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1.发明授权
公开(公告)号：US4863668A
公开(公告)日：1989-09-05
申请号：US247728
申请日：1988-09-22
CPC分类号： A61B17/1128 , A61L27/22 , B29C41/14 , A61B2017/00004 , A61L2430/32
摘要： A method of forming material including alternating layers of fibrin and collagen, formed into tubes, is disclosed for use in repairing transected nerve fibers either by tubulization of the approximated nerve ends, or as an artificial graft which are placed in the severed ends of the nerve, for promotion of nerve growth and regeneration. The new material is treated to reduce antigenicity and is resorbed into the body following regeneration of the nerve fibers.
摘要翻译： 形成材料的方法包括形成管的纤维蛋白和胶原的交替层，用于通过近似神经末端的管腔修复横切的神经纤维，或者作为放置在神经切断的末端的人造移植物 ，用于促进神经生长和再生。 治疗新材料以降低抗原性，并在再生神经纤维后吸收进入体内。
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2.发明授权Microbiological systems for phosphate extraction and distribution to plant root systems 失效用于磷酸盐提取和分配到植物根系的微生物系统
公开(公告)号：US4589226A
公开(公告)日：1986-05-20
申请号：US641341
申请日：1984-08-13
申请人： Larry J. Stensaas
发明人： Larry J. Stensaas
摘要： A package and method of its production, providing a means for transferring soluble phosphorus from a source supply to plant root systems without loss of phosphorus to surrounding soil structure by use of microorganisms. A source of soluble phosphorus is supported along with a plant seed and dormant, plant-beneficial microorganisms within the cell matrix of a cellulosic support device which may be formed into a configuration such as a capsule or ribbon. The cellulosic support device may also contain nutrients for encouraging plant growth upon germination of the plant seed. The fungal inoculum is obtained by propagation of the microorganism in symbiotic association with the root systems of host plants either hydroponically, or in soil, depending upon the microorganism species used. Spores, cryoprotected hyphae and the seed of a vector plant are combined at low temperature with a cellulosic material which is used to form the packages. The formed packages are rapidly freeze-dried, and stored. The carrier system is inoculated into soil and, under proper environmental conditions, the plant seed germinates and the microorganisms become active and develop a symbiotic relationship with the growing plant. Growth of the fungus in association with the roots of the vector plant distributes the microorganisms within the soil and serves to introduce them to other plants, allowing the microorganisms to recover phosphorus and other constituents from the soil and to deliver them to their host plant by a process of translocation. The growing plant provides a vehicle for inoculating other nearby plant roots with the microorganisms.
摘要翻译： 一种其生产的包装和方法，提供了将可溶性磷从源供应转移到植物根系而不通过使用微生物将磷转移到周围土壤结构的手段。 可溶性磷的来源与植物种子和纤维素支持装置的细胞基质内的休眠的植物有益的微生物一起被支撑，纤维素支持装置的细胞基质可以形成为诸如胶囊或丝带的构造。 纤维素支持装置还可以包含用于在植物种子发芽时促进植物生长的营养物质。 根据所使用的微生物种类，通过水解或土壤中的微生物与宿主植物的根系共生缔合而获得真菌接种物。 孢子，冷冻保护的菌丝和载体植物的种子在低温下与用于形成包装的纤维素材料组合。 形成的包装被快速冷冻干燥并储存。 载体系统接种在土壤中，在适当的环境条件下，植物种子发芽，微生物活跃，与生长的植物发生共生关系。 与植物根部相关的真菌的生长将微生物分布在土壤中并用于将它们引入其他植物中，从而允许微生物从土壤中回收磷和其他成分，并将它们通过一个 易位过程 生长的植物提供了用微生物接种其他附近植物根的载体。
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公开(公告)号：US4662884A
公开(公告)日：1987-05-05
申请号：US603835
申请日：1984-04-25
CPC分类号： A61F2/04 , A61B17/1128 , A61F2002/30235 , A61F2230/0069
摘要： The present invention is directed to prostheses and methods for promoting nerve regeneration. The proximal and distal ends of a severed nerve are brought into close proximity and are enclosed by a tubular prosthesis. In one preferred embodiment, a monosuture is used to hold the nerve ends in close proximity. A tight seal is formed between the prosthesis and the injured nerve so as to isolate the injured nerve within the prosthesis from the rest of the body of the host. Additionally, in one preferred embodiment, nerve grafts may be incorporated into the prosthesis and nerve regeneration promoting substances may be incorporated within the nerve graft to further enhance nerve regeneration. Prostheses and methods for inhibiting the formation of neuromas are also disclosed.
