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1.发明授权公开(公告)号：US09162005B2
公开(公告)日：2015-10-20
申请号：US11740284
申请日：2007-04-25
CPC分类号： A61K38/10 , A61L15/42 , A61L26/0061
摘要： A method has been developed of preventing or limiting formation of adhesions by administering to a site in need thereof, in the absence of or after bleeding or leakage of fluid has been substantially stopped, a self-assembling material which forms a barrier to formation of adhesions. In certain embodiments, the self assembling materials are peptidomimetics, nucleotidomimetics, di- and triblock copolymers, N-alkylacrylamides, or dendimers. These materials are also useful in a method for regeneration or repair of tissue or cells forming tissue.
摘要翻译： 已经开发了一种防止或限制粘连形成的方法，即在没有或在出血或泄漏之后基本上停止了有此需要的部位，形成粘连形成屏障的自组装材料 。 在某些实施方案中，自组装材料是肽模拟物，核苷酸模拟物，二 - 和三嵌段共聚物，N-烷基丙烯酰胺或树枝状物。 这些材料也可用于组织或细胞形成组织的再生或修复方法。
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2.发明申请公开(公告)号：US20080032934A1
公开(公告)日：2008-02-07
申请号：US11740284
申请日：2007-04-25
CPC分类号： A61K38/10 , A61L15/42 , A61L26/0061
摘要： A method has been developed of preventing or limiting formation of adhesions by administering to a site in need thereof, in the absence of or after bleeding or leakage of fluid has been substantially stopped, a self-assembling material which forms a barrier to formation of adhesions. In one embodiment, the self-assembling material comprises peptides having a sequence of amino acid residues conforming to one or more of Formulas I-IV: ((Xaa°′−Xaa+)x(Xaane1_Xaa−)y)n (I); ((Xaa′_Xaa)x(Xaa°e°−Xaa+)y)n (II); ((Xaa+−Xaa″e1)x(Xaa−Xaa″)y)n (III); and ((Xaa−XaaQe7)x(Xaa+Xaa1e″)y)n (IV), where Xaan′ represents an amino acid residue having a neutral charge; Xaa+ represents an amino acid residue having a positive charge; Xaa represents an amino acid residue having a negative charge; x and y are integers having a value of 1, 2 or 4, independently; and n is an integer having a value of 1-5. In another embodiment, the self assembling materials are peptidomimetics, nucleotidomimetics, di- and triblock copolymers, N-alkylacrylamides, or dendimers. These materials are also useful in a method for regeneration or repair of tissue or cells forming tissue.
摘要翻译： 已经开发了一种防止或限制粘连形成的方法，即在没有或在出血或泄漏之后基本上停止了有此需要的部位，形成粘连形成屏障的自组装材料 。 在一个实施方案中，自组装材料包含具有符合式I-IV中的一个或多个的氨基酸残基序列的肽：（（Xaa'-Xaa +）x（Xaa1-Xaa-）y）n（I）; （（Xaa'_Xaa）x（Xaa°e°-Xaa +）y）n（II）; （（Xaa + -Xaa“e1）x（Xaa-Xaa”）y）n（III）; 和（（Xaa-XaaQe7）x（Xaa + Xaa1e“）y）n（IV），其中Xaan'表示具有中性电荷的氨基酸残基; Xaa +表示具有正电荷的氨基酸残基; Xaa代表具有负电荷的氨基酸残基; x和y分别为1,2或4的整数; n为1〜5的整数。 在另一个实施方案中，自组装材料是肽模拟物，核苷酸模拟物，二 - 和三嵌段共聚物，N-烷基丙烯酰胺或树枝状体。 这些材料也可用于组织或细胞形成组织的再生或修复方法。
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3.发明授权Treatment of leaky or damaged tight junctions and enhancing extracellular matrix 有权治疗渗漏或损伤的紧密连接并增强细胞外基质公开(公告)号：US09415084B2
公开(公告)日：2016-08-16
申请号：US12049190
申请日：2008-03-14
摘要： Self assembling peptides and peptidomimetics can be utilized for the treatment and support of disorders associated with leaky or damaged tight junction and weak, diseased, or injured extracellular matrix. The self-assembling materials generally have alternating hydrophilic or hydrophobic residues or hydrophobic and/or hydrophilic sections which allow the material to react or interact with the glycoproteins found in the ECM. Diseases in which treatment with these materials applied to or near the site in need of treatment include diabetic retinopathy, sepsis, burns, and certain neurodegenerative diseases such as Parkinson's and Alzheimer's. The formulations can be administered by injection, spraying, topically or by catheter or via a wound dressing or other material to which it is applied and then applied to the site in need of treatment.
