公开(公告)号：US20060121005A1

公开(公告)日：2006-06-08

申请号：US11070841

申请日：2005-03-02

申请人： Ronald Berenson ,  Che Law ,  Mark Bonyhadi ,  Zahbea Saund ,  Stewart Craig ,  Alan Hardwick ,  Dale Kalamasz ,  David McMillen ,  Harjinder Chana

发明人： Ronald Berenson ,  Che Law ,  Mark Bonyhadi ,  Zahbea Saund ,  Stewart Craig ,  Alan Hardwick ,  Dale Kalamasz ,  David McMillen ,  Harjinder Chana

IPC分类号： A61K39/395 ,  C12N5/08 ,  A61K35/14

CPC分类号： C12N5/0636 ,  C12N2501/51 ,  C12N2501/515 ,  C12N2533/00

摘要： The present invention relates generally to methods for activating and expanding cells, and more particularly, to a novel method to activate and/or stimulate cells that maximizes the expansion of such cells to achieve dramatically high densities. In the various embodiments, cells are activated and expanded to very high densities in a short period of time. In certain embodiments, cells are activated and expanded to very high numbers of cells in a short period of time. Compositions of cells activated and expanded by the methods herein are further provided.

公开(公告)号：US20050153447A1

公开(公告)日：2005-07-14

申请号：US11001921

申请日：2004-12-02

申请人： Ronald Berenson ,  Che Law ,  Mark Bonyhadi ,  Narinder Saund ,  Stewart Craig ,  Alan Hardwick ,  Dale Kalamasz ,  David McMillen ,  Harjinder Chana

发明人： Ronald Berenson ,  Che Law ,  Mark Bonyhadi ,  Narinder Saund ,  Stewart Craig ,  Alan Hardwick ,  Dale Kalamasz ,  David McMillen ,  Harjinder Chana

IPC分类号： C12M1/00 ,  A61K35/12 ,  A61K39/00 ,  A61L27/38 ,  C07K16/28 ,  C12M3/00 ,  C12N5/0781 ,  C12N5/0783 ,  C12N5/0789 ,  C12N5/08

CPC分类号： A61L27/3804 ,  A61K2035/124 ,  A61K2039/5158 ,  A61K2039/57 ,  C07K16/2803 ,  C07K16/2806 ,  C07K16/2809 ,  C07K16/2812 ,  C07K16/2815 ,  C07K16/2818 ,  C07K16/2821 ,  C07K16/2827 ,  C07K16/2833 ,  C07K16/2845 ,  C07K16/2854 ,  C07K16/2866 ,  C07K16/2875 ,  C07K16/2878 ,  C07K16/289 ,  C07K16/2896 ,  C12N5/0635 ,  C12N5/0636 ,  C12N5/0647 ,  C12N2500/32 ,  C12N2501/23 ,  C12N2501/51 ,  C12N2501/515 ,  C12N2501/53 ,  C12N2501/59 ,  C12N2533/12 ,  C12N2533/14 ,  C12N2533/18 ,  C12N2533/30 ,  C12N2533/40 ,  C12N2533/54 ,  C12N2533/70 ,  C12N2533/72 ,  C12N2533/90

摘要： The present invention relates generally to methods for activating and expanding cells, and more particularly, to a novel method to activate and/or stimulate cells that maximizes the expansion of such cells to achieve dramatically high densities. In the various embodiments, cells are activated and expanded to very high densities in a short period of time. In certain embodiments, cells are activated and expanded to very high numbers of cells in a short period of time. Compositions of cells activated and expanded by the methods herein are further provided.

公开(公告)号：US20050214942A1

公开(公告)日：2005-09-29

申请号：US10984351

申请日：2004-11-08

申请人： Ronald Berenson ,  Che Law ,  Mark Bonyhadi ,  Narinder Saund ,  Stewart Craig ,  Alan Hardwick ,  Dale Kalamasz ,  David McMillen ,  Harjinder Chana

发明人： Ronald Berenson ,  Che Law ,  Mark Bonyhadi ,  Narinder Saund ,  Stewart Craig ,  Alan Hardwick ,  Dale Kalamasz ,  David McMillen ,  Harjinder Chana

IPC分类号： C12M1/00 ,  A61K35/12 ,  A61K39/00 ,  A61L27/38 ,  C07K16/28 ,  C12M3/00 ,  C12N5/0781 ,  C12N5/0783 ,  C12N5/0789 ,  C12N5/08

CPC分类号： A61L27/3804 ,  A61K2035/124 ,  A61K2039/5158 ,  A61K2039/57 ,  C07K16/2803 ,  C07K16/2806 ,  C07K16/2809 ,  C07K16/2812 ,  C07K16/2815 ,  C07K16/2818 ,  C07K16/2821 ,  C07K16/2827 ,  C07K16/2833 ,  C07K16/2845 ,  C07K16/2854 ,  C07K16/2866 ,  C07K16/2875 ,  C07K16/2878 ,  C07K16/289 ,  C07K16/2896 ,  C12N5/0635 ,  C12N5/0636 ,  C12N5/0647 ,  C12N2500/32 ,  C12N2501/23 ,  C12N2501/51 ,  C12N2501/515 ,  C12N2501/53 ,  C12N2501/59 ,  C12N2533/12 ,  C12N2533/14 ,  C12N2533/18 ,  C12N2533/30 ,  C12N2533/40 ,  C12N2533/54 ,  C12N2533/70 ,  C12N2533/72 ,  C12N2533/90

摘要： The present invention relates generally to methods for activating and expanding cells, and more particularly, to a novel method to activate and/or stimulate cells that maximizes the expansion of such cells to achieve dramatically high densities. In the various embodiments, cells are activated and expanded to very high densities in a short period of time. In certain embodiments, cells are activated and expanded to very high numbers of cells in a short period of time. Compositions of cells activated and expanded by the methods herein are further provided.

摘要翻译： 本发明一般涉及用于激活和扩增细胞的方法，更具体地，涉及一种激活和/或刺激细胞的新方法，其使这种细胞的扩增最大化以达到显着高的密度。 在各种实施例中，细胞被激活并在短时间内扩展到非常高的密度。 在某些实施方案中，细胞在短时间内被激活并扩增至非常高数量的细胞。 进一步提供通过本文方法激活和扩增的细胞的组成。