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    METHOD FOR PREPARATION OF RUTHENIUM-INDENYLIDENE CARBENE CATALYSTS
    4.
    发明申请
    METHOD FOR PREPARATION OF RUTHENIUM-INDENYLIDENE CARBENE CATALYSTS 有权
    制备亚苄基碳二亚胺催化剂的方法

    公开(公告)号：US20110190524A1

    公开(公告)日：2011-08-04

    申请号：US13122248

    申请日：2009-10-02

    申请人： Roland Winde ,  Ralf Karch ,  Andreas Rivas-Nass ,  Angelino Doppiu ,  Gerhard Peter ,  Eileen Woerner

    发明人： Roland Winde ,  Ralf Karch ,  Andreas Rivas-Nass ,  Angelino Doppiu ,  Gerhard Peter ,  Eileen Woerner

    IPC分类号： C07F15/00

    CPC分类号： C07F15/0046

    摘要： The present invention is directed to a method for the preparation of ruthenium indenylidene carbene catalysts of the type (L)(L′)X2Ru(II)(aryl-indenylidene). The method comprises the steps of reacting the precursor compound Ru(PPh3)nX2 (n=3-4) with a propargyl alcohol derivative in an cyclic diether solvent such as 1,4-dioxane at temperatures in the range of 80 to 130° C. and reaction times of 1 to 60 minutes. Optionally, additional neutral electron donor ligands such as PCy3, phobane ligands or NHC ligands are added to the reaction mixture for ligand exchange. The method includes a precipitation step for purification, after which the product is isolated. The ruthenium-indenylidene carbene catalysts are obtained in high purity and are used as catalysts for metathesis reactions (RCM, ROMP and CM) and as precursors for the synthesis of modified ruthenium carbene catalysts.

    摘要翻译： 本发明涉及一种（L）（L'）X2Ru（II）（芳基 - 亚茚基）类型的钌亚茚基碳烯催化剂的制备方法。 该方法包括以下步骤：使前体化合物Ru（PPh 3）n X 2（n = 3-4）与炔丙醇衍生物在环状二醚溶剂如1,4-二恶烷中的反应温度范围为80-130℃ ，反应时间为1〜60分钟。 任选地，向反应混合物中加入另外的中性电子给体配体如PCy3，phobane配体或NHC配体用于配体交换。 该方法包括用于纯化的沉淀步骤，之后分离产物。 获得高纯度的钌 - 亚茚基碳烯催化剂，并用作复分解反应（RCM，ROMP和CM）的催化剂，并用作合成改性钌卡宾催化剂的前体。

    RUTHENIUM COMPLEXES HAVING (P-P)-COORDINATED DIPHOSPHORUS DONOR LIGANDS AND PROCESSES FOR PREPARING THEM
    7.
    发明申请
    RUTHENIUM COMPLEXES HAVING (P-P)-COORDINATED DIPHOSPHORUS DONOR LIGANDS AND PROCESSES FOR PREPARING THEM 有权
    具有（P-P） - 相关二硫代磷酸酯配位体的钌络合物及其制备方法

    公开(公告)号：US20110112318A1

    公开(公告)日：2011-05-12

    申请号：US12935639

    申请日：2009-03-26

    申请人： Andreas Rivas-Nass ,  Ralf Karch ,  Roland Winde ,  Angelino Doppiu ,  Tina Schneider

    发明人： Andreas Rivas-Nass ,  Ralf Karch ,  Roland Winde ,  Angelino Doppiu ,  Tina Schneider

    IPC分类号： C07F5/02

    CPC分类号： C07F17/02 ,  B01J31/185 ,  B01J31/1865 ,  B01J31/2409 ,  B01J2231/643 ,  B01J2231/645 ,  B01J2531/821 ,  C07B53/00 ,  C07C51/36 ,  C07C53/126

    摘要： The invention relates to ruthenium complexes which have a chiral diphosphorus donor ligand and in which the ruthenium has the oxidation state (+11) and the chiral diphosphorus donor ligand has bidentate P—P coordination to the ruthenium. The ruthenium complexes are present in two forms (cationic type A and uncharged type B), are cyclic and have a four- to six-membered ring incorporating the diphosphorus donor ligand. The chiral diphosphorus donor ligands are selected from the group consisting of diphosphines, diphospholanes, diphosphites, diphosphonites and diazaphospholanes. Furthermore, processes for preparing the ruthenium complexes of types A and B, which are based on ligand exchange reactions, are described. The Ru complexes are used as catalysts for homogeneous asymmetric catalysis for preparing organic compounds.