摘要翻译： 自组装肽和肽模拟物可用于治疗和支持与渗漏或损伤的紧密连接和弱的，患病的或受损的细胞外基质相关的疾病。 自组装材料通常具有交替的亲水或疏水残基或疏水和/或亲水部分，其允许材料与ECM中发现的糖蛋白反应或相互作用。 应用于需要治疗的部位或附近的这些材料的治疗的疾病包括糖尿病性视网膜病变，败血症，烧伤和某些神经变性疾病如帕金森病和阿尔茨海默病。 制剂可以通过注射，喷雾，局部地或通过导管或通过其施用的伤口敷料或其它材料来施用，然后施用于需要治疗的部位。
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4.发明申请TREATMENT OF LEAKY OR DAMAGED TIGHT JUNCTIONS AND ENHANCING EXTRACELLULAR MATRIX 有权泄漏或损伤的轻微结节的治疗和增强细胞外基质公开(公告)号：US20080274979A1
公开(公告)日：2008-11-06
申请号：US12049190
申请日：2008-03-14
摘要： Self assembling peptides and peptidomimetics can be utilized for the treatment and support of disorders associated with leaky or damaged tight junction and weak, diseased, or injured extracellular matrix. The self-assembling materials generally have alternating hydrophilic or hydrophobic residues or hydrophobic and/or hydrophilic sections which allow the material to react or interact with the glycoproteins found in the ECM. Diseases in which treatment with these materials applied to or near the site in need of treatment include diabetic retinopathy, sepsis, burns, and certain neurodegenerative diseases such as Parkinson's and Alzheimer's. The formulations can be administered by injection, spraying, topically or by catheter or via a wound dressing or other material to which it is applied and then applied to the site in need of treatment.
摘要翻译： 自组装肽和肽模拟物可用于治疗和支持与渗漏或损伤的紧密连接和弱的，患病的或受损的细胞外基质相关的疾病。 自组装材料通常具有交替的亲水或疏水残基或疏水和/或亲水部分，其允许材料与ECM中发现的糖蛋白反应或相互作用。 应用于需要治疗的部位或附近的这些材料的治疗的疾病包括糖尿病性视网膜病变，败血症，烧伤和某些神经变性疾病如帕金森病和阿尔茨海默病。 制剂可以通过注射，喷雾，局部地或通过导管或通过其施用的伤口敷料或其它材料来施用，然后施用于需要治疗的部位。
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5.发明授权公开(公告)号：US09364513B2
公开(公告)日：2016-06-14
申请号：US12199670
申请日：2008-08-27
申请人： Rutledge Ellis-Behnke , Shuguang Zhang , Gerald Schneider , Kwok-Fai So , David Tay , Yu-Xiang Liang
发明人： Rutledge Ellis-Behnke , Shuguang Zhang , Gerald Schneider , Kwok-Fai So , David Tay , Yu-Xiang Liang
CPC分类号： A61L26/0047 , A61K9/0019 , A61K38/08 , A61K38/10 , A61L26/0066 , A61L2400/04
摘要： Compositions that include nanoscale structured materials or precursors thereof (e.g., self-assembling peptides) are described. The compositions can include other substances (e.g., a vasoconstrictor). Also described are methods for using the compositions to promote hemostasis, to protect the skin or wounds from contamination, to decontaminate a site upon removal of previously applied compositions that provided a protective coating, and to inhibit the movement of bodily substances other than blood. The compositions are also useful in isolating tissue, removing tissue, preserving tissue (for, e.g., subsequent transplantation or reattachment), and as bulking, stabilizing or hydrating agents. Medical devices that include the compositions (e.g., a stent or catheter), bandages or other wound dressings, sutures, and kits that include the compositions are also described.
