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1.发明授权Treatment of leaky or damaged tight junctions and enhancing extracellular matrix 有权治疗渗漏或损伤的紧密连接并增强细胞外基质公开(公告)号：US09415084B2
公开(公告)日：2016-08-16
申请号：US12049190
申请日：2008-03-14
摘要： Self assembling peptides and peptidomimetics can be utilized for the treatment and support of disorders associated with leaky or damaged tight junction and weak, diseased, or injured extracellular matrix. The self-assembling materials generally have alternating hydrophilic or hydrophobic residues or hydrophobic and/or hydrophilic sections which allow the material to react or interact with the glycoproteins found in the ECM. Diseases in which treatment with these materials applied to or near the site in need of treatment include diabetic retinopathy, sepsis, burns, and certain neurodegenerative diseases such as Parkinson's and Alzheimer's. The formulations can be administered by injection, spraying, topically or by catheter or via a wound dressing or other material to which it is applied and then applied to the site in need of treatment.
摘要翻译： 自组装肽和肽模拟物可用于治疗和支持与渗漏或损伤的紧密连接和弱的，患病的或受损的细胞外基质相关的疾病。 自组装材料通常具有交替的亲水或疏水残基或疏水和/或亲水部分，其允许材料与ECM中发现的糖蛋白反应或相互作用。 应用于需要治疗的部位或附近的这些材料的治疗的疾病包括糖尿病性视网膜病变，败血症，烧伤和某些神经变性疾病如帕金森病和阿尔茨海默病。 制剂可以通过注射，喷雾，局部地或通过导管或通过其施用的伤口敷料或其它材料来施用，然后施用于需要治疗的部位。
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2.发明申请公开(公告)号：US20120010140A1
公开(公告)日：2012-01-12
申请号：US12960607
申请日：2010-12-06
摘要： The present invention provides methods and compositions for enhancing regeneration and/or repair of neural tissue. One method include providing a nanoscale structured material at the site of injury, wherein the nanoscale structured material provides an environment that is permissive for regeneration of neural tissue and allows axon growth from a location on one side of a site of injury or barrier to a location on the other side of the site of injury or barrier. A second method includes introducing a composition comprising self-assembling peptides into the subject at the site of injury, wherein the peptides are amphiphilic peptides that comprise substantially equal proportions of hydrophobic and hydrophilic amino acids and are complementary and structurally compatible. A variety of compositions comprising a nanoscale structured material or precursor thereof, and an additional substance such as a regeneration promoting factor, are also provided. In certain embodiments of the invention the nanoscale structured material or precursor thereof comprises self-assembling peptides. The invention further provides compositions and methods for repair of an intervertebral disc, including nucleus pulpusos repair.
摘要翻译： 本发明提供用于增强神经组织再生和/或修复的方法和组合物。 一种方法包括在损伤部位提供纳米尺度结构材料，其中纳米尺度结构材料提供允许神经组织再生的环境，并允许轴突生长从受伤部位或障碍物位置一侧的位置 在伤害或障碍场所的另一边。 第二种方法包括将包含自组装肽的组合物在损伤部位引入受试者，其中所述肽是包含基本上相等比例的疏水和亲水氨基酸并且互补和结构相容的两亲性肽。 还提供了包含纳米尺度结构材料或其前体的多种组合物和另外的物质如再生促进因子。 在本发明的某些实施方案中，纳米级结构材料或其前体包含自组装肽。 本发明还提供了用于修复椎间盘的组合物和方法，包括髓核修复。
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3.发明申请COMPOSITIONS AND METHODS FOR CONTROLLING PROLIFERATION AND DIFFERENTIATION OF CELLS 有权用于控制细胞增殖和分化的组合物和方法公开(公告)号：US20110150844A1
公开(公告)日：2011-06-23
申请号：US12966612
申请日：2010-12-13
CPC分类号： A61K38/10 , A61K35/12 , C12N5/0068 , C12N2533/50
摘要： Methods and compositions for modulating cell differentiation, proliferation and morphology in vitro or in vivo are described. The methods include modifying the extracellular nanoenvironment of stem cells with a self-assembling peptide nanofiber scaffold. The extracellular nanoenvironment can be modified by changing the percentage of self-assembling peptides used to form the nanofiber scaffold, the concentration of cells in the nanofiber scaffold, the pH, or the amounts of serum. Modulating the extracellular nanoenvironment of cells in nanofiber scaffold allows for increased targeting of cell placement and therapeutic delivery, amplified by cell encapsulation and implantation.
