公开(公告)号：US09700638B2

公开(公告)日：2017-07-11

申请号：US14889215

申请日：2014-05-08

申请人： Rutgers, The State University of New Jersey ,  New Jersey Institute of Technology

发明人： Arkady Mustaev ,  David S. Perlin ,  Laura Wirpsza

IPC分类号： A61K49/00 ,  C07D219/08 ,  C07D401/12 ,  C07K7/64 ,  C07D405/14 ,  C07D498/06

CPC分类号： A61K49/0052 ,  A61K49/0026 ,  C07D219/08 ,  C07D401/12 ,  C07D405/14 ,  C07D498/06 ,  C07K7/64

摘要： The present invention provides compounds useful as novel near-infrared labels, compositions containing these compounds, and methods of using the near-infrared labels to identify targets in vitro, in situ and in vivo. The invention also provides small or large molecule conjugates between targeting agents and NIR labels, as well as methods and kits thereof, that can be used in diagnostics and treatment of diseases related to microbes in mammalian animals.

公开(公告)号：US09732378B2

公开(公告)日：2017-08-15

申请号：US14980342

申请日：2015-12-28

申请人： Rutgers, The State University of New Jersey ,  New Jersey Institute of Technology

发明人： Arkady Mustaev ,  Maxim Kozlov ,  Salvatore Marras ,  Lev Krasnoperov ,  Laura Wirpsza ,  Shyamala Pillai

IPC分类号： A61K49/00 ,  C07D215/227 ,  C12Q1/68 ,  C07D215/38 ,  C07D215/233 ,  C07D257/02 ,  C07H21/00 ,  C07K14/00 ,  G01N33/52 ,  G01N33/58

CPC分类号： C12Q1/6816 ,  A61K49/0021 ,  A61K49/0028 ,  A61K49/0052 ,  C07D215/227 ,  C07D215/233 ,  C07D215/38 ,  C07D257/02 ,  C07H21/00 ,  C07K14/00 ,  G01N33/52 ,  G01N33/582 ,  C12Q2565/1015 ,  C12Q2563/103

摘要： The invention relates to novel luminescent compositions of matter containing a fluorophore, synthetic methods for making the compositions, macromolecular conjugates of the compositions, and the use of the compositions in various methods of detection. The invention also provides kits containing the compositions and their conjugates for use in the methods of detection.

公开(公告)号：US20160194690A1

公开(公告)日：2016-07-07

申请号：US14980342

申请日：2015-12-28

申请人： Rutgers, The State University of New Jersey ,  New Jersey Institute of Technology

发明人： Arkady Mustaev ,  Maxim Kozlov ,  Salvatore Marras ,  Lev Krasnoperov ,  Laura Wirpsza ,  Shyamala Pillai

IPC分类号： C12Q1/68 ,  G01N33/52 ,  A61K49/00

CPC分类号： C12Q1/6816 ,  A61K49/0021 ,  A61K49/0028 ,  A61K49/0052 ,  C07D215/227 ,  C07D215/233 ,  C07D215/38 ,  C07D257/02 ,  C07H21/00 ,  C07K14/00 ,  G01N33/52 ,  G01N33/582 ,  C12Q2565/1015 ,  C12Q2563/103

摘要： The invention relates to novel luminescent compositions of matter containing a fluorophore, synthetic methods for making the compositions, macromolecular conjugates of the compositions, and the use of the compositions in various methods of detection. The invention also provides kits containing the compositions and their conjugates for use in the methods of detection.

公开(公告)号：US20160106867A1

公开(公告)日：2016-04-21

申请号：US14889215

申请日：2014-05-08

申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY ,  NEW JERSEY INSTITUTE OF TECHNOLOGY

发明人： Arkady Mustaev ,  David S. Perlin ,  Laura Wirpsza

IPC分类号： A61K49/00 ,  C07D401/12 ,  G01N33/58 ,  C07D405/14 ,  C07D498/06 ,  C07D219/08 ,  C07K7/64

CPC分类号： A61K49/0052 ,  A61K49/0026 ,  C07D219/08 ,  C07D401/12 ,  C07D405/14 ,  C07D498/06 ,  C07K7/64

摘要： The present invention provides compounds useful as novel near-infrared labels, compositions containing these compounds, and methods of using the near-infrared labels to identify targets in vitro, in situ and in vivo. The invention also provides small or large molecule conjugates between targeting agents and NIR labels, as well as methods and kits thereof, that can be used in diagnostics and treatment of diseases related to microbes in mammalian animals.

