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    Sample carrier for microscopy measurements
    5.
    发明授权
    Sample carrier for microscopy measurements 有权

    公开(公告)号：US11614609B2

    公开(公告)日：2023-03-28

    申请号：US17083659

    申请日：2020-10-29

    Applicant: S.D. Sight Diagnostics Ltd.

    Inventor： Noam Yorav-Raphael ,  Joseph Joel Pollak ,  Sarah Levy Schreier ,  Yochay Shlomo Eshel

    IPC: G01N21/64 ,  G02B21/00 ,  G02B21/36

    Abstract: Apparatus and methods for determining a property of a bodily sample using a microscope are described. A sample carrier includes a plurality of microscopy sample chambers configured to receive a least a portion of the bodily sample, while the sample is imaged by the microscope. Each of the microscopy sample chambers has an upper and a lower surface, and the microscopy sample chambers have respective heights between the upper and lower surfaces that are different from each other. The sample carrier defines a microscopy sample chamber inlet hole, that is fluid communication with all of the microscopy sample chambers, such as to facilitate filling of all of the microscopy sample chambers with the portion of the bodily sample, via the microscopy sample chamber inlet hole. Other applications are also described.

    Sample carrier for microscopy and optical density measurements
    6.
    发明授权
    Sample carrier for microscopy and optical density measurements 有权

    公开(公告)号：US11609413B2

    公开(公告)日：2023-03-21

    申请号：US17083775

    申请日：2020-10-29

    Applicant: S.D. Sight Diagnostics Ltd.

    Inventor： Noam Yorav-Raphael ,  Joseph Joel Pollak ,  Sarah Levy Schreier ,  Yochay Shlomo Eshel

    IPC: G02B21/00 ,  G01N21/64 ,  G02B21/36

    Abstract: Apparatus and methods are described for determining a property of a bodily sample using a microscope and optical-density-measurement apparatus, the apparatus including a sample carrier that includes a plurality of microscopy sample chambers configured to receive a first portion of the sample and to facilitate imaging of the first portion of the sample by the microscope, each of the microscopy sample chambers having an upper and a lower surface, and having respective heights between the upper and lower surfaces that are different from each other. The sample carrier includes at least one optical-density-measurement chamber configured to receive a second portion of the sample, and to facilitate optical density measurements being performed optical-density-measurement apparatus upon the second portion of the sample. Other applications are also described.

    CLASSIFICATION MODELS FOR ANALYZING A SAMPLE
    7.
    发明申请
    CLASSIFICATION MODELS FOR ANALYZING A SAMPLE 有权

    公开(公告)号：US20230026108A1

    公开(公告)日：2023-01-26

    申请号：US17783839

    申请日：2020-12-10

    Applicant: S.D. SIGHT DIAGNOSTICS LTD

    Inventor： Amir ZAIT ,  Dan GLUCK ,  Arnon HOURI YAFIN ,  David BRAILOVSKY ,  Yochay Shlomo ESHEL ,  Sarah LEVY ,  Joseph Joel POLLAK

    IPC: G06V20/69 ,  G06T7/00

    Abstract: Apparatus and methods are described including analyzing one or more microscopic images of the blood sample using a machine-learning classifier. An entity within the one or more microscopic images is identified using a first classification model, and a first estimated concentration of the entity within the sample is determined, based upon the entity as identified using the first classification model. The entity is identified within the one or more microscopic images using a second classification model, and a second estimated concentration of the entity within the sample is determined, based upon the entity as identified using the second classification model. The first and second estimated concentrations are compared to each other, and, in response to the comparison, a hybrid classification model that is a hybrid of the first and second classification models is used. Other applications are also described.

    METHOD AND SYSTEM FOR IMAGING A CELL SAMPLE
    8.
    发明申请
    METHOD AND SYSTEM FOR IMAGING A CELL SAMPLE 有权

    公开(公告)号：US20220138944A1

    公开(公告)日：2022-05-05

    申请号：US17576023

    申请日：2022-01-14

    Applicant: S.D. Sight Diagnostics Ltd.

    Inventor： Yuval GREENFIELD ,  Yonatan BILU ,  Joseph Joel POLLAK ,  Noam YORAV-RAPHAEL

    IPC: G06T7/00 ,  G02B7/38 ,  G02B21/24 ,  G06T7/507 ,  G02B21/16 ,  G02B21/36

    Abstract: Apparatus and methods are described for use with a cell sample that includes a plurality of cells disposed in a monolayer. A series of images associated with a series of depth levels of the cell sample are acquired, by performing a depth scan of cell sample with a microscope. One of the depth levels is identified as being an optimum focal plane for imaging one or more entities within the cell sample using the microscope, by identifying that a drop in image contrast occurs at the identified depth level relative to the image contrast of images acquired at depth levels within a given range of distances from the identified depth level. The cell sample is imaged using the microscope, by focusing the microscope at an investigative depth level that is based on the identified depth level. Other applications are also described.

    Sample carrier for optical measurements
    9.
    发明授权
    Sample carrier for optical measurements 有权

    公开(公告)号：US11307196B2

    公开(公告)日：2022-04-19

    申请号：US16098893

    申请日：2017-05-11

    Applicant: S.D. SIGHT DIAGNOSTICS LTD.

    Inventor： Joseph Joel Pollak ,  Sarah Levy Schreier ,  Yochay Shlomo Eshel ,  Amir Zait ,  Sharon Pecker ,  Trevor Ruggiero

    IPC: G01N33/50 ,  G01N21/31 ,  G01N21/59 ,  G01N21/64 ,  G01N21/03

    Abstract: Apparatus and methods are described for determining a property of a biological sample. A sample carrier (22) includes one or more sample chambers (40) that define at least a first region (42) and a second region (44), the height of the one or more sample chambers varying between the first and second regions in a predefined manner. A computer processor (28) receives data relating to a first optical measurement that is performed upon a portion of the sample that is disposed within the first region, receives data relating to a second optical measurement that is performed upon a portion of the sample that is disposed within the second region, and determines the property of the sample by using a relationship between the first optical measurement, the second optical measurement, and the predefined variation in height between the regions. Other applications are also described.

    SAMPLE CARRIER FOR OPTICAL MEASUREMENTS
    10.
    发明申请
    SAMPLE CARRIER FOR OPTICAL MEASUREMENTS 有权

    公开(公告)号：US20210072226A1

    公开(公告)日：2021-03-11

    申请号：US17082483

    申请日：2020-10-28

    Applicant: S.D. SIGHT DIAGNOSTICS LTD.

    Inventor： Joseph Joel Pollak ,  Sarah Levy Schreier ,  Yochay Shlomo Eshel ,  Amir Zait ,  Sharon Pecker ,  Trevor Ruggiero

    IPC: G01N33/50 ,  G01N21/31 ,  G01N21/59 ,  G01N21/64 ,  G01N21/03

    Abstract: Apparatus and methods are described including placing a sample into a sample carrier that comprises a plurality of regions having upper and lower surfaces, having respective heights that are different from each other, and being configured such that cells form a monolayer, the monolayer within respective regions of the sample carrier having respective, different densities from each other, due to the respective regions of the sample carrier having respective heights that are different from each other. Microscopic images are acquired of each of the plurality of regions. Measurements are performed upon cell types that have a relatively high density upon microscopic images of a region of the sample chamber having a relatively low height, and measurements are performed upon cell types that have a relatively low density upon microscopic images of a region of the sample chamber having a relatively great height. Other applications are also described.

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