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1.发明授权公开(公告)号：US09162005B2
公开(公告)日：2015-10-20
申请号：US11740284
申请日：2007-04-25
CPC分类号： A61K38/10 , A61L15/42 , A61L26/0061
摘要： A method has been developed of preventing or limiting formation of adhesions by administering to a site in need thereof, in the absence of or after bleeding or leakage of fluid has been substantially stopped, a self-assembling material which forms a barrier to formation of adhesions. In certain embodiments, the self assembling materials are peptidomimetics, nucleotidomimetics, di- and triblock copolymers, N-alkylacrylamides, or dendimers. These materials are also useful in a method for regeneration or repair of tissue or cells forming tissue.
摘要翻译： 已经开发了一种防止或限制粘连形成的方法，即在没有或在出血或泄漏之后基本上停止了有此需要的部位，形成粘连形成屏障的自组装材料 。 在某些实施方案中，自组装材料是肽模拟物，核苷酸模拟物，二 - 和三嵌段共聚物，N-烷基丙烯酰胺或树枝状物。 这些材料也可用于组织或细胞形成组织的再生或修复方法。
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2.发明授权Treatment of leaky or damaged tight junctions and enhancing extracellular matrix 有权治疗渗漏或损伤的紧密连接并增强细胞外基质公开(公告)号：US09415084B2
公开(公告)日：2016-08-16
申请号：US12049190
申请日：2008-03-14
摘要： Self assembling peptides and peptidomimetics can be utilized for the treatment and support of disorders associated with leaky or damaged tight junction and weak, diseased, or injured extracellular matrix. The self-assembling materials generally have alternating hydrophilic or hydrophobic residues or hydrophobic and/or hydrophilic sections which allow the material to react or interact with the glycoproteins found in the ECM. Diseases in which treatment with these materials applied to or near the site in need of treatment include diabetic retinopathy, sepsis, burns, and certain neurodegenerative diseases such as Parkinson's and Alzheimer's. The formulations can be administered by injection, spraying, topically or by catheter or via a wound dressing or other material to which it is applied and then applied to the site in need of treatment.
摘要翻译： 自组装肽和肽模拟物可用于治疗和支持与渗漏或损伤的紧密连接和弱的，患病的或受损的细胞外基质相关的疾病。 自组装材料通常具有交替的亲水或疏水残基或疏水和/或亲水部分，其允许材料与ECM中发现的糖蛋白反应或相互作用。 应用于需要治疗的部位或附近的这些材料的治疗的疾病包括糖尿病性视网膜病变，败血症，烧伤和某些神经变性疾病如帕金森病和阿尔茨海默病。 制剂可以通过注射，喷雾，局部地或通过导管或通过其施用的伤口敷料或其它材料来施用，然后施用于需要治疗的部位。
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3.发明申请TREATMENT OF LEAKY OR DAMAGED TIGHT JUNCTIONS AND ENHANCING EXTRACELLULAR MATRIX 有权泄漏或损伤的轻微结节的治疗和增强细胞外基质公开(公告)号：US20080274979A1
公开(公告)日：2008-11-06
申请号：US12049190
申请日：2008-03-14
摘要： Self assembling peptides and peptidomimetics can be utilized for the treatment and support of disorders associated with leaky or damaged tight junction and weak, diseased, or injured extracellular matrix. The self-assembling materials generally have alternating hydrophilic or hydrophobic residues or hydrophobic and/or hydrophilic sections which allow the material to react or interact with the glycoproteins found in the ECM. Diseases in which treatment with these materials applied to or near the site in need of treatment include diabetic retinopathy, sepsis, burns, and certain neurodegenerative diseases such as Parkinson's and Alzheimer's. The formulations can be administered by injection, spraying, topically or by catheter or via a wound dressing or other material to which it is applied and then applied to the site in need of treatment.
摘要翻译： 自组装肽和肽模拟物可用于治疗和支持与渗漏或损伤的紧密连接和弱的，患病的或受损的细胞外基质相关的疾病。 自组装材料通常具有交替的亲水或疏水残基或疏水和/或亲水部分，其允许材料与ECM中发现的糖蛋白反应或相互作用。 应用于需要治疗的部位或附近的这些材料的治疗的疾病包括糖尿病性视网膜病变，败血症，烧伤和某些神经变性疾病如帕金森病和阿尔茨海默病。 制剂可以通过注射，喷雾，局部地或通过导管或通过其施用的伤口敷料或其它材料来施用，然后施用于需要治疗的部位。
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