    摘要翻译： 本发明涉及具有手性二磷供体配体并且其中钌具有氧化态（+11）和手性二磷供体配体的钌配合物与钌具有双齿P-P配位体。 钌络合物以两种形式（阳离子型A和不带电荷的B）存在，是环状的并且具有掺入二磷供体配体的四至六元环。 手性二磷供体配体选自二膦，二磷脂，二亚磷酸酯，二膦酸酯和二氮杂磷杂环戊烷。 此外，描述了基于配体交换反应制备A型和B型钌络合物的方法。 Ru配合物用作制备有机化合物的均相不对称催化剂。

    Process for preparing dienyl-ruthenium complexes
    9.
    发明授权
    Process for preparing dienyl-ruthenium complexes 有权
    二烯基钌配合物的制备方法

    公开(公告)号：US08829220B2

    公开(公告)日：2014-09-09

    申请号：US12995537

    申请日：2009-05-30

    申请人： Angelino Doppiu ,  Andreas Rivas-Nass ,  Ralf Karch ,  Roland Winde

    发明人： Angelino Doppiu ,  Andreas Rivas-Nass ,  Ralf Karch ,  Roland Winde

    IPC分类号： C07F15/00 ,  C07F17/02

    CPC分类号： C07F15/0046 ,  C07F17/02

    摘要： The present invention relates to a single-stage process for preparing dienyl-ruthenium complexes of the formula Ru(+II)(dienyl)2, wherein an Ru(II) starting compound of the formula Ru(X)p(Y)q is reacted with a diene ligand in the presence of an inorganic and/or organic base in a single-stage process. Here, polar organic solvents, preferably mixtures of polar organic solvents with water, are used. The dienyl-ruthenium complexes prepared according to the invention are used as precursors for homogeneous catalysts, for producing functional coatings and for therapeutic applications.

    摘要翻译： 本发明涉及制备式Ru（+ II）（二烯基）2的二烯基 - 钌络合物的单阶段方法，其中式Ru（X）p（Y）q的Ru（II）起始化合物为 在单级方法中在无机和/或有机碱的存在下与二烯配体反应。 这里，使用极性有机溶剂，优选极性有机溶剂与水的混合物。 根据本发明制备的二烯基 - 钌络合物用作均相催化剂的前体，用于制备功能性涂层和用于治疗应用。

    Process for preparing ruthenium(0)-olefin complexes
    10.
    发明授权
    Process for preparing ruthenium(0)-olefin complexes 有权
    制备钌（O） - 烯烃络合物的方法

    公开(公告)号：US08716509B2

    公开(公告)日：2014-05-06

    申请号：US13505796

    申请日：2010-11-11

    申请人： Angelino Doppiu ,  Andreas Rivas-Nass ,  Ralf Karch ,  Roland Winde ,  Eileen Woerner

    发明人： Angelino Doppiu ,  Andreas Rivas-Nass ,  Ralf Karch ,  Roland Winde ,  Eileen Woerner

    IPC分类号： C07F15/00 ,  C23C16/00

    CPC分类号： C23C16/18 ,  A61K31/28 ,  B01J31/00

    摘要： The present invention relates to a process for preparing ruthenium(0)-olefin complexes of the (arene)(diene)Ru(0) type by reacting a ruthenium starting compound of the formula Ru(+II)(X)p(Y)q (in which X=an anionic group, Y=an uncharged two-electron donor ligand, p=1 or 2, q=an integer from 1 to 6), with a cyclohexadiene derivative or a diene mixture comprising a cyclohexadiene derivative, in the presence of a base. In this process, the arene bound in the (arene)(diene)Ru(0) complex is formed from this cyclohexadiene derivative by oxidation. Suitable ruthenium(II) starting compounds are, for example, RuCl2(acetonitrile)4, RuCl2(pyridine)4 or RuCl2(DMSO)4. The bases used are inorganic or organic bases. The ruthenium(0)-olefin complexes prepared by the process according to the invention have a high purity and can be used as precursors for homogeneous catalysts, for preparation of functional ruthenium- or ruthenium oxide-containing layers and for therapeutic applications.

    摘要翻译： 本发明涉及一种制备（芳烃）（二烯）Ru（O）型钌（O） - 烯烃络合物的方法，通过使式钌（+ II）（X）p（Y） q（其中X =阴离子基团，Y =不带电荷的双电子供体配体，p = 1或2，q = 1至6的整数）与环己二烯衍生物或包含环己二烯衍生物的二烯混合物 一个基地的存在。 在该方法中，通过氧化由该环己二烯衍生物形成（芳烃）（二烯）Ru（O）络合物中的芳烃。 合适的钌（II）起始化合物是例如RuCl 2（乙腈）4，RuCl 2（吡啶）4或RuCl 2（DMSO）4。 使用的碱是无机或有机碱。 通过本发明方法制备的钌（O） - 烯烃络合物具有高纯度，可用作均相催化剂的前体，用于制备功能性含钌或氧化钌层并用于治疗应用。