摘要:
Methods of treating headache with antipsychotics are provided. A kit for treating headache is also provided, comprising an antipsychotic and a device for rapid delivery of the antipsychotic.
摘要:
A device, method, and system for producing a condensation aerosol are disclosed. The device includes a chamber having an upstream opening and a downstream opening which allow gas to flow through the chamber, and a heat-conductive substrate located at a position between the upstream and downstream openings. Formed on the substrate is a drug composition film containing a therapeutically effective dose of a drug when the drug is administered in aerosol form. A heat source in the device is operable to supply heat to the substrate to produce a substrate temperature greater than 300° C., and to substantially volatilize the drug composition film from the substrate in a period of 2 seconds or less. The device produces an aerosol containing less than about 10% by weight drug composition degradation products and at least 50% of the drug composition of said film.
摘要:
The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.
摘要:
Aerosol drug delivery devices incorporating percussively activated heat packages are disclosed. The heat packages include a percussive igniter and a fuel capable of undergoing an exothermic oxidation-reduction reaction when ignited by the percussive igniter. The drug delivery devices disclosed can be activated by an actuation mechanism to vaporize a thin solid film comprising a drug disposed on the exterior of a hat package. Metal coordination complexes of volatile drugs, and in particular nicotine, from which the drug can be selectively vaporized when heated are also disclosed. The use of aerosol drug delivery devices comprising thin films of nicotine metal salt complexes for the treatment of nicotine craving and for effecting smoking cessation are also disclosed.
摘要:
The disclosure provides methods and compositions for providing an effective dose of an active agent and/or drug composition to a subject by inhalation. The methods of the disclosure are useful in determining a maximal effective dose that limits cardiovascular damage upon inhalation.
摘要:
A process and device for the recycling of asphalt including at least one one preheater unit. The preheater having a heater, scarifying rakes, and a bin to dispense aggregate. Also include is a recycling machine having a heater, scarifying rakes, a plurality of extension mills, a main mill, as well as a pug mill having first and second downwardly rotating rotors, the pug mill mixes asphalt and liquid additives together to form a homogenous mix; and at least one screed for laying the homogeneously mixed asphalt to grade.
摘要:
An undermount support for an appliance, and a method for using the support, the support including a frame that is: (a) assembled around the exterior periphery of the appliance; (b) located in supporting contact below the underside of a rim flange of the appliance; and (c) attached to cabinetry supporting a countertop or cooktop. The frame thereby enables the cabinetry to support the appliance by the rim flange.
摘要:
A lifting device such as a mobile crane having a main body and a boom, such as a lattice boom, for supporting a pile lead for, e.g., pile driving or continuous flight auger drilling, and a method of using same. A hydraulically operated mechanical spotter arm may be attached between the device body and the pile lead. Electronic position sensors on the spotter arm may be used to measure angular relationships between the pile lead and the spotter arm. Position sensors on a boom box on the boom may also be used. When the pile lead is swung, information from the sensors may be used by an electronic control system to automatically maintain the pile lead in a desirable position, limiting torque induced in the boom. The boom box position sensors may be used to counter-steer the spotter arm to further limit torque. The boom box may also be fitted with rubber springs to permit controlled pile lead deflection while limiting load transmitted to the boom. Other aspects of the invention will become apparent from the disclosure.
摘要:
A lifting device such as a mobile crane having a main body and a boom, such as a lattice boom, for supporting a pile lead for, e.g., pile driving or continuous flight auger drilling, and a method of using same. A hydraulically operated mechanical spotter arm may be attached between the device body and the pile lead. Electronic position sensors on the spotter arm may be used to measure angular relationships between the pile lead and the spotter arm. Position sensors on a boom box on the boom may also be used. When the pile lead is swung, information from the sensors may be used by an electronic control system to automatically maintain the pile lead in a desirable position, limiting torque induced in the boom. The boom box position sensors may be used to counter-steer the spotter arm to further limit torque. The boom box may also be fitted with rubber springs to permit controlled pile lead deflection while limiting load transmitted to the boom. Other aspects of the invention will become apparent from the disclosure.