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1.发明授权
公开(公告)号：US5244629A
公开(公告)日：1993-09-14
申请号：US749041
申请日：1991-08-27
申请人： Ross A. Caputo , Kern A. Moulton , Bryant A. Campbell, deceased , by Louise A. Campbell, legal representative
发明人： Ross A. Caputo , Kern A. Moulton , Bryant A. Campbell, deceased , by Louise A. Campbell, legal representative
CPC分类号： A61L2/20 , A61L2/14 , Y10S422/906 , Y10S422/907
摘要： A process for plasma sterilization including exposing an article in a sterilizing chamber to at least one combination sterilizing cycle. Each combination sterilizing cycle includes a pulsed treatment with gaseous antimicrobial agent, removal of the gaseous antimicrobial agent, and a plasma treatment. The pulsed treatment includes one or more pulse-vacuum cycles, each pulse-vacuum cycle includes the steps of evacuating the sterilizing chamber and exposing the article to the gaseous antimicrobial agent with a predetermined pressure profile during a predetermined time. The gaseous antimicrobial agent is preferably carried in a gas mixture with a nonreactive carrier gas. In one embodiment, the predetermined pressure is pulsed. In another embodiment, it is ramped. After the pulsed treatment, the antimicrobial agent is removed by evacuating the sterilizing chamber. The plasma treatment includes exposing the article to a plasma having essentially uncharged, highly reactive free radicals and atoms.
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2.发明授权
公开(公告)号：US5645796A
公开(公告)日：1997-07-08
申请号：US461412
申请日：1995-06-05
申请人： Ross A. Caputo , Thomas J. Amsler , Kangyan Du , Jeffery Jones , Kern A. Moulton , Bryant A. Campbell, deceased
发明人： Ross A. Caputo , Thomas J. Amsler , Kangyan Du , Jeffery Jones , Kern A. Moulton , Bryant A. Campbell, deceased
CPC分类号： A61L2/208 , A61L2/14 , A61L2/20 , A61L2202/23 , A61L2202/24 , Y10S422/906 , Y10S422/907
摘要： A process for plasma sterilization in which articles in a sterilizing chamber are taken through at least one combination sterilizing cycle. The articles to be sterilized may include the interior of a vessel or chamber. In that case, the vessel or chamber itself may serve as a sterilizing chamber and connects to the plasma generating chamber. Each combination sterilizing cycle includes a pulsed treatment with gaseous antimicrobial agent, removal of the gaseous antimicrobial agent, and a plasma treatment. The pulsed treatment includes one or more pulse-vacuum cycles, each pulse-vacuum cycle includes the steps of evacuating the sterilizing chamber and exposing the article to the gaseous antimicrobial agent with a predetermined pressure profile during a predetermined time. The gaseous antimicrobial agent is preferably carried in a gas mixture with a nonreactive carrier gas. In one embodiment, the predetermined pressure is pulsed. In another embodiment, it is ramped. After the pulsed treatment, the antimicrobial agent is removed by evacuating the sterilizing chamber. The plasma treatment includes exposure of the article to a plasma having essentially uncharged, highly reactive free radicals, molecules and atoms.
摘要翻译： 一种用于血浆灭菌的方法，其中灭菌室中的物品通过至少一个组合灭菌循环。 待消毒的物品可以包括容器或室的内部。 在这种情况下，容器或室本身可以用作灭菌室并连接到等离子体产生室。 每个组合灭菌循环包括用气体抗微生物剂进行脉冲处理，去除气态抗微生物剂和等离子体处理。 脉冲处理包括一个或多个脉冲真空循环，每个脉冲真空循环包括在预定时间内以预定的压力分布排空灭菌室并将制品暴露于气态抗微生物剂的步骤。 气态抗微生物剂优选在与非反应性载气的气体混合物中携带。 在一个实施例中，预定压力是脉冲的。 在另一个实施例中，它是斜坡的。 脉冲处理后，通过抽空灭菌室除去抗菌剂。 等离子体处理包括将物品暴露于具有基本上不带电的，高反应性的自由基，分子和原子的等离子体。
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3.发明授权
公开(公告)号：US5413758A
公开(公告)日：1995-05-09
申请号：US65859
申请日：1993-05-21
CPC分类号： A61L2/20 , A61L2/14 , Y10S422/906 , Y10S422/907
摘要： A process and equipment for plasma sterilization in which articles in a sterilizing chamber are taken through at least one combination sterilizing cycle. The articles to be sterilized may include the interior of a vessel or chamber. In that case, the vessel or chamber itself may serve as a sterilizing chamber and connects to the plasma generating chamber. Each combination sterilizing cycle includes a pulsed treatment with gaseous antimicrobial agent, removal of the gaseous antimicrobial agent, and a plasma treatment. The pulsed treatment includes one or more pulse-vacuum cycles, each pulse-vacuum cycle includes the steps of evacuating the sterilizing chamber and exposing the article to the gaseous antimicrobial agent with a predetermined pressure profile during a predetermined time. The gaseous antimicrobial agent is preferably carried in a gas mixture with a nonreactive carrier gas. In one embodiment, the predetermined pressure is pulsed. In another embodiment, it is ramped. After the pulsed treatment, the antimicrobial agent is removed by evacuating the sterilizing chamber. The plasma treatment includes exposure of the article to a plasma having essentially uncharged, highly reactive free radicals, molecules and atoms.
