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公开(公告)号：US5741243A
公开(公告)日：1998-04-21
申请号：US673941
申请日：1996-07-01
申请人： Ronita Kay Geckle , Terrence Bruce Mazer , Joseph Edward Walton , Carl Joseph Piontek , Susan Beth Duel , Andre Daab-Krzykowski , Mark Anthony McCamish , Robert Louis Joseph , William Guy Pierson
发明人： Ronita Kay Geckle , Terrence Bruce Mazer , Joseph Edward Walton , Carl Joseph Piontek , Susan Beth Duel , Andre Daab-Krzykowski , Mark Anthony McCamish , Robert Louis Joseph , William Guy Pierson
CPC分类号： A61M31/002 , A61J15/0026 , A61J15/0069 , A61M5/007 , A61M5/1407 , A61J15/00
摘要： A method is disclosed for modifying a liquid enteral nutritional product during delivery thereof from a supply container to a feeding tube delivering the nutritional product to the gastrointestinal tract of a patient. During enteral tube feeding the nutritional product passes through a formulation chamber, e.g., a drip chamber, having located therein at least one controlled release dosage form unit containing at least one beneficial agent. The beneficial agent may be selected from nutrients, medicaments, probiotics, or diagnostic agents or mixtures thereof, and any such together with a physiologically acceptable marker dye in controlled release dosage form and/or the same or different additional beneficial agent not in controlled release dosage form. Controlled release dosage forms may be of a conventional sustained release type or an osmotically driven delivery device.
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公开(公告)号：US5738651A
公开(公告)日：1998-04-14
申请号：US673449
申请日：1996-06-28
申请人： Joseph Edward Walton , Terrence Bruce Mazer , Ronita Kay Geckle , Carl Joseph Piontek , Susan Beth Duel , Andre Daab-Krzykowski , Mark Anthony McCamish , Robert Louis Joseph , William Guy Pierson
发明人： Joseph Edward Walton , Terrence Bruce Mazer , Ronita Kay Geckle , Carl Joseph Piontek , Susan Beth Duel , Andre Daab-Krzykowski , Mark Anthony McCamish , Robert Louis Joseph , William Guy Pierson
CPC分类号： A61M31/002 , A61J15/0026 , A61J15/0069 , A61M5/007 , A61M5/1407 , A61J15/00
摘要： An apparatus is disclosed for modifying a liquid enteral nutritional product during delivery thereof from a supply thereof, such as a hangable container, to a feeding tube delivering the liquid enteral nutritional product to the gastrointestinal tract of a patient. The apparatus has at least one formulation chamber, such as a drip chamber, with at least one controlled release dosage form unit in the form of a coated tablet, osmotically driven device, coated capsule, microencapsulated microspheres, agglomerated molecular sieving type material, or a quantity of fine hollow permeable fibers located therein. The controlled release dosage form unit or units contain at least one beneficial agent selected from nutrients, medicaments, probiotics, or diagnostic agents or mixtures thereof, to any of which a physiologically acceptable marker dye in controlled release dosage form and/or the same or different beneficial agent not in controlled release dosage form may be added. A liquid nutritional product flows through the formulation chamber during enteral tube feeding of a patient.
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3.发明授权Apparatus for adding marker dye to nutritional product during enteral tube feeding 失效用于在肠管喂养期间向营养产品中添加标记染料的装置
公开(公告)号：US5755689A
公开(公告)日：1998-05-26
申请号：US671876
申请日：1996-06-28
申请人： Terrence Bruce Mazer , Joseph Edward Walton , Ronita Kay Geckle , Carl Joseph Piontek , Susan Beth Duel , Andre Daab-Krzykowski , Robert Louis Joseph , William Guy Pierson , Thomas Daniel Loughrin , Thomas Walter Osip
发明人： Terrence Bruce Mazer , Joseph Edward Walton , Ronita Kay Geckle , Carl Joseph Piontek , Susan Beth Duel , Andre Daab-Krzykowski , Robert Louis Joseph , William Guy Pierson , Thomas Daniel Loughrin , Thomas Walter Osip
CPC分类号： A61M31/002 , A61J15/0026 , A61J15/0069 , A61M5/007 , A61M5/1407 , A61J15/00 , G01N33/02
摘要： An apparatus is useful for dye marking a liquid enteral nutritional product during delivery thereof from a supply container to a feeding tube delivering the nutritional product to the gastrointestinal tract of a patient. A formulation chamber, such as a drip chamber, is connectable to the supply container. At least one sustained release reservoir containing a physiologically acceptable marker dye is positioned within the formulation chamber, or if not, is included as part of a kit. The sustained release reservoir may be in the form of a coated tablet, osmotically driven device, coated capsule, microencapsulated microspheres, agglomerated molecular sieving material, or chopped hollow fibers having permeable walls. A liquid communication means connects the formulation chamber to the feeding tube of a patient. The marker dye may be a colorant dye or a fluorescing dye or a mixture thereof. In using the apparatus for dye marking the nutritional product is flowed through the apparatus and a feeding tube to enter the gastrointestinal tract of a patient.
