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1.发明申请Capsule pharmaceutical dosage form comprising a suspension formulation of an indolinone derivative 审中-公开胶囊药物剂型，其包含二氢吲哚衍生物的悬浮液制剂公开(公告)号：US20110301177A1
公开(公告)日：2011-12-08
申请号：US12995869
申请日：2009-06-04
申请人： Roman Messerschmid , Rudolf Binder , Thomas Bock , Werner Brox
发明人： Roman Messerschmid , Rudolf Binder , Thomas Bock , Werner Brox
IPC分类号： A61K31/496 , B65D85/00 , A61P37/00 , C07D403/12 , A61P35/00
CPC分类号： A61K9/4825 , A61K9/48 , A61K9/4816 , A61K9/4858 , A61K9/4866 , A61K31/404 , A61K31/496 , Y02A50/465
摘要： The present invention relates to a suspension formulation containing the active substance 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone-monoethanesulphonate, to a capsule pharmaceutical dosage form containing said suspension formulation, to a process for preparing said suspension formulation, to a process for preparing said capsule comprising said suspension formulation and to the packaging material for the finished capsule.
摘要翻译： 本发明涉及含有活性物质3-Z- [1-（4-（N - （（4-甲基 - 哌嗪-1-基） - 甲基羰基）-N-甲基 - 氨基） - 苯胺基） -1-苯基 - 亚甲基] -6-甲氧基羰基-2-二氢吲哚酮 - 单乙磺酸盐与包含所述悬浮液制剂的胶囊药物剂型相连，制备所述悬浮液制剂的方法涉及一种制备所述胶囊的方法，所述方法包括所述悬浮液制剂和 到成品胶囊的包装材料。
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公开(公告)号：US08545884B2
公开(公告)日：2013-10-01
申请号：US12995715
申请日：2009-06-05
申请人： Roman Messerschmid , Thomas Friedl
发明人： Roman Messerschmid , Thomas Friedl
CPC分类号： A61K9/0095 , A61K9/143 , A61K9/1623 , A61K9/1635 , A61K9/1652 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K31/517
摘要： The present invention relates to a pharmaceutical dosage form containing the active substance BIBW 2992 as the dimaleate salt, providing an immediate release profile of the active substance, further, the invention relates to compacted intermediates comprising BIBW 2992 dimaleate salt (BIBW 2992 MA2) in form of a powder prepared using a combined roller compaction and sieving step from BIBW 2992 MA2, intermediate blends prepared from said compacted intermediate as well as solid oral formulations providing an immediate release profile of the active substance, made from said compacted intermediate or from said intermediate blends ready for use/ingestion, e.g. capsule and tablet formulations such as uncoated or film-coated tablets prepared by direct-compression, and methods for their production.
摘要翻译： 本发明涉及含有活性物质BIBW 2992作为二马来酸盐的药物剂型，其提供活性物质的即时释放曲线。此外，本发明涉及包含BIBW 2992二马来酸盐（BIBW 2992 MA2）的压实中间体，其形式为 使用来自BIBW 2992MA2的组合辊压和筛分步骤制备的粉末，由所述压实中间体制备的中间体共混物以及提供由所述压实中间体或所述中间体共混物制成的活性物质的立即释放曲线的固体口服制剂 准备使用/摄入，例如 胶囊和片剂制剂，例如通过直接压片制备的未包衣或薄膜包衣片剂及其制备方法。
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3.发明申请Pharmaceutical dosage form for immediate release of an indolinone derivative 审中-公开用于立即释放二氢吲哚衍生物的药物剂型公开(公告)号：US20110190318A1
公开(公告)日：2011-08-04
申请号：US12995893
申请日：2009-06-04
IPC分类号： A61K31/496 , C07D403/12 , A61P35/00 , A61P37/00
CPC分类号： A61K31/496 , A61B5/48 , A61K9/0053 , A61K9/4858 , A61K31/404 , A61K47/14 , A61K47/24 , A61K47/44 , G09B19/00
摘要： The present invention relates to a pharmaceutical dosage form delivering an immediate release profile containing the active substance 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone-monoethanesulphonate.
