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37 条记录 (耗时 0.035 秒)

    Thieno[2,3-d]pyrimidine derivatives and salts thereof
    5.
    发明授权
    Thieno[2,3-d]pyrimidine derivatives and salts thereof 失效
    噻吩并[2,3-d]嘧啶衍生物及其盐

    公开(公告)号：US4695568A

    公开(公告)日：1987-09-22

    申请号：US685768

    申请日：1984-12-24

    申请人： Kunihiro Ninomiya ,  Issei Nitta ,  Akihiro Tobe ,  Mitsuo Egawa ,  Ryoji Kikumoto

    发明人： Kunihiro Ninomiya ,  Issei Nitta ,  Akihiro Tobe ,  Mitsuo Egawa ,  Ryoji Kikumoto

    IPC分类号： A61K31/505 ,  A61K31/55 ,  A61P25/24 ,  A61P25/26 ,  A61P25/28 ,  C07D495/04 ,  A61K31/38 ,  C07D239/00

    CPC分类号： C07D495/04

    摘要： This invention relates novel thieno[2,3-d]pyrimidine derivatives represented by the following general formula (I): ##STR1## or salts thereof; wherein R.sup.1 and R.sup.2 independently represent hydrogen, halogen or alkyl group having 1 to 6 carbon atoms; or R.sup.1 and R.sup.2 may concatenate to form a cycloalkylene group having 5 or 6 ring carbon atoms; R.sup.3 and R.sup.4 independently represent hydrogen or alkyl group having 1 to 6 carbon atoms; R.sup.5 represents a member selected from(1) hydrogen or alkyl having 1 to 6 carbon atoms,(2) ##STR2## in which m is an integer of from 1 to 3 and X represents halogen, or (3) ##STR3## in which R.sup.6 represents alkyl group having 1 to 6 carbon atoms; Ar represents substituted or unsubstituted phenyl, or 2- or 3-thienyl group; and n is 2 or 3. The derivatives of the invention can be used in the treatment of the various depression disease or the higher dysfunction of the brain.

    摘要翻译： 本发明涉及由以下通式（I）表示的新颖的噻吩并[2,3-d]嘧啶衍生物或其盐; 其中R 1和R 2独立地表示氢，卤素或具有1至6个碳原子的烷基; 或者R1和R2可以连接形成具有5或6个环碳原子的亚环烷基; R3和R4独立地表示氢或具有1-6个碳原子的烷基; R5表示选自（1）氢或具有1至6个碳原子的烷基的成员，（2）其中m是1至3的整数，X表示卤素，或（3）其中 R6代表具有1-6个碳原子的烷基; Ar表示取代或未取代的苯基，或2-或3-噻吩基; 并且n为2或3.本发明的衍生物可用于治疗各种抑郁症或较高的脑功能障碍。

    O-aminoalkylene (or aminoalkyleneoxy) phenylsulfone compounds having anti-ulcer effect
    7.
    发明授权
    O-aminoalkylene (or aminoalkyleneoxy) phenylsulfone compounds having anti-ulcer effect 失效
    具有抗溃疡作用的O-氨基亚烷基（或氨基亚烷氧基）苯基砜化合物

    公开(公告)号：US4734500A

    公开(公告)日：1988-03-29

    申请号：US838569

    申请日：1986-03-11

    申请人： Akihiro Tobe ,  Shinichiro Fujimori ,  Tomoshi Yamazaki ,  Mamoru Sugano ,  Ryoji Kikumoto ,  Issei Nitta

    发明人： Akihiro Tobe ,  Shinichiro Fujimori ,  Tomoshi Yamazaki ,  Mamoru Sugano ,  Ryoji Kikumoto ,  Issei Nitta

    IPC分类号： A61K31/135 ,  A61K31/19 ,  A61K31/195 ,  A61K31/215 ,  A61K31/22 ,  A61K31/275 ,  A61K31/495 ,  A61P1/04 ,  C07C47/11 ,  C07C67/00 ,  C07C313/00 ,  C07C317/22 ,  C07C317/32 ,  C07C317/44 ,  C07C317/46 ,  C07C317/48 ,  C07D295/08 ,  C07D295/092 ,  C07D295/096 ,  C07D333/76 ,  C07D333/50

    CPC分类号： C07D295/096 ,  C07D295/088 ,  C07D333/76

    摘要： A novel sulfone compound represented by the general formula (I) ##STR1## wherein R.sup.1 is cyclohexyl, phenyl; or a phenyl substituted with a group selected from nitro, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy and halogen; R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are respectively hydrogen, halogen, cyano or carbonyl, wherein R.sup.1 and R.sup.2 may form an o-phenylene or an o-phenylene substituted with at least one group selected from nitro C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy and halogen; X is oxygen or methylene; Y is --(CH.sub.2).sub.n --, wherein n is an integer of 0, 5 or 6, or ##STR2## wherein m is an integer 1-3; R.sup.6 is hydrogen, C.sub.1 -C.sub.3 alkyl, .omega.-alkylaminoalkyl, wherein each alkyl has 1-3 carbon atoms, or .omega.-dialkylaminoalkyl, wherein each alkyl has 1-3 carbon atoms; R.sup.7 is hydrogen or C.sub.1 -C.sub.3 alkyl; and R.sup.6 and R.sup.7 may form a ring together with N, or ##STR3## wherein R.sup.8 is hydrogen, C.sub.1 -C.sub.3 hydroxyalkyl or phenyl; or a pharmaceutically acceptable salt thereof is disclosed. The compound has anti-ulcer effect.

    摘要翻译： 由通式（I）表示的新型砜化合物其中R 1是环己基，苯基; 或被选自硝基，C 1 -C 3烷基，C 1 -C 3烷氧基和卤素的基团取代的苯基; R2，R3，R4和R5分别是氢，卤素，氰基或羰基，其中R1和R2可以形成被至少一个选自硝基C1-C3烷基，C1-C3烷氧基的基团取代的邻亚苯基或邻亚苯基 和卤素; X是氧或亚甲基; Y是 - （CH 2）n - ，其中n是0或5或6的整数，或者其中m是整数1-3; R6是氢，C1-C3烷基，ω-烷基氨基烷基，其中每个烷基具有1-3个碳原子，或ω-二烷基氨基烷基，其中每个烷基具有1-3个碳原子; R7是氢或C1-C3烷基; 并且R 6和R 7可以与N或其中R 8是氢，C 1 -C 3羟基烷基或苯基形成环; 或其药学上可接受的盐。 该化合物具有抗溃疡作用。