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公开(公告)号：US10968231B2
公开(公告)日：2021-04-06
申请号：US16497141
申请日：2018-03-29
发明人： Seiji Miwatashi , Yasufumi Miyamoto , Koji Watanabe , Yayoi Nakayama , Yuko Hitomi , Jumpei Aida , Nobuyuki Takakura , Hideki Furukawa , Naoyoshi Noguchi , Yasuhiro Hirata , Shizuo Kasai , Toshitake Kobayashi , Tsuyoshi Maekawa , Satoshi Sasaki , Shigemitsu Matsumoto
IPC分类号： C07D491/052 , C07D211/22 , C07D401/12 , C07D401/14
摘要： Provided is a novel aromatic ring compound which may have a GPR40 agonist activity and a GLP-1 secretagogue action. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof may have a GPR40 agonist activity and a GLP-1 secretagogue action, may be useful for the prophylaxis or treatment of cancer, obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia and the like, and may afford superior efficacy.
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公开(公告)号：US09365540B2
公开(公告)日：2016-06-14
申请号：US14371824
申请日：2013-01-11
发明人： Shizuo Kasai , Hideyuki Igawa , Masashi Takahashi , Tsuyoshi Maekawa , Keiko Kakegawa , Asato Kina , Jumpei Aida , Uttam Khamrai , Mrinalkanti Kundu
IPC分类号： C07D471/04 , C07D409/14 , C07D405/14 , C07D403/14 , C07D413/14 , C07D401/14 , C07D401/04 , C07D417/14
CPC分类号： C07D401/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The present invention provides an aromatic ring compound having a melanin-concentrating hormone receptor antagonistic action and useful as an agent for the prophylaxis or treatment of obesity and the like. The present invention relates to a compound represented by the formula wherein each symbol as defined in the specification, or a salt thereof.
摘要翻译： 本发明提供具有黑色素浓缩激素受体拮抗作用的芳香环化合物，可用作预防或治疗肥胖症等的药剂。 本发明涉及由下式表示的化合物或其盐，其中每个符号如本说明书中所定义。
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公开(公告)号：US10807987B2
公开(公告)日：2020-10-20
申请号：US16366710
申请日：2019-03-27
发明人： Yuya Oguro , Shigemitsu Matsumoto , Takeshi Wakabayashi , Norihito Tokunaga , Taku Kamei , Mitsuhiro Ito , Satoshi Mikami , Masaki Seto , Shinji Morimoto , Shinji Nakamura , Sachie Takashima , Masataka Murakami , Masaki Daini , Makoto Kamata , Minoru Nakamura , Yasufumi Wada , Hiroyuki Kakei , Kazuaki Takami , Taisuke Tawaraishi , Jumpei Aida , Kouichi Iwanaga , Satoshi Yamamoto
IPC分类号： C07D487/04 , A61K9/20 , A61K9/48 , C07D471/04 , A61P25/00
摘要： The present invention provides a heterocyclic compound having an antagonistic action on an NMDA receptor containing the NR2B subunit, and expected to be useful as an agent for the prophylaxis or treatment of major depression, bipolar disorder, migraine, pain, behavioral and psychological symptoms of dementia and the like.The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the description, or a salt thereof.
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公开(公告)号：US10106556B2
公开(公告)日：2018-10-23
申请号：US15563161
申请日：2016-03-29
发明人： Shuhei Ikeda , Tatsuki Koike , Jumpei Aida , Makoto Fushimi , Tomokazu Kusumoto , Hideyuki Sugiyama , Masako Miyazaki , Hidekazu Tokuhara , Yasushi Hattori , Makoto Kamata
IPC分类号： C07D498/04 , C07D413/14 , C07D401/06 , C07D413/06 , C07D417/14 , C07D471/04 , C07D401/10 , C07D413/10 , C12N9/99 , A61K31/454 , A61K31/4709 , A61K31/538 , A61K31/5383
摘要： The present invention provides a compound having an MAGL inhibitory action, which is expected to be useful as an agent for the prophylaxis or treatment of neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, traumatic brain injury, glaucoma, multiple sclerosis etc.), anxiety disorder, pains (e.g., inflammatory pain, cancerous pain, neurogenic pain etc.), epilepsy, depression and the like.The present invention relates a compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof.
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公开(公告)号：US11702419B2
公开(公告)日：2023-07-18
申请号：US17201878
申请日：2021-03-15
发明人： Yuya Oguro , Shigemitsu Matsumoto , Takeshi Wakabayashi , Norihito Tokunaga , Taku Kamei , Mitsuhiro Ito , Satoshi Mikami , Masaki Seto , Shinji Morimoto , Shinji Nakamura , Sachie Takashima , Masataka Murakami , Masaki Daini , Makoto Kamata , Minoru Nakamura , Yasufumi Wada , Hiroyuki Kakei , Kazuaki Takami , Taisuke Tawaraishi , Jumpei Aida , Kouichi Iwanaga , Satoshi Yamamoto
IPC分类号： C07D487/04 , A61K9/20 , A61K9/48 , C07D471/04 , A61P25/00
CPC分类号： C07D487/04 , A61K9/2095 , A61K9/4833 , A61P25/00 , C07D471/04
摘要： The present invention provides a heterocyclic compound having an antagonistic action on an NMDA receptor containing the NR2B subunit, and expected to be useful as an agent for the prophylaxis or treatment of major depression, bipolar disorder, migraine, pain, behavioral and psychological symptoms of dementia and the like.