摘要翻译： 本发明涉及用于促进神经再生的假体和方法。 切断的神经的近端和远端紧密接近，并被管状假体包围。 在一个优选实施例中，使用单缝来保持紧邻的神经末端。 在假体和受损的神经之间形成紧密的密封，以将假体中的受伤神经与主体的其余部分分离。 此外，在一个优选实施例中，神经移植物可以并入假体中，并且可以将神经再生促进物质并入神经移植物内以进一步增强神经再生。 还公开了抑制神经瘤形成的假体和方法。
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4.发明授权System and method for the fertilization of forest, farm and other large plant communities 失效森林，农场等大型植物群落施肥的制度和方法
公开(公告)号：US4581846A
公开(公告)日：1986-04-15
申请号：US662716
申请日：1984-10-19
申请人： Larry J. Stensaas
发明人： Larry J. Stensaas
摘要： A large first package, and method of its production, for providing soluble plant macronutrients and micronutrients in a timed-release form from a contained second package to an extensive plant community. The bale-like first package comprises a biodegradable cellulosic matrix of municipal waste or other energy-rich organic matter within which the second package is supported. The second package contains insoluble rock mineral and rock phosphate particles and bacterial second microorganisms in a nourishing and hydrated microenvironment which allows the microorganisms to grow, and to produce enzymes and organic acids which act on the mineral particles and thereby create soluble nutrient compounds. Alternatively, the second package contains commercially refined fertilizers packaged to dissolve in a timed-release fashion.The biodegradable package functions as it is introduced onto/into soil in association with vector plants. Upon hydration its microbial components become active so that macronutrients and micronutrients emanating from it are transferred first to the vector plants and thence to a series of recipient plants. Plants linked together by interroot microorganisms which provide for the distribution of nutrients to an extensive plant association and constitute active elements in a "radial cascade" of nutrients along concentration gradients. The microbial interlinked "source" and "sink" plants not only serve to buffer and transfer nutrients, but they also protect the soluble nutrient compounds from adsorption and loss to soil constituents.
摘要翻译： 一种大型的第一个包装及其生产方法，用于将时间释放形式的可溶性植物大量营养元素和微量营养素从包含的第二包装提供给广泛的植物群落。 捆包状的第一包装包括城市废物或其他能量丰富的有机物质的可生物降解的纤维素基质，其中第二包装被支撑在其中。 第二个包装在营养和水合微环境中含有不溶性岩石矿物和岩石磷酸盐颗粒和细菌第二微生物，其允许微生物生长，并产生作用于矿物颗粒的酶和有机酸，从而产生可溶性营养物质。 或者，第二包装包含以定时释放方式包装的商业精制肥料。 生物降解包装的作用是与向量植物相关联地引入/进入土壤。 在水合时，其微生物组分变得活跃，使得从其发出的大量营养素和微量营养素首先转移到载体植物，然后转移到一系列受体植物。 植物通过种间微生物连接在一起，其提供营养物质分布到广泛的植物关联，并且沿着浓度梯度在营养物质的“径向级联”中构成活性成分。 微生物相互关联的“源”和“水槽”植物不仅用于缓冲和转移营养，而且还保护可溶性营养物质免受土壤成分的吸附和损失。
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5.发明授权Prostheses and methods for promoting nerve regeneration and for inhibiting the formation of neuromas 失效用于促进神经再生和抑制神经瘤形成的假肢和方法
公开(公告)号：US4778467A
公开(公告)日：1988-10-18
申请号：US884088
申请日：1986-07-10
CPC分类号： A61F2/04 , A61B17/1128 , A61F2002/30235 , A61F2230/0069
摘要： The present invention is directed to prosthesis and methods for promoting nerve regeneration. The proximal and distal ends of a severed nerve are brought into close proximity and are enclosed by a tubular prosthesis. In one preferred embodiment, a epineurial or endoneurial monosuture is used to hold the nerve ends in close proximity. A tight seal is formed between the prosthesis and the injured nerve so as to isolate the injured nerve within the prosthesis from the rest of the body of the host. Additionally, in one preferred embodiment, nerve grafts may be incorporated into the prosthesis and nerve regeneration promoting substances may be incorporated within the nerve graft to further enhance nerve regeneration. In another preferred embodiment, a prosthesis is coated with a material which is slippery with relation to the surrounding body tissue and the prosthesis is formed of or coated with a material around the inside of the prosthesis which will substantially adhere to the severed nerve ends so as to prevent substantial movement of the severed nerve ends within the prosthesis. In yet another preferred embodiment, such an outside coating around the prosthesis terminates in two longitudinal flaps which serve to form a fluid-tight seal along the tubular prosthesis. In still another preferred embodiment, the ends of the prosthesis overlap and are formed so as to bias against each other in a spiral tube configuration, thereby providing for firm closure of the prosthesis around a variety of sizes of injured nerves. Also disclosed are various devices and methods for inhibiting the formation of neuromas, such as an open-ended tube or a neuroma-inhibition device formed as a cap member having a reservoir formed therein.