摘要翻译： 一种装置可用于将液体肠内营养产品在从供应容器输送到将营养产品输送到患者的胃肠道的喂食管中时进行标记。 诸如滴水室的配制室可连接到供应容器。 包含生理上可接受的标记染料的至少一个持续释放储存器位于制剂室内，或者如果不包含，则作为试剂盒的一部分。 持续释放储存器可以是包衣片剂，渗透驱动装置，包衣胶囊，微囊化微球，聚集分子筛材料或具有可渗透壁的切碎中空纤维的形式。 液体连通装置将制剂室连接到患者的进料管。 标记染料可以是着色剂染料或荧光染料或其混合物。 在使用染色标记设备时，营养产品流过设备和进料管进入患者的胃肠道。
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4.发明授权Method of adding marker dye to nutritional product during enternal tube feeding 失效在内管喂养期间向营养产品添加标记染料的方法
公开(公告)号：US5746715A
公开(公告)日：1998-05-05
申请号：US673446
申请日：1996-06-28
申请人： Terrence Bruce Mazer , Joseph Edward Walton , Ronita Kay Geckle , Carl Joseph Piontek , Susan Beth Duel , Andre Daab-Krzykowski , Robert Louis Joseph , William Guy Pierson , Thomas Daniel Loughrin , Thomas Walter Osip
发明人： Terrence Bruce Mazer , Joseph Edward Walton , Ronita Kay Geckle , Carl Joseph Piontek , Susan Beth Duel , Andre Daab-Krzykowski , Robert Louis Joseph , William Guy Pierson , Thomas Daniel Loughrin , Thomas Walter Osip
CPC分类号： A61M31/002 , A61J15/0026 , A61J15/0069 , A61M5/007 , A61M5/1407 , A61J15/00
摘要： A method for dye marking a liquid enteral nutritional product during delivery thereof from a supply container to a feeding tube delivering the nutritional product to the gastrointestinal tract of a patient includes the steps of: (1) providing apparatus such as a formulation chamber, e.g., a drip chamber, connectable to the supply container, with at least one sustained release reservoir containing a physiologically acceptable and dispersible marker dye positioned within the formulation chamber, and, liquid communication means connecting the formulation chamber to the feeding tube of a patient; (2) providing a supply container containing the nutritional product; (3) connecting the formulation chamber to the supply container and the liquid commmunication means to the feeding tube; and (4) flowing the dye-marked nutritional product through the apparatus and into the feeding tube. The sustained release reservoir may be a conventional slow release coated tablet, microspheres, or capsule type or an osmotically driven device. The marker dye may be a colorant dye or a fluorescing dye or a mixture thereof. If quick coloration is desired, the sustained release reservoir may be coated with a soluble layer of the marker dye or marker dye not in a sustained release reservoir may be placed in the formulation chamber along with a sustained release reservoir containing dye.
摘要翻译： 一种将液体肠内营养产品从供应容器输送至将营养产品输送到患者的胃肠道的喂食管中的染色标记方法包括以下步骤：（1）提供诸如配制室的装置， 可连接到供应容器的滴水室与至少一个包含位于配制室内的生理上可接受和可分散的标记染料的缓释储存器，以及将配制室连接到患者的进料管的液体连通装置; （2）提供容纳营养产品的供应容器; （3）将制剂室与供给容器和液体通信装置连接到进料管; 和（4）使染料标记的营养产品通过设备流入饲管。 持续释放储存器可以是常规的缓释包衣片剂，微球体或胶囊型或渗透驱动装置。 标记染料可以是着色剂染料或荧光染料或其混合物。 如果需要快速着色，则持续释放储存器可以涂覆有标记染料的可溶层或不在持续释放储存器中的标记染料，可以与含有染料的持续释放储存器一起放置在配制室中。
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公开(公告)号：US06440469B1
公开(公告)日：2002-08-27
申请号：US09397725
申请日：1999-09-17
申请人： John D. Suh , Karin M. Ostrom , Louis I. Ndife , Paul S. Anloague , James N. Chmura , Andre Daab-Krzykowski , Paul W. Johns , Diane M. Garcia , Terrence B. Mazer , Fu-i Mei
发明人： John D. Suh , Karin M. Ostrom , Louis I. Ndife , Paul S. Anloague , James N. Chmura , Andre Daab-Krzykowski , Paul W. Johns , Diane M. Garcia , Terrence B. Mazer , Fu-i Mei
IPC分类号： A61K3578
摘要： The present invention relates generally to a method of producing plant proteins for use in nutritional products that have reduced levels of phytoestrogens, manganese or nucleotides. More specifically, this invention is directed to a method of using ion exchange technology to remove phytoestrogens, manganese or nucleotides from plant proteins. This invention is also directed to the plant protein product resulting from the inventive process and to nutritional products that use the plant protein product as a source of amino nitrogen.