摘要翻译： 描述了用于在体外或体内调节细胞分化，增殖和形态的方法和组合物。 方法包括用自组装肽纳米纤维支架修饰干细胞的细胞外纳环境。 可以通过改变用于形成纳米纤维支架的自组装肽的百分比，纳米纤维支架中的细胞浓度，pH或血清的量来修饰细胞外的纳米环境。 在纳米纤维支架中调节细胞的细胞外纳米环境允许增加细胞放置和治疗递送的靶向，通过细胞包封和植入来扩增。
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4.发明申请COMPOSITIONS AND METHODS FOR PROMOTING HEMOSTASIS AND OTHER PHYSIOLOGICAL ACTIVITIES 有权用于促进HEMOSTASIS和其他生理活动的组合物和方法公开(公告)号：US20090111734A1
公开(公告)日：2009-04-30
申请号：US12199670
申请日：2008-08-27
申请人： Rutledge Ellis-Behnke , Shuguang Zhang , Gerald Schneider , Kwok-Fai So , David Tay , Yu-Xiang Liang
发明人： Rutledge Ellis-Behnke , Shuguang Zhang , Gerald Schneider , Kwok-Fai So , David Tay , Yu-Xiang Liang
CPC分类号： A61L26/0047 , A61K9/0019 , A61K38/08 , A61K38/10 , A61L26/0066 , A61L2400/04
摘要： Compositions that include nanoscale structured materials or precursors thereof (e.g., self-assembling peptides) are described. The compositions can include other substances (e.g., a vasoconstrictor). Also described are methods for using the compositions to promote hemostasis, to protect the skin or wounds from contamination, to decontaiminate a site upon removal of previously applied compositions that provided a protective coating, and to inhibit the movement of bodily substances other than blood. The compositions are also useful in isolating tissue, removing tissue, preserving tissue (for, e.g., subsequent transplantation or reattachment), and as bulking, stabilizing or hydrating agents. Medical devices that include the compositions (e.g., a stent or catheter), bandages or other wound dressings, sutures, and kits that include the compositions are also described.
摘要翻译： 描述了包括纳米尺度结构材料或其前体（例如，自组装肽）的组合物。 组合物可以包括其它物质（例如血管收缩剂）。 还描述了使用组合物促进止血，保护皮肤或伤口免受污染，去除先前施用的提供保护涂层的组合物并且抑制除了血液之外的身体物质的运动来去除部位的方法。 组合物还可用于分离组织，去除组织，保存组织（例如，随后的移植或重新连接）以及作为膨胀，稳定或保湿剂。 还描述了包括组合物（例如支架或导管），绷带或其他伤口敷料，缝合线和包括组合物的试剂盒的医疗装置。
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5.发明申请TREATMENT OF LEAKY OR DAMAGED TIGHT JUNCTIONS AND ENHANCING EXTRACELLULAR MATRIX 有权泄漏或损伤的轻微结节的治疗和增强细胞外基质公开(公告)号：US20080274979A1
公开(公告)日：2008-11-06
申请号：US12049190
申请日：2008-03-14
摘要： Self assembling peptides and peptidomimetics can be utilized for the treatment and support of disorders associated with leaky or damaged tight junction and weak, diseased, or injured extracellular matrix. The self-assembling materials generally have alternating hydrophilic or hydrophobic residues or hydrophobic and/or hydrophilic sections which allow the material to react or interact with the glycoproteins found in the ECM. Diseases in which treatment with these materials applied to or near the site in need of treatment include diabetic retinopathy, sepsis, burns, and certain neurodegenerative diseases such as Parkinson's and Alzheimer's. The formulations can be administered by injection, spraying, topically or by catheter or via a wound dressing or other material to which it is applied and then applied to the site in need of treatment.