摘要翻译： 描述了包括纳米尺度结构材料或其前体（例如，自组装肽）的组合物。 组合物可以包括其它物质（例如血管收缩剂）。 还描述了使用组合物促进止血，保护皮肤或伤口免受污染，去除先前施用的提供保护性涂层的组合物并去除除了血液以外的身体物质的运动时去除部位的方法。 组合物还可用于分离组织，去除组织，保存组织（例如，随后的移植或重新连接）以及作为膨胀，稳定或保湿剂。 还描述了包括组合物（例如支架或导管），绷带或其他伤口敷料，缝合线和包括组合物的试剂盒的医疗装置。
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6.发明申请Nano Cancer Barrier Device (NCBD) to Immobilize and Inhibit the Division of Metastic Cancer Stem Cells 有权纳米癌屏障装置（NCBD）固定和抑制甲状腺癌干细胞的分裂公开(公告)号：US20110144023A1
公开(公告)日：2011-06-16
申请号：US12967708
申请日：2010-12-14
摘要： The present invention provides methods, compositions, and kits wherein nanomaterials are used for inhibiting cancer stem cell division, colony formation, spheroid formation and self-renewal. The present invention also provides methods, compositions, and kits wherein nanomaterials are used for treating cancer, coating tumors, and inhibiting metastasis. The present invention also provides methods, compositions, and kits wherein nanomaterials are used for inducing cells to go into stasis. The present invention further provides methods for isolating tumors, inhibiting bleeding, and marking margins of tumors and organs during surgery with a nanomaterial.
摘要翻译： 本发明提供了方法，组合物和试剂盒，其中纳米材料用于抑制癌症干细胞分裂，集落形成，球形成和自我更新。 本发明还提供方法，组合物和试剂盒，其中纳米材料用于治疗癌症，涂覆肿瘤和抑制转移。 本发明还提供了使用纳米材料诱导细胞进入淤滞的方法，组合物和试剂盒。 本发明还提供了用纳米材料在手术期间分离肿瘤，抑制出血和标记肿瘤和器官的边缘的方法。
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公开(公告)号：US07846891B2
公开(公告)日：2010-12-07
申请号：US10968790
申请日：2004-10-18
摘要： The present invention provides methods and compositions for enhancing regeneration and/or repair of neural tissue. One method include providing a nanoscale structured material at the site of injury, wherein the nanoscale structured material provides an environment that is permissive for regeneration of neural tissue and allows axon growth from a location on one side of a site of injury or barrier to a location on the other side of the site of injury or barrier. A second method includes introducing a composition comprising self-assembling peptides into the subject at the site of injury, wherein the peptides are amphiphilic peptides that comprise substantially equal proportions of hydrophobic and hydrophilic amino acids and are complementary and structurally compatible. A variety of compositions comprising a nanoscale structured material or precursor thereof, and an additional substance such as a regeneration promoting factor, are also provided. In certain embodiments of the invention the nanoscale structured material or precursor thereof comprises self-assembling peptides. The invention further provides compositions and methods for repair of an intervertebral disc, including nucleus pulpusos repair.
摘要翻译： 本发明提供用于增强神经组织再生和/或修复的方法和组合物。 一种方法包括在损伤部位提供纳米尺度结构材料，其中纳米尺度结构材料提供允许神经组织再生的环境，并允许轴突生长从受伤部位或障碍物位置一侧的位置 在伤害或障碍场所的另一边。 第二种方法包括将包含自组装肽的组合物在损伤部位引入受试者，其中所述肽是包含基本上相等比例的疏水和亲水氨基酸并且互补和结构相容的两亲性肽。 还提供了包含纳米尺度结构材料或其前体的多种组合物和另外的物质如再生促进因子。 在本发明的某些实施方案中，纳米级结构材料或其前体包含自组装肽。 本发明还提供了用于修复椎间盘的组合物和方法，包括髓核修复。
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8.发明申请公开(公告)号：US20070203062A1
公开(公告)日：2007-08-30
申请号：US11411745
申请日：2006-04-25
申请人： Rutledge Ellis-Behnke , Shuguang Zhang , Gerald Schneider , Kwok-Fai So , David Tay , Yu-Xiang Liang
发明人： Rutledge Ellis-Behnke , Shuguang Zhang , Gerald Schneider , Kwok-Fai So , David Tay , Yu-Xiang Liang
CPC分类号： A61L26/0047 , A61K9/0019 , A61K38/08 , A61K38/10 , A61L26/0066 , A61L2400/04
摘要： Compositions that include nanoscale structured materials or precursors thereof (e.g., self-assembling peptides) are described. The compositions can include other substances (e.g., a vasoconstrictor). Also described are methods for using the compositions to promote hemostasis, to protect the skin or wounds from contamination, to decontaminate a site upon removal of previously applied compositions that provided a protective coating, and to inhibit the movement of bodily substances other than blood. The compositions are also useful in isolating tissue, removing tissue, preserving tissue (for, e.g., subsequent transplantation or reattachment), and as bulking, stabilizing or hydrating agents. Medical devices that include the compositions (e.g., a stent or catheter), bandages or other wound dressings, sutures, and kits that include the compositions are also described.
