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    Triazine derivatives
    5.
    发明授权
    Triazine derivatives 失效
    三嗪衍生物

    公开(公告)号：US06193960B1

    公开(公告)日：2001-02-27

    申请号：US09544852

    申请日：2000-04-06

    申请人： Georges Metzger ,  Dieter Reinehr ,  Helmut Luther

    发明人： Georges Metzger ,  Dieter Reinehr ,  Helmut Luther

    IPC分类号： A61K742

    CPC分类号： C07D251/52 ,  A61K8/4966 ,  A61K8/4993 ,  A61Q17/04 ,  C07D251/48 ,  C07D251/50 ,  C07D251/70

    摘要： The present invention relates to novel s-triazine compounds, processes for their preparation and the use of these novel compounds as UV filters in sunscreen compositions. The novel compounds are those of the formula The triazine compounds of the formula (1) according to the invention are distinguished by a high UV absorption and are particularly suitable as UV filters, i.e. for protecting ultra-violet-sensitive organic materials, in particular the skin and the hair of man and animals, from the harmful action of UV radiation.

    摘要翻译： 本发明涉及新型的三嗪化合物，它们的制备方法以及这些新化合物作为防晒组合物中的紫外线过滤剂的用途。新化合物是下式的那些：根据本发明的式（1）的三嗪化合物是 其特征在于高的紫外线吸收，并且特别适用于紫外线过滤器，即用于保护紫外线有害的紫外线辐射有害作用的紫外线敏感有机材料，特别是人和动物的皮肤和头发。

    Amino- and hydroxysubstituted triphenyl-s-triazines as stabilizers
    6.
    发明授权
    Amino- and hydroxysubstituted triphenyl-s-triazines as stabilizers 失效
    氨基和羟基取代的三苯基-s-三嗪作为稳定剂

    公开(公告)号：US07476699B2

    公开(公告)日：2009-01-13

    申请号：US11891554

    申请日：2007-08-10

    申请人： Dieter Reinehr ,  Georges Metzger ,  Peter Michaelis ,  Helmut Luther

    发明人： Dieter Reinehr ,  Georges Metzger ,  Peter Michaelis ,  Helmut Luther

    IPC分类号： C08K5/3492

    CPC分类号： A61K8/4966 ,  A61K31/785 ,  A61K2800/52 ,  A61Q17/04 ,  C07D251/24 ,  C07D265/22 ,  Y10S514/972

    摘要： The present invention provides compounds having the formula: in which R is hydrogen, hydroxy, halogen, C1-C20-alkyl, C4-C12cycloalkyl, C2-C20alkenyl, C2-C20alkynyl, C1-C20-alkoxy, C4-C12cycloalkoxy, C2-C20alkenoxy, C2-C20alkynoxy or C7-C13aralkyl; R1 and R2, independently, are hydrogen, C1-C20alkyl, C4-C12cycloalkyl, C7-C13 aralkyl, —C(═O)—R4 (in which R4 is C1-C20alkyl, C2-C20alkyl interrupted by 1 to 6 oxygen atoms, hetero-substituted C1-C20alkyl, C4-C12cycloalkyl, C2-C20alkenyl, C2-C20alkynyl, C1-C20-alkoxy, C4-C12cycloalkoxy, C2-C20alkenoxy, C2-C20alkynoxy, C6-C12 aryl, C6-C12 aryloxy or C7-C13 aralkyl), or —C(═O)—NH—R1 in which R1 has its previous significance; and R3 is hydrogen, halogen, hydroxy, C1-C20alkyl, C4-C12cycloalkyl, C2-C20alkenyl, C2-C20alkynyl, C1-C20-alkoxy, C4-C12cycloalkoxy, C2-C20alkenoxy, C2-C20alkynoxy, phenyl, C7-C13 aralkyl or —N(R1)(R2) in which R1 and R2 have their previous significance, or R1 and R2 together form a C4-C12 membered ring. The new triphenyltriazine compounds have improved absorption spectrum characteristics and superior resistance to exposure to UV light, relative to known triphenyltriazine compounds.