摘要翻译： 自组装肽和肽模拟物可用于治疗和支持与渗漏或损伤的紧密连接和弱的，患病的或受损的细胞外基质相关的疾病。 自组装材料通常具有交替的亲水或疏水残基或疏水和/或亲水部分，其允许材料与ECM中发现的糖蛋白反应或相互作用。 应用于需要治疗的部位或附近的这些材料的治疗的疾病包括糖尿病性视网膜病变，败血症，烧伤和某些神经变性疾病如帕金森病和阿尔茨海默病。 制剂可以通过注射，喷雾，局部地或通过导管或通过其施用的伤口敷料或其它材料来施用，然后施用于需要治疗的部位。
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6.发明申请Compositions and methods for affecting movement of contaminants, bodily fluids or other entities, and/or affecting other physiological conditions 有权影响污染物，体液或其他实体运动的组合物和方法，和/或影响其他生理条件公开(公告)号：US20080091233A1
公开(公告)日：2008-04-17
申请号：US11796132
申请日：2007-04-25
IPC分类号： A61L24/00
CPC分类号： A61K38/10 , A61K31/167 , A61L15/42 , A61L26/0061
摘要： Compositions which self-assemble under physiological conditions are formulated for application to wounds. The formulations include a pharmaceutically acceptable carrier or are provided as part of a medical device or coating. The formulations may also include other therapeutic, prophylactic or diagnostic agents. The formulation can be administered as appropriate for treatment of one or more disorders or conditions. For example, the formulation may be applied to repair an injury or during surgery of the lung, eye or dura, or following an epidural or spinal tap, to stop leakage of blood, interstitial fluid, or cerebrospinal fluid. The formulation may be administered to a burn or ulcer. The formulation may be dispersed in a suture or adhesive for administration at the time of or as released following suturing or gluing of a wound, thereby limiting bleeding, loss of tissue fluids, or other fluids such as those produced by parenchymal tissues such as the liver, pancreas, and gastrointestinal tract. The formulation may be applied to any site of bleeding, in a bandage, gauze, sponge, or other material, for immediate control of bleeding, or released later to control bleeding if the initial treatment such as suturing or pressure is insufficient. In one embodiment, the formulation is provided as a dry or lyophilized powder. In another embodiment, the material is provided in water. In another embodiment, the material is provided in combination with an oil and forms a laminate. In another embodiment, the formulation is provided as a coating on a device, for example a stent or a catheter. The material is also useful to isolate tissue, for preservation of tissue for subsequent transplantation or reattachment, and as a bulking, stabilizing or hydrating agent.
摘要翻译： 在生理条件下自组装的组合物被配制成用于伤口。 制剂包括药学上可接受的载体或作为医疗装置或涂层的一部分提供。 制剂还可以包括其它治疗剂，预防剂或诊断剂。 可以适当地施用制剂以治疗一种或多种病症或病症。 例如，该制剂可用于修复损伤或手术期间的肺，眼或硬膜，或硬膜外或脊髓抽头后，以阻止血液，间质液或脑脊液的渗漏。 制剂可以施用于烧伤或溃疡。 制剂可以分散在缝合线或粘合剂中，用于在缝合或胶合伤口之后进行施用或释放，从而限制出血，组织液或其它流体的损失，例如由实质组织如肝脏产生的那些 ，胰腺和胃肠道。 制剂可以应用于任何出血部位，绷带，纱布，海绵或其他材料，以便立即控制出血，或者如果初始治疗如缝合或压力不足，则稍后释放以控制出血。 在一个实施方案中，制剂作为干燥或冻干粉末提供。 在另一个实施方案中，将材料提供在水中。 在另一个实施方案中，该材料与油组合提供并形成层压体。 在另一个实施方案中，所述制剂作为涂层提供在装置例如支架或导管上。 该材料也可用于分离组织，用于保存用于随后的移植或再附着的组织，以及作为膨胀，稳定或保湿剂。
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公开(公告)号：US20060199778A1
公开(公告)日：2006-09-07
申请号：US10489512
申请日：2002-09-19
IPC分类号： A61K48/00 , A61K31/724 , A61K39/02
CPC分类号： B82Y5/00 , A61K31/724 , A61K47/6415 , A61K47/6951 , A61K48/00 , C12N15/87 , Y02A50/471 , Y02A50/473
摘要： The invention relates to compositions and methods for the non-viral delivery of nucleic acid molecules and/or organelles to cells in vitro and in vivo. The non-viral delivery complexes provided by the invention comprise cholera toxin B subunit or functional equivalents thereof and preferably cyclodextrin.
