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16 条记录 (耗时 0.017 秒)

    Glucan Gels
    2.
    发明申请
    Glucan Gels 有权
    葡聚糖凝胶

    公开(公告)号：US20130315979A1

    公开(公告)日：2013-11-28

    申请号：US13989594

    申请日：2011-11-29

    申请人： Rolf Engstad ,  Stein-Tore Solem ,  Dag-Eirik Ramsøy

    发明人： Rolf Engstad ,  Stein-Tore Solem ,  Dag-Eirik Ramsøy

    IPC分类号： A61K9/06 ,  A61L26/00 ,  A61L15/00 ,  A61K31/716

    CPC分类号： A61K9/06 ,  A61K9/0014 ,  A61K31/716 ,  A61L15/00 ,  A61L26/0023 ,  C08B37/0024 ,  C08J3/075 ,  C08J2305/00

    摘要： The present invention relates to a glucan having a weight average molar mass of 15,000 to 50,000 g/mol on a single chain basis and a weight average molar mass in aqueous solution on an aggregate basis of 4 to 20×105 g/mol and existing in gel form in aqueous solution at a concentration ≧1% at 25° C. and neutral pH and having a melting temperature (gel to sol) of 35 to 60° C. when the glucan is dissolved in water at a concentration of 2%, methods for the production thereof, medical uses thereof, physical supports having the glucan applied thereto or impregnated thereon and in vitro methods of proliferation of skin cells which comprise contacting a population of skin cells with the glucan.

    摘要翻译： 本发明涉及基于单链的重均摩尔质量为15,000〜50,000g / mol，聚合物的水溶液中的重均摩尔质量为4〜20×10 5 g / mol的葡聚糖， 凝胶形式在25℃和中性pH浓度> 1％的水溶液中，当葡聚糖以2％的浓度溶于水中时，其熔融温度（凝胶至溶胶）为35至60℃。 其生产方法，其医疗用途，具有施用于其上或浸渍有葡聚糖的物理载体和皮肤细胞增殖的体外方法，其包括使一群皮肤细胞与葡聚糖接触。

    Glucan gels
    3.
    发明授权
    Glucan gels 有权
    葡聚糖凝胶

    公开(公告)号：US09314432B2

    公开(公告)日：2016-04-19

    申请号：US13989594

    申请日：2011-11-29

    申请人： Rolf Engstad ,  Stein-Tore Solem ,  Dag-Eirik Ramsøy

    发明人： Rolf Engstad ,  Stein-Tore Solem ,  Dag-Eirik Ramsøy

    IPC分类号： A61L15/00 ,  A61K9/06 ,  C08B37/00 ,  C08J3/075 ,  A61K31/716 ,  A61L26/00

    CPC分类号： A61K9/06 ,  A61K9/0014 ,  A61K31/716 ,  A61L15/00 ,  A61L26/0023 ,  C08B37/0024 ,  C08J3/075 ,  C08J2305/00

    摘要： The present invention relates to a glucan having a weight average molar mass of 15,000 to 50,000 g/mol on a single chain basis and a weight average molar mass in aqueous solution on an aggregate basis of 4 to 20×105 g/mol and existing in gel form in aqueous solution at a concentration ≧1% at 25° C. and neutral pH and having a melting temperature (gel to sol) of 35 to 60° C. when the glucan is dissolved in water at a concentration of 2%, methods for the production thereof, medical uses thereof, physical supports having the glucan applied thereto or impregnated thereon and in vitro methods of proliferation of skin cells which comprise contacting a population of skin cells with the glucan.

