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公开(公告)号：US5786331A
公开(公告)日：1998-07-28
申请号：US465391
申请日：1995-06-05
申请人： Ronald W. Barrett , Stephen D. Yanofsky , David Baldwin , Jeff W. Jacobs , Phillipe R. Bovy , Ellen M. Leahy , Richard S. Pottorf
发明人： Ronald W. Barrett , Stephen D. Yanofsky , David Baldwin , Jeff W. Jacobs , Phillipe R. Bovy , Ellen M. Leahy , Richard S. Pottorf
IPC分类号： A61K38/00 , C07K14/545 , A61K38/08 , C07K7/04
CPC分类号： C07K14/545 , A61K38/00
摘要： Peptides that bind to the interleukin-1 type I receptor (IL-1RtI) can be used to assay the amount of IL-1R, or an IL-1R agonist or antagonist, in a sample and comprise a sequence of amino acids selected from the group consisting of (1) WXXXGZ.sub.1 W where Z.sub.1 is L, I, A, or Q; (2) XXQZ.sub.5 YZ.sub.6 XX where Z.sub.5 is P or Aze where Aze is azetidine; and Z.sub.6 is S, A, V, or L; and (3) Z.sub.23 NZ.sub.24 SZ.sub.25 Z.sub.26 Z.sub.27 Z.sub.28 Z.sub.29 Z.sub.30 L where Z.sub.23 is D or Y; Z.sub.24 is D or S; Z.sub.25 is S or W; Z.sub.26 is S or Y; Z.sub.27 is D or V; Z.sub.28 is S or W; Z.sub.29 is F or L; and Z.sub.30 is D or L; and where each amino acid is indicated by standard one letter abbreviation; and each X can be selected from any one of the 20 genetically coded L-amino acids or the stereoisomeric D-amino acids. Also provided are peptides which bind to the IL-1RtI, which are 11 to 40 amino acids in length, which comprise the core sequence of amino acids: Z.sub.31 XWZ.sub.32 Z.sub.33 Z.sub.34 Z.sub.35 Z.sub.36 QZ.sub.37 Z.sub.38 where each letter represents the standard one letter abbreviation for an amino acid or an analog thereof; X is selected from the group of natural or unnatural amino acids; Z.sub.37 is a natural or unnatural cyclic amino acid; Z.sub.31 is selected from phenylalanine and acetylated phenylalanine; Z.sub.32 is a natural or unnatural amino acid; Z.sub.33 is selected from proline and pipecolic acid; Z.sub.34 is selected from glycine, d-alanine, d-valine, sarcosine and aminoisobutyric acid; Z.sub.35 is a natural or unnatural amino acid and Z.sub.36 is selected from tyrosine, phosphotyrosine, phenylalanine and tryptophan; and Z.sub.38 is selected from tyrosinamide and substituted tyrosinamide.
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公开(公告)号：US5861476A
公开(公告)日：1999-01-19
申请号：US464538
申请日：1995-06-05
申请人： Ronald W. Barrett , Stephen D. Yanofsky , David Baldwin , Jeff W. Jacobs , Phillipe R. Bovy , Ellen M. Leahy , Richard S. Pottorf
发明人： Ronald W. Barrett , Stephen D. Yanofsky , David Baldwin , Jeff W. Jacobs , Phillipe R. Bovy , Ellen M. Leahy , Richard S. Pottorf
IPC分类号： A61K38/00 , C07K14/545 , C07K7/04 , A61K38/04
CPC分类号： C07K14/545 , A61K38/00 , Y10S930/141
