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公开(公告)号：US09700638B2
公开(公告)日：2017-07-11
申请号：US14889215
申请日：2014-05-08
发明人： Arkady Mustaev , David S. Perlin , Laura Wirpsza
IPC分类号： A61K49/00 , C07D219/08 , C07D401/12 , C07K7/64 , C07D405/14 , C07D498/06
CPC分类号： A61K49/0052 , A61K49/0026 , C07D219/08 , C07D401/12 , C07D405/14 , C07D498/06 , C07K7/64
摘要： The present invention provides compounds useful as novel near-infrared labels, compositions containing these compounds, and methods of using the near-infrared labels to identify targets in vitro, in situ and in vivo. The invention also provides small or large molecule conjugates between targeting agents and NIR labels, as well as methods and kits thereof, that can be used in diagnostics and treatment of diseases related to microbes in mammalian animals.
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公开(公告)号：US20160106867A1
公开(公告)日：2016-04-21
申请号：US14889215
申请日：2014-05-08
发明人： Arkady Mustaev , David S. Perlin , Laura Wirpsza
IPC分类号： A61K49/00 , C07D401/12 , G01N33/58 , C07D405/14 , C07D498/06 , C07D219/08 , C07K7/64
CPC分类号： A61K49/0052 , A61K49/0026 , C07D219/08 , C07D401/12 , C07D405/14 , C07D498/06 , C07K7/64
摘要： The present invention provides compounds useful as novel near-infrared labels, compositions containing these compounds, and methods of using the near-infrared labels to identify targets in vitro, in situ and in vivo. The invention also provides small or large molecule conjugates between targeting agents and NIR labels, as well as methods and kits thereof, that can be used in diagnostics and treatment of diseases related to microbes in mammalian animals.
摘要翻译： 本发明提供了可用作新型近红外标记的化合物，含有这些化合物的组合物，以及使用近红外标记在体外，原位和体内鉴定靶标的方法。 本发明还提供靶向剂和NIR标记之间的小分子或大分子缀合物，以及其可用于诊断和治疗哺乳动物中与微生物有关的疾病的方法和试剂盒。
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公开(公告)号：US09732378B2
公开(公告)日：2017-08-15
申请号：US14980342
申请日：2015-12-28
发明人： Arkady Mustaev , Maxim Kozlov , Salvatore Marras , Lev Krasnoperov , Laura Wirpsza , Shyamala Pillai
IPC分类号： A61K49/00 , C07D215/227 , C12Q1/68 , C07D215/38 , C07D215/233 , C07D257/02 , C07H21/00 , C07K14/00 , G01N33/52 , G01N33/58
CPC分类号： C12Q1/6816 , A61K49/0021 , A61K49/0028 , A61K49/0052 , C07D215/227 , C07D215/233 , C07D215/38 , C07D257/02 , C07H21/00 , C07K14/00 , G01N33/52 , G01N33/582 , C12Q2565/1015 , C12Q2563/103
摘要： The invention relates to novel luminescent compositions of matter containing a fluorophore, synthetic methods for making the compositions, macromolecular conjugates of the compositions, and the use of the compositions in various methods of detection. The invention also provides kits containing the compositions and their conjugates for use in the methods of detection.
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公开(公告)号：US20160194690A1
公开(公告)日：2016-07-07
申请号：US14980342
申请日：2015-12-28
发明人： Arkady Mustaev , Maxim Kozlov , Salvatore Marras , Lev Krasnoperov , Laura Wirpsza , Shyamala Pillai
CPC分类号： C12Q1/6816 , A61K49/0021 , A61K49/0028 , A61K49/0052 , C07D215/227 , C07D215/233 , C07D215/38 , C07D257/02 , C07H21/00 , C07K14/00 , G01N33/52 , G01N33/582 , C12Q2565/1015 , C12Q2563/103
摘要： The invention relates to novel luminescent compositions of matter containing a fluorophore, synthetic methods for making the compositions, macromolecular conjugates of the compositions, and the use of the compositions in various methods of detection. The invention also provides kits containing the compositions and their conjugates for use in the methods of detection.
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