摘要翻译： 本发明涉及递送含有活性物质3-Z- [1-（4-（N - （（4-甲基 - 哌嗪-1-基） - 甲基羰基）-N-甲基的立即释放曲线的药物剂型 - 氨基） - 苯胺基）-1-苯基 - 亚甲基] -6-甲氧基羰基-2-二氢吲哚酮 - 单乙磺酸盐。
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公开(公告)号：US06900246B2
公开(公告)日：2005-05-31
申请号：US10045835
申请日：2002-01-11
CPC分类号： B05B7/00 , B05B17/04 , Y10S261/78
摘要： A method for generating an aerosol includes the step of guiding a gas which flows at supersonic velocity and which has input particles suspended therein in such a way that a compression shock occurs. The input particles are broken down into smaller output particles upon crossing the compression shock. A device for generating an aerosol is also provided.
摘要翻译： 用于产生气溶胶的方法包括引导以超音速流动的气体的步骤，并且其中输入颗粒悬浮在其中，使得发生压缩冲击。 输入粒子在穿过压缩冲击时被分解成更小的输出粒子。 还提供了一种用于产生气溶胶的装置。
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公开(公告)号：US09555001B2
公开(公告)日：2017-01-31
申请号：US13785365
申请日：2013-03-05
申请人： Masanori Ito , Kenji Egusa , Kyle Kleinbeck , Roman Messerschmid , Peter Schneider , Venkata Voleti
发明人： Masanori Ito , Kenji Egusa , Kyle Kleinbeck , Roman Messerschmid , Peter Schneider , Venkata Voleti
IPC分类号： A61K9/20 , A61K31/522 , A61K31/155 , A61K31/7048 , A61K9/24 , A61K9/00 , A61K45/06 , A61K9/28
CPC分类号： A61K9/2866 , A61K9/0065 , A61K9/2031 , A61K9/2081 , A61K9/209 , A61K9/2853 , A61K31/155 , A61K31/522 , A61K31/7048 , A61K45/06 , A61K2300/00
摘要： The present invention relates to pharmaceutical compositions comprising fixed dose combinations of a DPP-4 inhibitor drug and/or a SGLT-2 inhibitor drug, and metformin XR, processes for the preparation thereof, and their use to treat certain diseases.
摘要翻译： 本发明涉及包含DPP-4抑制剂药物和/或SGLT-2抑制剂药物的固定剂量组合和二甲双胍XR的药物组合物，其制备方法及其用于治疗某些疾病的用途。
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公开(公告)号：US20110142929A1
公开(公告)日：2011-06-16
申请号：US12995715
申请日：2009-06-05
申请人： Roman Messerschmid , Thomas Friedl
发明人： Roman Messerschmid , Thomas Friedl
CPC分类号： A61K9/0095 , A61K9/143 , A61K9/1623 , A61K9/1635 , A61K9/1652 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K31/517
摘要： The present invention relates to a pharmaceutical dosage form containing the active substance BIBW 2992 as the dimaleate salt, providing an immediate release profile of the active substance, further, the invention relates to compacted intermediates comprising BIBW 2992 dimaleate salt (BIBW 2992 MA2) in form of a powder prepared using a combined roller compaction and sieving step from BIBW 2992 MA2, intermediate blends prepared from said compacted intermediate as well as solid oral formulations providing an immediate release profile of the active substance, made from said compacted intermediate or from said intermediate blends ready for use/ingestion, e.g. capsule and tablet formulations such as uncoated or film-coated tablets prepared by direct-compression, and methods for their production.
摘要翻译： 本发明涉及含有活性物质BIBW 2992作为二马来酸盐的药物剂型，其提供活性物质的即时释放曲线。此外，本发明涉及包含BIBW 2992二马来酸盐（BIBW 2992 MA2）的压实中间体，其形式为 使用来自BIBW 2992MA2的组合辊压和筛分步骤制备的粉末，由所述压实中间体制备的中间体共混物以及提供由所述压实中间体或所述中间体共混物制成的活性物质的立即释放曲线的固体口服制剂 准备使用/摄入，例如 胶囊和片剂制剂，例如通过直接压片制备的未包衣或薄膜包衣片剂及其制备方法。
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