The present invention relates to a compound represented by the formula (I):
wherein each symbol is as described in the description, or a salt thereof.-
6.发明授权公开(公告)号：US09624170B2
公开(公告)日：2017-04-18
申请号：US15108000
申请日：2014-12-25
发明人： Tatsuki Koike , Makoto Fushimi , Jumpei Aida , Shuhei Ikeda , Tomokazu Kusumoto , Hideyuki Sugiyama , Hidekazu Tokuhara
IPC分类号： C07D207/273 , C07D401/12 , C07D403/12 , C07D403/14 , C07D409/12 , C07D471/04 , C07D405/12 , C07D417/14 , C07D417/12 , C07D413/12 , C07D403/04 , C07D401/14
CPC分类号： C07D207/273 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention aims to provide a compound having an MAGL inhibitory action, and useful as a prophylactic or therapeutic agent for neurodegenerative diseases (e.g., Alzheimer's disease, Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis, traumatic brain injury, glaucoma, multiple sclerosis and the like), anxiety disorder, pain (e.g., inflammatory pain, carcinomatous pain, nervous pain and the like), epilepsy and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.
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公开(公告)号：US09199963B2
公开(公告)日：2015-12-01
申请号：US14325564
申请日：2014-07-08
发明人： Hideyuki Igawa , Masashi Takahashi , Keiko Kakegawa , Minoru Ikoma , Jumpei Aida
IPC分类号： C07D401/00 , A61K31/4965 , C07D401/04 , C07D401/14 , C07D409/14 , C07D417/14 , C07D405/14
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： Provided is a compound having a melanin-concentrating hormone receptor antagonistic action and is useful as an agent for the prophylaxis or treatment of obesity and the like. A compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
摘要翻译： 提供具有黑色素浓集激素受体拮抗作用的化合物，并且可用作预防或治疗肥胖症等的药剂。 由式（I）表示的化合物或其盐，其中每个符号如说明书中所定义。
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公开(公告)号：US11186565B2
公开(公告)日：2021-11-30
申请号：US16499432
申请日：2018-03-29
发明人： Seiji Miwatashi , Yasufumi Miyamoto , Koji Watanabe , Yayoi Nakayama , Yuko Hitomi , Jumpei Aida , Nobuyuki Takakura , Hideki Furukawa , Naoyoshi Noguchi , Yasuhiro Hirata , Kazuaki Takami , Norihito Tokunaga , Tomohiro Okawa , Akito Shibuya , Shizuo Kasai , Toshitake Kobayashi , Tsuyoshi Maekawa
IPC分类号： C07D401/12 , C07C59/72 , C07D211/22 , C07D213/64 , C07D401/10 , C07D401/14 , C07D413/10
摘要： Provided is a novel aromatic ring compound which may have a GPR40 agonist activity and a GLP-1 secretagogue action. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof may have a GPR40 agonist activity and a GLP-1 secretagogue action, may be useful for the prophylaxis or treatment of cancer, obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia and the like, and may afford superior efficacy.
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公开(公告)号：US10323026B2
公开(公告)日：2019-06-18
申请号：US15474192
申请日：2017-03-30
发明人： Shuhei Ikeda , Hideyuki Sugiyama , Jumpei Aida , Hidekazu Tokuhara , Tomohiro Okawa , Yuya Oguro , Minoru Nakamura , Masataka Murakami
IPC分类号： C07D413/14 , C07D401/08 , C07D405/14 , C07D413/08 , C07D401/06 , C07D413/06
摘要： The present invention provides a compound having an MAGL inhibitory action, and useful as an agent for the prophylaxis or treatment of neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, traumatic brain injury, glaucoma, multiple sclerosis etc.), anxiety disorder, pains (e.g., inflammatory pain, cancerous pain, neurogenic pain etc.), epilepsy, depression and the like.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
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公开(公告)号：US09776962B2
公开(公告)日：2017-10-03
申请号：US14898633
申请日：2014-08-08
发明人： Jumpei Aida , Yayoi Yoshitomi , Yuko Hitomi , Naoyoshi Noguchi , Yasuhiro Hirata , Hideki Furukawa , Akito Shibuya , Koji Watanabe , Yasufumi Miyamoto , Tomohiro Okawa , Nobuyuki Takakura , Seiji Miwatashi
IPC分类号： C07D211/34 , C07D211/22 , C07D213/30 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/10 , C07D413/14
CPC分类号： C07D211/34 , C07D211/22 , C07D213/30 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/10 , C07D413/14
摘要： Provided is a novel aromatic ring compound having a GPR40 agonist activity and a GLP-1 secretagogue action. A compound represented by the formula: wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a GPR40 agonist activity and a GLP-1 secretagogue action, is useful for the prophylaxis or treatment of cancer, obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia and the like, and affords superior efficacy.
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