摘要翻译： 用于等离子体灭菌的方法和设备，其中消毒室中的物品通过至少一个组合灭菌循环。 待消毒的物品可以包括容器或室的内部。 在这种情况下，容器或室本身可以用作灭菌室并连接到等离子体产生室。 每个组合灭菌循环包括用气体抗微生物剂进行脉冲处理，去除气态抗微生物剂和等离子体处理。 脉冲处理包括一个或多个脉冲真空循环，每个脉冲真空循环包括在预定时间内以预定的压力分布排空灭菌室并将制品暴露于气态抗微生物剂的步骤。 气态抗微生物剂优选在与非反应性载气的气体混合物中携带。 在一个实施例中，预定压力是脉冲的。 在另一个实施例中，它是斜坡的。 脉冲处理后，通过抽空灭菌室除去抗菌剂。 等离子体处理包括将物品暴露于具有基本上不带电的，高反应性的自由基，分子和原子的等离子体。
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公开(公告)号：US5288460A
公开(公告)日：1994-02-22
申请号：US962895
申请日：1992-10-19
摘要： A method for plasma sterilization within a controlled temperature range includes exposing the interior of a chamber and any articles therein to a gas plasma flowing from a plasma generating chamber until the temperature in the chamber rises to a preselected maximum temperature. The flow of the plasma gas to the chamber is terminated when the temperature in the chamber falls to a temperature below the preselected maximum temperature. These steps are repeated until sterilization of the interior of the chamber or any articles therein is effected. The temperature below the preselected maximum temperature when gas plasma flow is again initiated is preferably not more than 3.degree. C. below the preselected maximum temperature. The gas plasma can be generated from a gas mixture that includes oxidizing and/or reducing agents. Preferably the pressure in the sterilizing chamber rises to from 0.1 to 10 torr when the gas plasma is flowing into the chamber, and the pressure in the sterilizing chamber falls to a lower pressure when the gas plasma flow into the sterilizing chamber is terminated. The articles to be sterilized include the interior of a vessel or chamber. The vessel or chamber itself serves as a sterilizing chamber and connects to the plasma generating chamber.
摘要翻译： 在受控温度范围内的等离子体灭菌的方法包括将室内和其中的任何物品暴露于从等离子体发生室流出的气体等离子体，直到室内的温度上升到预选的最高温度。 当室内的温度下降到低于预选的最高温度的温度时，等离子体气体流到室的流动被终止。 重复这些步骤，直到对室内或其中的任何物品进行杀菌。 当再次启动气体等离子体流时，低于预选最大温度的温度优选不低于预选最高温度3摄氏度。 气体等离子体可以由包括氧化和/或还原剂的气体混合物产生。 当气体等离子体流入室时，灭菌室中的压力优选上升至0.1〜10乇，当终止气体等离子体流入灭菌室时，灭菌室内的压力下降到较低的压力。 待灭菌的物品包括容器或室的内部。 容器或室本身用作灭菌室并连接到等离子体产生室。
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公开(公告)号：US5593649A
公开(公告)日：1997-01-14
申请号：US462982
申请日：1995-06-05
CPC分类号： A61L2/14 , H05H1/46 , Y10S422/906
摘要： A canister is provided that is adapted for use in a plasma induced sterilization process. The canister contains a gas mixture that is pressurized to between about 2200 psig to about 2500 psig. The gas mixture has about 2.0 to 2.4 (v/v) percent hydrogen and about 2.6 to 3.0 (v/v) percent oxygen, and the rest of the gas mixture is noble gas or a mixture of noble gases.
