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公开(公告)号：US20090182025A1
公开(公告)日：2009-07-16
申请号：US12300415
申请日：2007-06-07
申请人： Ryan Thomas Backer , Matthew Joseph Fisher , Sean Patrick Hollinshead , Steven Lee Kuklish , Edward C.R. Smith , Kumiko Takeuchi
发明人： Ryan Thomas Backer , Matthew Joseph Fisher , Sean Patrick Hollinshead , Steven Lee Kuklish , Edward C.R. Smith , Kumiko Takeuchi
IPC分类号： A61K31/425 , C07D275/03 , A61P25/00
CPC分类号： C07D275/03
摘要： This application relates to a substituted carboxamide compound of formula I, or a pharmaceutically acceptable salt thereof, as defined herein, a pharmaceutical composition thereof, and its use in treating pain.
摘要翻译： 本申请涉及如本文所定义的式I的取代的甲酰胺化合物或其药学上可接受的盐，其药物组合物及其在治疗疼痛中的用途。
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公开(公告)号：US07960419B2
公开(公告)日：2011-06-14
申请号：US12300415
申请日：2007-06-07
申请人： Ryan Thomas Backer , Matthew Joseph Fisher , Sean Patrick Hollinshead , Steven Lee Kuklish , Edward C R Smith , Kumiko Takeuchi
发明人： Ryan Thomas Backer , Matthew Joseph Fisher , Sean Patrick Hollinshead , Steven Lee Kuklish , Edward C R Smith , Kumiko Takeuchi
IPC分类号： A61K31/425 , C07D275/03 , A61P25/04
CPC分类号： C07D275/03
摘要： This application relates to a substituted carboxamide compound of formula I, or a pharmaceutically acceptable salt thereof, as defined herein, a pharmaceutical composition thereof, and its use in treating pain.
摘要翻译： 本申请涉及如本文所定义的式I的取代的甲酰胺化合物或其药学上可接受的盐，其药物组合物及其在治疗疼痛中的用途。
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公开(公告)号：US07314879B2
公开(公告)日：2008-01-01
申请号：US10500476
申请日：2003-01-21
申请人： Ryan Thomas Backer , Caño Ivan Collado , Oscar De Frutos-Garcia , Christopher William Doecke , Matthew Joseph Fisher , Steven Lee Kuklish , Vincent Mancuso , Michael John Martinelli , Jeffrey Thomas Mullaney , Paul Leslie Ornstein , Chaoyu Xie
发明人： Ryan Thomas Backer , Caño Ivan Collado , Oscar De Frutos-Garcia , Christopher William Doecke , Matthew Joseph Fisher , Steven Lee Kuklish , Vincent Mancuso , Michael John Martinelli , Jeffrey Thomas Mullaney , Paul Leslie Ornstein , Chaoyu Xie
IPC分类号： A61K31/496 , C07D401/12 , C07D405/12 , C07D407/12
CPC分类号： C07D217/26 , C07D209/44 , C07D211/26 , C07D211/96 , C07D295/033 , C07D309/04 , C07D335/02 , C07D401/12 , C07D405/12 , C07D409/12
摘要： The present invention relates to melanocortin receptor agonist of the formula (I): which is useful in the treatment for obesity, diabetes, and male and/or female sexual dysfunction
摘要翻译： 本发明涉及式（I）的黑皮质素受体激动剂：其可用于治疗肥胖症，糖尿病和男性和/或女性性功能障碍
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4.发明授权公开(公告)号：US07157463B2
公开(公告)日：2007-01-02
申请号：US10466249
申请日：2002-01-23
申请人： Ryan Thomas Backer , Karin Briner , Christopher William Doecke , Matthew Joseph Fisher , Steven Lee Kuklish , Vincent Mancuso , Michael John Martinelli , Jeffrey Thomas Mullaney , Chaoyu Xie