    摘要翻译： 本发明提供具有下式的化合物：其中R是氢，羟基，卤素，C 1 -C 20烷基，C 4 -C 12环烷基，C 2 -C 20烯基，C 2 -C 20炔基，C 1 -C 20烷氧基，C 4 -C 12环烷氧基，C 2 -C 20链烯氧基 ，C 2 -C 20炔氧基或C 7 -C 13芳烷基; R 1和R 2独立地是氢，C 1 -C 20烷基，C 4 -C 12环烷基，C 7 -C 13芳烷基，-C（-O）-R 4（其中R 4是C 1 -C 20烷基，被1至6个氧原子间断的C 2 -C 20烷基， C 1 -C 20烷基，C 2 -C 20炔基，C 1 -C 20烷氧基，C 4 -C 12环烷氧基，C 2 -C 20烯烃氧基，C 2 -C 20炔氧基，C 6 -C 12芳基，C 6 -C 12芳氧基或C 7 -C 13 芳烷基）或-C（-O）-NH-R 1，其中R 1具有其先前的含义; 并且R 3是氢，卤素，羟基，C 1 -C 20烷基，C 4 -C 12环烷基，C 2 -C 20烯基，C 2 -C 20炔基，C 1 -C 20烷氧基，C 4 -C 12环烷氧基，C 2 -C 20链烯氧基，C 2 -C 20炔氧基，苯基，C 7 -C 13芳烷基或 -N（R 1）（R 2），其中R 1和R 2具有其先前的含义，或者R 1和R 2一起形成C 4 -C 12元环。 相对于已知的三苯基三嗪化合物，新的三苯基三嗪化合物具有改善的吸收光谱特性和对UV光的暴露性优异的抗性。

    Amino- and hydroxysubstituted triphenyl-S-triazines as stabilizers
    8.
    发明申请
    Amino- and hydroxysubstituted triphenyl-S-triazines as stabilizers 失效

    公开(公告)号：US20070274933A1

    公开(公告)日：2007-11-29

    申请号：US11891554

    申请日：2007-08-10

    申请人： Dieter Reinehr ,  Georges Metzger ,  Peter Michaelis ,  Helmut Luther

    发明人： Dieter Reinehr ,  Georges Metzger ,  Peter Michaelis ,  Helmut Luther

    IPC分类号： A61K31/785 ,  A61K47/22 ,  A61K8/00 ,  A61Q17/04

    CPC分类号： A61K8/4966 ,  A61K31/785 ,  A61K2800/52 ,  A61Q17/04 ,  C07D251/24 ,  C07D265/22 ,  Y10S514/972

    摘要： The present invention provides compounds having the formula: in which R is hydrogen, hydroxy, halogen, C1-C20-alkyl, C4-C12cycloalkyl, C2-C20alkenyl, C2-C20alkynyl, C1-C20-alkoxy, C4-C12cycloalkoxy, C2-C20alkenoxy, C2-C20alkynoxy or C7-C13aralkyl; R1 and R2, independently, are hydrogen, C1-C20alkyl, C4-C12cycloalkyl, C7-C13 aralkyl, —C(═O)—R4 (in which R4 is C1-C20alkyl, C2-C20alkyl interrupted by 1 to 6 oxygen atoms, hetero-substituted C1-C20alkyl, C4-C12cycloalkyl, C2-C20alkenyl, C2-C20alkynyl, C1-C20-alkoxy, C4-C12cycloalkoxy, C2-C20alkenoxy, C2-C20alkynoxy, C6-C12 aryl, C6-C12 aryloxy or C7-C13 aralkyl), or —C(═O)—NH—R1 in which R1 has its previous significance; and R3 is hydrogen, halogen, hydroxy, C1-C20alkyl, C4-C12cycloalkyl, C2-C20alkenyl, C2-C20alkynyl, C1-C20-alkoxy, C4-C12cycloalkoxy, C2-C20alkenoxy, C2-C20alkynoxy, phenyl, C7-C13 aralkyl or —N(R1)(R2) in which R1 and R2 have their previous significance, or R1 and R2 together form a C4-C12 membered ring. The new triphenyltriazine compounds have improved absorption spectrum characteristics and superior resistance to exposure to UV light, relative to known triphenyltriazine compounds.

    Cosmetic use of Bis(resorcinyl)triazine derivatives
    9.
    发明授权
    Cosmetic use of Bis(resorcinyl)triazine derivatives 失效
    双（间苯二酚）三嗪衍生物的化妆品用途