摘要翻译： 提供适于在等离子体诱导的灭菌过程中使用的罐。 该罐包含加压至约2200psig至约2500psig之间的气体混合物。 气体混合物具有约2.0至2.4（v / v）％的氢气和约2.6至3.0（v / v）的氧气，其余的气体混合物是惰性气体或稀有气体的混合物。
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公开(公告)号：US5413760A
公开(公告)日：1995-05-09
申请号：US885299
申请日：1992-05-18
CPC分类号： H05H1/46 , A61L2/14 , Y10S422/906
摘要： A plasma sterilizer and method employ essentially uncharged, highly reactive free radicals, atoms and excited molecules of a gas mixture to sterilize articles. The gas mixture includes oxidizing and/or reducing agents and is ionized into a plasma having ionization products that include highly destructive components in the form of charged particles and ultra-violet radiation. A plasma distribution device blocks the ultra-violet radiation and facilitates the recombination of the charged particles such that essentially uncharged, highly reactive free radicals, atoms and excited molecules of the gas mixture are delivered to the articles.
摘要翻译： 等离子体灭菌器和方法使用基本上不带电的，高反应性的自由基，气体混合物的原子和激发分子来消毒物品。 气体混合物包括氧化和/或还原剂，并且被电离成具有电离产物的等离子体，其包括带电粒子和紫外辐射形式的高度破坏性的组分。 等离子体分配装置阻挡紫外线辐射并促进带电粒子的复合，使得将气体混合物的基本上不带电的，高反应性的自由基，原子和激发的分子输送到制品中。
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公开(公告)号：US5472664A
公开(公告)日：1995-12-05
申请号：US213613
申请日：1994-03-21
摘要： A method for plasma sterilization comprises exposing an article to be sterilized to a neutral active species of a plasma generated from a premixed gas mixture comprising oxygen, hydrogen, and a noble gas. The exposure of the article to the plasma is carried out at reduced pressures and a chamber temperature of less than 63.degree. C. for a time period sufficient to effect sterilization. The apparatus for plasma sterilization of articles comprises a plasma generator, a sterilizing chamber, and a source of pressurized gas mixture in fluid communication with the plasma generator. The source of pressurized gas mixture has a noble gas and a substantially nonflammable mixture of hydrogen and oxygen, which is preferably between about 2.0 to 2.4 (v/v) percent hydrogen and between 2.6 to 3.0 (v/v) percent oxygen.
摘要翻译： 用于等离子体灭菌的方法包括将待灭菌的物品暴露于由包含氧气，氢气和惰性气体的预混合气体混合物产生的等离子体活性物质中。 将物品暴露于等离子体中，在低于63℃的室温下进行足够灭菌的时间。 用于物品等离子体灭菌的装置包括等离子体发生器，灭菌室和与等离子体发生器流体连通的加压气体混合物源。 加压气体混合物的来源具有惰性气体和基本上不可燃的氢气和氧气的混合物，其优选在约2.0至2.4（v / v）％的氢气和2.6至3.0（v / v）％的氧气之间。
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8.发明授权Plasma sterilizer apparatus using a non-flammable mixture of hydrogen and oxygen 失效使用氢和氧的不易燃混合物的等离子灭菌装置
公开(公告)号：US5650693A
公开(公告)日：1997-07-22
申请号：US463088
申请日：1995-06-05
摘要： An apparatus for plasma sterilization of articles is provided that comprises a plasma generator and a sterilizing chamber. The plasma generator has an inlet for receiving a premixed gas mixture from a pressurized source. The pressurized gas mixture source is a single container (or multiple containers with the same contents), having a noble gas and further having a non-flammable mixture of hydrogen and oxygen.
