公开(公告)号：US10351608B2

公开(公告)日：2019-07-16

申请号：US14821494

申请日：2015-08-07

Applicant: Rosalind Franklin University of Medicine and Science

Inventor： Bruce L. Riser

IPC: C07K14/47 ,  A61K38/17 ,  A61K38/04 ,  A61K9/00 ,  A61K35/12 ,  A61K38/10 ,  C07K14/475 ,  A61K35/28 ,  A61K35/51

Abstract: The present invention provides a method for treating a human patient with a pathology by administering to the subject an effective amount of an agent selected from the group of: native full-length CCN3 proteins; analog CCN3 full-length proteins with native cysteine residues substituted by a replacement amino acid; CCNp native peptide fragments having from about 12 to about 20 amino acids; analog CCNp peptide fragments with native cysteine residues substituted with a replacement amino acid; and combinations thereof.

公开(公告)号：US20150337020A1

公开(公告)日：2015-11-26

申请号：US14821494

申请日：2015-08-07

Applicant: Rosalind Franklin University of Medicine and Science

Inventor： Bruce L. Riser

IPC: C07K14/47 ,  A61K35/12 ,  A61K38/17 ,  A61K9/00

CPC classification number: C07K14/47 ,  A61K9/0014 ,  A61K35/12 ,  A61K35/28 ,  A61K35/51 ,  A61K38/04 ,  A61K38/10 ,  A61K38/1709 ,  C07K14/4743 ,  C07K14/475 ,  A61K2300/00

Abstract: The present invention provides a method for treating a human patient with a pathology by administering to the subject an effective amount of an agent selected from the group of: native full-length CCN3 proteins; analog CCN3 full-length proteins with native cysteine residues substituted by a replacement amino acid; CCNp native peptide fragments having from about 12 to about 20 amino acids; analog CCNp peptide fragments with native cysteine residues substituted with a replacement amino acid; and combinations thereof.

Abstract translation: 本发明提供了一种通过向受试者施用有效量的选自以下的药物来治疗病人的病人的方法：天然全长CCN3蛋白; 具有由置换氨基酸取代的天然半胱氨酸残基的模拟CCN3全长蛋白; 具有约12至约20个氨基酸的CCNp天然肽片段; 具有被置换氨基酸取代的天然半胱氨酸残基的模拟CCNp肽片段; 及其组合。