruthenium- or ruthenium oxide-containing layers and for therapeutic applications.

    摘要翻译： 本发明涉及一种制备（芳烃）（二烯）Ru（O）型钌（O） - 烯烃络合物的方法，通过使式钌（+ II）（X）p（Y） q（其中X =阴离子基团，Y =不带电荷的双电子供体配体，p = 1或2，q = 1至6的整数）与环己二烯衍生物或包含环己二烯衍生物的二烯混合物 一个基地的存在。 在该方法中，通过氧化由该环己二烯衍生物形成（芳烃）（二烯）Ru（O）络合物中的芳烃。 合适的钌（II）起始化合物是例如RuCl 2（乙腈）4，RuCl 2（吡啶）4或RuCl 2（DMSO）4。 使用的碱是无机或有机碱。 通过本发明方法制备的钌（O） - 烯烃络合物具有高纯度，可用作均相催化剂的前体，用于制备功能性含钌或氧化钌层并用于治疗应用。