摘要翻译： 本发明涉及在体外和体内将核酸分子和/或细胞器非病毒递送至细胞的组合物和方法。 由本发明提供的非病毒递送复合物包含霍乱毒素B亚基或其功能等同物，优选环糊精。
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公开(公告)号：US20050287186A1
公开(公告)日：2005-12-29
申请号：US10968790
申请日：2004-10-18
摘要： The present invention provides methods and compositions for enhancing regeneration and/or repair of neural tissue. One method include providing a nanoscale structured material at the site of injury, wherein the nanoscale structured material provides an environment that is permissive for regeneration of neural tissue and allows axon growth from a location on one side of a site of injury or barrier to a location on the other side of the site of injury or barrier. A second method includes introducing a composition comprising self-assembling peptides into the subject at the site of injury, wherein the peptides are amphiphilic peptides that comprise substantially equal proportions of hydrophobic and hydrophilic amino acids and are complementary and structurally compatible. A variety of compositions comprising a nanoscale structured material or precursor thereof, and an additional substance such as a regeneration promoting factor, are also provided. In certain embodiments of the invention the nanoscale structured material or precursor thereof comprises self-assembling peptides. The invention further provides compositions and methods for repair of an intervertebral disc, including nucleus pulpusos repair.
摘要翻译： 本发明提供用于增强神经组织再生和/或修复的方法和组合物。 一种方法包括在损伤部位提供纳米尺度结构材料，其中纳米尺度结构材料提供允许神经组织再生的环境，并允许轴突生长从受伤部位或障碍物位置一侧的位置 在伤害或障碍场所的另一边。 第二种方法包括将包含自组装肽的组合物在损伤部位引入受试者，其中所述肽是包含基本上相等比例的疏水和亲水氨基酸并且互补和结构相容的两亲性肽。 还提供了包含纳米尺度结构材料或其前体的多种组合物和另外的物质如再生促进因子。 在本发明的某些实施方案中，纳米级结构材料或其前体包含自组装肽。 本发明还提供了用于修复椎间盘的组合物和方法，包括髓核修复。
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公开(公告)号：US09327010B2
公开(公告)日：2016-05-03
申请号：US11411745
申请日：2006-04-25
申请人： Rutledge Ellis-Behnke , Shuguang Zhang , Gerald Schneider , Kwok-Fai So , David Tay , Yu-Xiang Liang
发明人： Rutledge Ellis-Behnke , Shuguang Zhang , Gerald Schneider , Kwok-Fai So , David Tay , Yu-Xiang Liang
CPC分类号： A61L26/0047 , A61K9/0019 , A61K38/08 , A61K38/10 , A61L26/0066 , A61L2400/04
摘要： Compositions that include nanoscale structured materials or precursors thereof (e.g., self-assembling peptides) are described. The compositions can include other substances (e.g., a vasoconstrictor). Also described are methods for using the compositions to promote hemostasis, to protect the skin or wounds from contamination, to decontaminate a site upon removal of previously applied compositions that provided a protective coating, and to inhibit the movement of bodily substances other than blood. The compositions are also useful in isolating tissue, removing tissue, preserving tissue (for, e.g., subsequent transplantation or reattachment), and as bulking, stabilizing or hydrating agents. Medical devices that include the compositions (e.g., a stent or catheter), bandages or other wound dressings, sutures, and kits that include the compositions are also described.
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10.发明授权公开(公告)号：US09162005B2
公开(公告)日：2015-10-20
申请号：US11740284
申请日：2007-04-25
CPC分类号： A61K38/10 , A61L15/42 , A61L26/0061
摘要： A method has been developed of preventing or limiting formation of adhesions by administering to a site in need thereof, in the absence of or after bleeding or leakage of fluid has been substantially stopped, a self-assembling material which forms a barrier to formation of adhesions. In certain embodiments, the self assembling materials are peptidomimetics, nucleotidomimetics, di- and triblock copolymers, N-alkylacrylamides, or dendimers. These materials are also useful in a method for regeneration or repair of tissue or cells forming tissue.
摘要翻译： 已经开发了一种防止或限制粘连形成的方法，即在没有或在出血或泄漏之后基本上停止了有此需要的部位，形成粘连形成屏障的自组装材料 。 在某些实施方案中，自组装材料是肽模拟物，核苷酸模拟物，二 - 和三嵌段共聚物，N-烷基丙烯酰胺或树枝状物。 这些材料也可用于组织或细胞形成组织的再生或修复方法。
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