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    Drug and excipient aerosol compositions
    2.
    发明申请
    Drug and excipient aerosol compositions 审中-公开
    药物和赋形剂气溶胶组合物

    公开(公告)号：US20070286816A1

    公开(公告)日：2007-12-13

    申请号：US11744799

    申请日：2007-05-04

    申请人： Ron Hale ,  Joshua Rabinowitz ,  Daniel Myers ,  Amy Lu ,  Alejandro Zaffaroni

    发明人： Ron Hale ,  Joshua Rabinowitz ,  Daniel Myers ,  Amy Lu ,  Alejandro Zaffaroni

    IPC分类号： A61K9/12

    CPC分类号： A61K9/0004 ,  A61K9/007 ,  A61K9/0078 ,  A61K9/12 ,  A61K31/4468 ,  A61K31/519 ,  A61K31/5415 ,  A61K31/5517 ,  A61K31/553 ,  A61M11/002 ,  A61M11/005 ,  A61M11/04 ,  A61M11/041 ,  A61M11/042 ,  A61M11/047 ,  A61M15/00 ,  A61M2207/00

    摘要： The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided. The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.

    摘要翻译： 本发明提供用于治疗疾病和/或间歇或急性病症的新型凝结气溶胶。 这些凝结气溶胶几乎没有或没有热解降解产物，其特征在于MMAD为1-3微米。 这些气溶胶是通过在使薄膜上的气体通过膜的同时，快速加热涂覆有厚度为0.05至20μm的药物的薄膜的基材，以形成用于吸入的理想颗粒尺寸的颗粒。 还提供了包含药物和用于产生冷凝气溶胶的装置的试剂盒。 包含在试剂盒中的装置通常具有用于加热药物的元件，其作为膜被涂覆在基底上并且当药物以气溶胶形式施用时含有治疗有效剂量的药物，以及允许蒸气冷却的元件 以形成气溶胶。 还公开了使用这些气溶胶和试剂盒的方法。

    Drug condensation aerosols and kits
    3.
    发明申请
    Drug condensation aerosols and kits 审中-公开
    药物冷凝气溶胶和试剂盒

    公开(公告)号：US20070122353A1

    公开(公告)日：2007-05-31

    申请号：US11504419

    申请日：2006-08-15

    申请人： Ron Hale ,  Craig Hodges ,  Peter Lloyd ,  Amy Lu ,  Daniel Myers ,  Joshua Rabinowitz ,  Martin Wensley ,  Jeffrey McKinney ,  Alejandro Zaffaroni

    发明人： Ron Hale ,  Craig Hodges ,  Peter Lloyd ,  Amy Lu ,  Daniel Myers ,  Joshua Rabinowitz ,  Martin Wensley ,  Jeffrey McKinney ,  Alejandro Zaffaroni

    IPC分类号： A61K9/14

    CPC分类号： A61K9/0004 ,  A61K9/007 ,  A61K9/0078 ,  A61K9/12 ,  A61K31/4468 ,  A61K31/519 ,  A61K31/5415 ,  A61K31/5517 ,  A61K31/553 ,  A61M11/002 ,  A61M11/005 ,  A61M11/04 ,  A61M11/041 ,  A61M11/042 ,  A61M11/047 ,  A61M15/00 ,  A61M2207/00

    摘要： The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.

    摘要翻译： 本发明提供用于治疗疾病和/或间歇或急性病症的新型凝结气溶胶。 这些凝结气溶胶几乎没有或没有热解降解产物，其特征在于MMAD为1-3微米。 这些气溶胶是通过在使薄膜上的气体通过膜的同时，快速加热涂覆有厚度为0.05至20μm的药物的薄膜的基材，以形成用于吸入的理想颗粒尺寸的颗粒。 还提供了包含药物和用于产生冷凝气雾剂的装置的试剂盒。典型地，试剂盒中所含的装置具有用于加热药物的元件，其在基底上以薄膜形式包被，并含有治疗有效剂量的药物 药物以气溶胶形式施用，并且允许蒸气冷却以形成气溶胶的元素。 还公开了使用这些气溶胶和试剂盒的方法。