摘要翻译： 提供了一种用于等离子体发生器和灭菌室的等离子体灭菌装置。 等离子体发生器具有用于从加压源接收预混气体混合物的入口。 加压气体混合物源是具有惰性气体并且还具有氢和氧的不可燃混合物的单个容器（或具有相同含量的多个容器）。
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公开(公告)号：US5084239A
公开(公告)日：1992-01-28
申请号：US576235
申请日：1990-08-31
摘要： A process for plasma sterilization comprising exposing an article in a sterilizing chamber to at least one cycle comprising a pulsed treatment with gaseous antimicrobial agent and a plasma treatment. The pulsed treatment comprises at least two pulse-vacuum cycles, each pulse-vacuum cycle comprising the steps of exposing the article to the gaseous antimicrobial agent at a pressure of from 4 to 18 torr and reducing the pressure in the sterilizing chamber to from 0.1 to 4 torr. The plasma treatment comprising exposing the article to a plasma generated from gases selected from the group consisting essentially of argon, helium, nitrogen, oxygen, hydrogen and mixtures thereof, the exposure to the plasma being carried out at a pressure of from 0.1 to 10 torr and a temperature of less than 80.degree. C. The antimicrobial agent is selected from the group consisting of hydrogen peroxide, a peracid antimicrobial agent, and mixtures thereof, the peracid antimicrobial agent being selected from the group consisting of saturated and unsaturated peralkanoic acids having from 1 to 8 carbon atoms and halogenated derivatives thereof.
摘要翻译： 一种用于等离子体灭菌的方法，包括将消毒室中的物品暴露于至少一个循环，包括用气态抗微生物剂进行脉冲处理和等离子体处理。 脉冲处理包括至少两个脉冲真空循环，每个脉冲真空循环包括以4至18托的压力将制品暴露于气态抗微生物剂的步骤，并将灭菌室中的压力降至0.1至 4托 等离子体处理包括将制品暴露于从基本上由氩，氦，氮，氧，氢及其混合物组成的组中选出的气体产生的等离子体中，暴露于等离子体的压力为0.1至10托 并且温度低于80℃。抗微生物剂选自过氧化氢，过酸性抗微生物剂及其混合物，所述过酸抗微生物剂选自饱和和不饱和的过氧烷酸，其具有 1至8个碳原子及其卤化衍生物。
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10.发明授权Process and apparatus for plasma sterilizing with pulsed antimicrobial agent treatment 失效用脉冲抗菌剂处理等离子体灭菌的方法和装置公开(公告)号：US06261518B1
公开(公告)日：2001-07-17
申请号：US09183775
申请日：1998-10-30
申请人： Ross A. Caputo , Thomas J. Amsler , Kangyan Du , Jeffery Jones , Kern A. Moulton , Bryant A. Campbell
发明人： Ross A. Caputo , Thomas J. Amsler , Kangyan Du , Jeffery Jones , Kern A. Moulton , Bryant A. Campbell
IPC分类号： A61L214
CPC分类号： A61L2/208 , A61L2/14 , A61L2/20 , A61L2202/23 , A61L2202/24 , Y10S422/906 , Y10S422/907
摘要： A process and equipment for plasma sterilization in which articles in a sterilizing chamber are taken through at least one combination sterilizing cycle. The articles to be sterilized may include the interior of a vessel or chamber. In that case, the vessel or chamber itself may serve as a sterilizing chamber and connects to the plasma generating chamber. Each combination sterilizing cycle includes a pulsed treatment with gaseous antimicrobial agent, removal of the gaseous antimicrobial agent, and a plasma treatment. The pulsed treatment includes one or more pulse-vacuum cycles, each pulse-vacuum cycle includes the steps of evacuating the sterilizing chamber and exposing the article to the gaseous antimicrobial agent with a predetermined pressure profile during a predetermined time. The gaseous antimicrobial agent is preferably carried in a gas mixture with a nonreactive carrier gas. In one embodiment, the predetermined pressure is pulsed. In another embodiment, it is ramped. After the pulsed treatment, the antimicrobial agent is removed by evacuating the sterilizing chamber. The plasma treatment includes exposure of the article to a plasma having essentially uncharged, highly reactive free radicals, molecules and atoms.
摘要翻译： 用于等离子体灭菌的方法和设备，其中消毒室中的物品通过至少一个组合灭菌循环。 待消毒的物品可以包括容器或室的内部。 在这种情况下，容器或室本身可以用作灭菌室并连接到等离子体产生室。 每个组合灭菌循环包括用气体抗微生物剂进行脉冲处理，去除气态抗微生物剂和等离子体处理。 脉冲处理包括一个或多个脉冲真空循环，每个脉冲真空循环包括在预定时间内以预定的压力分布排空灭菌室并将制品暴露于气态抗微生物剂的步骤。 气态抗微生物剂优选在与非反应性载气的气体混合物中携带。 在一个实施例中，预定压力是脉冲的。 在另一个实施例中，它是斜坡的。 脉冲处理后，通过抽空灭菌室除去抗菌剂。 等离子体处理包括将物品暴露于具有基本上不带电的，高反应性的自由基，分子和原子的等离子体。
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