摘要翻译： 本发明提供了可用作新型近红外标记的化合物，含有这些化合物的组合物，以及使用近红外标记在体外，原位和体内鉴定靶标的方法。 本发明还提供靶向剂和NIR标记之间的小分子或大分子缀合物，以及其可用于诊断和治疗哺乳动物中与微生物有关的疾病的方法和试剂盒。

公开(公告)号：US09586907B2

公开(公告)日：2017-03-07

申请号：US14512884

申请日：2014-10-13

申请人： Rutgers, The State University of New Jersey

发明人： Arkady Mustaev ,  Natalia Kurepina

IPC分类号： A61K31/26 ,  C07C331/00 ,  A61K31/21 ,  C07D233/64 ,  C07C331/20 ,  C07C331/22 ,  C07C331/30 ,  C07C331/28 ,  C07D209/14 ,  C07D213/24

CPC分类号： C07D233/64 ,  C07C331/20 ,  C07C331/22 ,  C07C331/28 ,  C07C331/30 ,  C07C2603/20 ,  C07C2603/50 ,  C07C2603/74 ,  C07D209/14 ,  C07D213/24

摘要： Provided herein are compositions of matter and pharmaceutical compositions thereof, for use in inhibiting the growth of various microbial pathogens, including bacteria, fungi, protozoa, and viral pathogens. Also provided herein are methods of treating microbial diseases/infections and cancer with the compositions. The compositions are additionally useful in wood preservation and food preservation by inhibition of microbial growth.

摘要翻译： 本文提供了用于抑制各种微生物病原体（包括细菌，真菌，原生动物和病毒病原体）的生长的物质及其药物组合物的组合物。 本文还提供了用组合物治疗微生物疾病/感染和癌症的方法。 通过抑制微生物生长，组合物另外可用于木材保存和食品保存。

公开(公告)号：US10241116B2

公开(公告)日：2019-03-26

申请号：US15206984

申请日：2016-07-11

申请人： Rutgers, The State University of New Jersey

发明人： Arkady Mustaev ,  Salvatore A. E. Marras

IPC分类号： G01N33/58 ,  A61K49/00 ,  C07F5/00 ,  C12Q1/68 ,  A61K47/55 ,  C12Q1/6818

摘要： The invention relates to novel luminescent compositions of matter containing two fluorophores (sensitizers), synthetic methods for making the compositions, macromolecular conjugates of the compositions, and the use of the compositions and their conjugates in various methods of detection. The invention also provides kits containing the compositions and their conjugates for use in the methods of detection.

公开(公告)号：US20170016907A1

公开(公告)日：2017-01-19

申请号：US15206984

申请日：2016-07-11

申请人： Rutgers, The State University of New Jersey

发明人： Arkady Mustaev ,  Salvatore A. E. Marras

IPC分类号： G01N33/58 ,  C07F5/00 ,  C12Q1/68

CPC分类号： G01N33/582 ,  A61K47/55 ,  A61K47/552 ,  A61K49/0019 ,  A61K49/0021 ,  C07F5/00 ,  C12Q1/6818 ,  G01N2458/30 ,  G01N2458/40

摘要： The invention relates to novel luminescent compositions of matter containing two fluorophores (sensitizers), synthetic methods for making the compositions, macromolecular conjugates of the compositions, and the use of the compositions and their conjugates in various methods of detection. The invention also provides kits containing the compositions and their conjugates for use in the methods of detection.

摘要翻译： 本发明涉及含有两种荧光团（敏化剂）的物质的新型发光组合物，用于制备组合物的合成方法，组合物的大分子共轭物，以及组合物及其缀合物在各种检测方法中的用途。 本发明还提供了包含用于检测方法的组合物及其缀合物的试剂盒。

公开(公告)号：US20150246887A1

公开(公告)日：2015-09-03

申请号：US14512884

申请日：2014-10-13

申请人： Rutgers, The State University of New Jersey

发明人： Arkady Mustaev ,  Natalia Kurepina

IPC分类号： C07D233/64 ,  C07C331/22 ,  C07D213/24 ,  C07C331/28 ,  C07D209/14 ,  C07C331/20 ,  C07C331/30

CPC分类号： C07D233/64 ,  C07C331/20 ,  C07C331/22 ,  C07C331/28 ,  C07C331/30 ,  C07C2603/20 ,  C07C2603/50 ,  C07C2603/74 ,  C07D209/14 ,  C07D213/24

摘要： Provided herein are compositions of matter and pharmaceutical compositions thereof, for use in inhibiting the growth of various microbial pathogens, including bacteria, fungi, protozoa, and viral pathogens. Also provided herein are methods of treating microbial diseases/infections and cancer with the compositions. The compositions are additionally useful in wood preservation and food preservation by inhibition of microbial growth.

公开(公告)号：US20150098905A1

公开(公告)日：2015-04-09

申请号：US14399772

申请日：2013-05-08

申请人： Rutgers, The State University of New Jersey

发明人： David S. Perlin ,  Guillermo Garcia-Effron ,  Arkady Mustaev

IPC分类号： A61K49/00

CPC分类号： A61K49/0056 ,  A61K49/0021 ,  A61K49/0026 ,  A61K49/0052 ,  A61K49/085 ,  A61K49/14 ,  A61K51/0497 ,  A61K51/088

摘要： The present invention relates to targeting agents and methods: of using the targeting agents to detect a fungal cell in a subject.

摘要翻译： 本发明涉及靶向剂和方法：使用靶向剂检测受试者中的真菌细胞。