    摘要翻译： 本发明涉及基于单链的重均摩尔质量为15,000〜50,000g / mol，聚合物的水溶液中的重均摩尔质量为4〜20×10 5 g / mol的葡聚糖， 凝胶形式的水溶液中，浓度为2％时，葡聚糖溶于水中，浓度≥25℃，中性pH，熔点（凝胶至溶胶）为35〜60℃。 其生产方法，其医疗用途，具有施用于其上或浸渍有葡聚糖的物理支持体和皮肤细胞增殖的体外方法，其包括使一群皮肤细胞与葡聚糖接触。

    Glucans
    5.
    发明申请
    Glucans 有权
    葡聚糖

    公开(公告)号：US20130310338A1

    公开(公告)日：2013-11-21

    申请号：US13989580

    申请日：2011-11-29

    申请人： Rolf Engstad ,  Thor Nøkland

    发明人： Rolf Engstad ,  Thor Nøkland

    IPC分类号： A61K31/716 ,  A61K9/06

    CPC分类号： A61K31/716 ,  A61K9/06 ,  A61K9/70 ,  A61K31/00 ,  C08B37/0024

    摘要： The present invention relates to a glucan having a weight average molar mass of 15,000 to 50,000 g/mol on a single chain basis and a weight average molar mass in aqueous solution on an aggregate basis of 4 to 20×105 g/mol and existing in gel form in aqueous solution at a concentration ≧1% at 25° C. and neutral pH and having a melting temperature (gel to sol) of 30 to 44° C. when the glucan is dissolved in water at a concentration of 2%, methods for the production thereof, medical uses thereof, physical supports having the glucan applied thereto or impregnated thereon and in vitro methods of proliferation of skin cells which comprise contacting a population of skin cells with the glucan.

    摘要翻译： 本发明涉及基于单链的重均摩尔质量为15,000〜50,000g / mol，聚合物的水溶液中的重均摩尔质量为4〜20×10 5 g / mol的葡聚糖， 凝胶形式在25℃和浓度为2％时溶解在水中的溶液温度（凝胶至溶胶）为25℃，中性pH为1％的水溶液， 其生产方法，其医疗用途，具有施用于其上或浸渍有葡聚糖的物理载体和皮肤细胞增殖的体外方法，其包括使一群皮肤细胞与葡聚糖接触。

    Method of treating/preventing mucositis
    6.
    发明申请
    Method of treating/preventing mucositis 审中-公开
    治疗/预防粘膜炎的方法

    公开(公告)号：US20060079481A1

    公开(公告)日：2006-04-13

    申请号：US10962314

    申请日：2004-10-08

    申请人： Rolf Engstad

    发明人： Rolf Engstad

    IPC分类号： A61K31/716

    CPC分类号： A61K31/716

    摘要： A method of treating and/or preventing mucositis which is an inflammation and ulceration of the mucous membranes, typically resulting from a toxic reaction to chemotherapy and/or radiotherapy by the application of water soluble immunomodulatory β-glucan.

    摘要翻译： 一种治疗和/或预防粘膜炎的方法，其是粘膜的炎症和溃疡，通常是通过施用水溶性免疫调节性β-葡聚糖对化学疗法和/或放射疗法的毒性反应引起的。

    Glucans
    9.
    发明授权
    Glucans 有权

    公开(公告)号：US09623043B2

    公开(公告)日：2017-04-18

    申请号：US13989580

    申请日：2011-11-29

    申请人： Rolf Engstad ,  Thor Nøkland

    发明人： Rolf Engstad ,  Thor Nøkland

    IPC分类号： C08B37/00 ,  A61K31/716 ,  A61K31/00 ,  A61K9/06

    CPC分类号： A61K31/716 ,  A61K9/06 ,  A61K9/70 ,  A61K31/00 ,  C08B37/0024

    摘要： The present invention relates to a glucan having a weight average molar mass of 15,000 to 50,000 g/mol on a single chain basis and a weight average molar mass in aqueous solution on an aggregate basis of 4 to 20×105 g/mol and existing in gel form in aqueous solution at a concentration ≧1% at 25° C. and neutral pH and having a melting temperature (gel to sol) of 30 to 44° C. when the glucan is dissolved in water at a concentration of 2%, methods for the production thereof, medical uses thereof, physical supports having the glucan applied thereto or impregnated thereon and in vitro methods of proliferation of skin cells which comprise contacting a population of skin cells with the glucan.