发明人： Ryan Thomas Backer , Karin Briner , Christopher William Doecke , Matthew Joseph Fisher , Steven Lee Kuklish , Vincent Mancuso , Michael John Martinelli , Jeffrey Thomas Mullaney , Chaoyu Xie
IPC分类号： A61K31/496 , C07D401/12 , C07D403/12 , C07D403/14
CPC分类号： C07D401/12 , C07D209/44 , C07D217/26 , C07D401/14
摘要： The present invention relates to melanocortin receptor agonists of formula I, which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction
摘要翻译： 本发明涉及式I的黑皮质素受体激动剂，其可用于治疗肥胖症，糖尿病和男性和/或女性性功能障碍
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公开(公告)号：US07169777B2
公开(公告)日：2007-01-30
申请号：US10466250
申请日：2002-01-23
申请人： Ryan Thomas Backer , Karin Briner , Ivan Collado Caño , Oscar De Frutos Garcia , Christopher William Doecke , Matthew Joseph Fisher , Cristina Garcia-Paredes , Steven Lee Kuklish , Vincent Mancuso , Michael John Martinelli , Ana Isabel Mateo Herranz , Jeffrey Thomas Mullaney , Paul Leslie Ornstein , Zhipei Wu , Chaoyu Xie
发明人： Ryan Thomas Backer , Karin Briner , Ivan Collado Caño , Oscar De Frutos Garcia , Christopher William Doecke , Matthew Joseph Fisher , Cristina Garcia-Paredes , Steven Lee Kuklish , Vincent Mancuso , Michael John Martinelli , Ana Isabel Mateo Herranz , Jeffrey Thomas Mullaney , Paul Leslie Ornstein , Zhipei Wu , Chaoyu Xie
IPC分类号： A61K31/496 , A61K31/5377 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14 , A61K31/551
CPC分类号： C07D209/48 , A61K38/00 , C07D209/44 , C07D217/12 , C07D217/16 , C07D217/26 , C07K5/06191
摘要： The present invention relates to melanocortin receptor agonist of the formula I useful in the treatment of obesity, diabetes, and male and/or female sexual dysfunction
摘要翻译： 本发明涉及式I的黑皮质素受体激动剂，其用于治疗肥胖症，糖尿病以及男性和/或女性性功能障碍
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6.发明申请Novel Imidazole-2-Benzamide Compounds Useful for the Treatment of Osteoarthritis 失效用于治疗骨关节炎的新型咪唑-2-苯甲酰胺化合物公开(公告)号：US20120157506A1
公开(公告)日：2012-06-21
申请号：US13327803
申请日：2011-12-16
IPC分类号： A61K31/4168 , A61P29/00 , A61P25/00 , C07D233/88
CPC分类号： C07D233/88
摘要： The present invention provides compounds of the formula below or pharmaceutical salts thereof, wherein R1, R2 and R3 are as described herein; methods of treating osteoarthritis using the compounds; and a process for preparing the compounds.
摘要翻译： 本发明提供下式的化合物或其药用盐，其中R 1，R 2和R 3如本文所述; 使用该化合物治疗骨关节炎的方法; 和制备该化合物的方法。
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7.发明授权Imidazole-2-benzamide compounds useful for the treatment of osteoarthritis 失效可用于治疗骨关节炎的咪唑-2-苯甲酰胺化合物公开(公告)号：US08252831B2
公开(公告)日：2012-08-28
申请号：US13327803
申请日：2011-12-16
IPC分类号： A61K31/4168 , C07D233/88
CPC分类号： C07D233/88
摘要： The present invention provides compounds of the formula below or pharmaceutical salts thereof, wherein R1, R2 and R3 are as described herein; methods of treating osteoarthritis using the compounds; and a process for preparing the compounds.
摘要翻译： 本发明提供下式的化合物或其药用盐，其中R 1，R 2和R 3如本文所述; 使用该化合物治疗骨关节炎的方法; 和制备该化合物的方法。
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