摘要： Peptides that bind to the interleukin-1 type I receptor (IL-1RtI) can be used to assay the amount of IL-1R, or an IL-1R agonist or antagonist, in a sample and comprise a sequence of amino acids selected from the group consisting of (1) WXXXGZ.sub.1 W where Z.sub.1 is L, I, A, or Q; (2) XXQZ.sub.5 YZ.sub.6 XX where Z.sub.5 is P or Aze where Aze is azetidine; and Z.sub.6 is S, A, V, or L; and (3) Z.sub.23 NZ.sub.24 SZ.sub.25 Z.sub.26 Z.sub.27 Z.sub.28 Z.sub.29 Z.sub.30 L where Z.sub.23 is D or Y; Z.sub.24 is D or S; Z.sub.25 is S or W; Z.sub.26 is S or Y; Z.sub.27 is D or V; Z.sub.28 is S or W; Z.sub.29 is F or L; and Z.sub.30 is D or L; and where each amino acid is indicated by standard one letter abbreviation; and each X can be selected from any one of the 20 genetically coded L-amino acids or the stereoisomeric D-amino acids. Also provided are peptides which bind to the IL-1RtI, which are 11 to 40 amino acids in length, which comprise the core sequence of amino acids:Z.sub.31 XWZ.sub.32 Z.sub.33 Z.sub.34 Z.sub.35 Z.sub.36 QZ.sub.37 Z.sub.38where each letter represents the standard one letter abbreviation for an amino acid or an analog thereof; X is selected from the group of natural or unnatural amino acids; Z.sub.37 is a natural or unnatural cyclic amino acid; Z.sub.31 is selected from phenylalanine and acetylated phenylalanine; Z.sub.32 is a natural or unnatural amino acid; Z.sub.33 is selected from proline and pipecolic acid; Z.sub.34 is selected from glycine, d-alanine, d-valine, sarcosine and aminoisobutyric acid; Z.sub.35 is a natural or unnatural amino acid and Z.sub.36 is selected from tyrosine, phosphotyrosine, phenylalanine and tryptophan; and Z.sub.38 is selected from tyrosinamide and substituted tyrosinamide.
摘要翻译： 结合白细胞介素-1 I型受体（IL-1RtI）的肽可用于测定样品中IL-1R或IL-1R激动剂或拮抗剂的量，并且包含选自以下的氨基酸序列： 由（1）WXXXGZ1W组成的组，其中Z1是L，I，A或Q; （2）XXQZ5YZ6XX其中Z5为P或Aze，其中Aze为氮杂环丁烷; Z6为S，A，V或L; 和（3）Z23NZ24SZ25Z26Z27Z28Z29Z30L其中Z23为D或Y; Z24是D或S; Z25为S或W; Z26为S或Y; Z27为D或V; Z28为S或W; Z29为F或L; Z30为D或L; 并且其中每个氨基酸由标准单字母缩写指示; 并且每个X可以选自20个遗传编码的L-氨基酸或立体异构体D-氨基酸中的任一个。 还提供了与IL-1RtI结合的肽，其长度为11至40个氨基酸，其包含氨基酸的核心序列：Z31XWZ32Z33Z34Z35Z36QZ37Z38，其中每个字母表示氨基酸或其类似物的标准单字母缩写; X选自天然或非天然氨基酸组; Z37是天然或非天然环状氨基酸; Z31选自苯丙氨酸和乙酰化苯丙氨酸; Z32是天然或非天然氨基酸; Z33选自脯氨酸和哌啶酸; Z34选自甘氨酸，d-丙氨酸，d-缬氨酸，肌氨酸和氨基异丁酸; Z35是天然或非天然氨基酸，Z36选自酪氨酸，磷酸酪氨酸，苯丙氨酸和色氨酸; Z38选自酪氨酰胺和取代的酪氨酰胺。
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公开(公告)号：US5767234A
公开(公告)日：1998-06-16
申请号：US383474
申请日：1995-02-01
IPC分类号： A61K38/00 , C07K14/545 , C07K5/00 , C07K7/00
CPC分类号： C07K14/545 , A61K38/00
摘要： Peptides that bind to the interleukin-1 type I receptor (IL-1RtI) can be used to assay the amount of IL-1R, or an IL-1R agonist or antagonist, in a sample and comprise a sequence of amino acids selected from the group consisting of (1) WXXXGZ.sub.1 W (SEQ ID NO: 2) where Z.sub.1 is L, I, A, or Q; (2) XXQZ.sub.5 YZ.sub.6 XX where (SEQ ID NO: 1) Z.sub.5 is P or Aze where Aze is azetidine; and Z.sub.6 is S, A, V, or L; and (3) Z.sub.23 NZ.sub.24 SZ.sub.25 Z.sub.26 Z.sub.27 Z.sub.28 Z.sub.29 Z.sub.30 L (SEQ ID NO: 313) where Z.sub.23 is D or Y; Z.sub.24 is D or S; Z.sub.25 is S or W; Z.sub.26 is S or Y; Z.sub.27 is D or V; Z.sub.28 is S or W; Z.sub.29 is F or L; and Z.sub.30 is D or L; and where each amino acid is indicated by standard one letter abbreviation; and each X can be selected from any one of the 20 genetically coded L-amino acids or the stereoisomeric D-amino acids.