    公开(公告)号：US06221342B1

    公开(公告)日：2001-04-24

    申请号：US09485948

    申请日：2000-02-17

    申请人： Dietmar Hüglin ,  Helmut Luther ,  Dieter Reinehr

    发明人： Dietmar Hüglin ,  Helmut Luther ,  Dieter Reinehr

    IPC分类号： A61K742

    CPC分类号： A61Q17/04 ,  A61K8/4966

    摘要： A description is given of the use of bis(resorcinyl)triazines of formula (1) wherein R1 and R2 are each independently of the other hydrogen; C1-C18alkyl; C2-C18alkenyl; a radical of formula —CH2—CH(—OH)—CH2—O—T1; a radical of formula (1a); or a radical of radical of formula (1b); R3 and R4 are each independently of the other hydrogen or C1-C5alkyl; R5 is hydroxy; C1-C5alkoxy which is unsubstituted or substituted by one or several OH groups; amino; mono- or di-C1-C5alkylamino; M; a radical of formula (1c); (1d); (1e); (1f); (1g); or (1h); R6 is a direct bond; a straight-chain or branched C1-C4alkylene radical or a radical of formula (a) or (b); R7, R8 and R9 are each independently of one another C1-C18alkyl; C1-C18alkoxy or a radical of formula (1i), R10, R11 and R12 are each independently of one another C1-C14alkyl which is unsubstituted or substitued by one or several OH groups; R13 is hydrogen; M; C1-C5alkyl; or a radical of formula (c) R14 is C1-C5alkyl; M is a metal cation; T1 is hydrogen; or C1-C8alkyl; m1 is 1 to 3; m2 is 2 to 14; and p1 is 0; or a number from 1 to 5, for protecting human and animal skin and hair from the damaging effect of UV radiation. The compounds used according to this invention are very powerful UVA absorbers with fractions in the UVB range and are particularly suitable as sunscreens in cosmetic, pharmaceutical and veterinary compositions.

    摘要翻译： 给出了使用式（1）的双（间苯二酚）三嗪的用途，其中R 1和R 2各自独立地为氢; C1-C18烷基; C 2 -C 18烯基; 式-CH 2 -CH（-OH）-CH 2 -O-T 1的基团; 式（1a）的基团; 或式（1b）的基团的基团; R 3和R 4各自独立地为另一个氢或C 1 -C 5烷基; R5是羟基; 未被取代或被一个或多个OH基团取代的C 1 -C 5烷氧基; 氨基; 单或二-C 1 -C 5烷基氨基; M; 式（1c）的基团; （1d）; （1e）; （1f）; （1g）; 或（1h）; R6是直接的债券; 直链或支链C 1 -C 4亚烷基或式（a）或（b）的基团; R 7，R 8和R 9各自独立地为C 1 -C 18烷基; C 1 -C 18烷氧基或式（1i）的基团，R 10，R 11和R 12各自独立地为彼此未被取代或被一个或几个OH基取代的C 1 -C 14烷基; R13是氢; M; C1-C5烷基; 或式（c）的基团R 14是C 1 -C 5烷基; M是金属阳离子; T1是氢; 或C 1 -C 8烷基; m1为1〜3; m2为2〜14; p1为0; 或1至5个数字，用于保护人体和动物皮肤和头发免受紫外线辐射的破坏作用。 根据本发明使用的化合物是在UVB范围内具有级分的非常强大的UVA吸收剂，并且特别适合作为化妆品，药​​物和兽医组合物中的防晒剂。

    Indolin derivatives as sun protection agents
    10.
    发明授权
    Indolin derivatives as sun protection agents 失效
    吲哚衍生物作为防晒剂

    公开(公告)号：US06358496B1

    公开(公告)日：2002-03-19

    申请号：US09806349

    申请日：2001-03-29

    申请人： Rudolf Zink ,  Helmut Luther

    发明人： Rudolf Zink ,  Helmut Luther

    IPC分类号： A61K742

    CPC分类号： C07D403/04 ,  A61K8/492 ,  A61K8/4966 ,  A61Q17/04 ,  C07D209/12 ,  C07D209/14 ,  C07D209/24

    摘要： There is described the use of indoline derivatives of formula wherein R1 is hydrogen; C1-C5alkyl; C1-C18alkoxy; or halogen; R2 is C1-C8alkyl; C5-C7cycloalkyl; C6-C10aryl; R3 is C1-C18alkyl or a radical of formula R4 is hydrogen; or a radical of formula R5 is  C1-C18alkoxy; or a radical of formula R6 and R7 are each independently of the other hydrogen; or C1-C5alkyl; R8 is hydrogen; C1-C5alkyl; C5-C7cycloalkyl; phenyl; phenyl-C1-C3alkyl; R9 is C1-C18alkyl; X is halogen; a radical of formula n is 0; or 1, as light-protective agents.

    摘要翻译： 描述了使用二氢吲哚衍生物的方法，其中R1是氢; C1-C5烷基; C1-C18烷氧基; 或卤素; R 2为C 1 -C 8烷基; C5-C7环烷基; C 6 -C 10芳基; R 3是C 1 -C 18烷基或式R4的基团是氢; 或式R 5的基团是C 1 -C 18烷氧基; 或式R6和R7的基团各自独立地为氢; 或C 1 -C 5烷基; R 8是氢; C1-C5烷基; C5-C7环烷基; 苯基; 苯基-C 1 -C 3烷基; R 9为C 1 -C 18烷基; X为卤素; 一个民族主义者是0; 或1，作为防光剂。