    AEROSOL DELIVERY SYSTEM AND USES THEREOF
    5.
    发明申请
    AEROSOL DELIVERY SYSTEM AND USES THEREOF 审中-公开
    航空运输系统及其用途

    公开(公告)号：US20080038363A1

    公开(公告)日：2008-02-14

    申请号：US11687466

    申请日：2007-03-16

    申请人： Alejandro Zaffaroni ,  Joshua Rabinowitz

    发明人： Alejandro Zaffaroni ,  Joshua Rabinowitz

    IPC分类号： A61K9/14 ,  A61K31/5513 ,  A61P25/00 ,  A61K31/5517

    CPC分类号： A61M11/041 ,  A61M11/001 ,  A61M11/005 ,  A61M11/042 ,  A61M11/048 ,  A61M15/002

    摘要： A device, method, and system for producing a condensation aerosol are disclosed. The device includes a chamber having an upstream opening and a downstream opening which allow gas to flow through the chamber, and a heat-conductive substrate located at a position between the upstream and downstream openings. Formed on the substrate is a drug composition film containing a therapeutically effective dose of a drug when the drug is administered in aerosol form. A heat source in the device is operable to supply heat to the substrate to produce a substrate temperature greater than 300 oC, and to substantially volatilize the drug composition film from the substrate in a period of 2 seconds or less. The device produces an aerosol containing less than about 10% by weight drug composition degradation products and at least 50% of the drug composition of said film.

    摘要翻译： 公开了一种用于生产冷凝气雾剂的装置，方法和系统。 该装置包括具有允许气体流过腔室的上游开口和下游开口的腔室，以及位于上游和下游开口之间位置的导热基底。 在基质上形成药物组合物膜，当药物以气溶胶形式施用时，其含有治疗有效剂量的药物。 装置中的热源可操作以向基板供应热量以产生大于300℃的基板温度，并且在2秒或更短的时间段内基本上使药物组合物膜从基板挥发。 该装置产生含有小于约10重量％的药物组合物降解产物和所述膜的药物组合物的至少50％的气溶胶。

    Delivery of diazepam through an inhalation route
    6.
    发明申请
    Delivery of diazepam through an inhalation route 失效
    通过吸入路线递送地西泮

    公开(公告)号：US20060269486A1

    公开(公告)日：2006-11-30

    申请号：US11500736

    申请日：2006-08-07

    申请人： Joshua Rabinowitz ,  Alejandro Zaffaroni

    发明人： Joshua Rabinowitz ,  Alejandro Zaffaroni

    IPC分类号： A61K9/14 ,  A61L9/04

    CPC分类号： A61K9/0073 ,  A61K9/007 ,  A61K31/5513 ,  Y10S514/958

    摘要： The present invention relates to the delivery of compounds for the treatment of anxiety disorders and symptoms of such disorders through an inhalation route. Specifically, it relates to aerosols containing diazepam that are used in inhalation therapy. In a method aspect of the present invention, diazepam is administered to a patient through an inhalation route. The method comprises: a) heating a thin layer of diazepam on a solid support to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% drug degradation products. In a kit aspect of the present invention, a kit for delivering diazepam through an inhalation route is provided which comprises: a) a thin coating of a diazepam composition; and, b) a device for dispending said thin coating as a condensation aerosol.

    摘要翻译： 本发明涉及通过吸入途径递送用于治疗焦虑症和这种病症症状的化合物。 具体来说，它涉及用于吸入治疗的含有地西泮的气溶胶。 在本发明的方法方面，通过吸入途径向患者施用地西泮。 该方法包括：a）在固体支持物上加热薄层的地西泮以形成蒸气; 和b）使空气通过加热的蒸气以产生具有小于5％药物降解产物的气溶胶颗粒。 在本发明的试剂盒方面，提供了用于通过吸入途径递送地西泮的试剂盒，其包括：a）地西泮组合物的薄涂层; 和b）用于将所述薄涂层作为冷凝气溶胶进行排放的装置。