摘要翻译： 本发明一般涉及一种生产植物蛋白的方法，所述植物蛋白用于降低植物雌激素，锰或核苷酸水平的营养产品中。 更具体地，本发明涉及使用离子交换技术从植物蛋白中去除植物雌激素，锰或核苷酸的方法。 本发明还涉及由本发明方法产生的植物蛋白质产物和使用植物蛋白产物作为氨基氮源的营养产品。
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6.发明授权Method of altering composition of nutritional product during enteral tube feeding 失效改变肠管喂养期间营养产品组成的方法
公开(公告)号：US5531734A
公开(公告)日：1996-07-02
申请号：US372408
申请日：1995-01-13
申请人： Ronita K. Geckle , Terrence B. Mazer , Joseph E. Walton , Carl J. Piontek , Susan B. Duel , Andre Daab-Krzykowski , Mark A. McCamish , Robert L. Joseph , William G. Pierson
发明人： Ronita K. Geckle , Terrence B. Mazer , Joseph E. Walton , Carl J. Piontek , Susan B. Duel , Andre Daab-Krzykowski , Mark A. McCamish , Robert L. Joseph , William G. Pierson
CPC分类号： A61M31/002 , A61J15/0026 , A61J15/0069 , A61M5/007 , A61M5/1407 , A61J15/00
摘要： A method is disclosed for modifying a liquid enteral nutritional product during delivery thereof from a supply container to a feeding tube delivering the nutritional product to the gastrointestinal tract of a patient. During enteral tube feeding the nutritional product passes through a formulation chamber, e.g., a drip chamber, having located therein at least one controlled release dosage form unit containing at least one beneficial agent. The beneficial agent may be selected from nutrients, medicaments, probiotics, or diagnostic agents or mixtures thereof, and any such together with a physiologically acceptable marker dye in controlled release dosage form and/or the same or different additional beneficial agent not in controlled release dosage form. Controlled release dosage forms may be of a conventional sustained release type or an osmotically driven delivery device.
摘要翻译： 公开了一种用于在将液体肠内营养产品从供应容器输送到将营养产品输送到患者的胃肠道的进料管中时，用于改变液体肠内营养产品的方法。 在肠管喂养期间，营养产品通过配制室，例如滴注室，其中至少含有至少一种含有至少一种有益剂的控释剂型单元。 有益药物可以选自营养物，药物，益生菌或诊断剂或其混合物，以及任何这些与控制释放剂型中的生理学上可接受的标记染料和/或不是控制释放剂量的相同或不同的附加有益剂 形成。 受控释放剂型可以是常规的缓释型或渗透驱动的输送装置。
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7.发明授权Apparatus for adding marker dye to nutritional product during enternal tube feeding 失效在内管喂养期间添加标记染料至营养产品的装置
公开(公告)号：US5531682A
公开(公告)日：1996-07-02
申请号：US372266
申请日：1995-01-13
申请人： Terrence B. Mazer , Joseph E. Walton , Ronita K. Geckle , Carl J. Piontek , Susan B. Duel , Andre Daab-Krzykowski , Robert L. Joseph , William G. Pierson , Thomas D. Loughrin , Thomas W. Osip
发明人： Terrence B. Mazer , Joseph E. Walton , Ronita K. Geckle , Carl J. Piontek , Susan B. Duel , Andre Daab-Krzykowski , Robert L. Joseph , William G. Pierson , Thomas D. Loughrin , Thomas W. Osip
CPC分类号： A61M31/002 , A61J15/0026 , A61J15/0069 , A61M5/007 , A61M5/1407 , A61J15/00 , G01N33/02
摘要： An apparatus is useful for dye marking a liquid enteral nutritional product during delivery thereof from a supply container to a feeding tube delivering the nutritional product to the gastrointestinal tract of a patient. A formulation chamber, such as a drip chamber, is connectable to the supply container. At least one sustained release reservoir containing a physiologically acceptable marker dye is positioned within the formulation chamber, or if not, is included as part of a kit. The sustained release reservoir may be in the form of a coated tablet, osmotically driven device, coated capsule, microencapsulated microspheres, agglomerated molecular sieving material, or chopped hollow fibers having permeable walls. A liquid communication means connects the formulation chamber to the feeding tube of a patient. The marker dye may be a colorant dye or a fluorescing dye or a mixture thereof. In using the apparatus for dye marking the nutritional product is flowed through the apparatus and a feeding tube to enter the gastrointestinal tract of a patient.