摘要翻译： 结合白细胞介素-1 I型受体（IL-1RtI）的肽可用于测定样品中IL-1R或IL-1R激动剂或拮抗剂的量，并且包含选自以下的氨基酸序列： 由（1）WXXXGZ1W（SEQ ID NO：2）组成的组，其中Z1是L，I，A或Q; （2）XXQZ5YZ6XX其中（SEQ ID NO：1）Z5为P或Aze，其中Aze为氮杂环丁烷; Z6为S，A，V或L; 和（3）Z23NZ24SZ25Z26Z27Z28Z29Z30L（SEQ ID NO：313），其中Z23是D或Y; Z24是D或S; Z25为S或W; Z26为S或Y; Z27为D或V; Z28为S或W; Z29为F或L; Z30为D或L; 并且其中每个氨基酸由标准单字母缩写指示; 并且每个X可以选自20个遗传编码的L-氨基酸或立体异构体D-氨基酸中的任一个。
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公开(公告)号：US5608035A
公开(公告)日：1997-03-04
申请号：US190788
申请日：1994-02-02
IPC分类号： A61K38/00 , C07K14/545 , A61K38/02 , C07K5/00 , C07K7/00
CPC分类号： C07K14/545 , A61K38/00
摘要： Peptides that bind to the interleukin-1 type I receptor (IL-1RtI) can be used to assay the amount of IL-1R, or an IL-1R agonist or antagonist, in a sample and comprise a sequence of amino acids selected from the group consisting of (1) WXXXGZ.sub.1 W (SEQ ID NO: 1) where Z.sub.1 is L, I, A, or Q; (2) XXQZ.sub.5 YZ.sub.6 XX (SEQ ID NO: 6) where Z.sub.5 is P or Aze where Aze is azetidine; and Z.sub.6 is S, A, V, or L; and (3) Z.sub.23 NZ.sub.24 SZ.sub.25 Z.sub.26 Z.sub.27 Z.sub.28 Z.sub.29 Z.sub.30 L (SEQ ID NO: 17) where Z.sub.23 is D or Y; Z.sub.24 is D or S; Z.sub.25 is S or W; Z.sub.26 is S or Y; Z.sub.27 is D or V; Z.sub.28 is S or W; Z.sub.29 is F or L; and Z.sub.30 is D or L; and where each amino acid is indicated by standard one letter abbreviation; and each X can be selected from any one of the 20 genetically coded L-amino acids or the stereoisomeric D-amino acids.
摘要翻译： 结合白细胞介素-1 I型受体（IL-1RtI）的肽可用于测定样品中IL-1R或IL-1R激动剂或拮抗剂的量，并且包含选自以下的氨基酸序列： 由（1）WXXXGZ1W（SEQ ID NO：1）组成的组，其中Z1是L，I，A或Q; （2）其中Z5为P的XXQZ5YZ6XX（SEQ ID NO：6）或其中Aze为氮杂环丁烷的Aze; Z6为S，A，V或L; 和（3）Z23NZ24SZ25Z26Z27Z28Z29Z30L（SEQ ID NO：17），其中Z23是D或Y; Z24是D或S; Z25为S或W; Z26为S或Y; Z27为D或V; Z28为S或W; Z29为F或L; Z30为D或L; 并且其中每个氨基酸由标准单字母缩写指示; 并且每个X可以选自20个遗传编码的L-氨基酸或立体异构体D-氨基酸中的任一个。
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