摘要翻译： 描述了包括纳米尺度结构材料或其前体（例如，自组装肽）的组合物。 组合物可以包括其它物质（例如血管收缩剂）。 还描述了使用组合物促进止血，保护皮肤或伤口免受污染，去除先前施用的提供保护性涂层的组合物并去除除了血液以外的身体物质的运动时去除部位的方法。 组合物还可用于分离组织，去除组织，保存组织（例如，随后的移植或重新连接）以及作为膨胀，稳定或保湿剂。 还描述了包括组合物（例如支架或导管），绷带或其他伤口敷料，缝合线和包括组合物的试剂盒的医疗装置。
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9.发明授权Nano cancer barrier device (NCBD) to immobilize and inhibit the division of metastic cancer stem cells 有权纳米癌症屏障装置（NCBD）用于固定和抑制转移性干细胞的分裂公开(公告)号：US09439941B2
公开(公告)日：2016-09-13
申请号：US12967708
申请日：2010-12-14
摘要： The present invention provides methods, compositions, and kits wherein nanomaterials are used for inhibiting cancer stem cell division, colony formation, spheroid formation and self-renewal. The present invention also provides methods, compositions, and kits wherein nanomaterials are used for treating cancer, coating tumors, and inhibiting metastasis. The present invention also provides methods, compositions, and kits wherein nanomaterials are used for inducing cells to go into stasis. The present invention further provides methods for isolating tumors, inhibiting bleeding, and marking margins of tumors and organs during surgery with a nanomaterial.
摘要翻译： 本发明提供了方法，组合物和试剂盒，其中纳米材料用于抑制癌症干细胞分裂，集落形成，球形成和自我更新。 本发明还提供方法，组合物和试剂盒，其中纳米材料用于治疗癌症，涂覆肿瘤和抑制转移。 本发明还提供了使用纳米材料诱导细胞进入淤滞的方法，组合物和试剂盒。 本发明还提供了用纳米材料在手术期间分离肿瘤，抑制出血和标记肿瘤和器官的边缘的方法。
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公开(公告)号：US09327010B2
公开(公告)日：2016-05-03
申请号：US11411745
申请日：2006-04-25
申请人： Rutledge Ellis-Behnke , Shuguang Zhang , Gerald Schneider , Kwok-Fai So , David Tay , Yu-Xiang Liang
发明人： Rutledge Ellis-Behnke , Shuguang Zhang , Gerald Schneider , Kwok-Fai So , David Tay , Yu-Xiang Liang
CPC分类号： A61L26/0047 , A61K9/0019 , A61K38/08 , A61K38/10 , A61L26/0066 , A61L2400/04
摘要： Compositions that include nanoscale structured materials or precursors thereof (e.g., self-assembling peptides) are described. The compositions can include other substances (e.g., a vasoconstrictor). Also described are methods for using the compositions to promote hemostasis, to protect the skin or wounds from contamination, to decontaminate a site upon removal of previously applied compositions that provided a protective coating, and to inhibit the movement of bodily substances other than blood. The compositions are also useful in isolating tissue, removing tissue, preserving tissue (for, e.g., subsequent transplantation or reattachment), and as bulking, stabilizing or hydrating agents. Medical devices that include the compositions (e.g., a stent or catheter), bandages or other wound dressings, sutures, and kits that include the compositions are also described.
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