摘要翻译： 一种装置可用于将液体肠内营养产品在从供应容器输送到将营养产品输送到患者的胃肠道的喂食管中时进行标记。 诸如滴水室的配制室可连接到供应容器。 包含生理上可接受的标记染料的至少一个持续释放储存器位于制剂室内，或者如果不包含，则作为试剂盒的一部分。 持续释放储存器可以是包衣片剂，渗透驱动装置，包衣胶囊，微囊化微球，聚集分子筛材料或具有可渗透壁的切碎中空纤维的形式。 液体连通装置将制剂室连接到患者的进料管。 标记染料可以是着色剂染料或荧光染料或其混合物。 在使用染色标记设备时，营养产品流过设备和进料管进入患者的胃肠道。
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公开(公告)号：US5248804A
公开(公告)日：1993-09-28
申请号：US986651
申请日：1992-12-08
申请人： Christy A. Nardelli , Terrence B. Mazer , Arthur J. C. L. Hogarth , John D. Suh , Andre Daab-Krzykowski , Leona M. Pickett , Harold W. Keller , William J. Nelson
发明人： Christy A. Nardelli , Terrence B. Mazer , Arthur J. C. L. Hogarth , John D. Suh , Andre Daab-Krzykowski , Leona M. Pickett , Harold W. Keller , William J. Nelson
IPC分类号： A23J1/14
CPC分类号： A23J1/14
摘要： A novel process for the removal of phytate from protein using ion exchange has been developed. The process involves the upflow passage of a protein slurry at an elevated temperature through a strong base anion exchanger in the chloride form. The weak base anion sites inherent to the resin have been converted to the free base form. The anion exchange material can easily be regenerated. The process can be used on-line, yields phytate removal of greater than 90%, has high (greater than 90%) protein recovery, is cost-effective, and is environmentally friendly.
摘要翻译： 已经开发了使用离子交换从蛋白质中去除植酸盐的新方法。 该方法包括蛋白质浆液在升高的温度下通过氯离子形式的强碱阴离子交换剂。 树脂固有的弱碱阴离子位点已经转化为游离碱形式。 阴离子交换材料可以容易地再生。 该过程可以在线使用，产生植酸盐去除率大于90％，具有高（大于90％）的蛋白质回收率，具有成本效益，是环保的。
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公开(公告)号：US6020471A
公开(公告)日：2000-02-01
申请号：US710236
申请日：1996-09-13
IPC分类号： A23J3/14 , A23J3/16 , A23L5/20 , A23L11/30 , C07H17/07 , C07D311/36 , C07D311/40
摘要： The present invention relates generally to a method of isolating phytoestrogens isoflavones from plant material. More specifically, this invention is directed to a method of using ion exchange technology to isolate phytoestrogens from plant protein isolates and to the phytoestrogen so isolated.
摘要翻译： 本发明一般涉及从植物材料中分离植物雌激素异黄酮的方法。 更具体地，本发明涉及使用离子交换技术从植物蛋白分离物和如此分离的植物雌激素中分离植物雌激素的方法。
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公开(公告)号：US5804234A
公开(公告)日：1998-09-08
申请号：US713904
申请日：1996-09-13
申请人： John D. Suh , Karin M. Ostrom , Louis I. Ndife , Paul S. Anloague , James N. Chmura , Andre Daab-Krzykowski , Paul W. Johns , Diane M. Garcia , Terrence B. Mazer , Fu-I Mei
发明人： John D. Suh , Karin M. Ostrom , Louis I. Ndife , Paul S. Anloague , James N. Chmura , Andre Daab-Krzykowski , Paul W. Johns , Diane M. Garcia , Terrence B. Mazer , Fu-I Mei
摘要： The present invention relates generally to a method of producing plant proteins for use in nutritional products that have reduced levels of phytoestrogens, manganese or nucleotides. More specifically, this invention is directed to a method of using ion exchange technology to remove phytoestrogens, manganese or nucleotides from plant proteins. This invention is also directed to the plant protein product resulting from the inventive process and to nutritional products that use the plant protein product as a source of amino nitrogen.
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