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公开(公告)号：US11584950B2
公开(公告)日：2023-02-21
申请号：US16705941
申请日：2019-12-06
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Joseph Joel Pollak , Daniel Levner , Yonatan Bilu , Arnon Houri Yafin , Noam Yorav-Raphael , Yuval Greenfield
Abstract: Apparatus and methods for use with a blood sample are described. The blood sample is stained with Hoechst stain and Acridine Orange stain. A plurality of images of the blood sample are acquired. An object is identified as being a white blood cell candidate. A first stained area, which is stained by the Hoechst stain and which is disposed within the white blood cell candidate, is identified. A second stained area, which is stained by the Acridine Orange stain and which is disposed within the white blood cell candidate, is identified. A white blood cell is detected by determining that structural features of the stained areas satisfy predetermined criteria associated with a white blood cell. Other applications are also described.
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公开(公告)号：US10831013B2
公开(公告)日：2020-11-10
申请号：US14914329
申请日：2014-08-26
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Noam Yorav Raphael , Yuval Greenfield , Joseph Joel Pollak , Yonatan Bilu
Abstract: Methods, systems and computer program products relating to digital microscopy are disclosed. A digital microscopy method may comprise capturing a plurality of overlapping images of a sample, wherein the capturing of at least one of the plurality of images is performed while the sample and a focal plane are in relative motion along an optical axis at a speed greater than zero; and processing the plurality of images using a reference criterion to determine a reference relative arrangement of the focal plane and the sample along the optical axis.
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公开(公告)号：US11803964B2
公开(公告)日：2023-10-31
申请号：US17576023
申请日：2022-01-14
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yuval Greenfield , Yonatan Bilu , Joseph Joel Pollak , Noam Yorav-Raphael
CPC classification number: G06T7/0012 , G02B7/38 , G02B21/16 , G02B21/244 , G02B21/361 , G02B21/367 , G06T7/507 , G06T2207/10056 , G06T2207/30024
Abstract: Apparatus and methods are described for use with a cell sample that includes a plurality of cells disposed in a monolayer. A series of images associated with a series of depth levels of the cell sample are acquired, by performing a depth scan of cell sample with a microscope. One of the depth levels is identified as being an optimum focal plane for imaging one or more entities within the cell sample using the microscope, by identifying that a drop in image contrast occurs at the identified depth level relative to the image contrast of images acquired at depth levels within a given range of distances from the identified depth level. The cell sample is imaged using the microscope, by focusing the microscope at an investigative depth level that is based on the identified depth level. Other applications are also described.
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Patent Agency Ranking
公开(公告)号：US11100634B2
公开(公告)日：2021-08-24
申请号：US16232124
申请日：2018-12-26
Applicant: S.D. SIGHT DIAGNOSTICS LTD.
Inventor： Yuval Greenfield , Yonatan Bilu , Joseph Joel Pollak , Noam Yorav-Raphael
Abstract: Apparatus and methods are described for use with a cell sample. For each of one or more imaging fields of the cell sample, a depth scan of the cell sample is performed using a microscope. One of the depth levels is identified as being an optimum focal plane for imaging one or more entities within the sample using the microscope, at least partially in response to detecting that the depth level corresponds to a drop in image contrast relative to image contrast at other depth levels. Based upon the depth level identified as being the optimum focal plane for each of the one or more imaging fields of the cell sample, a scanning depth interval over which to perform a depth scan of the cell sample at a further imaging field is defined. Other applications are also described.
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公开(公告)号：US10176565B2
公开(公告)日：2019-01-08
申请号：US14285672
申请日：2014-05-23
Applicant: S.D. SIGHT DIAGNOSTICS LTD.
Inventor： Yuval Greenfield , Yonatan Bilu , Joseph Joel Pollak , Noam Yorav-Raphael
Abstract: The present disclosure provides a method of determining a reference depth level within a cell sample. The method comprises obtaining data representative of a series of images captured by performing a depth scan of the cell sample using a digital microscope, the series of images being associated with a series of depth levels of the cell sample; processing said data for detecting at least one depth level corresponding to a drop in image contrast; and identifying the detected depth level as the reference depth level.
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公开(公告)号：US11295440B2
公开(公告)日：2022-04-05
申请号：US16706159
申请日：2019-12-06
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yuval Greenfield , Yonatan Bilu , Joseph Joel Pollak , Noam Yorav-Raphael
Abstract: Apparatus and methods are described for use with a sample that includes a plurality of red blood cells. A series of images associated with a series of depth levels of the sample are acquired, by performing a depth scan of the sample with a microscope. One of the depth levels is identified as being an optimum focal plane for imaging one or more entities within the sample using the microscope, by identifying that a drop in image contrast occurs at the identified depth level. The sample is imaged using the microscope, by focusing the microscope at an investigative depth level that is based on the identified depth level. Other applications are also described.
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公开(公告)号：US20200181680A1
公开(公告)日：2020-06-11
申请号：US16705941
申请日：2019-12-06
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Joseph Joel Pollak , Daniel Levner , Yonatan Bilu , Arnon Houri Yafin , Noam Yorav-Raphael , Yuval Greenfield
Abstract: Apparatus and methods for use with a blood sample are described. The blood sample is stained with Hoechst stain and Acridine Orange stain. A plurality of images of the blood sample are acquired. An object is identified as being a white blood cell candidate. A first stained area, which is stained by the Hoechst stain and which is disposed within the white blood cell candidate, is identified. A second stained area, which is stained by the Acridine Orange stain and which is disposed within the white blood cell candidate, is identified. A white blood cell is detected by determining that structural features of the stained areas satisfy predetermined criteria associated with a white blood cell. Other applications are also described.
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公开(公告)号：US20190130567A1
公开(公告)日：2019-05-02
申请号：US16232124
申请日：2018-12-26
Applicant: S.D. SIGHT DIAGNOSTICS LTD.
Inventor： Yuval Greenfield , Yonatan Bilu , Joseph Joel Pollak , Noam Yorav-Raphael
Abstract: Apparatus and methods are described for use with a cell sample. For each of one or more imaging fields of the cell sample, a depth scan of the cell sample is performed using a microscope. One of the depth levels is identified as being an optimum focal plane for imaging one or more entities within the sample using the microscope, at least partially in response to detecting that the depth level corresponds to a drop in image contrast relative to image contrast at other depth levels. Based upon the depth level identified as being the optimum focal plane for each of the one or more imaging fields of the cell sample, a scanning depth interval over which to perform a depth scan of the cell sample at a further imaging field is defined. Other applications are also described.
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