公开(公告)号：US10968231B2

公开(公告)日：2021-04-06

申请号：US16497141

申请日：2018-03-29

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED ,  SCOHIA PHARMA, INC

Inventor： Seiji Miwatashi ,  Yasufumi Miyamoto ,  Koji Watanabe ,  Yayoi Nakayama ,  Yuko Hitomi ,  Jumpei Aida ,  Nobuyuki Takakura ,  Hideki Furukawa ,  Naoyoshi Noguchi ,  Yasuhiro Hirata ,  Shizuo Kasai ,  Toshitake Kobayashi ,  Tsuyoshi Maekawa ,  Satoshi Sasaki ,  Shigemitsu Matsumoto

IPC: C07D491/052 ,  C07D211/22 ,  C07D401/12 ,  C07D401/14

Abstract: Provided is a novel aromatic ring compound which may have a GPR40 agonist activity and a GLP-1 secretagogue action. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof may have a GPR40 agonist activity and a GLP-1 secretagogue action, may be useful for the prophylaxis or treatment of cancer, obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia and the like, and may afford superior efficacy.

公开(公告)号：US11518763B2

公开(公告)日：2022-12-06

申请号：US17299659

申请日：2019-12-04

Applicant: SCOHIA PHARMA, INC.

Inventor： Shigemitsu Matsumoto ,  Ryoma Hara ,  Naoyoshi Noguchi ,  Hideto Fukushi ,  Ayumu Niida ,  Satoshi Sasaki ,  Minoru Ikoma ,  Toshitake Kobayashi ,  Tsuyoshi Maekawa

IPC: C07D471/18 ,  C07D491/22 ,  C07D498/16 ,  C07D498/22

Abstract: A compound represented by the following formula (I): wherein each symbol in the formula is as described herein or a salt thereof has an NRF2 activating activity, and is expected to be useful as a preventive or therapeutic agent for diseases associated with oxidative stress, in particular, hepatic disease (for example, non-alcoholic steatohepatitis (NASH)), cardiovascular disease (for example, heart failure or pulmonary arterial hypertension), lung disease (for example, chronic obstructive pulmonary disease (COPD)), kidney disease (for example, chronic kidney disease (CKD) or acute kidney injury (AKI)), central nervous system disease (for example, Parkinson's disease), mitochondrial disease (for example, Friedreich motor ataxia, mitochondrial myopathy), inflammatory disease (for example, multiple sclerosis (MS), inflammatory bowel disease (IBD)), sickle cell disease, cancer, or the like.