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公开(公告)号：US6127390A
公开(公告)日：2000-10-03
申请号：US164482
申请日：1998-10-01
IPC分类号： C07D401/06 , A61K31/44
CPC分类号： C07D401/06
摘要： The present invention is directed to compounds which inhibit prenyl-protein transferase (FTase) and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.
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公开(公告)号：US5939439A
公开(公告)日：1999-08-17
申请号：US995744
申请日：1997-12-22
申请人： Neville J. Anthony , Samuel L. Graham , Lekhanh O. Tran , Ian M. Bell , S. Jane deSolms , Robert P. Gomez , Michelle Sparks Kuo , William C. Lumma, Jr. , Debra S. Perlow , Anthony W. Shaw , John S. Wai , Steven D. Young
发明人： Neville J. Anthony , Samuel L. Graham , Lekhanh O. Tran , Ian M. Bell , S. Jane deSolms , Robert P. Gomez , Michelle Sparks Kuo , William C. Lumma, Jr. , Debra S. Perlow , Anthony W. Shaw , John S. Wai , Steven D. Young
IPC分类号： C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/14 , C07D417/14 , C07D471/04 , C07D401/04 , A61K31/44
CPC分类号： C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/14 , C07D417/14 , C07D471/04
摘要： The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
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公开(公告)号：US06525074B2
公开(公告)日：2003-02-25
申请号：US09757251
申请日：2001-01-09
IPC分类号： C07D49818
CPC分类号： C07D403/04 , C07D413/04 , C07D419/04
摘要： The present invention is directed to peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.
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公开(公告)号：US06316436B1
公开(公告)日：2001-11-13
申请号：US09455627
申请日：1999-12-07
申请人： S. Jane deSolms , Anthony W. Shaw
发明人： S. Jane deSolms , Anthony W. Shaw
IPC分类号： A61K3155
CPC分类号： C07D498/18
摘要： The present invention is directed to compounds which inhibit prenyl-protein transferase and particularly, the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
摘要翻译： 本发明涉及抑制异戊烯基 - 蛋白转移酶，特别是癌基因蛋白Ras的法呢基化的化合物。 本发明还涉及含有本发明化合物的化疗组合物和抑制法呢基蛋白转移酶的方法和癌基因蛋白Ras的法呢基化。
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公开(公告)号：US06127366A
公开(公告)日：2000-10-03
申请号：US166271
申请日：1998-10-05
IPC分类号： C07D233/24 , C07D401/12 , A61K31/535 , C07D413/06
CPC分类号： C07D401/12 , C07D233/24
摘要： The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the famesylation of the oncogene protein Ras.
摘要翻译： 本发明涉及抑制法呢基蛋白转移酶（FTase）和致癌基因蛋白Ras的法呢基化的化合物。 本发明进一步涉及含有本发明化合物的化疗组合物和抑制法呢基蛋白转移酶的方法和癌基因蛋白Ras的甲酰化。
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公开(公告)号：US5817678A
公开(公告)日：1998-10-06
申请号：US749254
申请日：1996-11-15
IPC分类号： C07D233/24 , C07D401/12 , A61K31/445
CPC分类号： C07D233/24 , C07D401/12
摘要： The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
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公开(公告)号：US06413964B1
公开(公告)日：2002-07-02
申请号：US09757213
申请日：2001-01-09
IPC分类号： A61K3155
CPC分类号： C07D515/08
摘要： The present invention is directed to peptidomimetic macrocyclic compounds of the formula A: wherein W is a heterocycle, V is a heterocycle or aryl moiety and Z1 is a suitably substituted aryl or heterocycle moiety. The instant compounds inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.
摘要翻译： 本发明涉及式A的拟肽大环化合物：其中W是杂环，V是杂环或芳基，Z1是适当取代的芳基或杂环部分。 本发明化合物抑制异戊烯基 - 蛋白质转移酶和癌基因蛋白Ras的异戊烯化。 本发明还涉及含有本发明化合物的化疗组合物和抑制异戊烯基 - 蛋白质转移酶和癌基因蛋白Ras的异戊烯化的方法。
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公开(公告)号：US06350755B1
公开(公告)日：2002-02-26
申请号：US09757218
申请日：2001-01-09
申请人： S. Jane deSolms , Anthony W. Shaw
发明人： S. Jane deSolms , Anthony W. Shaw
IPC分类号： A61P3500
CPC分类号： C07D498/18 , C07D515/18
摘要： The present invention is directed to peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.
摘要翻译： 本发明涉及抑制异戊烯基 - 蛋白转移酶和致癌基因蛋白Ras的异戊烯化的拟肽大环化合物。 本发明还涉及含有本发明化合物的化疗组合物和抑制异戊烯基 - 蛋白质转移酶和癌基因蛋白Ras的异戊烯化的方法。
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公开(公告)号：US06566385B2
公开(公告)日：2003-05-20
申请号：US09757217
申请日：2001-01-09
IPC分类号： A61K314178
CPC分类号： C07D405/04 , C07D413/04
摘要： The present invention is directed to peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.
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公开(公告)号：US06297239B1
公开(公告)日：2001-10-02
申请号：US09167180
申请日：1998-10-06
申请人： S. Jane deSolms , John H. Hutchinson , Anthony W. Shaw , Samuel L. Graham , Terrence M. Ciccarone
发明人： S. Jane deSolms , John H. Hutchinson , Anthony W. Shaw , Samuel L. Graham , Terrence M. Ciccarone
IPC分类号： A61K314174
CPC分类号： C07D233/64 , C07D231/12 , C07D233/56 , C07D233/90 , C07D249/08 , C07D401/12
摘要： The present invention is directed to compounds which inhibit a prenyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting a prenyl-protein transferase and the prenylation of the oncogene protein Ras.
摘要翻译： 本发明涉及抑制异戊烯基 - 蛋白转移酶（FTase）和癌基因蛋白Ras的法呢基化的化合物。 本发明还涉及含有本发明化合物的化学治疗组合物和抑制异戊烯基 - 蛋白质转移酶和致癌基因蛋白Ras的异戊烯基化的方法。
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