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1.发明授权Treating bladder tumor cells using fibronectin attachment protein as a target 有权使用纤连蛋白附着蛋白作为靶标治疗膀胱肿瘤细胞公开(公告)号：US09518114B2
公开(公告)日：2016-12-13
申请号：US13884427
申请日：2011-11-11
CPC分类号： A61K38/164 , A61K47/64 , A61K47/6835 , A61K47/6881 , A61K47/6913 , A61K47/6927 , A61K2039/505 , C07K16/12 , C07K16/1278 , C07K16/28 , C07K16/3038
摘要： Composition and methods are disclosed for utilizing micro-aggregation of FAP-containing complexes to promote their fast internalization. This approach allows the uptake of cytotoxic cargo coupled to either FAP-Antibodies or FAP-liposome complexes by tumor bladder cells. Importantly, this approach is efficient even under serum-free conditions such as the ones found in the lumen of the bladder.
摘要翻译： 公开了组合物和方法，以利用含有FAP的络合物的微聚集来促进其快速内化。 这种方法允许通过肿瘤膀胱细胞摄取与FAP-抗体或FAP-脂质体复合物偶联的细胞毒性物质。 重要的是，即使在无血清条件下，这种方法也是有效的，例如在膀胱内腔中发现的那些。
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2.发明申请TREATING BLADDER TUMOR CELLS USING FIBRONECTIN ATTACHMENT PROTEIN AS A TARGET 有权使用纤维蛋白连接蛋白作为目标治疗刀片肿瘤细胞公开(公告)号：US20130230584A1
公开(公告)日：2013-09-05
申请号：US13884427
申请日：2011-11-11
IPC分类号： C07K16/28
CPC分类号： A61K38/164 , A61K47/64 , A61K47/6835 , A61K47/6881 , A61K47/6913 , A61K47/6927 , A61K2039/505 , C07K16/12 , C07K16/1278 , C07K16/28 , C07K16/3038
摘要： Composition and methods are disclosed for utilizing micro-aggregation of FAP-containing complexes to promote their fast internalization. This approach allows the uptake of cytotoxic cargo coupled to either FAP-Antibodies or FAP-liposome complexes by tumor bladder cells. Importantly, this approach is efficient even under serum-free conditions such as the ones found in the lumen of the bladder.
摘要翻译： 公开了组合物和方法，以利用含有FAP的络合物的微聚集来促进其快速内化。 这种方法允许通过肿瘤膀胱细胞摄取与FAP-抗体或FAP-脂质体复合物偶联的细胞毒性物质。 重要的是，即使在无血清条件下，这种方法也是有效的，例如在膀胱内腔中发现的那些。
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3.发明申请Methods and compositions for delivery of an enhanced response to antigenic substrates 审中-公开递送对抗原底物的增强反应的方法和组合物公开(公告)号：US20060018880A1
公开(公告)日：2006-01-26
申请号：US11041851
申请日：2005-01-24
申请人： Timothy Ratliff , David Lubaroff , D. Siemens , Bennett Elzey
发明人： Timothy Ratliff , David Lubaroff , D. Siemens , Bennett Elzey
CPC分类号： A61K38/208 , A61K38/191 , A61K38/2013 , A61K39/0011 , A61K48/00
摘要： A novel immunostimulating delivery system is disclosed which provides for generation of a specific antibody response and specific T cell response to delivered antigens. According to the invention, the antigen or a nucleotide encoding the same is contained within, impregnated in or associated with a biocompatible collagen based carrier composition. Methods and compositions for practicing the same are disclosed.
摘要翻译： 公开了一种新型免疫刺激递送系统，其提供特异性抗体应答和对递送抗原的特异性T细胞应答的产生。 根据本发明，抗原或编码该抗原的核苷酸包含在生物相容性胶原基载体组合物中，浸渍于或与生物相容性胶原基载体组合物相连。 公开了用于实施该方法和组合物的方法和组合物。
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4.发明授权Method of inducing tumor cell apoptosis using trail/Apo-2 ligand gene transfer 失效使用踪迹/ Apo-2配体基因转移诱导肿瘤细胞凋亡的方法公开(公告)号：US06900185B1
公开(公告)日：2005-05-31
申请号：US09547742
申请日：2000-04-12
IPC分类号： A61K38/17 , A61K48/00 , A61P35/00 , C07K14/705 , C12N15/12 , A01N43/04 , A01N63/00 , C07H21/04 , C12N15/00 , C12N15/63
CPC分类号： C07K14/70575 , A61K38/00 , A61K38/208 , A61K38/217 , A61K45/06 , A61K48/00 , C12N2799/022 , A61K2300/00
摘要： The present invention is directed to methods for inhibiting tumor cell growth, causing tumor regression or eliminating tumor cells in a mammal afflicted with a tumor by administering to a TRAIL-sensitive cell a vector having a DNA expression cassette containing a promoter and a DNA sequence encoding TRAIL, wherein the expression of TRAIL results in tumor inhibition, regression or elimination.
摘要翻译： 本发明涉及抑制肿瘤细胞生长的方法，通过向TRAIL敏感细胞施用具有含有启动子的DNA表达盒的载体和编码有启动子的DNA序列的载体，导致肿瘤消退或消除患有肿瘤的哺乳动物的肿瘤细胞的方法 TRAIL，其中TRAIL的表达导致肿瘤抑制，消退或消除。
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