摘要翻译： 本发明涉及用于促进神经再生的假体和方法。 切断的神经的近端和远端紧密接近，并被管状假体包围。 在一个优选实施例中，使用神经节或内膜单节使得紧密接近的神经末端。 在假体和受损的神经之间形成紧密的密封，以将假体中的受伤神经与主体的其余部分分离。 此外，在一个优选实施例中，神经移植物可以并入假体中，并且可以将神经再生促进物质并入神经移植物内以进一步增强神经再生。 在另一个优选实施例中，假体用相对于周围身体组织滑动的材料涂覆，并且假体由假体附近的材料形成或涂覆，该材料将基本上粘附到切断的神经末端，以便 以防止假体中切断的神经末梢的实质运动。 在另一个优选实施例中，假体周围的这种外部涂层终止于两个纵向翼片，其用于沿着管状假体形成流体密封的密封。 在另一优选实施例中，假体的端部重叠并形成为以螺旋管构造彼此偏压，从而提供围绕各种尺寸的受伤神经的假体的牢固关闭。 还公开了用于抑制神经瘤形成的各种装置和方法，例如形成为具有在其中形成的储液器的盖构件的开口管或神经阻滞装置。
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6.发明授权Plant fertilization using a microbiological system for phosphorus extraction and distribution 失效使用微生物系统进行植物施肥，用于磷提取和分配
公开(公告)号：US4589225A
公开(公告)日：1986-05-20
申请号：US474354
申请日：1983-03-11
申请人： Larry J. Stensaas
发明人： Larry J. Stensaas
摘要： A primary package, and method of its production, for transferring soluble phosphorus from a secondary package within the primary package to plant root systems without adsorptive loss of phosphorus to surrounding soil constituents.The secondary package contains insoluble rock phosphate particles and a second contingent of microorganisms in a nutrient hydrogen mocroenvironment which allows the microorganisms to act on those phosphate particles to create soluble forms of phosphorus. Alternatively, the secondary package contains granules of commercially refined phosphorus fertilizer packaged to dissolve in a regulated, timed-release fashion.The primary package comprises a cellulosic support device which may be wet, moist or dry, and within which the secondary package is supported along with a vector plant seed or seedling and propagules of primary, plant-beneficial microorganisms. The primary package may be formed into desired configurations and may contain self-adhesive or gel-forming materials.The primary package system is introduced into soil and, under proper environmental conditions, a vector plant develops and the microorganisms become active and form a symbiotic relationship with the vector plant. The growing plant provides a vehicle for inoculating other nearby plant roots with the microorganisms. The microorganisms then transfer soluble phosphorus from the secondary package to the vector plant and then to other plants by a process of translocation. The vector plant may also serve as a buffer for soluble phosphorus and as an agent for the conversion of inorganic to organic forms of soluble phosphorus through its conversion to biomass.
摘要翻译： 一种初级包装及其生产方法，用于将可溶性磷从初级包装中的二级包装转移到植物根系，而磷对周围土壤成分的吸附损失。 次级包装包含不溶性磷酸岩石颗粒和营养氢环境中的第二个微生物组合，其允许微生物作用于这些磷酸盐颗粒以产生可溶形式的磷。 或者，二次包装包含商业上精制的磷肥的颗粒，其包装以调节的，定时释放的方式溶解。 初级包装包括纤维素支持装置，其可以是湿的，潮湿的或干燥的，并且其中二次包装与载体植物种子或幼苗以及初级植物有益微生物的繁殖体一起被支撑在该纤维素支持装置内。 初级包装可以形成所需的构型并且可以包含自粘或凝胶形成材料。 将初级包装系统引入土壤中，在适当的环境条件下，发展载体植物，微生物变得活跃，与载体植物形成共生关系。 生长的植物提供了用微生物接种其他附近植物根的载体。 微生物然后将可溶性磷从次级包装转移到载体植物中，然后通过易位过程转移到其他植物。 载体植物还可以用作可溶性磷的缓冲剂，并且作为通过其转化为生物质将无机转化为有机形式的可溶性磷的试剂。
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